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    • 6. 发明申请
    • ARIPIPRAZOLE AND HALOPERIDOL PAMOATE SALTS
    • 阿维哌唑和哈罗哌糖酸钠盐
    • WO2005016261A2
    • 2005-02-24
    • PCT/US2004/024344
    • 2004-07-29
    • ALKERMES CONTROLLED THERAPEUTIC. IIGRECO, KristynWRIGHT, James
    • GRECO, KristynWRIGHT, James
    • A61K
    • C07D211/52A61K31/445
    • The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole.
    • 本发明涉及氟哌啶醇和阿立哌唑的双羟萘酸盐产生优异的长效和/或延长释放特征的发现。 因此,在本发明的一个方面,本发明包括氟哌啶醇或阿立哌唑的双羟萘酸盐。 优选地,双羟萘酸盐的特征在于氟哌啶醇与双羟萘酸的比例为1:1或2:1。 双羟萘酸盐可以是结晶的,例如针或致密晶体,如图中所述。 本发明还涉及治疗有需要的个体的方法,其包括施用包含氟哌啶醇和阿立哌唑的双羟萘酸盐的药物组合物。