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1. 发明申请

WO2008128951A1 OXADIAZOLE SUBSTITUTED INDAZOLE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE (S1P) AGONISTS 审中-公开
标题翻译：用作磷酸1-磷酸（S1P）激动剂的奥氮唑取代的吲哚衍生物
公开(公告)号：WO2008128951A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054647
申请日：2008-04-17
申请人： GLAXO GROUP LIMITED , AHMED, Mahmood , GIBLIN, Gerard, Martin, Paul , MYATT, James , NORTON, David , RIVERS, Dean, Andrew
发明人： AHMED, Mahmood , GIBLIN, Gerard, Martin, Paul , MYATT, James , NORTON, David , RIVERS, Dean, Andrew
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4245 , A61P37/00
CPC分类号： C07D413/14 , C07D413/04
摘要： The present invention provides compounds of formula (I) or salts thereof, having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated by S1P1 receptors.
摘要翻译：本发明提供具有药理活性的式（I）化合物或其盐，其制备方法，含有它们的药物组合物及其在治疗由S1P1受体介导的各种疾病中的用途。

2. 发明申请

WO2008074820A1 OXADIAZOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS 审中-公开
标题翻译： OXADIAZOLE衍生物作为S1P1受体激动剂
公开(公告)号：WO2008074820A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064181
申请日：2007-12-19
申请人： GLAXO GROUP LIMITED , AHMED, Mahmood , MYATT, James , NORTON, David , RIVERS, Dean, Andrew
发明人： AHMED, Mahmood , MYATT, James , NORTON, David , RIVERS, Dean, Andrew
IPC分类号： C07D413/10 , C07D413/14 , A61K31/4245 , A61P37/00
CPC分类号： C07D413/14 , C07D413/10
摘要： The present invention relates to novel oxadiazole compounds of formula (I) having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译：本发明涉及具有药理学活性的式（I）的恶二唑化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。

3. 发明申请

WO2008074821A1 INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS 审中-公开
标题翻译：作为S1P1受体激动剂的吲哚衍生物
公开(公告)号：WO2008074821A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064185
申请日：2007-12-19
申请人： GLAXO GROUP LIMITED , AHMED, Mahmood , MYATT, James , NORTON, David , RIVERS, Dean, Andrew
发明人： AHMED, Mahmood , MYATT, James , NORTON, David , RIVERS, Dean, Andrew
IPC分类号： C07D413/04 , C07D413/14 , A61K31/405 , A61P37/00
CPC分类号： C07D413/14 , C07D413/04
摘要： The invention relates to compounds of formula (I) wherein one of R 5 and R 6 is hydrogen or R 2 and the other is (a) processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or disorders which are mediated via the S1P1 receptor.
摘要翻译：本发明涉及式（I）化合物，其中R 5和R 6中的一个是氢或R 2，另一个是（a ）制备方法，含有它们的药物组合物及其在治疗通过S1P1受体介导的病症或病症中的用途。

4. 发明申请

WO2009050227A1 PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION 审中-公开
标题翻译：抑制β-淀粉样肽生产的吡啶衍生物
公开(公告)号：WO2009050227A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063950
申请日：2008-10-16
申请人： GLAXO GROUP LIMITED , EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , HALL, Adrian , JOHNSON, Matthew, Russell , LE, Joelle , MITCHELL, William, Leonard , MYATT, James , NORTON, David , PRICE, Helen, Susanne
发明人： EATHERTON, Andrew, John , GIBLIN, Gerard, Martin, Paul , HALL, Adrian , JOHNSON, Matthew, Russell , LE, Joelle , MITCHELL, William, Leonard , MYATT, James , NORTON, David , PRICE, Helen, Susanne
IPC分类号： C07D403/10 , A61K31/501
CPC分类号： C07D403/10
摘要： The present invention relates to novel compounds that inhibit the production of β- amyloid peptide (1-42), processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
摘要翻译：本发明涉及抑制β-淀粉样蛋白肽（1-42）的制备，其制备方法，含有它们的组合物及其用于治疗特征在于β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。

5. 发明申请

WO2010007074A1 PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：吡咯并[1,5-A]吡啶衍生物
公开(公告)号：WO2010007074A1
公开(公告)日：2010-01-21
申请号：PCT/EP2009/059013
申请日：2009-07-15
申请人： GLAXO GROUP LIMITED , HEER, Jag, Paul , NORTON, David , WARD, Simon, E
发明人： HEER, Jag, Paul , NORTON, David , WARD, Simon, E
IPC分类号： C07D487/04 , A61K31/519 , A61P25/04
CPC分类号： C07D487/04
摘要： The present invention relates to novel piperazine derivatives; to processes for their preparation; to pharmaceutical compositions containing the derivatives; and to the use of the derivatives in therapy to treat diseases for which blocking the Ca v 2.2 calcium channels is beneficial.
摘要翻译：本发明涉及新的哌嗪衍生物; 进行准备; 含有该衍生物的药物组合物; 以及在治疗中使用衍生物治疗阻断Cav2.2钙通道有益的疾病。

6. 发明申请

WO2009071519A1 OXADIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS 审中-公开
标题翻译：奥沙利多衍生物及其作为非线性乙酰胆碱受体调节剂
公开(公告)号：WO2009071519A1
公开(公告)日：2009-06-11
申请号：PCT/EP2008/066567
申请日：2008-12-02
申请人： GLAXO GROUP LIMITED , NORTON, David , SKIDMORE, John , WARD, Robert, William , WILSON, David, Matthew
发明人： NORTON, David , SKIDMORE, John , WARD, Robert, William , WILSON, David, Matthew
IPC分类号： C07D271/113 , A61K31/4245 , A61P25/00
CPC分类号： C07D271/113
摘要： The present invention relates to novel oxadiazole derivatives as nAChR agonists having pharmacological activity, processes for their preparation, compositions containing them and their use in the treatment of neurological, psychiatric disorders and gastrointestinal disorders.
摘要翻译：本发明涉及新型恶二唑衍生物作为具有药理活性的nAChR激动剂，其制备方法，含有它们的组合物及其在治疗神经，精神疾病和胃肠道疾病中的用途。

7. 发明申请

WO2006136817A1 ELECTROSPINNING OF FIBRES 审中-公开
标题翻译：电纺丝
公开(公告)号：WO2006136817A1
公开(公告)日：2006-12-28
申请号：PCT/GB2006/002268
申请日：2006-06-20
申请人： THE UNIVERSITY OF SHEFFIELD , RYAN, Anthony, John , NORTON, David
发明人： RYAN, Anthony, John , NORTON, David
IPC分类号： D01D5/00
CPC分类号： D01D5/0092
摘要： A method for the production of an array of aligned fibres by electrospinning, which comprises forming a focused electrostatic field between a body having an orifice, maintained at a first electric potential, and a counter electrode, maintained at a second electric potential, the modulus of said second electric potential being greater than the modulus of said first electric potential, introducing a solution of a polymer in a volatile solvent into the electrostatic field through the orifice such that the polymer solution flows from the orifice towards the counter electrode in the form of a charged jet or stream, said jet or stream having a path length at least a portion of which is substantially straight, disposing a collector means in the path of the jet or stream at a position within the substantially straight portion thereof at which the solvent has evaporated sufficiently for the jet or stream to solidify, and moving the collector means relative to the jet or stream to deposit aligned fibres on the collector means.
摘要翻译：一种用于通过静电纺丝制备排列的纤维阵列的方法，其包括在维持在第一电位的具有孔口的主体和保持在第二电位的对电极之间形成聚焦的静电场，所述第二电位大于所述第一电位的模量，将聚合物在挥发性溶剂中的溶液通过所述孔引入静电场，使得所述聚合物溶液以所述孔的形式从所述孔向所述对电极流动所述射流或流具有其至少一部分基本上直的路径长度，将收集器装置设置在射流或物流的路径中，其位置处于溶剂蒸发的基本上直的部分内充分地使射流或流固化，并使收集器相对于射流或流移动以沉积对准 d纤维在收集器上。

8. 发明申请

WO2012080735A1 ASK1 INHIBITING PYRROLOPYRIMIDINE DERIVATIVES 审中-公开
标题翻译： ASK1抑制吡咯啉衍生物
公开(公告)号：WO2012080735A1
公开(公告)日：2012-06-21
申请号：PCT/GB2011/052484
申请日：2011-12-15
申请人： CONVERGENCE PHARMACEUTICALS LIMITED , WITTY, David R. , NORTON, David , TIERNEY, Jason Paul , LORTHIOIR, Ghislaine , SIME, Mairi , PHILPOTT, Karen Louise
发明人： WITTY, David R. , NORTON, David , TIERNEY, Jason Paul , LORTHIOIR, Ghislaine , SIME, Mairi , PHILPOTT, Karen Louise
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4523 , A61K31/519 , A61K31/5377 , C07D401/04 , C07D401/14
摘要： This invention relates to pyrrolopyrimidine derivatives of formula (I): where R 1 , X, p, R 4 , R 2 and R 3 are as defined herein, and their use as pharmaceuticals.
摘要翻译：本发明涉及式（I）的吡咯并嘧啶衍生物：其中R 1，X，p，R 4，R 2和R 3如本文所定义，及其作为药物的用途。

9. 发明申请

WO2011095809A1 DISINFECTANT MATERIALS AND METHODS 审中-公开
标题翻译：消毒材料与方法
公开(公告)号：WO2011095809A1
公开(公告)日：2011-08-11
申请号：PCT/GB2011/050180
申请日：2011-02-03
申请人： MAUVE TECHNOLOGY LTD. , NORTON, David
发明人： NORTON, David
IPC分类号： A01N59/06 , A01N59/08 , A61L2/18
CPC分类号： A01N59/08 , A01N59/00 , A01N59/06 , A61K33/20 , A01N25/02 , A01N37/04 , A01N37/36 , A01N2300/00
摘要： A disinfectant combination comprises a first supply of a water-soluble hypochlorite; and a second supply of at least one saturated, water-soluble, physiologically acceptable carboxylic acid in solution in an alcoholic solvent which comprises ethanol and optionally water. The combination is used in a method of disinfection, in which a dosed amount of the first supply is mixed with a dosed amount of the second supply to form a disinfectant in situ, and the resulting combined solution, optionally diluted with further water, is applied to a surface or article to be disinfected. In a preferred embodiment, the combination is used for disinfection of endoscopes.
摘要翻译：消毒剂组合包括第一次供应水溶性次氯酸盐; 以及在包含乙醇和任选的水的醇溶剂中在溶液中第二次供应至少一种饱和的，水溶性的生理上可接受的羧酸。该组合用于消毒方法，其中将第一供应量的剂量与定量量的第二供应物混合以原位形成消毒剂，并且将所得到的组合溶液任选地用另外的水稀释，到要消毒的表面或物品。在优选实施例中，该组合用于消毒内窥镜。

10. 发明申请

WO2011086377A1 PIPERAZINE DERIVATIVES FOR BLOCKING Cav2.2 CALCIUM CHANNELS 审中-公开
标题翻译：用于阻断Cav2.2钙通道的哌嗪衍生物
公开(公告)号：WO2011086377A1
公开(公告)日：2011-07-21
申请号：PCT/GB2011/050050
申请日：2011-01-14
申请人： CONVERGENCE PHARMACEUTICALS LIMITED , HEER, Jag Paul , CRIDLAND, Andrew Peter , NORTON, David
发明人： HEER, Jag Paul , CRIDLAND, Andrew Peter , NORTON, David
IPC分类号： A61K31/496 , C07D217/26 , C07D251/48 , C07D401/06 , A61P25/02 , A61P29/00
CPC分类号： C07D401/06 , A61K31/496 , C07D215/48 , C07D217/26 , C07D251/48
摘要： The present invention relates to novel piperazine compounds; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Ca v 2.2 calcium channels is beneficial and to treat diseases for which blocking the Ca v 2.2 and Ca v 3.2 calcium channels is beneficial, e.g. to treat pain.
摘要翻译：本发明涉及新型哌嗪化合物; 含有该化合物的药物组合物; 以及在治疗中使用化合物治疗阻断Cav2.2钙通道有益的疾病并治疗阻断Cav2.2和Cav3.2钙通道的疾病是有益的。治疗疼痛。

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