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1. 发明申请

WO2006099255A2 SYSTEMS AND METHODS TO PERFORM ASSAYS FOR DETECTING OR QUANTIFYING ANALYTES WITHIN SAMPLES 审中-公开
标题翻译：执行样品检测或定量分析的样品的系统和方法
公开(公告)号：WO2006099255A2
公开(公告)日：2006-09-21
申请号：PCT/US2006008823
申请日：2006-03-10
申请人： GEN PROBE INC , CARRICK JAMES M , DAVIS CHRISTOPHER BRANDON , HEINZ ROBERT E , KNIGHT BYRON J , LAIR GARY D , LI FLORENCE F , LI HAITO , LIGHT JAMES P , MACIOSZEK JERZY A , NGUYEN THANH N , SCALESE ROBERT F
发明人： CARRICK JAMES M , DAVIS CHRISTOPHER BRANDON , HEINZ ROBERT E , KNIGHT BYRON J , LAIR GARY D , LI FLORENCE F , LI HAITO , LIGHT JAMES P , MACIOSZEK JERZY A , NGUYEN THANH N , SCALESE ROBERT F
IPC分类号： G01N35/02
CPC分类号： G01N21/6428 , B01L7/52 , C12Q1/6813 , C12Q1/6851 , G01N21/6454 , G01N21/76 , G01N35/00693 , G01N35/0092 , G01N35/0098 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/04 , G01N35/1002 , G01N2021/6419 , G01N2021/6421 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441 , G01N2035/00346 , G01N2035/00356 , G01N2035/00524 , G01N2035/0097 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2035/0455 , G01N2035/0491 , G01N2035/103 , G01N2201/0415 , Y10S435/808 , Y10S435/809 , Y10T436/113332 , Y10T436/25 , C12Q2537/165
摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.
摘要翻译：用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。自动化容器输送系统将样品容器从一个站移动到另一个站。执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

2. 发明申请

WO2006113854A3 SAMPLE TUBE HOLDER 审中-公开
标题翻译：样品管座
公开(公告)号：WO2006113854A3
公开(公告)日：2007-07-19
申请号：PCT/US2006014847
申请日：2006-04-19
申请人： GEN PROBE INC , KNIGHT BYRON J , TALMER MARK A , SANDOVAL ARTHUR G , HOWARD ROBERT A , HIPOLITO ROMMEL M , SCALESE ROBERT F
发明人： KNIGHT BYRON J , TALMER MARK A , SANDOVAL ARTHUR G , HOWARD ROBERT A , HIPOLITO ROMMEL M , SCALESE ROBERT F
IPC分类号： B01L9/06
CPC分类号： G01N35/025 , B01L9/06 , B01L2200/025 , B01L2300/021 , G01N2035/0446 , G01N2035/0451 , G01N2035/0465 , Y10S435/809
摘要： A sample tube holder for restricting vertical and lateral movement of sample tubes. The sample tube holder has sample tube compartments with sets of finger springs for maintaining sample tubes in substantially vertical orientations and a retainer for limiting vertical mobility of the sample tubes. Fluid transfer devices access the sample tubes through openings in the retainer aligned above the sample tube compartments. A guide structure having openings formed therein is included to restrict lateral movement of caps associated with the sample tubes. Tabs at a base of the sample tube holder and hold-downs fixed to a stationary structure adjacent a conveyor restrict vertical movement of the sample tube holder during automated sampling procedures.
摘要翻译：用于限制样品管的垂直和横向移动的样品管支架。样品管支架具有样品管隔室，其具有用于将样品管保持在基本垂直取向的一组指状弹簧和用于限制样品管的垂直流动性的保持器。流体输送装置通过样品管隔室中的定位器上的开口进入样品管。包括其中形成有开口的引导结构被包括以限制与样品管相关联的盖的横向移动。在样品管支架的基部处的突片和固定到邻近输送机的固定结构的压紧件在自动采样过程中限制了样品管支架的垂直运动。

3. 发明申请

WO2010132885A3 METHOD AND APPARATUS FOR EFFECTING TRANSFER OF REACTION RECEPTACLES IN AN INSTRUMENT FOR MULTI-STEP ANALYTICAL PROCEDURES 审中-公开
标题翻译：用于多步骤分析程序的仪器中用于反应反应的转移的方法和装置
公开(公告)号：WO2010132885A3
公开(公告)日：2011-03-03
申请号：PCT/US2010035143
申请日：2010-05-17
申请人： GEN PROBE INC , HAGEN NORBERT D , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
发明人： HAGEN NORBERT D , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
IPC分类号： G01N35/04
CPC分类号： B65G47/901 , G01N35/026 , G01N35/04 , G01N2035/0413 , G01N2035/0422 , G01N2035/0484
摘要： Systems for effecting transfer of reaction receptacles between modules of an instrument for performing multi-step analytical procedures and for adjusting for variations in the positions of such modules includes a receptacle carrier supported on a track on which the carrier translates between different modules located adjacent to the track. The carrier includes a receptacle distribution head supported on a receptacle carrier carriage. The distribution head includes a receptacle moving mechanism adapted to move receptacles into and out of the distribution head and into and out of a module. The carriage is engaged with the track and adapted for translation along the track. Drive systems effect powered translation of the carriage, powered elevation and rotation of the distribution head, and powered movement of receptacles into and out of the distribution head. A transfer position locating system automatically determines a receptacle transfer position of the receptacle carrier with respect to each module.
摘要翻译：用于实现用于执行多步分析程序的仪器的模块之间的反应容器的传送和用于调整这些模块的位置的变化的反应容器的传送系统包括支撑在轨道上的容器载体，载体在该轨道上平移，跟踪。托架包括支撑在插座托架上的插座分配头。分配头包括插座移动机构，其适于将插座移入和分出头部并进出模块。滑架与轨道接合并适应轨道的翻译。驱动系统影响滑架的动力翻转，分配头的动力升降和旋转，以及插座进出分配头的动力运动。传送位置定位系统自动确定插座托架相对于每个模块的插座传送位置。

4. 发明申请

WO2010132887A3 CONTAMINATION CONTROL FOR LIQUID HANDLING 审中-公开
标题翻译：液体处理污染控制
公开(公告)号：WO2010132887A3
公开(公告)日：2011-02-17
申请号：PCT/US2010035146
申请日：2010-05-17
申请人： GEN PROBE INC , CLARK CRAIG B , GILKER JOHN M , HAGEN NORBERT D , HORN TOM R , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
发明人： CLARK CRAIG B , GILKER JOHN M , HAGEN NORBERT D , HORN TOM R , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
IPC分类号： B01L9/06 , G01N35/00 , G01N35/10
CPC分类号： G06Q10/087 , B01L9/06 , B01L2200/023 , B01L2200/06 , B01L2200/141 , B01L2300/021 , G01N35/1004
摘要： A structure (10) for holding sample-containing receptacles includes a cover (40) with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element (44) adjacent each opening (42) engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.
摘要翻译：用于保持含有样品的容器的结构（10）包括其中形成有孔的盖（40），通过所述盖（40）可以用诸如机器人移液器的物质转移机构接近所述容器。当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。邻近每个开口（42）的粘性排除元件（44）与粘性材料串接合，并且当机构相对于去除元件以规定的路径移动时，将串从机构中移出。被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。

5. 发明申请

WO2007095244A3 DRIP SHIELD 审中-公开
公开(公告)号：WO2007095244A3
公开(公告)日：2007-11-01
申请号：PCT/US2007003824
申请日：2007-02-12
申请人： GEN PROBE INC , KNIGHT BYRON J
发明人： KNIGHT BYRON J
IPC分类号： G01N35/02 , B01L9/00
CPC分类号： G01N35/026 , B01L9/06 , G01N35/1016 , G01N2035/00287 , G01N2035/102 , Y10T436/11 , Y10T436/111666 , Y10T436/114998 , Y10T436/2575
摘要： A drip shield includes cover members that define a protective canopy over sample receptacles to prevent unwanted material from being deposited into the receptacles. The cover members cooperate to define at least one access hole through the drip shield to permit access to a sample receptacle by a pipette tip through the access hole. One of the cover members is moveable with respect to another cover member between a closed stated defining the access hole and an open state permitting a pipette tip extending through the access hole to be laterally conveyed relative to the drip shield and out of the access hole. In a preferred embodiment, a system control feature automatically determines if a pipette tip might have been left in a sample receptacle and extending through the access hole of the drip shield and thereby cause the sample receptacle and pipette tip to be conveyed laterally relative to the drip shield while the one cover member moves from the closed to the open state to permit the pipette tip to be conveyed out of the access hole.
摘要翻译：滴水屏蔽包括盖构件，其在样品容器上限定保护罩，以防止不需要的材料沉积到容器中。盖构件协作以限定通过滴水屏蔽的至少一个进入孔，以允许通过移液管尖端通过进入孔进入样品容器。盖构件中的一个可相对于另一盖构件在关闭状态限定出入孔和打开状态之间移动，打开状态允许延伸穿过进入孔的移液管尖端相对于滴水屏蔽物横向输送并且进出通路孔。在优选实施例中，系统控制特征自动地确定移液器吸头是否可能已经留在样品容器中并延伸穿过滴水屏蔽的入口孔，从而使样品容器和移液管尖端相对于滴液横向输送屏蔽，同时一个盖构件从关闭状态移动到打开状态，以允许移液管尖端从进入孔传送出去。

6. 发明申请

WO2014153116A2 APPARATUS FOR INDEXING AND AGITATING FLUID CONTAINERS 审中-公开
标题翻译：用于引导和制造流体容器的装置
公开(公告)号：WO2014153116A2
公开(公告)日：2014-09-25
申请号：PCT/US2014029161
申请日：2014-03-14
申请人： GEN PROBE INC
发明人： BUSE DAVID AARON , KNIGHT BYRON J
IPC分类号： B01F11/00
CPC分类号： B01F15/00837 , B01F9/0016 , B01F9/22 , B01F11/0014 , B01L3/523 , B01L2200/026 , B01L2200/142 , B65D23/00 , G01N2035/00524
摘要： An apparatus configured for mixing the contents of one or more fluid containers includes a fluid container support platform configured to hold one or more fluid containers. The fluid container support platform is configured to index the container to one or more specified locations and to be moved in an orbital path about an orbital center independently of the rotation about the central axis of rotation. The apparatus further includes an indexing drive system configured to effect indexing movement of the container support platform and a vortex drive system configured to effect powered orbital movement of the container support platform about the orbital center. An evaporation limiting insert placed within containers reduces exposure of the fluid contents of the container to atmospheric air, thereby reducing susceptibility of the fluid contents to evaporation.
摘要翻译：被配置为混合一个或多个流体容器的内容物的装置包括被配置为容纳一个或多个流体容器的流体容器支撑平台。流体容器支撑平台构造成将容器指向一个或多个指定位置，并且可围绕中心旋转轴线的旋转独立于围绕轨道中心的轨道路径移动。该装置还包括分配驱动系统，其被配置为实现容器支撑平台的分度运动;以及涡旋驱动系统，其配置成实现容器支撑平台围绕轨道中心的动力轨道运动。放置在容器内的蒸发限制插入物减少容器的流体内容物暴露于大气中，从而降低流体内容物蒸发的易感性。

7. 发明申请

WO2014151996A3 SYSTEMS, METHODS, AND APPARATUSES FOR PERFORMING AUTOMATED REAGENT-BASED ASSAYS 审中-公开
标题翻译：用于执行基于自动化试剂的测定的系统，方法和装置
公开(公告)号：WO2014151996A3
公开(公告)日：2014-12-04
申请号：PCT/US2014026789
申请日：2014-03-13
申请人： GEN PROBE INC
发明人： KNIGHT BYRON J , BUSE DAVID , GROELI JULIAN
IPC分类号： B01L3/00
CPC分类号： G01N35/1002 , B01L3/502 , B01L3/5082 , B01L3/50825 , B01L3/5085 , B01L3/50853 , B01L3/50855 , B01L3/523 , B01L3/527 , B01L2200/02 , B01L2200/025 , B01L2200/026 , B01L2200/0668 , B01L2200/0689 , B01L2200/141 , B01L2200/142 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L2300/046 , B01L2300/047 , B01L2300/048 , B01L2300/0609 , B01L2300/0829 , B01L2300/0832 , B01L2300/0838 , B01L2300/0851 , B01L2300/0858 , B01L2300/12 , B01L2400/0406 , B65B69/00 , B65D1/0207 , B65D1/34 , B65D1/36 , B65D17/50 , B65D39/0017 , B65D39/0029 , B65D2539/003 , C12Q1/686 , G01N30/6091 , G01N35/0099 , G01N35/026 , G01N35/10 , G01N35/1079 , G01N2035/00287 , Y10T436/11
摘要： System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.
摘要翻译：提供了用于执行基于自动化试剂的分析的系统，装置和方法。还提供了用于将盖自动附接到反应容器的方法，以及从加盖的反应容器自动移除盖。

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