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1. 发明申请

WO2009005579A1 HIGH AFFINITY FLUOROCHROME BINDING PEPTIDES 审中-公开
标题翻译：高亲和力荧光素结合肽
公开(公告)号：WO2009005579A1
公开(公告)日：2009-01-08
申请号：PCT/US2008007329
申请日：2008-06-12
申请人： GEN HOSPITAL CORP , KELLY KIMBERLY , WEISSLEDER RALPH
发明人： KELLY KIMBERLY , WEISSLEDER RALPH
IPC分类号： G01N21/76
CPC分类号： C07K7/06 , C07K2319/33 , C07K2319/60
摘要： The present invention contemplates strategies comprising small molecule, cell permeable probes that allow site-specific protein labeling for visualizing biological processes. In one embodiment, the present invention contemplates a series of short peptide sequences comprising high affinity binding (i.e., for example, subnanomolar affinity (0.53 nM) for indocyanine fluorochromes. In one embodiment, the peptide sequences comprise a 5 pmol detection limit for indocyanine fluorochromes. In one embodiment, the present invention contemplates methods comprising high affinity peptide-fluorochrome binding pairs in biological applications including, but not limited to, enzyme linked immunoabsorbent assay (ELISA), fluorescence activated cell sorting (FACS), microscopy (i.e., for example scanning electromicroscopy), Western Blots, histochemistry, protein and cell based tracking both in vitro and in vivo.
摘要翻译：本发明考虑包含允许位点特异性蛋白质标记以使生物学过程可视化的小分子细胞渗透性探针的策略。在一个实施方案中，本发明设想了一系列包含高亲和力结合（即例如对于吲哚菁荧光染料的亚纳摩尔亲和力（0.53nM））的短肽序列。在一个实施方案中，肽序列包含对吲哚菁荧光染料的5pmol检测限（ELISA），荧光激活细胞分选（FACS），显微术（即，例如，但不限于，生物学应用，包括但不限于高亲和力肽 - 荧光染料结合对的方法）扫描电子显微镜），蛋白质印迹，组织化学，蛋白质和基于细胞的体外和体内跟踪。

2. 发明申请

WO2009129220A2 PLECTIN-1 TARGETED AGENTS FOR DETECTION AND TREATMENT OF PANCREATIC DUCTAL ADENOCARCINOMA 审中-公开
标题翻译：用于检测和治疗胰腺癌腺癌的PLECTIN-1靶向药剂
公开(公告)号：WO2009129220A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040480
申请日：2009-04-14
申请人： GERERAL HOSPITAL CORP , KELLY KIMBERLY , WEISSLEDER RALPH , BARDEESY NABEEL
发明人： KELLY KIMBERLY , WEISSLEDER RALPH , BARDEESY NABEEL
IPC分类号： C07K7/06 , A61K38/08 , A61K49/14 , G01N33/574 , G01N33/68
CPC分类号： A61K49/14 , A61K38/00 , A61K38/08 , A61K47/64 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/1818 , B82Y5/00 , C07K7/06 , C07K16/18 , G01N33/531 , G01N33/533 , G01N33/54326 , G01N33/54346 , G01N33/57438
摘要： Described herein are compositions and methods for cancer cell biomarkers, such as pancreatic ductal adenocarcinoma (PDAC) cell biomarkers, and binding molecules for diagnosis and treatment of cancer, e.g., PDAC. Methods of identifying "accessible" proteomes are disclosed for identifying cancer biomarkers, such as plectin-1, a PDAC biomarker. Additionally, imaging compositions are provided comprising magnetofluorescent nanoparticles conjugated to peptide ligands for identifying PDACs.
摘要翻译：本文描述了用于癌细胞生物标志物的组合物和方法，例如胰腺导管腺癌（PDAC）细胞生物标志物和用于诊断和治疗癌症的结合分子，例如PDAC。公开了识别“可及”蛋白质组的方法用于鉴定癌症生物标志物，例如plectin-1，PDAC生物标志物。此外，提供了包含与肽配体缀合的磁荧光纳米颗粒以鉴定PDAC的成像组合物。

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