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1. 发明申请

WO2007127976A3 PARTICLE BASED MOLDING 审中-公开
公开(公告)号：WO2007127976A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/067776
申请日：2007-04-30
申请人： GEORGIA TECH RESEARCH CORPORATION , PARK, Jung-hwan , ALLEN, Mark, G. , PRAUSNITZ, Mark, R.
发明人： PARK, Jung-hwan , ALLEN, Mark, G. , PRAUSNITZ, Mark, R.
IPC分类号： A61K9/14
摘要： Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold.

2. 发明申请

WO2009005568A1 METHODS AND APPARATUS FOR SURFACE ABLATION 审中-公开
标题翻译：表面消除的方法和装置
公开(公告)号：WO2009005568A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/006853
申请日：2008-05-30
申请人： GEORGIA TECH RESEARCH CORPORATION , PRAUSNITZ, Mark, R. , ALLEN, Mark, G. , PARK, Jung-Hwan , LEE, Jeong Woo , GADIRAJU, Priya, D.
发明人： PRAUSNITZ, Mark, R. , ALLEN, Mark, G. , PARK, Jung-Hwan , LEE, Jeong Woo , GADIRAJU, Priya, D.
IPC分类号： A61B18/14
CPC分类号： A61N1/327 , A61B18/14 , A61B2018/1213 , A61N1/0412 , A61N1/0428
摘要： The various embodiments of the present invention relate generally to methods and apparatus for surface ablation. More particularly, various embodiments of the present invention are related to methods and apparatus for ablation of barrier surfaces, such as skin, to increase the permeability of the barrier surface. Embodiments of the present invention comprise rapid thermo-mechanical ablation of the skin by a microfluidic jet generated by an arc discharge to produce micron-scale holes localized to the stratum corneum, which increases skin permeability.
摘要翻译：本发明的各种实施例一般涉及用于表面消融的方法和装置。更具体地，本发明的各种实施例涉及用于消除阻挡表面（例如皮肤）的方法和装置，以增加阻挡表面的渗透性。本发明的实施例包括通过由电弧放电产生的微流体射流对皮肤进行快速热机械消融，以产生定位于角质层的微米级孔，这增加了皮肤渗透性。

3. 发明申请

WO2007131050A2 METHOD FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE 审中-公开
标题翻译：使用MICRONEEDLE将药物递送至眼用组织的方法
公开(公告)号：WO2007131050A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/068055
申请日：2007-05-02
申请人： GEORGIA TECH RESEARCH CORPORATION , EMORY UNIVERSITY , PRAUSNITZ, Mark, R. , JIANG, Ninghao , EDELHAUSER, Henry, F.
发明人： PRAUSNITZ, Mark, R. , JIANG, Ninghao , EDELHAUSER, Henry, F.
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61M2037/0061
摘要： Methods and devices are provided for administering a drug to a patient's eye. The methods include (a) inserting a hollow microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma; and (b) infusing a fluid drug formulation through the microneedle and into the sclera or cornea. It further may include partially retracting the microneedle before infusion to enhance delivery. Alternatively, the methods may include (a) inserting a solid microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma, wherein the solid microneedle comprises a first quantity of a drug formulation and inserting causes the solid microneedle to form a pocket in the sclera or corneal stroma; and (b) releasing the drug formulation into the pocket to form a drug depot, whereby a drug is released from the depot. The methods and devices may include an array of multiple microneedles.
摘要翻译：提供了用于向患者的眼睛施用药物的方法和装置。所述方法包括（a）将中空微针插入巩膜或角膜基质中而不穿透巩膜或角膜基质; 和（b）将流体药物制剂通过微针注入巩膜或角膜。它还可以包括在输注之前部分缩回微针以增强递送。或者，所述方法可以包括（a）将固体微针插入巩膜或角膜基质中而不穿透巩膜或角膜基质，其中所述固体微针包含第一量的药物制剂并且插入导致固体微针形成口袋在巩膜或角膜基质中; 和（b）将药物制剂释放到口袋中以形成药物库，由此从药剂库释放药物。所述方法和装置可以包括多个微针的阵列。

4. 发明申请

WO2011139713A3 METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE 审中-公开
公开(公告)号：WO2011139713A3
公开(公告)日：2011-11-10
申请号：PCT/US2011/033987
申请日：2011-04-26
申请人： EMORY UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION , PRAUSNITZ, Mark, R. , EDELHAUSER, Henry, F. , PATEL, Samirkumar, Rajnikant
发明人： PRAUSNITZ, Mark, R. , EDELHAUSER, Henry, F. , PATEL, Samirkumar, Rajnikant
IPC分类号： A61M5/31 , A61M5/00
摘要： Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidai space of the eye, w herein the infused fluid drug formulation flow s w ithin the suprachoroidai space away from the insertion site during the infusion. The fluid drug formulation may How circumferentially tow ard the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.

5. 发明申请

WO2006128034A1 MICRONEEDLES AND METHODS FOR MICROINFUSION 审中-公开
标题翻译： MICROINFUSION的MICRONEEDLES和方法
公开(公告)号：WO2006128034A1
公开(公告)日：2006-11-30
申请号：PCT/US2006/020546
申请日：2006-05-25
申请人： GEORGIA TECH RESEARCH CORPORATION , WANG, Ping, M. , PRAUSNITZ, Mark, R. , MARTANTO, Wijaya
发明人： WANG, Ping, M. , PRAUSNITZ, Mark, R. , MARTANTO, Wijaya
IPC分类号： A61M37/00 , A61B17/20 , A61B10/00
CPC分类号： A61B17/205 , A61B10/0045 , A61B2010/008 , A61M37/0015 , A61M2037/003 , A61M2037/0061
摘要： Methods and devices are provided for delivering a drug to or withdrawing a fluid from a biological tissue, such the skin, sclera, cornea, and conjunctiva. One method includes the steps of inserting at least one microneedle into the biological tissue; partially retracting the at least one microneedle from the tissue; and then delivering at least one drug formulation into the biological tissue via the partially retracted at least one microneedle. The microneedle deforms and penetrates the biological tissue during the insertion step, and the retraction step at least partially relaxes the tissue deformation while maintaining at least part of the tissue penetration, facilitating drug delivery or fluid withdrawal.
摘要翻译：提供了用于将药物递送至生物组织（例如皮肤，巩膜，角膜和结膜）或从生物组织排出流体的方法和装置。一种方法包括将至少一个微针插入生物组织的步骤; 从所述组织部分地缩回所述至少一个微针; 然后经由部分缩回的至少一个微针将至少一种药物制剂递送到生物组织中。微针在插入步骤期间变形并渗透生物组织，并且缩回步骤至少部分地缓和组织变形，同时保持组织穿透的至少一部分，促进药物递送或液体抽出。

6. 发明申请

WO2005000382A3 DRILLING MICRONEEDLE DEVICE 审中-公开
公开(公告)号：WO2005000382A3
公开(公告)日：2005-01-06
申请号：PCT/US2004/017850
申请日：2004-06-04
申请人： GEORGIA TECH RESEARCH CORPORATION , WANG, Ping, Ming , PRAUSNITZ, Mark, R.
发明人： WANG, Ping, Ming , PRAUSNITZ, Mark, R.
IPC分类号： A61B5/15
摘要： Rotating microneedles and microneedle arrays are disclosed that “drill” holes into a biological barrier, such as skin. The holes can be of controlled depth and diameter and suitable for microsurgery, administering drugs and withdrawal of body fluids.

7. 发明申请

WO2009094394A1 MICRONEEDLE DEVICES AND METHODS OF DRUG DELIVERY OR FLUID WITHDRAWAL 审中-公开
标题翻译： MICRONEEDLE设备和药物递送或流体提取方法
公开(公告)号：WO2009094394A1
公开(公告)日：2009-07-30
申请号：PCT/US2009/031589
申请日：2009-01-21
申请人： GEORGIA TECH RESEARCH CORPORATION , PRAUSNITZ, Mark, R. , LEE, Jeong Woo
发明人： PRAUSNITZ, Mark, R. , LEE, Jeong Woo
IPC分类号： A61M5/162
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0053
摘要： Microneedle devices and methods of manufacture and use thereof are prov ided. The devices may be used in controlled delivery- of drug across or into a biological barrier, such as skin, or fluid withdrawal from a biological barrier. Tn one case, the device includes a base substrate which comprises a drug dispersed in a swelSable matrix materia]; and one or more microneedles extending from the base substrate, wherein the one or more microneedles comprise a water-soluble or water-swellabie material, wherein the one or more microneedles will dissolve or swell following insertion into the biological barrier, providing a transport pathway for the drug to pass from the base substrate into the biological barrier.
摘要翻译：微针装置及其制造方法和使用方法。这些装置可以用于药物的控制递送，穿过或进入生物屏障，例如皮肤，或从生物屏障中排出液体。在一种情况下，该装置包括基础基底，其包含分散在可膨胀的基质材料中的药物]; 以及一个或多个从所述基底基底延伸的微针，其中所述一个或多个微针包括水溶性或水溶胀材料，其中所述一个或多个微针在插入所述生物屏障之后会溶解或溶胀，从而提供用于该药物从基底层传递到生物屏障。

8. 发明申请

WO2008011625A3 MICRONEEDLE DEVICES AND METHODS OF DRUG DELIVERY OR FLUID WITHDRAWAL 审中-公开
公开(公告)号：WO2008011625A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/074123
申请日：2007-07-23
申请人： GEORGIA TECH RESEARH CORPORATION , PRAUSNITZ, Mark, R. , LEE, Jeong, Woo
发明人： PRAUSNITZ, Mark, R. , LEE, Jeong, Woo
IPC分类号： A61M5/00
摘要： Microneedle devices and methods of manufacture and use thereof are provided. In one embodiment, a device is provided for sustained delivery of drug across or into a biological barrier, such as skin. The device may include a base substrate which comprises a drug dispersed in a matrix material; and one or more microneedles extending from the base substrate, wherein the one or more microneedles comprise a water-soluble or water-swellable material, wherein the one or more microneedles will dissolve or swell following insertion into the biological barrier, providing a transport pathway for the drug to pass from the base substrate into the biological barrier.

9. 发明申请

WO2018204515A1 TARGETED DRUG DELIVERY METHODS USING A MICRONEEDLE 审中-公开
公开(公告)号：WO2018204515A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/030688
申请日：2018-05-02
申请人： GEORGIA TECH RESEARCH CORPORATION
发明人： JUNG, Jae, Hwan , PRAUSNITZ, Mark, R.
IPC分类号： A61K9/16 , A61P27/02
摘要： The present disclosure provides methods for administering formulations to the suprachoroidal space of the eye to achieve targeted drug delivery to a desired site of action within the eye. The methods include using a pushing formulation that includes a material such as a gel that expands due to physiochemical cues; or using an electric field to affect the movement of a formulation within the suprachoroidal space; or a combination of a pushing formulation with an electric field.

10. 发明申请

WO2016073410A1 METHODS OF USING MICRONEEDLE VACCINE FORMULATIONS TO ELICIT IN ANIMALS PROTECTIVE IMMUNITY AGAINST RABIES VIRUS 审中-公开
标题翻译：使用微生物疫苗制剂在动物实验中的方法对RABIES病毒的保护性免疫
公开(公告)号：WO2016073410A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/058725
申请日：2015-11-03
申请人： MERIAL, INC. , GEORGIA TECH RESEARCH CORPORATION
发明人： CHIANG, Yu-Wei , PRAUSNITZ, Mark, R. , DEWITT, Kristopher, Daniel , ARYA, Jaya
IPC分类号： A61K39/12 , A61B17/20 , A61B5/15
CPC分类号： A61K9/0021 , A61B5/150984 , A61B17/20 , A61B17/205 , A61K39/12 , A61K39/205 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/552 , A61M37/0015 , A61M2037/0046 , A61M2037/0061 , C12N7/00 , C12N2760/20034 , C12N2760/20134
摘要： The present invention relates to microneedle vaccine formulations, as well as methods of use thereof to provide animals, including canines, protective immunity against infection and disease caused by rabies viruses. Once placed onto the skin of the animals, the microneedle formulations dissolve quickly into the surrounding skin, where the antigens then elicit in the animals high and protective levels of rabies virus neutralizing antibodies.
摘要翻译：本发明涉及微针疫苗制剂，以及其用于提供动物，包括犬科动物的保护性免疫和由狂犬病病毒引起的疾病的方法。一旦放置在动物的皮肤上，微针制剂迅速溶解到周围的皮肤中，其中抗原然后在动物中引起高的保护水平的狂犬病病毒中和抗体。

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