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1. 发明申请

WO2008005217A3 IRON(II)-CONTAINING TREATMENTS FOR HYPERPHOSPHATEMIA 审中-公开
标题翻译：铁（II） - 治疗高磷血症
公开(公告)号：WO2008005217A3
公开(公告)日：2008-02-21
申请号：PCT/US2007014688
申请日：2007-06-25
申请人： GENZYME CORP , HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
发明人： HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
IPC分类号： A61K31/295 , A61K9/14 , A61K33/26
CPC分类号： A61K33/26 , A61K9/145 , A61K9/146 , A61K31/295 , A61K31/785 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprises a pharmaceutically acceptable ferrous iron compound; an amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Alternatively, a pharmaceutica composition comprises a pharmaceutically acceptable ferrous iron compound and pharmaceutically acceptable carrier, wherein the ferrous iron compound is selecte from the group consisting of iron(II) acetate, iron(II) citrate, iron(II) ascorbate, iron(II) oxalate, iron(II) oxide, iron(II) carbonate, iron(II) carbonate saccharated, iron(II) formate, iron(II) sulfate, iron(II) chloride, iron(II) acetylacetonate and combinations thereof. A method of treating a subject with hyperphosphatemia comprises administering to the subject an effective amount of a pharmaceutical composition as described above.
摘要翻译：药物组合物包含药学上可接受的亚铁化合物; 胺聚合物或其药学上可接受的盐和药学上可接受的载体。或者，药物组合物包含药学上可接受的亚铁化合物和药学上可接受的载体，其中亚铁化合物选自乙酸铁（II），柠檬酸铁（II），抗坏血酸铁（II），抗坏血酸铁（II））草酸盐，氧化铁（II），碳酸铁（II），糖化的碳酸铁（II），甲酸铁（II），硫酸铁（II），氯化铁（II），乙酰丙酮铁（II）及其组合。治疗高磷血症患者的方法包括给予患者有效量的上述药物组合物。

2. 发明申请

WO2008042222A3 AMIDE DENDRIMER COMPOSITIONS 审中-公开
标题翻译：酰胺树脂组合物
公开(公告)号：WO2008042222A3
公开(公告)日：2008-12-18
申请号：PCT/US2007020852
申请日：2007-09-26
申请人： GENZYME CORP , DHAL PRADEEP K , HARRIS DAVID J , HOLMES-FARLEY STEPHEN RANDALL , HUVAL CHAD C , NIVOROZHKIN VITALY , SHUTTS BRUCE
发明人： DHAL PRADEEP K , HARRIS DAVID J , HOLMES-FARLEY STEPHEN RANDALL , HUVAL CHAD C , NIVOROZHKIN VITALY , SHUTTS BRUCE
IPC分类号： A61K8/72
CPC分类号： C08G69/40 , A61K8/72 , A61K31/785 , C07C235/08 , C07C237/10 , C08G83/003 , C08L101/00
摘要： Amide compounds, amide polymers, compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, amide compounds and amide polymers may include a core derived from an amide polyol and an organic polyacid or ester.
摘要翻译：酰胺化合物，酰胺聚合物，包括酰胺化合物和酰胺聚合物的组合物可用于结合目标离子，例如动物胃肠道中的含磷化合物。在一些情况下，酰胺化合物和酰胺聚合物可以包括衍生自酰胺多元醇和有机多元酸或酯的核。

3. 发明申请

WO2007130463A3 AMINE CONDENSATION POLYMERS AS PHOSPHATE SEQUESTRANTS 审中-公开
标题翻译：氨基聚合聚合物作为磷酸酯序列
公开(公告)号：WO2007130463A3
公开(公告)日：2008-01-03
申请号：PCT/US2007010650
申请日：2007-05-02
申请人： GENZYME CORP , HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
发明人： HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
IPC分类号： C08G73/02
CPC分类号： A61K31/785 , C08G73/02 , C08G73/0206
摘要： Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a -CH 2 CH 2 - group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.
摘要翻译：公开了一种聚合物或其生理上可接受的盐。聚合物包含聚合的多官能胺单体。胺单体包含至少两个胺基团和至少两个通过-CH 2 CH 2 - 基团连接的无环氮原子，条件是胺单体不是乙二胺或二亚乙基三胺。所公开的聚合物可用于结合需要这种治疗的受试者中的阴离子。

4. 发明申请

WO2007027566A3 METHOD FOR REMOVING PHOSPHATE AND POLYMER USED THEREFORE 审中-公开
标题翻译：用于去除磷酸盐和聚合物的方法
公开(公告)号：WO2007027566A3
公开(公告)日：2007-12-13
申请号：PCT/US2006033437
申请日：2006-08-25
申请人： GENZYME CORP , HUVAL CHAD C , HOLMES-FARLEY STEPHEN RANDALL , DHAL PRADEEP K
发明人： HUVAL CHAD C , HOLMES-FARLEY STEPHEN RANDALL , DHAL PRADEEP K
IPC分类号： A61K31/785 , A61K31/787 , C08F226/02 , C08F226/04 , C08F226/06
CPC分类号： A61K31/785 , A61K31/77 , A61K31/787 , C08F226/02 , C08F226/04 , C08F226/06
摘要： Polymers and compositions utilizing such polymers are disclosed for treating hyperphosphatemia and other illnesses associated with elevated serum phosphate levels. Phosphate binding polymers, or a pharmaceutically acceptable salt of the polymers, comprise pendent groups extending from a backbone of the polymer. Each pendent group comprises at least two nitrogen-bearing functional groups which bind phosphate. Variations of such polymer and compositions are disclosed.
摘要翻译：公开了使用这种聚合物的聚合物和组合物用于治疗与高血清磷酸盐水平升高相关的高磷酸盐血症和其它疾病。磷酸酯结合聚合物或聚合物的药学上可接受的盐包括从聚合物主链延伸的侧基。每个侧基包含至少两个结合磷酸盐的含氮官能团。公开了这种聚合物和组合物的变化。

5. 发明申请

WO2007056405A8 MAGNESIUM-CONTAINING POLYMERS FOR HYPERPHOSPHATEMIA 审中-公开
标题翻译：用于高磷血症的含镁聚合物
公开(公告)号：WO2007056405A8
公开(公告)日：2007-08-02
申请号：PCT/US2006043402
申请日：2006-11-07
申请人： GENZYME CORP , HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
发明人： HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
CPC分类号： A61K31/785 , A61K31/132 , A61K33/06 , A61K2300/00
摘要： A pharmaceutical composition comprising an aliphatic amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable magnesium compound comprising a magnesium ion is disclosed. A method of treating hyperphosphatemia in a patient is also disclosed. The method comprises the step of administering to the subject an effective amount of the disclosed pharmaceutical composition.
摘要翻译：公开了包含脂族胺聚合物或其药学上可接受的盐和包含镁离子的药学上可接受的镁化合物的药物组合物。还公开了一种治疗患者高磷酸盐血症的方法。该方法包括向受试者施用有效量的所公开的药物组合物的步骤。

6. 发明申请

WO2007056405A3 MAGNESIUM-CONTAINING POLYMERS FOR THE TREATMENT OF HYPERPHOSPHATEMIA 审中-公开
标题翻译：用于治疗高磷酸镁的含镁聚合物
公开(公告)号：WO2007056405A3
公开(公告)日：2007-11-08
申请号：PCT/US2006043402
申请日：2006-11-07
申请人： GENZYME CORP , HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
发明人： HUVAL CHAD C , DHAL PRADEEP K , HOLMES-FARLEY STEPHEN RANDALL
IPC分类号： A61K31/132 , A61K33/06
CPC分类号： A61K31/785 , A61K31/132 , A61K33/06 , A61K2300/00
摘要： A pharmaceutical composition comprising an aliphatic amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable magnesium compound comprising a magnesium ion is disclosed. A method of treating hyperphosphatemia in a patient is also disclosed. The method comprises the step of administering to the subject an effective amount of the disclosed pharmaceutical composition.
摘要翻译：公开了包含脂族胺聚合物或其药学上可接受的盐和包含镁离子的药学上可接受的镁化合物的药物组合物。还公开了一种治疗患者高磷血症的方法。该方法包括向受试者施用有效量的所公开的药物组合物的步骤。

7. 发明申请

WO2008027551A3 DENDRIMER COMPOSITIONS 审中-公开
标题翻译： DENDRIMER组合物
公开(公告)号：WO2008027551A3
公开(公告)日：2008-11-06
申请号：PCT/US2007019201
申请日：2007-08-31
申请人： GENZYME CORP , COOPER CHRISTOPHER , DHAL PRADEEP K , GIMI RAYOMAND H , HARRIS DAVID J , HOLMES-FARLEY STEPHEN RANDALL , HUVAL CHAD C , LEE EDWARD
发明人： COOPER CHRISTOPHER , DHAL PRADEEP K , GIMI RAYOMAND H , HARRIS DAVID J , HOLMES-FARLEY STEPHEN RANDALL , HUVAL CHAD C , LEE EDWARD
IPC分类号： A61K8/72
CPC分类号： C07C217/08 , A61K31/785
摘要： Amine compounds, amine polymers, crosslinked amine polymers and pharmaceutical compositions comprising the same may include polyhydroxy-containing cores that may be substituted with amine groups and may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.
摘要翻译：胺化合物，胺聚合物，交联胺聚合物和包含其的药物组合物可包括可被胺基团取代并可用于治疗高磷酸盐血症或从动物（包括人类）的胃肠道去除离子的含多羟基核心。

8. 发明申请

WO2004085448A3 UNSATURATED PHOSPHINYL-PHOSPHONATE PHOSPHATE TRANSPORT INHIBITORS 审中-公开
标题翻译：不饱和磷磷酸盐磷酸盐运输抑制剂
公开(公告)号：WO2004085448A3
公开(公告)日：2005-01-20
申请号：PCT/US2004008038
申请日：2004-03-17
申请人： GENZYME CORP , HUVAL CHAD C , DIOS ANGELES
发明人： HUVAL CHAD C , DIOS ANGELES
IPC分类号： A61K31/663 , A61P3/14 , A61P19/08 , C07F9/38 , C07F9/40
CPC分类号： C07F9/4012 , A61K31/663 , C07F9/3821
摘要： A method of inhibiting phosphate transport in a subject in need of phosphate transport inhibition includes the step of administering to the subject an effective amount of a compound containing a double bond or triple bond directly adjacent to a phosphinyl phosphonate group. The invention also includes compounds containing such unsaturated phosphinyl phosphonate groups and methods of preparing these compounds.
摘要翻译：在需要磷酸盐转运抑制的受试者中抑制磷酸盐转运的方法包括向受试者施用有效量的含有与膦酸膦基团直接相邻的双键或三键的化合物的步骤。本发明还包括含有这些不饱和膦基膦酸酯基团的化合物及其制备方法。

9. 发明申请

WO2008011047A2 AMINE DENDRIMERS 审中-公开
公开(公告)号：WO2008011047A2
公开(公告)日：2008-01-24
申请号：PCT/US2007016240
申请日：2007-07-16
申请人： GENZYME CORP , HOLMES-FARLEY S RANDALL , DAHL PRADEEP K , HUVAL CHAD C
发明人： HOLMES-FARLEY S RANDALL , DAHL PRADEEP K , HUVAL CHAD C
IPC分类号： A61K49/10
CPC分类号： C07C211/14 , A61K31/785 , A61K47/59 , A61K47/595
摘要： Ion binding compounds and compositions may include compounds, polymers and compositions that include amine moieties. Ion binding polymers may be crosslinked amine polymers and may be used to remove ions, such as phosphate ions, from the gastrointestinal tract of animals, such as humans. Such compounds, polymers and compositions may be used therapeutically to treat a variety of medical conditions, such as hyperphosphatemia.
摘要翻译：离子结合化合物和组合物可以包括包括胺部分的化合物，聚合物和组合物。离子结合聚合物可以是交联的胺聚合物，并且可以用于从诸如人的动物的胃肠道中去除离子，例如磷酸根离子。这些化合物，聚合物和组合物可用于治疗各种医学病症，例如高磷酸血症。

10. 发明申请

WO03080630A2 PHOSPHATE TRANSPORT INHIBITORS 审中-公开
标题翻译：磷酸盐运输抑制剂
公开(公告)号：WO03080630A2
公开(公告)日：2003-10-02
申请号：PCT/US0308449
申请日：2003-03-19
申请人： GENZYME CORP , JOZEFIAK THOMAS , BASTOS CECILIA M , HUVAL CHAD C
发明人： JOZEFIAK THOMAS , BASTOS CECILIA M , HUVAL CHAD C
IPC分类号： A61K45/00 , A61K31/663 , A61K31/785 , A61P5/18 , A61P7/00 , A61P13/12 , A61P19/00 , A61P19/10 , A61P43/00 , C07F9/30 , C07F9/32 , C07F9/38 , C07F9/40 , C07F9/553 , C07F9/655 , C08F8/40 , C08F30/02 , C07F9/02
CPC分类号： C07F9/65502 , C07F9/3821 , C07F9/4012 , C07F9/5537 , C08F8/40 , C08F30/02 , Y02P20/55
摘要： Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I). R1 and R2 are independently -H, an electron withdrawing group or a C1-C10 alkyl group. Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or -CR1R2P(O)(OH)-. R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from -C1, -Br, -F, -CN, -NO2, -OR , -N(R )2, -COOR , -CON(R )2, -COR , -S(O)R , -S(O)2R , -S(O)2N(R )2, -NR S(O)2R , -NR COR , a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group. Each R is independently -H, lower alkyl, substituted lower alkyl, aryl or substituted aryl. Each Rb is independently -H, a lower alkyl group, or a phosphate protecting group.
摘要翻译：公开了由结构式（I）表示的磷酸盐转运抑制化合物。 R1和R2独立地为-H，吸电子基团或C1-C10烷基。 Y是共价键，取代的亚甲基，未取代的亚甲基或-CR 1 R 2 P（O）（OH） - 。 R 3是任选地包含一个或多个胺，铵，醚，硫醚或亚苯基连接基团的烃基，任选地包含一个或多个胺，铵，醚，硫醚或亚苯基连接基团的取代烃基，杂芳基，取代的杂芳基基团或被一个或多个选自-C 1，-Br，-F，-CN，-NO 2，-OR a，-N（R a）2，-COOR a， -CON（R a）2，-COR a，-S（O）R a，-S（O）2 R a，-S（O）2 N（R a）2， -NR a S（O）2 R a，-NR a COR a，卤代低级烷基，芳基，取代芳基或卤代烷氧基。每个R a独立地为-H，低级烷基，取代的低级烷基，芳基或取代的芳基。每个R b独立地为-H，低级烷基或磷酸酯保护基团。

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