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1. 发明申请

WO2004020582A3 MAMMALIAN GENES INVOLVED IN RAPAMYCIN RESISTANCE AND TUMORGENESIS: RAPR6 GENES 审中-公开
标题翻译：涉及雷帕霉素抗性和致瘤性的哺乳动物基因：RAPR6基因
公开(公告)号：WO2004020582A3
公开(公告)日：2004-11-11
申请号：PCT/US0326075
申请日：2003-08-15
申请人： FUNCTIONAL GENETICS INC , LI LIMIN , AGHDASI BAHMAN
发明人： LI LIMIN , AGHDASI BAHMAN
IPC分类号： A61K38/00 , C07K14/47 , A61K31/711 , A61K38/16 , C07H21/04 , C07K14/435 , C07K16/18 , C12N15/85 , C12P21/00 , C12Q1/68
CPC分类号： C12Q1/6886 , A61K38/00 , C07K14/47 , C12Q2600/136 , C12Q2600/158
摘要： The invention provides nucleotide sequence of a novel mammalian gene, the RapR6 gene, which is involved in resistance and tumorgenesis, and amino acid sequences of the encoded proteins. The present invention also provides methods and compositions for regulating rapamycin resistance and/or tumorgenesis by modulating the expression and /or the activity of RapR6 gene. The invention also provides methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression and/or activity of RapR6 gene. The invention also provides methods and compositions for diagnosing and screening RapR6 mediated rapamycin resistance and/or tumorgenesis in patients. The invention further provides host cells a portion of whose RapR6 gene can be reversibly expressed, and to methods of using the RapR6 gene in evaluation and screening for drugs which regulate rapamycin resistance and/or tumorgenesis.
摘要翻译：本发明提供了新型哺乳动物基因的核苷酸序列，涉及抗性和肿瘤发生的RapR6基因，以及编码蛋白质的氨基酸序列。本发明还提供了通过调节RapR6基因的表达和/或活性来调节雷帕霉素抗性和/或肿瘤发生的方法和组合物。本发明还提供了通过调节RapR6基因的表达和/或活性来治疗疾病例如癌症的方法和组合物。本发明还提供了用于诊断和筛选患者中RapR6介导的雷帕霉素抗性和/或肿瘤发生的方法和组合物。本发明进一步提供其RapR6基因可被可逆表达的部分宿主细胞，以及使用RapR6基因评估和筛选调节雷帕霉素抗性和/或肿瘤发生的药物的方法。

2. 发明申请

WO2004020581A3 MAMMALIAN GENES INVOLVED IN RAPAMYCIN RESISTANCE AND TUMORGENESIS: RAPR7 GENES 审中-公开
标题翻译：参与RAPAMYCIN抗性和肿瘤发生的MAMMALIAN基因：RAPR7基因
公开(公告)号：WO2004020581A3
公开(公告)日：2005-04-21
申请号：PCT/US0326073
申请日：2003-08-15
申请人： FUNCTIONAL GENETICS INC , LI LIMIN , AGHDASI BAHMAN
发明人： LI LIMIN , AGHDASI BAHMAN
IPC分类号： A61K38/00 , C07K14/47 , C07K1/00 , C07K14/00
CPC分类号： C12Q1/6886 , A61K38/00 , C07K14/47 , C12Q2600/136
摘要： The invention provides nucleotide sequence of a novel mammalian gene which is involved in rapamycin resistance and tumorgenesis, the RapR7 gene, and amino acid sequences of its encoded proteins, and fragments and derivatives and analogs thereof. The present invention also provides methods and compositions for regulating rapamycin resistance and/or tumorgenesis by modulating the expression and/or the activity of RapR7 gene. The invention also provides methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression and/or activity of RapR7 gene. The invention also provides methods and compositions for diagnosing and screening RapR7 mediated rapamycin resistance and/or tumorgenesis in patients. The invention further provides host cells whose RapR7 gene can be reversibly overexpressed, and to methods of using the RapR7 gene in evaluation and screening for drugs which regulate rapamycin resistance and/or tumorgenesis.
摘要翻译：本发明提供参与雷帕霉素抗性和肿瘤发生的新型哺乳动物基因的核苷酸序列，RapR7基因及其编码的蛋白质的氨基酸序列及其片段及其衍生物和类似物。本发明还提供了通过调节RapR7基因的表达和/或活性来调节雷帕霉素抗性和/或肿瘤发生的方法和组合物。本发明还提供了通过调节RapR7基因的表达和/或活性来治疗疾病例如癌症的方法和组合物。本发明还提供用于诊断和筛选患者中RapR7介导的雷帕霉素抗性和/或肿瘤发生的方法和组合物。本发明还提供其RapR7基因可以可逆地过表达的宿主细胞，以及使用RapR7基因评估和筛选调节雷帕霉素抗性和/或肿瘤发生的药物的方法。

3. 发明申请

WO2004071462A2 METHODS AND COMPOSITIONS FOR TREATMENT OF VIRAL INFECTIONS BASED ON TSG101-VPS28 INTERACTION 审中-公开
标题翻译：用于治疗基于TSG101-VPS28相互作用的病毒感染的方法和组合
公开(公告)号：WO2004071462A2
公开(公告)日：2004-08-26
申请号：PCT/US2004004518
申请日：2004-02-12
申请人： UNIV JOHNS HOPKINS , FUNCTIONAL GENETICS INC , YU XIAO-FANG , LIU BINDONG , LI LIMIN
发明人： YU XIAO-FANG , LIU BINDONG , LI LIMIN
IPC分类号： A61K20060101 , A61K38/17 , C07H21/04 , C07K16/00 , C07K17/00 , C12N5/02 , C12N15/00 , G01N33/53 , A61K
CPC分类号： A61K38/1709 , C12N15/113 , C12N2310/14 , C12Q1/701 , G01N33/6872 , G01N2333/16 , G01N2500/02 , G01N2500/10
摘要： The invention provides methods and compositions based on the interaction of TSG101 and VPS28 proteins for treatment of viral infections, including HIV infections. The invention also provides TSG101-VPS28 based methods and compositions for evaluation and screening of drugs which can be used for treating viral infections.
摘要翻译：本发明提供了基于TSG101和VPS28蛋白质相互作用以治疗病毒感染（包括HIV感染）的方法和组合物。本发明还提供了用于评估和筛选可用于治疗病毒感染的药物的基于TSG101-VPS28的方法和组合物。

4. 发明申请

WO2008064072A2 ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS 审中-公开
标题翻译： ANTI-TSG101抗体及其用于治疗病毒感染的用途
公开(公告)号：WO2008064072A2
公开(公告)日：2008-05-29
申请号：PCT/US2007084808
申请日：2007-11-15
申请人： FUNCTIONAL GENETICS INC , LI LIMIN , KINCH MICHAEL , GOLDBLATT MICHAEL
发明人： LI LIMIN , KINCH MICHAEL , GOLDBLATT MICHAEL
IPC分类号： A61K39/42
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/18 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/76
摘要： The present invention provides antibodies that bind to the C-terminal region of TSG101. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV and Ebola virus infection.
摘要翻译：本发明提供了结合TSG101的C-末端区域的抗体。本发明还提供了使用TSG101抗体治疗病毒感染（包括HIV和埃博拉病毒感染）的方法。

5. 发明申请

WO2004031209A3 ANTI-TSG101 ANTIBODIES AND THEIR USES FOR TREATMENT OF VIRAL INFECTIONS 审中-公开
标题翻译： ANTI-TSG101抗体及其用于治疗病毒感染的用途
公开(公告)号：WO2004031209A3
公开(公告)日：2005-01-13
申请号：PCT/US0331233
申请日：2003-10-01
申请人： FUNCTIONAL GENETICS INC , LI LIMIN
发明人： LI LIMIN
IPC分类号： C07K16/10 , C07K16/32 , C12Q1/70 , C07K16/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/1045 , C07K16/1081 , C07K16/18 , C07K16/32 , C07K2317/34 , C07K2317/76
摘要： The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invention further provides methods of detecting viral infected cells using TSG101 antibodies.
摘要翻译：本发明提供了使用结合TSG101蛋白来抑制或减少病毒产生的抗体的方法。本发明还提供了使用TSG101抗体治疗病毒感染（包括HIV感染）的方法。本发明还提供了使用TSG101抗体检测病毒感染细胞的方法。

6. 发明申请

WO2008140571A3 METHODS AND COMPOSITIONS FOR TREATING INFLUENZA 审中-公开
标题翻译：用于治疗流感的方法和组合物
公开(公告)号：WO2008140571A3
公开(公告)日：2009-03-26
申请号：PCT/US2007084759
申请日：2007-11-15
申请人： FUNCTIONAL GENETICS INC , LI LIMIN , KINCH MICHAEL , GOLDBLATT MICHAEL
发明人： LI LIMIN , KINCH MICHAEL , GOLDBLATT MICHAEL
IPC分类号： A61K31/7088
CPC分类号： A61K48/00 , A61K2039/505 , C07K14/47 , C07K16/18 , C12N2760/16111
摘要： Genes relating to resistance to infection by influenza virus are identified. The genes and the gene products (i.e., the polynucleotides transcribed from and polypeptides encoded by the genes) can be used for the prevention and treatment of influenza. The genes and the gene products can also be used to screen agents that modulate the gene expression or the activities of the gene products.
摘要翻译：鉴定了与流感病毒感染抵抗有关的基因。基因和基因产物（即从该基因转录的多核苷酸和由该基因编码的多肽）可用于预防和治疗流行性感冒。基因和基因产物也可用于筛选调节基因表达或基因产物活性的试剂。

7. 发明申请

WO02057427A3 MAMMALIAN TUMOR SUSCEPTIBILITY GENE PRODUCTS AND THEIR USES 审中-公开
标题翻译： MAMMALIAN肿瘤基因产物及其用途
公开(公告)号：WO02057427A3
公开(公告)日：2003-12-04
申请号：PCT/US0201947
申请日：2002-01-18
申请人： UNIV LELAND STANFORD JUNIOR , COHEN STANLEY N , LI LIMIN
发明人： COHEN STANLEY N , LI LIMIN
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61P3/00 , A61P5/00 , A61P25/28 , A61P35/00 , A61P37/06 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/15 , C07K16/00 , C07K16/30
CPC分类号： C07K14/47 , C07K16/18
摘要： The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein.
摘要翻译：本发明提供用于调节细胞中泛素化的方法和组合物。特别地，本发明提供了包含泛素调节结构域的纯化多肽。本发明还提供了使用这种多肽筛选试剂，产生抗体和治疗疾病如增殖性疾病，神经变性疾病，自身免疫性疾病，代谢疾病和发育异常的方法。本发明进一步提供结合泛素调节结构域的抗体以及调节细胞中泛素化的试剂和抗体，例如通过调节TSG101蛋白和MDM2蛋白之间的相互作用。

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