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1. 发明申请

WO2008063996A2 THERAPEUTIC TARGETING OF ESCORT PROTEINS 审中-公开
标题翻译： ESCORT蛋白的治疗靶点
公开(公告)号：WO2008063996A2
公开(公告)日：2008-05-29
申请号：PCT/US2007084512
申请日：2007-11-13
申请人： FUNCTIONAL GENETICS INC , DUAN ROXANNE , KINCH MICHAEL , GOLDBLATT MICHAEL
发明人： DUAN ROXANNE , KINCH MICHAEL , GOLDBLATT MICHAEL
IPC分类号： A61K39/395 , A61K39/00 , A61P37/00
CPC分类号： C07K16/18
摘要： The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.
摘要翻译：本发明通过向哺乳动物宿主提供针对护送蛋白（如Th1g101）的抗体来提供对病毒性疾病的抑制。这些蛋白质出现在细胞的表面上，因此可以通过循环其抗体而结合。通过在细胞表面结合护送蛋白，病毒颗粒的出芽被抑制。病毒感染初始细胞，但不能逃避该细胞大量感染身体。

2. 发明申请

WO2008133711A3 RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION 审中-公开
标题翻译：随机同源基因刺激增强抗体生产
公开(公告)号：WO2008133711A3
公开(公告)日：2009-02-12
申请号：PCT/US2007082972
申请日：2007-10-30
申请人： FUNCTIONAL GENETICS INC , DUAN ROXANNE , GOLDBLATT MICHAEL
发明人： DUAN ROXANNE , GOLDBLATT MICHAEL
IPC分类号： C12N15/01
CPC分类号： C07K16/00
摘要： The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume.
摘要翻译：本发明反映了通过随机纯合基因扰动方法转化的细胞系增强或减少除感兴趣抗体之外的细胞系的基因的表达模式的目标抗体的增强的抗体表达。与通过RHGP转化之前与抗体表达细胞系亲本相比，转化细胞系表现出1.5GP以上RHGP转化细胞留置量的比生产率SPR。可以设计敲除或反义构建体以减少靶基因的表达，启动子可以被插入以增强靶基因的表达。由转化的细胞系表达的抗体在用RHGP转化之前表现出其亲本细胞系的结合特性，并且增加所述细胞在给定体积中的所述抗体的总体积产量。

3. 发明申请

WO2008133711A9 RANDOM HOMOZYGOUS GENE PERTURBATION TO ENHANCE ANTIBODY PRODUCTION 审中-公开
标题翻译：随机同源基因刺激增强抗体生产
公开(公告)号：WO2008133711A9
公开(公告)日：2008-12-31
申请号：PCT/US2007082972
申请日：2007-10-30
申请人： FUNCTIONAL GENETICS INC , DUAN ROXANNE , GOLDBLATT MICHAEL
发明人： DUAN ROXANNE , GOLDBLATT MICHAEL
IPC分类号： C12P21/06
CPC分类号： C07K16/00
摘要： The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates, SPR, for the RHGP transformed cell liens of 1.5 or more, as compared with the antibody expressing cell line parents prior to transformation by RHGP. A knock out or anti-sense construct may be devised to reduce expression of the target gene, a promoter may be inserter to enhance expression of the target gene. The antibodies expressed by the transformed cell lines exhibit the binding properties of their parent cell lines prior to transformation with RHGP, and increase Total Volumetric Production of said antibody by said cells in a given volume.
摘要翻译：本发明反映了通过随机纯合基因扰动方法转化的细胞系增强或减少除感兴趣抗体之外的细胞系的基因的表达模式的目标抗体的增强的抗体表达。与通过RHGP转化之前与抗体表达细胞系亲本相比，转化细胞系表现出1.5GP以上RHGP转化细胞留置量的比生产率SPR。可以设计敲除或反义构建体以减少靶基因的表达，启动子可以被插入以增强靶基因的表达。由转化的细胞系表达的抗体在用RHGP转化之前表现出其亲本细胞系的结合特性，并且增加所述细胞在给定体积中的所述抗体的总体积产量。

4. 发明申请

WO9839446A3 70 human secreted proteins 审中-公开
标题翻译： 70种人体分泌的蛋白质
公开(公告)号：WO9839446A3
公开(公告)日：1998-12-23
申请号：PCT/US9804482
申请日：1998-03-06
申请人： HUMAN GENOME SCIENCES INC , RUBEN STEVEN M , ROSEN CRAIG A , FISCHER CARRIE L , SOPPET DANIEL R , CARTER KENNETH C , BEDNARIK DANIEL P , ENDRESS GREGORY A , YU GUO-LIANG , NI JIAN , FENG PING , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M , DUAN ROXANNE , HU JING-SHAN , GRAVES KIMBERLY A , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A , MOORE PAUL A , YU YANGGU , LAFLEUR DAVID W , LI YI , ZENG ZHIZHEN , KYAW HLA
发明人： RUBEN STEVEN M , ROSEN CRAIG A , FISCER DANIEL R , SOPPET DANIEL R , CARTER KENNETH C , BEDNARIK DANIEL P , ENDRESS GREGORY A , YU GUO-LIANG , NI JIAN , FENG PING , YOUNG PAUL E , GREENE JOHN M , FERRIE ANN M , DUAN ROXANNE , HU JING-SHAN , GRAVES KIMBERLY A , OLSEN HENRIK S , EBNER REINHARD , BREWER LAURIE A , MOORE PAUL A , SHI YANGGU , LAFLEUR DAVID W , LI YI , ZENG ZHIZHEN , KYAW HLA
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N5/02 , C12N15/11 , C12N15/12 , G01N33/68 , A61K38/17 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/47 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to 70 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

5. 发明申请

WO9837194A9 ELL2, A MEMBER OF AN ELL FAMILY OF RNA POLYMERASE II ELONGATION FACTORS 审中-公开
标题翻译： ELL2，RNA聚合酶II的ELL家族成员延伸因子
公开(公告)号：WO9837194A9
公开(公告)日：2001-06-14
申请号：PCT/US9803177
申请日：1998-02-19
申请人： HUMAN GENOME SCIENCES INC , OKLAHOMA MED RES FOUND , DUAN ROXANNE , SHILATIFARD ALI , CONAWAY JOAN W , CONAWAY RONALD C
发明人： DUAN ROXANNE , SHILATIFARD ALI , CONAWAY JOAN W , CONAWAY RONALD C
IPC分类号： A61K38/00 , A61P35/00 , C07K14/47 , C12N1/21 , C12N15/12 , A61K31/70 , A61K35/00 , C07K16/18 , C12Q1/68 , G01N33/53 , G01N33/60 , G01N33/68
CPC分类号： C07K14/4702 , A61K38/00
摘要： ELL2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ELL2 polypeptides and polynucleotides in the design of protocols for the treatment of neoplastic disorders, among others and diagnostic assays for such conditions.
摘要翻译：公开了通过重组技术产生这种多肽的ELL2多肽和多核苷酸和方法。还公开了在设计用于治疗肿瘤性疾病的方案中的ELL2多肽和多核苷酸的方法以及用于这些病症的诊断测定法。

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