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1. 发明申请

WO2010132883A1 METHOD AND APPARATUS FOR EFFECTING AUTOMATED MOVEMENT OF A MAGNET IN AN INSTRUMENT FOR PERFORMING A MAGNETIC SEPARATION PROCEDURE 审中-公开
标题翻译：用于执行磁性分离程序的仪器中磁体的自动运动的方法和装置
公开(公告)号：WO2010132883A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/035138
申请日：2010-05-17
申请人： GEN-PROBE INCORPORATED , DAVIS, Christopher Brandon , HAGEN, Norbert D. , KNIGHT, Byron J. , OPALSKY, David , TUGGLE, James T.
发明人： DAVIS, Christopher Brandon , HAGEN, Norbert D. , KNIGHT, Byron J. , OPALSKY, David , TUGGLE, James T.
IPC分类号： B03C1/28 , B03C1/033
CPC分类号： B01L3/52 , B01L3/561 , B01L9/52 , B01L2300/0609 , B01L2300/12 , B03C1/0332 , B03C1/12 , B03C1/14 , B03C1/28 , B03C1/286 , B03C1/288 , B03C2201/18 , B03C2201/26 , B25J11/00 , B65B3/04 , C12N15/1013 , G01N35/0098 , Y10T29/49815
摘要： Methods, systems, and apparatus are provided for automated isolation of selected analytes, to which magnetically-responsive solid supports are bound, from other components of a sample. An apparatus for performing an automated magnetic separation procedure includes a mechanism for effecting linear movement of a magnet between operative and non-operative positions with respect to a receptacle device. A receptacle holding station within which a receptacle device may be temporarily stored prior to moving the receptacle to the apparatus for performing magnetic separation includes magnets for applying a magnetic field to the receptacle device held therein, thereby drawing at least a proton of the magnetically-responsive solid supports out of suspension before the receptacle device is moved to the magnetic separation station. An automated receptacle transport mechanism moves the receptacle devices between the apparatus for performing magnetic separation and the receptacle holding station.
摘要翻译：提供了方法，系统和装置，用于自动分离来自样品的其它组分的选定的分析物，其中磁响应固体支持物被结合。用于执行自动磁分离程序的装置包括用于在相对于插座装置的操作位置和非操作位置之间实现磁体的线性移动的机构。在将容器移动到用于执行磁性分离的装置之前可以临时存储插座装置的容器保持站包括用于向保持在其中的插座装置施加磁场的磁体，从而至少吸取磁响应的质子在插座装置移动到磁选分离台之前，固体支撑体不能悬挂。自动插座传送机构使插座装置在用于执行磁分离的装置和插座保持台之间移动。

2. 发明申请

WO2018064491A1 COMPOSITIONS ON PLASMA-TREATED SURFACES 审中-公开
标题翻译：等离子体处理过的表面上的组合物
公开(公告)号：WO2018064491A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/054325
申请日：2017-09-29
申请人： GEN-PROBE INCORPORATED
发明人： KNIGHT, Byron J. , OPALSKY, David
IPC分类号： C08J7/06 , C08J7/18
摘要： The disclosure provides solid compositions such as lyophilisates adhered to surfaces such as plasma-treated surfaces and related methods, uses, kits, intermediates, starting materials, and downstream products.
摘要翻译：本公开提供了固体组合物，例如粘附于表面的冻干物，例如等离子体处理的表面和相关方法，用途，试剂盒，中间体，起始材料和下游产物。

3. 发明申请

WO2010132887A2 CONTAMINATION CONTROL FOR LIQUID HANDLING 审中-公开
标题翻译：液体处理污染控制
公开(公告)号：WO2010132887A2
公开(公告)日：2010-11-18
申请号：PCT/US2010/035146
申请日：2010-05-17
申请人： GEN-PROBE INCORPORATED , CLARK, Craig B. , GILKER, John M. , HAGEN, Norbert D. , HORN, Tom R. , KNIGHT, Byron J. , OPALSKY, David , RHUBOTTOM, Jason F.
发明人： CLARK, Craig B. , GILKER, John M. , HAGEN, Norbert D. , HORN, Tom R. , KNIGHT, Byron J. , OPALSKY, David , RHUBOTTOM, Jason F.
IPC分类号： B01L9/06
CPC分类号： G06Q10/087 , B01L9/06 , B01L2200/023 , B01L2200/06 , B01L2200/141 , B01L2300/021 , G01N35/1004
摘要： A structure for holding sample-containing receptacles includes a cover with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element adjacent each opening engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.
摘要翻译：用于保持含有样品的容器的结构包括其中形成有孔的盖，通过该盖可以用诸如机器人移液器的物质转移机构接近容器。当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。邻近每个开口的粘性排除元件与该粘性材料串接合，并且当机构相对于移除元件以规定的路径移动时，将该绳从机构中移出。被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。

4. 发明申请

WO2007095244A2 DRIP SHIELD 审中-公开
公开(公告)号：WO2007095244A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003824
申请日：2007-02-12
申请人： GEN-PROBE INCORPORATED , KNIGHT, Byron J.
发明人： KNIGHT, Byron J.
CPC分类号： G01N35/026 , B01L9/06 , G01N35/1016 , G01N2035/00287 , G01N2035/102 , Y10T436/11 , Y10T436/111666 , Y10T436/114998 , Y10T436/2575
摘要： A drip shield includes cover members that define a protective canopy over sample receptacles to prevent unwanted material from being deposited into the receptacles. The cover members cooperate to define at least one access hole through the drip shield to permit access to a sample receptacle by a pipette tip through the access hole. One of the cover members is moveable with respect to another cover member between a closed stated defining the access hole and an open state permitting a pipette tip extending through the access hole to be laterally conveyed relative to the drip shield and out of the access hole. In a preferred embodiment, a system control feature automatically determines if a pipette tip might have been left in a sample receptacle and extending through the access hole of the drip shield and thereby cause the sample receptacle and pipette tip to be conveyed laterally relative to the drip shield while the one cover member moves from the closed to the open state to permit the pipette tip to be conveyed out of the access hole.
摘要翻译：滴水罩包括覆盖件，其在样品容器上限定了保护罩，以防止不想要的材料沉积到容器中。盖构件配合以限定穿过滴水罩的至少一个进入孔，以允许移液管尖端通过进入孔进入样品容器。其中一个盖构件相对于另一个盖构件是可移动的，该闭合构造限定了进入孔和打开状态，允许穿过进入孔延伸的移液管尖端相对于滴水盖横向地输送并从进入孔中移出。在优选实施例中，系统控制特征自动确定移液管尖端是否可能已经留在样品容器中并且延伸通过滴液罩的进入孔并且由此导致样品容器和移液管尖端相对于滴液侧向传送屏蔽，同时一个封盖构件从关闭状态移动到打开状态，以允许移液管吸头从出入孔输出。

5. 发明申请

WO2018160979A1 EVAPORATION-LIMITING INSERTS FOR REAGENT CONTAINERS AND RELATED METHODS OF USE 审中-公开
公开(公告)号：WO2018160979A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020680
申请日：2018-03-02
申请人： GEN-PROBE INCORPORATED
发明人： KNIGHT, Byron J. , CHABOT, Vincent
IPC分类号： B01L3/00
摘要： An insert for a liquid-holding container may include a body comprising a wall, open first and second ends, and a lumen extending from the open first end to the open second end. The insert also may include a plurality of first openings formed in the wall, the first openings being situated between the first and second ends, and each of the first openings defining an area, and one or more second openings formed in the wall, the one or more second openings being situated between the first and second ends, each of the one or more second openings defining an area that is greater than the area defined by any of the first openings, where at least one of the one or more second openings is situated closer to the first end than any of the first openings, and wherein each of the first and second openings is sized to permit the passage of a liquid.

6. 发明申请

WO2012016142A1 METHOD, SYSTEM AND APPARATUS FOR INCORPORATING CAPACITIVE PROXIMITY SENSING IN AN AUTOMATED FLUID TRANSFER PROCEDURE 审中-公开
标题翻译：在自动流体传输程序中并入电容式近似感测的方法，系统和装置
公开(公告)号：WO2012016142A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045890
申请日：2011-07-29
申请人： GEN-PROBE INCORPORATED , KNIGHT, Byron J. , OPALSKY, David , SCHROETER, Brian
发明人： KNIGHT, Byron J. , OPALSKY, David , SCHROETER, Brian
IPC分类号： G01N35/10
CPC分类号： G01N35/1011 , G01F23/263 , G01N2035/1013
摘要： A fluid transfer apparatus includes a fluid transfer probe, a fluid level detection system, and a tip detection system. The fluid level detection system is configured to detect contact by the fluid transfer probe with a fluid surface within a receptacle from a signal based on the capacitance of the fluid transfer probe. The tip detection system is configured to detect the presence or absence of a tip at a distal end of the fluid transfer probe from a signal based on the capacitance of the fluid transfer probe.
摘要翻译：液体输送装置包括流体转移探针，液位检测系统和尖端检测系统。流体液位检测系统配置成基于流体转移探针的电容从信号中检测流体转移探针与容器内的流体表面的接触。尖端检测系统被配置为基于流体转移探针的电容从信号中检测流体转移探针的远端处的尖端的存在或不存在。

7. 发明申请

WO2021195083A1 FLUID CONTAINER 审中-公开
公开(公告)号：WO2021195083A1
公开(公告)日：2021-09-30
申请号：PCT/US2021/023683
申请日：2021-03-23
申请人： GEN-PROBE INCORPORATED
发明人： BUSE, David , KNIGHT, Byron J.
IPC分类号： B01L3/00 , G01N35/10 , B01L2200/025 , B01L2200/141 , B01L2200/16 , B01L2300/021 , B01L2300/044 , B01L2300/0832 , B01L2300/0858 , B01L2300/123 , B01L3/523 , B65D51/002 , G01N2035/00277 , G01N35/0099 , G01N35/1079
摘要： A container includes a base with a top wall, a vessel depending from a top wall aperture in the top wall, a fluid retainer projecting above the top wall and surrounding the top wall aperture, and a skirt surrounding the vessel and including opposed grooves for gripping the container. A lid is disposed on a top end of the base and includes a cover wall with a lid aperture generally aligned with the top wall aperture of the base. A septum is disposed between the top wall of the base and the cover wall with a portion of the septum disposed between the lid aperture and the top wall aperture. Fluid retainer/return structure is configured to prevent fluid deposited on the septum from dripping off the container and to allow at least a portion of the fluid deposited on the septum to run off the septum and into the vessel.

8. 发明申请

WO2017023934A1 APPARATUS FOR MAINTAINING A CONTROLLED ENVIRONMENT 审中-公开
标题翻译：用于维护控制环境的装置
公开(公告)号：WO2017023934A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/045166
申请日：2016-08-02
申请人： GEN-PROBE INCORPORATED
发明人： KNIGHT, Byron J.
IPC分类号： F26B5/06 , A01N1/02 , B01L9/06 , F26B25/06
CPC分类号： F26B5/06 , A01N1/0252 , A01N1/0289 , B01L7/00 , B01L9/06 , B01L2200/0689 , B01L2300/042 , B01L2300/0829 , B01L2300/1894 , B01L2400/049 , F26B25/063
摘要： A lyophilization nest and method of using the same is described herein. In various embodiments, the lyophilization nest is configured to support one or more receptacles each supporting one or more substances within an interior space of the lyophilization nest. The interior space may be in fluid communication with the exterior of the lyophilization nest through one or more vent holes extending through a surface of the lyophilization nest. Each of the one or more vent holes have a corresponding sealing element configured to selectively form an air-tight seal within the vent holes, such that a controlled environment may be maintained within the interior space when the ambient conditions surrounding the lyophilization nest are not lyophilization conditions. The one or more sealing elements may be operable while the lyophilization nest is positioned within a sealed lyophilizer by depressing the sealing elements into corresponding vent holes to form the air-tight seal.
摘要翻译：本文描述了冻干巢及其使用方法。在各种实施方案中，冻干巢构造成支撑一个或多个容纳物，每个容器支撑在冻干巢的内部空间内的一种或多种物质。内部空间可以通过穿过冷冻干燥器表面的一个或多个通气孔与冻干巢的外部流体连通。一个或多个通气孔中的每一个具有相应的密封元件，其被配置为在通气孔内选择性地形成气密密封，使得当围绕冻干巢的环境条件未被冷冻干燥时，可以在内部空间内保持受控环境条件。一个或多个密封元件可以是可操作的，同时通过将密封元件压入相应的通气孔以形成气密密封，将冻干窝定位在密封的冻干机内。

9. 发明申请

WO2016200933A1 METHODS AND DEVICES FOR CALIBRATING AND/OR MONITORING OPTICAL MEASUREMENT DEVICES 审中-公开
标题翻译：用于校准和/或监测光学测量装置的方法和装置
公开(公告)号：WO2016200933A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036439
申请日：2016-06-08
申请人： GEN-PROBE INCORPORATED
发明人： HAGEN, Norbert D. , OPALSKY, David , WALKER, George T. , KNIGHT, Byron J.
IPC分类号： G01N21/27 , G01N21/64
CPC分类号： G01N21/64 , G01N21/276 , G01N21/645
摘要： An optical signal detection module includes an optical measurement device (OMD) configured to detect an optical emission signal from an emission signal source placed in a signaldetecting position of the OMD. The optical signal detection module also includes a cover moveable between a closed position covering the signal-detecting position and an open position not covering the signal-detecting position. The cover includes an optical reference material that emits a reference emission detectable by the OMD. The cover is configured so that, when the cover is in the closed position, the inner surface is in the signal-detecting position of the OMD so that the OMD detects the reference emission. The optical signal detection module can also include a drive assembly coupled to the cover and configured to move the cover between the open position and the closed position. In some embodiments, the OMD can include a fluorometer.
摘要翻译：光信号检测模块包括被配置为从位于OMD的信号检测位置的发射信号源检测光发射信号的光学测量装置（OMD）。光信号检测模块还包括可在覆盖信号检测位置的关闭位置和不覆盖信号检测位置的打开位置之间移动的盖。该盖包括发射由OMD可检测的参考发射的光学参考物质。盖被配置为使得当盖处于关闭位置时，内表面处于OMD的信号检测位置，使得OMD检测参考发射。光信号检测模块还可以包括耦合到盖并被构造成在打开位置和关闭位置之间移动盖的驱动组件。在一些实施方案中，OMD可以包括荧光计。

10. 发明申请

WO2016164740A1 SAMPLE TESTING SYSTEMS AND METHODS WITH AUTOMATED CLEANING 审中-公开
标题翻译：样品测试系统和自动清洗方法
公开(公告)号：WO2016164740A1
公开(公告)日：2016-10-13
申请号：PCT/US2016/026669
申请日：2016-04-08
申请人： GEN-PROBE INCORPORATED
发明人： HAGEN, Norbert D. , KNIGHT, Byron J. , OPALSKY, David
IPC分类号： B08B11/00 , G01N21/03 , G01N21/15 , B08B9/00 , B08B1/00
CPC分类号： G01N21/15 , B08B1/00 , B08B9/00 , B08B2240/02 , G01N35/00623 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2021/152 , G01N2035/00277 , G02B6/3866
摘要： A sample testing system includes a test receptacle support structure, an optical element positioned for transmitting electromagnetic radiation emitted or reflected by a sample disposed in a test receptacle supported by the test receptacle support structure, a cleaning member, and an automated transport arm configured to (i) detachably couple the cleaning member, (ii) move the detachably-coupled cleaning member into a position proximate to and/or contacting the optical element, and (iii) decouple the cleaning member.
摘要翻译：样品测试系统包括测试容器支撑结构，光学元件，定位成用于传送由设置在由测试插座支撑结构支撑的测试插座中的样本发射或反射的电磁辐射，清洁部件和自动化传输臂， i）可拆卸地联接清洁构件，（ii）将可拆卸地联接的清洁构件移动到靠近和/或接触光学元件的位置，以及（iii）将清洁构件分离。

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