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1. 发明申请

WO2004075835A2 METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开
标题翻译：治疗癌症的方法
公开(公告)号：WO2004075835A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005042
申请日：2004-02-20
申请人： GENENTECH INC. , GERRITSEN, Mary, E. , PEALE, Franklin, V., Jr. , WU, Thomas, D.
发明人： GERRITSEN, Mary, E. , PEALE, Franklin, V., Jr. , WU, Thomas, D.
IPC分类号： A61K
CPC分类号： G01N33/57438 , A61K48/00 , A61K2039/505 , C07K14/82 , C07K16/30 , C07K16/3076 , G01N33/57484 , G01N2333/726 , G01N2500/00
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞如肾细胞癌的基因组中扩增的基因的鉴定。预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。本发明涉及新型的诊断和治疗肿瘤的方法，例如肾细胞癌或Wilms肿瘤。

2. 发明申请

WO2004093892A2 METHODS AND COMPOSITIONS FOR SELECTIVE MODULATION OF VASCULARIZATION 审中-公开
标题翻译：用于选择性调节血管的方法和组合物
公开(公告)号：WO2004093892A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011501
申请日：2004-04-14
申请人： GENENTECH, INC. , GERRITSEN, Mary, E. , HONGO, Jo-Anne, S. , ZLOT, Constance, H.
发明人： GERRITSEN, Mary, E. , HONGO, Jo-Anne, S. , ZLOT, Constance, H.
IPC分类号： A61K38/00
CPC分类号： C07K14/575 , A61K38/00
摘要： The invention provides methods and compositions for modulating vascularization and angiogensis, including selective modulation of stages of multi-step vascularization and angiogenesis.
摘要翻译：本发明提供了调节血管形成和血管生成的方法和组合物，包括选择性调节多步血管形成和血管发生的阶段。

3. 发明申请

WO2003032813A3 METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开
公开(公告)号：WO2003032813A3
公开(公告)日：2003-04-24
申请号：PCT/US2002/033020
申请日：2002-10-16
申请人： GENENTECH INC.
发明人： GERRITSEN, Mary, E. , PEALE, Franklin, V., Jr. , WU, Thomas, D.
IPC分类号： C07K16/00
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma.

4. 发明申请

WO2003032813A2 METHODS FOR THE TREATMENT OF CARCINOMA 审中-公开
标题翻译：治疗癌症的方法
公开(公告)号：WO2003032813A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/033020
申请日：2002-10-16
申请人： GENENTECH INC.
发明人： GERRITSEN, Mary, E. , PEALE, Franklin, V., Jr. , WU, Thomas, D.
IPC分类号： A61B
CPC分类号： C07K16/2866
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞如肾细胞癌的基因组中扩增的基因的鉴定。预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。因此，由扩增的基因编码的蛋白质被认为是某些癌症如肾细胞癌的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。本发明涉及新型的诊断和治疗肿瘤的方法，如肾细胞癌。

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