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1. 发明申请

WO2003089476A1 CROSS-LINKED HYALURONATE COMPOUNDS 审中-公开
标题翻译：交联HYALENONATE化合物
公开(公告)号：WO2003089476A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/011830
申请日：2003-04-17
申请人： GENZYME CORPORATION , CALIAS, Pericles , GIANOLIO, Diego, A. , MILLER, Robert, J.
发明人： CALIAS, Pericles , GIANOLIO, Diego, A. , MILLER, Robert, J.
IPC分类号： C08B37/00
CPC分类号： C07D203/04 , C08B37/0072
摘要： There is disclosed a cross-linked hyaluronate compound obtained by reacting a sodium hyaluronate compound with a polyfunctional aziridine compound as a cross-linking agent. The polyfunctional aziridine compound was added to hyaluronan of various molecular weights in an equivalent ratio of HA/AZ of 1:1 to 1:10, preferably, 1:3 to 1:10, more preferably, 1:3 to 1:5; most preferably 1:4 to 1:5.. The polymeric hydrogel compounds obtained are useful to prevent the formation of post-operative adhesions, designing tissue engineering applications, and the like.
摘要翻译：公开了通过使透明质酸钠化合物与作为交联剂的多官能氮丙啶化合物反应得到的交联透明质酸盐化合物。将多官能氮丙啶化合物以等于1：1至1:10，优选1:3至1:10，更优选1:3至1:5的HA / AZ比例加入各种分子量的透明质酸中; 最优选1:4至1:5。所获得的聚合物水凝胶化合物可用于防止术后粘连的形成，设计组织工程应用等。

2. 发明申请

WO2003089026A1 AZIRIDINE COMPOUNDS AND THEIR USE IN MEDICAL DEVICES 审中-公开
标题翻译： AZIRIDINE化合物及其在医疗器械中的应用
公开(公告)号：WO2003089026A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/012139
申请日：2003-04-17
申请人： GENZYME CORPORATION , GIANOLIO, Diego, A. , JOHNSTON, Erika, E. , MILLER, Robert, J.
发明人： GIANOLIO, Diego, A. , JOHNSTON, Erika, E. , MILLER, Robert, J.
IPC分类号： A61L33/00
CPC分类号： A61L33/0029 , A61L29/085 , A61L31/10 , A61L33/0094 , Y10T428/31504
摘要： There are disclosed novel uses of aziridine compounds. The aziridine compounds can be formed into films by plasma deposition on a wide variety of substrates. The films prevent biofouling, impart biocompatible or antithrombotic properties, and can immobilize therapeutic and pharmaceutical agents to provide a drug delivery system.
摘要翻译：公开了氮丙啶化合物的新用途。氮丙啶化合物可以通过在各种基材上的等离子体沉积形成膜。该膜防止生物污损，赋予生物相容性或抗血栓性质，并且可以固定治疗剂和药剂以提供药物递送系统。

3. 发明申请

WO2005115489A2 ADHERENT POLYMERIC COMPOSITIONS 审中-公开
标题翻译：附加聚合物组合物
公开(公告)号：WO2005115489A2
公开(公告)日：2005-12-08
申请号：PCT/US2005/018159
申请日：2005-05-23
申请人： GENZYME CORPORATION , JARRETT, Peter, K. , MILLER, Robert, J. , MESSIER, Kenneth, A. , PHILBROOK, C., Michael , KRAMER, Hildegard, M. , KABLIK, J., Jeffrey , JOHNSTON, Erika, E. , AVILA, Luis, Z. , COURY, Arthur, J.
发明人： JARRETT, Peter, K. , MILLER, Robert, J. , MESSIER, Kenneth, A. , PHILBROOK, C., Michael , KRAMER, Hildegard, M. , KABLIK, J., Jeffrey , JOHNSTON, Erika, E. , AVILA, Luis, Z. , COURY, Arthur, J.
IPC分类号： A61L24/00
CPC分类号： A61L31/06 , A61L24/0042 , A61L24/043 , A61L27/34 , A61L31/10 , C08L71/02
摘要： Described herein are adhesive polymeric compositions and methods for using the compositions. The composition are adherent to the applied surface. The compositions, in certain embodiments, are biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications. The adherent polymeric compositions comprise a polymerized macromer network and an additive mixed or entangled in the polymerized macromer. The additive is bonded to a surface by at least one covalent bond or by secondary interactions and is not covalently bonded to the polymerized macromer network. Alternatively, the additive is bonded to the surface by at least one covalent bond and is also bonded to the macromer network. The disclosed compositions can be used as an improved barrier, coating or drug delivery system that due to the additive is highly adherent to an applied surface. The compositions of the present invention are typically non-toxic, water miscible and have adaptable characteristics depending on the macromers and additives used. For example, specific macromers can be used for targeted bioresorption rate and/or degradation rate of the applied composition.
摘要翻译：本文描述的是粘合聚合物组合物和使用该组合物的方法。组合物附着在所施加的表面上。在某些实施方案中，组合物是可生物降解的和生物相容的，并且可以设计成具有针对不同手术和治疗应用的选择性的适应性和弹性。粘附的聚合物组合物包含聚合的大分子单体网络和在聚合的大分子单体中混合或缠结的添加剂。添加剂通过至少一个共价键或通过二次相互作用结合到表面上，并且不共价键合到聚合的大分子单体网络上。或者，添加剂通过至少一个共价键与表面键合，并且也结合到大分子单体网络上。所公开的组合物可以用作改进的屏障，涂层或药物递送系统，由于添加剂与施加的表面高度粘附。根据所使用的大分子单体和添加剂，本发明的组合物通常是无毒的，水可混溶的并具有适应性的特征。例如，特定的大分子单体可用于所施用组合物的靶向生物再吸收速率和/或降解速率。

4. 发明申请

WO2004000382A1 SILICONE BLENDS AND COMPOSITES FOR DRUG DELIVERY 审中-公开
标题翻译：硅胶和用于药物递送的复合材料
公开(公告)号：WO2004000382A1
公开(公告)日：2003-12-31
申请号：PCT/US2003/019676
申请日：2003-06-20
申请人： GENZYME CORPORATION , RATNER, Buddy , KWOK, Connie , WALLINE, Katie , JOHNSTON, Erika , MILLER, Robert, J.
发明人： RATNER, Buddy , KWOK, Connie , WALLINE, Katie , JOHNSTON, Erika , MILLER, Robert, J.
IPC分类号： A61L27/44
CPC分类号： A61K9/0024 , A61K9/2031 , A61K9/2036 , A61K9/7007 , A61K48/00 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/602 , A61L2420/06 , A61L2420/08 , C08L83/04
摘要： The present invention provides a composition for use in delivering a drug into the body of a mammal, wherein the composition comprises silicone elastomer, an adjuvant polymer, and the drug. This composition may be part of an implantable medical device, such as a stent or a vascular or other graft or sheath, among other configurations. When the compositions are used as coating, the coating may further include a topcoat of silicone or silicone and adjuvant polymer mixture.
摘要翻译：本发明提供了用于将药物递送到哺乳动物体内的组合物，其中所述组合物包含硅氧烷弹性体，辅助聚合物和药物。该组合物可以是植入式医疗装置的一部分，例如支架或血管或其它移植物或鞘，以及其它构型。当组合物用作涂层时，涂层还可以包括硅氧烷或硅氧烷和助剂聚合物混合物的面漆。

5. 发明申请

WO2010075010A2 OLIGOSACCHARIDE-PROTEIN CONJUGATES 审中-公开
标题翻译：寡糖 - 蛋白质结合蛋白
公开(公告)号：WO2010075010A2
公开(公告)日：2010-07-01
申请号：PCT/US2009/067775
申请日：2009-12-11
申请人： GENZYME CORPORATION , PAN, Clark , KONOWICZ, Paul, A. , AVILA, Luis, Z. , STEFANO, James, E. , REARDON, Michael, R. , HARRAHY, John , ZHOU, Qun , YOUNG, Lauren , FINN, Patrick , ZHENG, Xiaoyang , MILLER, Robert, J. , KUTZKO, Joseph
发明人： PAN, Clark , KONOWICZ, Paul, A. , AVILA, Luis, Z. , STEFANO, James, E. , REARDON, Michael, R. , HARRAHY, John , ZHOU, Qun , YOUNG, Lauren , FINN, Patrick , ZHENG, Xiaoyang , MILLER, Robert, J. , KUTZKO, Joseph
IPC分类号： A61K47/48 , A61P3/00
CPC分类号： C07H15/04 , A61K47/61
摘要： Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide- glycoprotein conjugate.
摘要翻译：本文提供包含蛋白质和式I-VI之一的寡糖的缀合物。本文还提供包含这种缀合物的药物组合物。本文还提供了通过施用寡糖 - 糖蛋白缀合物来治疗哺乳动物中的溶酶体贮积病症的方法。

6. 发明申请

WO2010054170A2 SYSTEM AND METHOD OF INCREASING POKER TOURNAMENT POOLS AND NUMBER OF PAYOUT POSITIONS 审中-公开
标题翻译：增加扑克游戏数量和支付位置数量的系统和方法
公开(公告)号：WO2010054170A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/063516
申请日：2009-11-06
申请人： NARDIZZI, Robert, V. , MILLER, Robert, J.
发明人： NARDIZZI, Robert, V. , MILLER, Robert, J.
IPC分类号： A63F1/00 , A63F9/24 , A63F13/12
CPC分类号： A63F1/18 , A63F2001/005 , G07F17/32 , G07F17/3244 , G07F17/3276 , G07F17/3293
摘要： A second optional poker tournament fee allows participating players a chance to receive a payout when finishing the poker tournament in one of one or more extra bubble spots. So, if the player finishes close to the conventional bubble position the player may receive a payout if he or she paid the second optional fee. The number of extra spots is based on the number of second optional fees paid. In one version, if no players finish in the extra bubble spots the house collects the second optional fees as profits. In another version, the second optional fees, or a portion thereof, are used to increase the payouts associated with the conventional payout scheme independent of the second optional fees.
摘要翻译：第二个可选的扑克锦标赛费用允许参赛球员有机会在一个或多个额外的气泡点之一完成扑克锦标赛时获得支付。因此，如果玩家完成接近传统的泡泡位置，玩家可以在支付第二个可选费用的情况下收到付款。额外点数是根据支付的第二个可选费用的数量。在一个版本中，如果没有玩家在额外的泡沫点完成，房子收取第二个可选费用作为利润。在另一版本中，第二可选费用或其一部分用于增加与常规支付方案相关联的支付，而不依赖于第二可选费用。

7. 发明申请

WO2011017130A1 COMPLIANT ENERGY STORING STRUCTURAL SHEET 审中-公开
标题翻译：合规能源储存结构
公开(公告)号：WO2011017130A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/043445
申请日：2010-07-27
申请人： THE PAPER BATTERY CO. , MILLER, Robert, J. , ALLEN, George , SIMMONS, Trevor, J.
发明人： MILLER, Robert, J. , ALLEN, George , SIMMONS, Trevor, J.
IPC分类号： H01G9/00
CPC分类号： H01G9/048 , H01G9/004 , H01G9/02 , H01G9/155 , H01G11/36 , H01M2/22 , H01M4/02 , H01M4/0402 , H01M4/0419 , H01M4/08 , H01M4/8828 , H01M6/40 , H01M8/0228 , H01M8/0245 , H01M14/00 , H01M14/005 , H01M2300/0094 , Y02E60/13 , Y02E60/50
摘要： Disclosed herein is a structural sheet includes an energy storage density that is greater than 10-mWh/ft2 and is capable of withstanding greater than 5-KPa stress under at least 5% strain.
摘要翻译：本文公开了一种结构片，其包括大于10-mWh / ft 2的能量存储密度，并且能够在至少5％应变下耐受大于5KPa的应力。

8. 发明申请

WO2004060196A1 DENTAL IMPLANT 审中-公开
标题翻译：牙科植入物
公开(公告)号：WO2004060196A1
公开(公告)日：2004-07-22
申请号：PCT/US2003/038393
申请日：2003-12-02
申请人： MILLER, Robert, J.
发明人： MILLER, Robert, J.
IPC分类号： A61C8/00
CPC分类号： A61C8/0022
摘要： The dental implant includes a body with a coronal end and an apical end. The implant intraosseous region includes a tapered thread which has a constant depth on an apical edge. A coronal edge to the thread varies in profile. There is equal spacing between the apical end and the coronal end of the implant. The coronal edge varies in profile, and can have a profile formed of two or three components. There is at least two cutting actions of the thread to permit for effective implantation in the bone without leading to microfracture.
摘要翻译：牙科植入物包括具有冠状端和顶端的身体。植入物骨内区域包括在顶端具有恒定深度的锥形螺纹。螺纹的冠状边缘在轮廓上变化。在植入物的顶端和冠状端之间具有相等的间距。冠状边缘轮廓变化，并且可以具有由两个或三个部件形成的轮廓。螺纹有至少两个切割动作，以允许有效地植入骨中而不导致微裂缝。

9. 发明申请

WO2012158293A1 THERMOPLASTIC INDUCTION WELDING APPARATUS AND METHOD 审中-公开
标题翻译：热塑性感应焊接设备及方法
公开(公告)号：WO2012158293A1
公开(公告)日：2012-11-22
申请号：PCT/US2012/033794
申请日：2012-04-16
申请人： THE BOEING COMPANY , MATSEN, Marc, R. , NEGLEY, Mark, A. , GEREN, William, P. , MILLER, Robert, J.
发明人： MATSEN, Marc, R. , NEGLEY, Mark, A. , GEREN, William, P. , MILLER, Robert, J.
IPC分类号： B29C65/36 , H05B6/10
CPC分类号： B29C65/3676 , B29C65/3612 , B29C65/3644 , B29C65/3668 , B29C66/00145 , B29C66/1122 , B29C66/41 , B29C66/474 , B29C66/524 , B29C66/721 , B29C66/7212 , B29C66/7392 , B29C66/73921 , B29C66/7394 , B29C66/8122 , B29C66/8126 , B29C66/81457 , B29K2905/12 , B29K2995/0008 , B29L2031/3076 , H05B6/105 , H05B2206/023 , B29K2307/04 , B29K2309/08 , B29K2909/02
摘要： A thermoplastic welding apparatus (100) includes a thermoplastic welding tool (101), at least one tooling surface (103) in the thermoplastic welding tool (101), a magnetic induction coil (102) in the thermoplastic welding tool (101) and generally encircling the at least one tooling surface (103) and at least one smart susceptor (116) in the thermoplastic welding tool (101) at the at least one tooling surface (103). The magnetic induction coil (102) is adapted to generate a magnetic flux field (122) oriented generally parallel to a plane of the at least one smart susceptor (106).
摘要翻译：热塑性焊接设备（100）包括热塑性焊接工具（101），热塑性焊接工具（101）中的至少一个工具表面（103），热塑性焊接工具（101）中的磁感应线圈（102）在所述至少一个工具表面（103）处包围所述至少一个工具表面（103）和所述热塑性焊接工具（101）中的至少一个智能基座（116）。磁感应线圈（102）适于产生大致平行于至少一个智能基座（106）的平面定向的磁通场（122）。

10. 发明申请

WO2004097141A2 HARD SURFACE-VENEER ENGINEERED SURFACING TILES AND METHODS 审中-公开
标题翻译：硬表面工程工程表面和方法
公开(公告)号：WO2004097141A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/012987
申请日：2004-04-24
申请人： SHAW INDUSTRIES GROUP, INC. , MILLER, Robert, J.
发明人： MILLER, Robert, J.
IPC分类号： E04F
CPC分类号： B32B21/02 , B32B7/02 , B32B9/04 , B32B9/042 , B32B17/06 , B32B17/062 , B32B2307/536 , B32B2309/105 , B32B2419/04 , C04B33/24 , C04B2235/77 , C04B2235/96 , E04F13/0862 , E04F13/14 , E04F15/042 , E04F15/085 , E04F2201/0153 , E04F2201/026 , Y10T428/166 , Y10T428/167 , Y10T428/19 , Y10T428/195 , Y10T428/23929 , Y10T428/23986 , Y10T428/24942 , Y10T428/252 , Y10T428/315 , Y10T428/31504
摘要： A modular tile assembly having a substantially rigid substrate, at least one sealant layer, and at least one stone, ceramic, or porcelain tile. A bottom surface of a first sealant layer being bonded to an upper surface of the substrate and a top surface of a second sealant layer being bonded to a lower surface of the substrate. The tile being bonded to at least a portion of the top surface of the first sealant layer. In one example, the substrate is provided with a tongue or a groove defined in any one, combination, or each of the respective side edges of the substrate, as desired.
摘要翻译：一种具有基本刚性基底，至少一个密封剂层和至少一个石头，陶瓷或瓷砖的模块化瓦片组件。第一密封剂层的底表面被接合到基底的上表面，第二密封剂层的顶表面接合到基底的下表面。该瓦片被粘合到第一密封剂层的顶表面的至少一部分上。在一个示例中，根据需要，基板设置有限定在基板的任何一个，组合或每个相应侧边缘中的舌部或凹槽。

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