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1. 发明申请

WO2012106382A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF 审中-公开
标题翻译： AEROSOL派尼酮和吡咯烷类似物的化合物及其用途
公开(公告)号：WO2012106382A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023406
申请日：2012-01-31
申请人： GENOA PHARMACEUTICALS, INC. , SURBER, Mark, William
发明人： SURBER, Mark, William
IPC分类号： A01N43/40 , A61K9/72 , A61K31/44
CPC分类号： A61K31/4418 , A61K9/0078 , A61M15/009 , A61M2202/064
摘要： Formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. Pirfenidone or pyridone analog compound formulations and delivery options allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include formulations, kits, and devices. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.
摘要翻译：用于气雾化的吡非尼酮或吡啶酮类似物化合物的制剂，并且使用这种制剂用于气雾剂施用吡非尼酮或吡啶酮类似物化合物，用于预防或治疗各种纤维化和炎性疾病，包括与肺，心脏，肾脏，肝脏，眼睛和眼睛相关的疾病中枢神经系统。吡非尼酮或吡啶酮类似物化合物制剂和递送选项可有效地局部输送吡非尼酮或吡啶酮类似物。组合物包括制剂，试剂盒和装置。方法包括用于生产和使用所述组合物的吸入程序，适应症和制造方法。

2. 发明申请

WO2014018668A3 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS 审中-公开
标题翻译： AEROSOL PIRFENIDONE和PYRIDONE类似物化合物
公开(公告)号：WO2014018668A3
公开(公告)日：2014-01-30
申请号：PCT/US2013/051880
申请日：2013-07-24
申请人： GENOA PHARMACEUTICALS, INC.
发明人： SURBER, Mark, William
IPC分类号： A61K9/72 , A61K31/44
摘要： Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.
摘要翻译：本文公开了用于雾化的吡非尼酮或吡啶酮类似物化合物的制剂，以及用于气雾剂给药吡非尼酮或吡啶酮类似物化合物用于预防或治疗各种纤维化和炎性疾病，包括与肺，心脏，肾脏，肝脏，眼睛和中枢神经系统。在一些实施方案中，本文所述的吡非尼酮或吡啶酮类似物化合物制剂和递送选项允许有效地局部递送吡非尼酮或吡啶酮类似物化合物。组合物包括本文所述的所有制剂，试剂盒和装置组合。方法包括用于生产和使用所述组合物的吸入程序，适应症和生产过程。

3. 发明申请

WO2015106150A1 AEROSOL PIRFENIDONE AND PYRIDONE ANALOG COMPOUNDS AND USES THEREOF 审中-公开
标题翻译： AEROSOL派尼酮和吡咯烷类似物的化合物及其用途
公开(公告)号：WO2015106150A1
公开(公告)日：2015-07-16
申请号：PCT/US2015/010890
申请日：2015-01-09
申请人： GENOA PHARMACEUTICALS INC.
发明人： SURBER, Mark, William
IPC分类号： A61K31/4418
CPC分类号： A61K31/4418 , A61K9/0078 , A61K31/573 , A61K47/02 , A61K47/12 , A61M11/001 , A61M11/005 , A61M11/02
摘要： Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.
摘要翻译：本文公开了吡非尼酮或吡啶酮类似物化合物的制剂，用于气雾化和使用这种制剂用于气雾剂施用吡非尼酮或吡啶酮类似物化合物，用于预防或治疗各种纤维化和炎性疾病，包括与肺，心脏，肾脏，肝脏相关的疾病，眼睛和中枢神经系统。在一些实施方案中，本文所述的吡非尼酮或吡啶酮类似物化合物制剂和递送选择允许吡非尼酮或吡啶酮类似物化合物的有效局部递送。组合物包括本文所述的所有制剂，试剂盒和装置组合。方法包括用于生产和使用所述组合物的吸入程序，适应症和制造方法。

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