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1. 发明申请

WO2014159066A3 APPARATUS FOR DETECTING SIGNAL EMISSIONS FROM A PLURALITY OF FLUORESCENT SOURCES 审中-公开
标题翻译：检测来自多种荧光源的信号排放的装置
公开(公告)号：WO2014159066A3
公开(公告)日：2014-12-24
申请号：PCT/US2014021820
申请日：2014-03-07
申请人： GEN PROBE INC
发明人： HAGEN NORBERT D , OPALSKY DAVID
IPC分类号： G01N21/25 , G01N21/64
CPC分类号： G02B6/3668 , G01N21/253 , G01N21/6452 , G01N2021/6484 , G02B6/06 , G02B6/08 , G02B6/3672 , G02B6/4214 , G02B6/4246 , G02B6/4269
摘要： An indexing signal detection module (100) is configured to index one or more signal detectors (200) past each of a plurality of sources of detectable signal emissions to detect or measure a signal emitted by each source. A plurality of signal transmission conduits (180) transmit signal emitted by the sources from a first end of each conduit to a second end of each conduit where the signal may be detected by a signal detector. A conduit reformatter (150) is configured to secure the first ends of the respective signal transmission conduits in a first spatial arrangement corresponding to a spatial arrangement of the signal emission sources and to secure the second ends of the respective signal transmission conduits in a second spatial arrangement different from the first spatial arrangement.
摘要翻译：索引信号检测模块（100）被配置为将一个或多个信号检测器（200）转移经过多个可检测信号发射源中的每一个，以检测或测量由每个源发射的信号。多个信号传输管道（180）将源发射的信号从每个管道的第一端传送到每个管道的第二端，其中信号可由信号检测器检测。导管重新配置器（150）被配置为以对应于信号发射源的空间布置的第一空间布置来固定相应的信号传输导管的第一端，并且将相应的信号传输导管的第二端固定在第二空间安排不同于第一空间布置。

2. 发明申请

WO2014022532A2 SYSTEM, METHOD, AND APPARATUS FOR AUTOMATED INCUBATION 审中-公开
标题翻译：用于自动孵化的系统，方法和装置
公开(公告)号：WO2014022532A2
公开(公告)日：2014-02-06
申请号：PCT/US2013052966
申请日：2013-07-31
申请人： GEN PROBE INC
发明人： BUSE DAVID , COMBS DAVID HOWARD , HAGEN NORBERT D , OPALSKY DAVID , RICHARDSON BRUCE , PRASAD ANITA , MORAVICK KEITH , MOORE TYLER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , B01L7/52 , B01L9/06 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N21/6452 , G01N2021/6482 , G01N2021/6484
摘要： System, apparatus, and method for cycling the temperature of at least one receptacle holder that is adapted for use in an automated instrument capable of performing nucleic acid- based amplification tests. Also provided are methods for conducting automated, random- access incubation processes using the same.
摘要翻译：用于循环适用于能够执行基于核酸的扩增测试的自动化仪器中的至少一个容器保持器的温度的系统，设备和方法。还提供了使用该方法进行自动化，随机访问孵育过程的方法。

3. 发明申请

WO2010132885A3 METHOD AND APPARATUS FOR EFFECTING TRANSFER OF REACTION RECEPTACLES IN AN INSTRUMENT FOR MULTI-STEP ANALYTICAL PROCEDURES 审中-公开
标题翻译：用于多步骤分析程序的仪器中用于反应反应的转移的方法和装置
公开(公告)号：WO2010132885A3
公开(公告)日：2011-03-03
申请号：PCT/US2010035143
申请日：2010-05-17
申请人： GEN PROBE INC , HAGEN NORBERT D , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
发明人： HAGEN NORBERT D , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
IPC分类号： G01N35/04
CPC分类号： B65G47/901 , G01N35/026 , G01N35/04 , G01N2035/0413 , G01N2035/0422 , G01N2035/0484
摘要： Systems for effecting transfer of reaction receptacles between modules of an instrument for performing multi-step analytical procedures and for adjusting for variations in the positions of such modules includes a receptacle carrier supported on a track on which the carrier translates between different modules located adjacent to the track. The carrier includes a receptacle distribution head supported on a receptacle carrier carriage. The distribution head includes a receptacle moving mechanism adapted to move receptacles into and out of the distribution head and into and out of a module. The carriage is engaged with the track and adapted for translation along the track. Drive systems effect powered translation of the carriage, powered elevation and rotation of the distribution head, and powered movement of receptacles into and out of the distribution head. A transfer position locating system automatically determines a receptacle transfer position of the receptacle carrier with respect to each module.
摘要翻译：用于实现用于执行多步分析程序的仪器的模块之间的反应容器的传送和用于调整这些模块的位置的变化的反应容器的传送系统包括支撑在轨道上的容器载体，载体在该轨道上平移，跟踪。托架包括支撑在插座托架上的插座分配头。分配头包括插座移动机构，其适于将插座移入和分出头部并进出模块。滑架与轨道接合并适应轨道的翻译。驱动系统影响滑架的动力翻转，分配头的动力升降和旋转，以及插座进出分配头的动力运动。传送位置定位系统自动确定插座托架相对于每个模块的插座传送位置。

4. 发明申请

WO2014153193A9 DIAGNOSTIC SYSTEMS AND METHODS 审中-公开
标题翻译：诊断系统和方法
公开(公告)号：WO2014153193A9
公开(公告)日：2015-01-15
申请号：PCT/US2014029538
申请日：2014-03-14
申请人： GEN PROBE INC
发明人： BUSE DAVID AARON , OPALSKY DAVID , RHUBOTTOM JASON , HAGEN NORBERT , TIDD JENNIFER
IPC分类号： B01L7/00
CPC分类号： C12Q1/6806 , B01L3/50825 , B01L3/527 , B01L3/565 , B01L7/5255 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , C12Q1/686 , G01N35/04 , G01N2035/0418 , G01N2035/0436
摘要： A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.
摘要翻译：诊断系统进行第一次核酸扩增反应和第二次不同的核酸扩增反应。诊断系统包括隔室，其被配置为至少存储包含用于进行样品制备过程的第一体积试剂的第一体积试剂容器和包含用于进行第一反应的第二体积试剂的第二体试试剂容器。所述系统包括被配置为存储至少一个包含用于进行第二反应的多个单位剂量试剂的单位剂量包装的室。诊断系统被配置为使用提供给诊断系统的多个样本中的每一个上的第一批量试剂进行样品制备过程。该系统配置为在第一样品子集上使用第二本体试剂进行第一反应，并且在第二样品子集上使用多个第一单位剂量试剂进行第二反应。

5. 发明申请

WO2014153193A3 DIAGNOSTIC SYSTEMS AND METHODS 审中-公开
标题翻译：诊断系统和方法
公开(公告)号：WO2014153193A3
公开(公告)日：2014-11-27
申请号：PCT/US2014029538
申请日：2014-03-14
申请人： GEN PROBE INC
发明人： BUSE DAVID AARON , OPALSKY DAVID , RHUBOTTOM JASON , HAGEN NORBERT , TIDD JENNIFER
IPC分类号： B01L7/00
CPC分类号： C12Q1/6806 , B01L3/50825 , B01L3/527 , B01L3/565 , B01L7/5255 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , C12Q1/686 , G01N35/04 , G01N2035/0418 , G01N2035/0436
摘要： A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.
摘要翻译：诊断系统进行第一次核酸扩增反应和第二次不同的核酸扩增反应。诊断系统包括隔室，其被配置为至少存储包含用于进行样品制备过程的第一体积试剂的第一体积试剂容器和包含用于进行第一反应的第二体积试剂的第二体试试剂容器。所述系统包括被配置为存储至少一个包含用于进行第二反应的多个单位剂量试剂的单位剂量包装的室。诊断系统被配置为使用提供给诊断系统的多个样本中的每一个上的第一批量试剂进行样品制备过程。该系统配置为在第一样品子集上使用第二本体试剂进行第一反应，并且在第二样品子集上使用多个第一单位剂量试剂进行第二反应。

6. 发明申请

WO2013036941A3 AUTOMATED SAMPLE HANDLING INSTRUMENTATION, SYSTEMS, PROCESSES, AND METHODS 审中-公开
标题翻译：自动样品处理仪器，系统，过程和方法
公开(公告)号：WO2013036941A3
公开(公告)日：2014-05-08
申请号：PCT/US2012054481
申请日：2012-09-10
申请人： GEN PROBE INC , SILBERT ROLF , OPALSKY DAVID
发明人： SILBERT ROLF , OPALSKY DAVID
IPC分类号： G01N15/06 , G01N13/02
CPC分类号： G01N35/1004 , C40B60/12 , G01F23/265 , G01N35/00732 , G01N35/0099 , G01N35/1002 , G01N35/1016 , G01N35/1079 , G01N2035/00524 , G01N2035/00752 , G01N2035/00811 , G01N2035/00831 , G01N2035/00861 , G01N2035/0405 , G01N2035/1062
摘要： The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.
摘要翻译：本发明提供了一种用于自动处理生物样品的处理站，用于生物样品处理或测定仪器内的消耗品的自动化实时库存控制的系统，用于处理生物样品的高通量随机存取自动化仪器，用于样品的加工或分析，以及自动粘液样检测和消除的过程。还公开了使用所公开的仪器，粘液样检测方法和处理和/或分析样品的系统的方法。

7. 发明申请

WO2012064940A8 SYSTEM AND METHOD FOR TRACKING ITEMS DURING A PROCESS 审中-公开
标题翻译：在一个过程中追踪项目的系统和方法
公开(公告)号：WO2012064940A8
公开(公告)日：2012-12-20
申请号：PCT/US2011060159
申请日：2011-11-10
申请人： GEN PROBE INC , HAGEN NORBERT D , OPALSKY DAVID
发明人： HAGEN NORBERT D , OPALSKY DAVID
IPC分类号： G01N35/00
CPC分类号： G06Q10/087 , G01N35/00732 , G01N2035/00752 , G01N2035/00782 , G01N2035/00801 , G01N2035/00831 , G01N2035/00841
摘要： A system and method for tracking items, such as receptacles, during a process employs a rack configured to hold one or more receptacles. Each receptacle includes a machine-readable label providing information regarding the receptacle, such as contents thereof and process(es) to be performed thereon, and each receptacle-receiving position of the rack has associated therewith a machine-readable label identifying the receptacle receiving location. The rack also includes a memory element to which electronic data may be written. A label reading device reads the machine-readable label on each receptacle and the position-indicating, machine-readable labels on the rack. Information obtained from the machine-readable labels is written to the memory element, so that for subsequent processing of the receptacles carried on the rack, information relating to each of the receptacles can be obtained by reading the information written to the memory element. A tamper prevention element provides an indication of whether the rack may have been tampered with after data is written to the memory element.
摘要翻译：用于在过程期间跟踪物品（诸如插座）的系统和方法采用配置成容纳一个或多个插座的机架。每个插座包括提供关于插座的信息的机器可读标签，例如其内容和要在其上执行的处理，并且机架的每个插座接收位置具有与其相关联的机器可读标签，其标识插座接收位置。机架还包括可以写入电子数据的存储元件。标签读取装置读取每个插座上的机器可读标签和机架上的位置指示机器可读标签。从机器可读标签获得的信息被写入存储元件，因此为了随后处理在机架上承载的插座，可以通过读取写入存储元件的信息来获得与每个插座有关的信息。防篡改元件提供了在将数据写入存储元件之后是否可能篡改了机架的指示。

8. 发明申请

WO2010132887A3 CONTAMINATION CONTROL FOR LIQUID HANDLING 审中-公开
标题翻译：液体处理污染控制
公开(公告)号：WO2010132887A3
公开(公告)日：2011-02-17
申请号：PCT/US2010035146
申请日：2010-05-17
申请人： GEN PROBE INC , CLARK CRAIG B , GILKER JOHN M , HAGEN NORBERT D , HORN TOM R , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
发明人： CLARK CRAIG B , GILKER JOHN M , HAGEN NORBERT D , HORN TOM R , KNIGHT BYRON J , OPALSKY DAVID , RHUBOTTOM JASON F
IPC分类号： B01L9/06 , G01N35/00 , G01N35/10
CPC分类号： G06Q10/087 , B01L9/06 , B01L2200/023 , B01L2200/06 , B01L2200/141 , B01L2300/021 , G01N35/1004
摘要： A structure (10) for holding sample-containing receptacles includes a cover (40) with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element (44) adjacent each opening (42) engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.
摘要翻译：用于保持含有样品的容器的结构（10）包括其中形成有孔的盖（40），通过所述盖（40）可以用诸如机器人移液器的物质转移机构接近所述容器。当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。邻近每个开口（42）的粘性排除元件（44）与粘性材料串接合，并且当机构相对于去除元件以规定的路径移动时，将串从机构中移出。被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。

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