专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0041531A3 SERINE PROTEASE INHIBITORS 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂
公开(公告)号：WO0041531A3
公开(公告)日：2001-08-16
申请号：PCT/US0000673
申请日：2000-01-11
申请人： GENENTECH INC , ALIAGAS MARTIN IGNACIO , ARTIS DEAN R , DINA MICHAEL S , FLYGARE JOHN A , GOLDSMITH RICHARD A , MUNROE REGINA A , OLIVERO ALAN G , PASTOR RICHARD , RAWSON THOMAS E , ROBARGE KIRK D , SUTHERLIN DANIEL P , WEESE KENNETH J , ZHOU AIHE , ZHU YAN
发明人： ALIAGAS-MARTIN IGNACIO , ARTIS DEAN R , DINA MICHAEL S , FLYGARE JOHN A , GOLDSMITH RICHARD A , MUNROE REGINA A , OLIVERO ALAN G , PASTOR RICHARD , RAWSON THOMAS E , ROBARGE KIRK D , SUTHERLIN DANIEL P , WEESE KENNETH J , ZHOU AIHE , ZHU YAN
IPC分类号： C07D333/34 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/381 , A61P7/02 , A61P9/10 , C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51 , C07C257/16 , C07C311/06 , C07C311/21
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having structure (A) are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译：具有结构（A）的化合物可用于抑制丝氨酸蛋白酶，例如TF /因子VIIa，因子Xa，凝血酶和激肽释放酶。这些化合物可用于预防和/或治疗凝血障碍的方法。

2. 发明申请

WO2011003065A3 PYRAZOLOPYRIMIDINE JAK INHIBITOR COMPOUNDS AND METHODS 审中-公开
标题翻译：吡唑并嘧啶JAK抑制剂化合物和方法
公开(公告)号：WO2011003065A3
公开(公告)日：2011-05-19
申请号：PCT/US2010040906
申请日：2010-07-02
申请人： GENENTECH INC , GIBBONS PAUL , HANAN EMILY , LIU WENDY , LYSSIKATOS JOSEPH P , MAGNUSON STEVEN R , MENDONCA ROHAN , PASTOR RICHARD , RAWSON THOMAS E , SIU MICHAEL , ZAK MARK E , ZHOU AIHE , ZHU BING-YAN
发明人： GIBBONS PAUL , HANAN EMILY , LIU WENDY , LYSSIKATOS JOSEPH P , MAGNUSON STEVEN R , MENDONCA ROHAN , PASTOR RICHARD , RAWSON THOMAS E , SIU MICHAEL , ZAK MARK E , ZHOU AIHE , ZHU BING-YAN
IPC分类号： C07D487/04 , A61K31/437 , A61P35/00 , C07D403/12
CPC分类号： C07D487/04
摘要： A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.
摘要翻译：其中R 1，R 2和R 3在本文中定义的式I化合物，对映异构体，非对映异构体，互变异构体或其药学上可接受的盐可用作一种或多种Janus激酶的抑制剂。公开了包含式I化合物和药学上可接受的载体，佐剂或载体的药物组合物，以及对患者中Janus激酶活性的抑制作出反应的疾病或病症的严重程度的治疗或减轻的方法。

3. 发明申请

WO2008086389A3 RECLOSEABLE PACKAGE 审中-公开
标题翻译：可拆卸包装
公开(公告)号：WO2008086389A3
公开(公告)日：2008-11-06
申请号：PCT/US2008050570
申请日：2008-01-09
申请人： AVERY DENNISON CORP , HAYNES KELLY WINEGARDEN , HOLBERT VICTOR PAUL , KILBOURNE KERRI , PASTOR RICHARD
发明人： HAYNES KELLY WINEGARDEN , HOLBERT VICTOR PAUL , KILBOURNE KERRI , PASTOR RICHARD
IPC分类号： B65D25/04 , B65D75/58
CPC分类号： B65D75/5838 , B65D25/04 , B65D75/366 , B65D2101/0007 , B65D2575/367 , B65D2575/368 , B65D2585/88
摘要： A rigid or semi-rigid package (100) or container comprising a body (110), a cover (120), and a resealable label (130). The body may have a tray or cup-like structure defining an interior region (114) for housing one or more items. The cover includes a reclosure section (122) defined by perforated or die-cut punch line(s) (124). The resealable label is disposed along the outer surface of the back cover and overlies the reclosure section. The label is releasably attached to the outer tray surface in at least a portion of an area exterior to the perimeter of the reclosure section, but has a "sufficient bond strength relative to the reclosure section such that the reclosure section detaches from the cover along the punch line when the label is peeled away from the cover for the first time such that the opening (124) is uncovered, which allows access to the interior (114) of the container.
摘要翻译：包括主体（110），盖（120）和可重新密封的标签（130）的刚性或半刚性包装（100）或容器。主体可以具有限定用于容纳一个或多个物品的内部区域（114）的托盘或杯状结构。所述盖包括由穿孔或冲切冲孔线（124）限定的重新闭合部分（122）。可再密封标签沿着后盖的外表面设置并覆盖在重合闸部分上。该标签在再闭合部分的周边的外部的至少一部分区域中可释放地附接到外部托盘表面，但是具有“相对于重新闭合部分的足够的粘结强度，使得重新闭合部分沿盖当标签首次从盖上剥离时，使得开口（124）未被覆盖，这允许进入容器的内部（114）的冲孔线。

4. 发明申请

WO2008086390A3 RECLOSEABLE CONTAINER 审中-公开
标题翻译：可拆卸集装箱
公开(公告)号：WO2008086390A3
公开(公告)日：2008-08-21
申请号：PCT/US2008050571
申请日：2008-01-09
申请人： AVERY DENNISON CORP , HAYNES KELLY WINEGARDEN , HOLBERT VICTOR PAUL , KILBOURNE KERRI , PASTOR RICHARD
发明人： HAYNES KELLY WINEGARDEN , HOLBERT VICTOR PAUL , KILBOURNE KERRI , PASTOR RICHARD
IPC分类号： B65D75/36
CPC分类号： B65D75/366 , B65D2575/366 , B65D2575/368
摘要： A rigid or semi-rigid package (100) or container comprising a body (110), a cover (130), and a resealable closure. The body may have a tray (112) or cup- like structure defining an interior region (114) for housing one or more items. The tray includes a reclosure section (124) defined by perforated or die-cut punch line(s) (126). A resealable label (140) is disposed along the outer surface of the tray and overlies the reclosure section. The label is releasably attached to the outer tray surface in at least a portion of an area along the perimeter of the reclosure section. The label is sufficiently adhered to at least a portion of the reclosure section such that the reclosure section remains attached to the label when the label is peeled away from the outer tray surface to uncover an opening (122) in the body and allow access to the interior of the container.
摘要翻译：刚性或半刚性包装（100）或容器，其包括主体（110），盖（130）和可重新密封的封闭件。主体可以具有限定用于容纳一个或多个物品的内部区域（114）的托盘（112）或杯状结构。托盘包括由穿孔或冲切切割线（126）限定的重新闭合部分（124）。可重新密封的标签（140）沿托盘的外表面设置并覆盖在重合闸部分上。标签在沿着重合闸部分的周边的区域的至少一部分中可释放地附接到外托盘表面。标签充分地粘附在重合闸部分的至少一部分上，使得当标签从外托盘表面剥离时，重新闭合部分保持附接到标签上，以露出主体中的开口（122）并允许接近容器内部

5. 发明申请

WO2007136714A2 INTEGRASE INHIBITORS 审中-公开
标题翻译：综合抑制剂
公开(公告)号：WO2007136714A2
公开(公告)日：2007-11-29
申请号：PCT/US2007011851
申请日：2007-05-16
申请人： GILEAD SCIENCES INC , CAI ZHENHONG R , JABRI SALMAN Y , JIN HAOLUN , LANSDOWN RACHAEL A , METOBO SAMUEL E , MISH MICHAEL L , PASTOR RICHARD
发明人： CAI ZHENHONG R , JABRI SALMAN Y , JIN HAOLUN , LANSDOWN RACHAEL A , METOBO SAMUEL E , MISH MICHAEL L , PASTOR RICHARD
CPC分类号： C07D471/04
摘要： Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
摘要翻译：公开了三环化合物，其受保护的中间体以及用于抑制HIV整合酶的方法。

6. 发明申请

WO2016086200A1 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS 审中-公开
标题翻译： 4,5,6,7-四氢-1H-吡唑并[4,3-C]吡啶-3-胺化合物，其为CBP和/或EP300抑制剂
公开(公告)号：WO2016086200A1
公开(公告)日：2016-06-02
申请号：PCT/US2015062794
申请日：2015-11-25
申请人： GENENTECH INC , CONSTELLATION PHARMACEUTICALS INC
发明人： ROMERO F ANTHONY , MAGNUSON STEVEN , PASTOR RICHARD , TSUI VICKIE HSIAO-WEI , MURRAY JEREMY , CRAWFORD TERRY , ALBRECHT BRIAN K , COTE ALEXANDRE , TAYLOR ALEXANDER M , LAI KWONG WAH , CHEN KEVIN X , BRONNER SARAH , ADLER MARC , EGEN JACKSON , LIAO JIANGPENG , WANG FEI , CYR PATRICK , ZHU BING-YAN , KAUDER STEVEN
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： A61K31/437 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07D471/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
摘要翻译：本发明涉及式（I）或式（II）化合物及其盐，其中式（I）的R 1 -R 4和式（II）的R 1 -R 3具有本文定义的任何值，组合物及其用途。该化合物可用作CBP和/或EP300的抑制剂。还包括包含式（II）的式（I）化合物或其药学上可接受的盐的药物组合物，以及在治疗各种CBP和/或EP300介导的病症中使用这些化合物和盐的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式