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1. 发明申请

WO2016122797A1 ADJUSTABLE BILAYER CAPACITANCE STRUCTURE FOR BIOMEDICAL DEVICES 审中-公开
标题翻译：用于生物医学设备的可调节双层电容结构
公开(公告)号：WO2016122797A1
公开(公告)日：2016-08-04
申请号：PCT/US2015/066418
申请日：2015-12-17
申请人： GENIA TECHNOLOGIES, INC.
发明人： HOVIS, Jennifer , TIAN, Hui , CHEN, Roger, J.A.
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/487
CPC分类号： G01N33/48721
摘要： A nanopore sequencing device is disclosed. The nanopore sequencing device includes a working electrode. It further includes a dielectric layer, wherein a portion of the dielectric layer is disposed horizontally adjacent to the working electrode and a portion of the dielectric layer is disposed above and covering a portion of the working electrode, and wherein the dielectric layer forms a well having an opening above an uncovered portion of the working electrode. A base surface area of the working electrode is greater than a base surface area of the opening above the uncovered portion of the working electrode.
摘要翻译：公开了一种纳米孔测序装置。纳米孔测序装置包括工作电极。还包括电介质层，其中电介质层的一部分水平地邻近工作电极设置，并且介电层的一部分设置在工作电极的一部分上方并覆盖其中，并且其中介电层形成具有在工作电极的未覆盖部分上方的开口。工作电极的基面面积大于工作电极的未覆盖部分上方开口的基面面积。

2. 发明申请

WO2017050719A1 DIFFERENTIAL OUTPUT OF ANALOG MEMORIES STORING NANOPORE MEASUREMENT SAMPLES 审中-公开
标题翻译：存储纳米测量样品的模拟记忆体的差分输出
公开(公告)号：WO2017050719A1
公开(公告)日：2017-03-30
申请号：PCT/EP2016/072221
申请日：2016-09-20
申请人： GENIA TECHNOLOGIES, INC. , F. HOFFMANN-LA ROCHE AG
发明人： MANEY, Bill , FERNANDEZ-GOMEZ, Santiago , TIAN, Hui
IPC分类号： G01N33/487
CPC分类号： G01N27/26 , B82Y35/00 , G01N33/48721
摘要： A nanopore measurement circuit is disclosed. The nanopore measurement circuit includes a nanopore electrode, a first analog memory and a second analog memory. The nanopore measurement circuit also includes a switch network that selectively connects the nanopore electrode to at least one of the first analog and the second analog memory.
摘要翻译：公开了一种纳米孔测量电路。纳米孔测量电路包括纳米孔电极，第一模拟存储器和第二模拟存储器。纳米孔测量电路还包括开关网络，其选择性地将纳米孔电极连接到第一模拟和第二模拟存储器中的至少一个。

3. 发明申请

WO2017050720A1 ENCODING STATE CHANGE OF NANOPORE TO REDUCE DATA SIZE 审中-公开
标题翻译：编辑NANOPORE的状态变化来减少数据大小
公开(公告)号：WO2017050720A1
公开(公告)日：2017-03-30
申请号：PCT/EP2016/072222
申请日：2016-09-20
申请人： GENIA TECHNOLOGIES, INC. , F. HOFFMANN-LA ROCHE AG
发明人： FERNANDEZ-GOMEZ, Santiago , MANEY, Bill , TIAN, Hui , SHIN, Seung
IPC分类号： G01N33/487
CPC分类号： G01N27/40 , G01N33/48721
摘要： A system includes a circuit configured to detect a voltage corresponding to an electrical measurement of a nanopore. The system also includes a component configured to compare the voltage to another voltage. Based at least in part on the comparison, a one bit indicator is determined. The one bit indicator indicates whether the voltage indicates a change in a state of the nanopore. In the event it is determined that the voltage indicates the change in the state of the nanopore, a multiple bit signal is provided for output.
摘要翻译：系统包括被配置为检测对应于纳米孔的电测量的电压的电路。该系统还包括被配置为将电压与另一电压进行比较的部件。至少部分地基于比较，确定一位指示符。一位指示器指示电压是否表示纳米孔状态的变化。在确定电压指示纳米孔状态的变化的情况下，提供多位信号用于输出。

4. 发明申请

WO2016099673A1 NANOPORE-BASED SEQUENCING WITH VARYING VOLTAGE STIMULUS 审中-公开
标题翻译：基于纳米级的测量与变化的电压STIMULUS
公开(公告)号：WO2016099673A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/058533
申请日：2015-11-01
申请人： GENIA TECHNOLOGIES, INC.
发明人： CHEN, Roger, J., A. , TIAN, Hui , MANEY, Bill
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , B01L3/50273 , B01L2400/0421 , C12Q1/6869 , G01N27/44743 , G01N33/48721 , C12Q2565/607 , C12Q2565/631
摘要： A method of analyzing a molecule in a nanopore is disclosed. A voltage is applied across a nanopore that is inserted in a membrane by coupling the nanopore to a voltage source. The nanopore is decoupled from the voltage source. After the decoupling, a rate of decay of the voltage across the nanopore is determined. A molecule in the nanopore is distinguished from other possible molecules based on the determined rate of decay of the voltage across the nanopore.
摘要翻译：公开了分析纳米孔中分子的方法。通过将纳米孔耦合到电压源，跨越插入膜中的纳米孔施加电压。纳米孔与电压源分离。在解耦之后，确定纳米孔上电压的衰减速率。基于确定的纳米孔上的电压衰减速率，纳米孔中的分子与其它可能的分子区分开来。

5. 发明申请

WO2016073318A1 EXPORTING MEASUREMENTS OF NANOPORE ARRAYS 审中-公开
标题翻译：纳米级阵列的出口测量
公开(公告)号：WO2016073318A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/058531
申请日：2015-11-01
申请人： GENIA TECHNOLOGIES, INC.
发明人： CHEN, Roger, J., A. , TIAN, Hui , FERNANDEZ-GOMEZ, Santiago
IPC分类号： G06F19/22
CPC分类号： G01N33/48721 , B82Y15/00 , C12Q1/6869 , G06F19/22
摘要： A method of exporting measurements of a nanopore sensor on a nanopore based sequencing chip is disclosed. An electrical characteristic associated with the nanopore sensor is measured. The electrical characteristic associated with the nanopore sensor is processed. A summary for the electrical characteristic and one or more previous electrical characteristics is determined. The summary for the electrical characteristic and the one or more previous electrical characteristics are exported. Determining the summary includes determining that the electrical characteristic and at least a portion of the one or more previous electrical characteristics correspond to a base call event at the nanopore sensor. The summary represents the electrical characteristic and the at least a portion of the one or more previous electrical characteristics.
摘要翻译：公开了一种在基于纳米孔的测序芯片上输出纳米孔传感器测量的方法。测量与纳米孔传感器相关的电特性。处理与纳米孔传感器相关的电特性。确定电特性和一个或多个先前电特性的总结。导出了电气特性和一个或多个以前的电气特性的总结。确定总结包括确定电特性和一个或多个先前的电特性的至少一部分对应于纳米孔传感器处的基本呼叫事件。总结表示电特性和一个或多个先前电特性的至少一部分。

6. 发明申请

WO2015148127A1 NANOPORE-BASED SEQUENCING CHIPS USING STACKED WAFER TECHNOLOGY 审中-公开
标题翻译：基于NANOPORE的测序仪使用堆叠式WAFER技术
公开(公告)号：WO2015148127A1
公开(公告)日：2015-10-01
申请号：PCT/US2015/019973
申请日：2015-03-11
申请人： GENIA TECHNOLOGIES, INC.
发明人： TIAN, Hui
IPC分类号： C12Q1/00 , C12Q1/68 , C12M1/34
CPC分类号： G01N33/48721
摘要： A nanopore based sequencing chip is disclosed. The sequencing chip comprises a first portion made from a first wafer. The first portion includes an array of nanopore cells. The first portion further includes a measurement circuit connected to one or more nanopore cells, the measurement circuit producing an output measurement signal. The first portion further includes one or more vias transmitting the output measurement signal. The sequencing chip further includes a second portion made from a second wafer, the second portion comprising one or more corresponding vias receiving the output measurement signal.
摘要翻译：公开了一种基于纳米孔的测序芯片。测序芯片包括由第一晶片制成的第一部分。第一部分包括纳米孔细胞阵列。第一部分还包括连接到一个或多个纳米孔单元的测量电路，测量电路产生输出测量信号。第一部分还包括传输输出测量信号的一个或多个通孔。排序芯片还包括由第二晶片制成的第二部分，第二部分包括接收输出测量信号的一个或多个相应的通孔。

7. 发明申请

WO2016100749A1 NANOPORE-BASED SEQUENCING WITH VARYING VOLTAGE STIMULUS 审中-公开
标题翻译：基于纳米级的测量与变化的电压STIMULUS
公开(公告)号：WO2016100749A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066520
申请日：2015-12-17
申请人： GENIA TECHNOLOGIES, INC.
发明人： CHEN, Roger, J.A. , TIAN, Hui , MANEY, Bill
IPC分类号： G01N27/22 , G01R27/26 , C12Q1/68
CPC分类号： G01N27/228 , C12Q1/6869 , G01N27/3273 , G01N27/44791 , G01N33/48721 , C12Q2527/125 , C12Q2565/607 , C12Q2565/629 , C12Q2565/631
摘要： A method of analyzing a molecule is disclosed. A voltage source is selectively connected to or disconnected from a capacitor using a switch controlled by a reset signal. A charge is stored in a capacitor when the voltage source is connected to the capacitor. The capacitor is discharged through a nanopore in a membrane when the voltage source is disconnected from the capacitor. A duty cycle of the reset signal is determined such that the voltage source and the capacitor is connected for at least a one tenth portion of a reset signal period and disconnected for a remaining portion of the reset signal period, such that a voltage across the nanopore is maintained at a higher level during the portion of the reset signal period in which the connection is maintained than during the remaining portion of the reset signal period in which the connection is not maintained.
摘要翻译：公开了分析分子的方法。使用由复位信号控制的开关，电压源选择性地连接到电容器或从电容器断开。当电压源连接到电容器时，电容被存储在电容器中。当电压源与电容器断开时，电容器通过膜中的纳米孔排出。确定复位信号的占空比，使得电压源和电容器连接至复位信号周期的至少十分之一，并且对于复位信号周期的剩余部分断开，使得跨越纳米孔的电压在维持连接的复位信号周期的部分期间维持在比不保持连接的复位信号周期的剩余部分期间更高的电平。

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