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1. 发明申请

WO2009094035A1 APPARATUS AND METHODS FOR EARLY STAGE PERITONITIS DETECTION AND FOR IN VIVO TESTING OF BODILY FLUIDS 审中-公开
标题翻译：用于早期阶段的早期检测和体液检测的装置和方法
公开(公告)号：WO2009094035A1
公开(公告)日：2009-07-30
申请号：PCT/US2008/052062
申请日：2008-01-25
申请人： FRESENIUS MEDICAL CARE HOLDINGS, INC. , LANDHERR, Frank, Joseph , LAN, Jay, M.
发明人： LANDHERR, Frank, Joseph , LAN, Jay, M.
IPC分类号： A61M1/00 , A61B5/00
CPC分类号： A61B5/14507 , A61B5/0084 , A61M1/28 , A61M2205/331 , G01N15/1459 , G01N21/53 , G01N2015/008
摘要： The invention provides, inter alia, automated medical methods and apparatus that test PD effluent in a flow path (e.g., with an APD system or CAPD setup) to detect, for example, the onset of peritonitis, based on optical characteristics of the effluent resolved at cellular scales of distance. For example, according to one aspect of the invention, an APD machine includes, in an effluent flow path, apparatus for early stage peritonitis detection comprising an illumination source and a detector. The source is arranged to illuminate peritoneal effluent in a chamber that forms part of the flow path, and the detector is arranged to detect illuminant scattered by the effluent. The detector detects that reflected or scattered illuminant at a cellular scale of resolution, e.g., on a scale such that separate cellular-sized biological (or other) components in the effluent can be distinguished from one another based on scattering events detected by the detector. Other aspects of the invention provide automated medical testing methods and apparatus that detect the onset of peritonitis and other bodily conditions by testing fluids in the body in vivo, e.g., the patient's peritoneum. Such apparatus and methods utilize a first fiber optic bundle to carry illuminant from a source of the type described above into a bodily organ or cavity, and a second fiber optic bundle to carry illuminant scattered by fluid in that organ or cavity to a detector as described above.
摘要翻译：本发明尤其提供了一种自动化医疗方法和装置，其基于流出物的光学特性来测定PD流出物在流动路径（例如，使用APD系统或CAPD装置）中以检测例如腹膜炎的发作，在距离的细胞尺度。例如，根据本发明的一个方面，APD机器在流出物流路中包括用于早期腹膜炎检测的装置，其包括照明源和检测器。来源设置为照射形成流路的一部分的室中的腹膜流出物，并且检测器被布置成检测由流出物散射的发光体。检测器以分辨率的细胞尺度（例如，尺度）检测反射或散射的光源，使得流出物中的分离的细胞大小的生物（或其他）组分可以基于由检测器检测到的散射事件彼此区分开。本发明的其它方面提供了自动化的医学测试方法和装置，其通过在体内测试体内的流体（例如患者的腹膜）来检测腹膜炎和其他身体状况的发作。这种设备和方法利用第一光纤束将源自上述类型的光源的发光体携带到身体器官或空腔中，以及第二光纤束将第二光纤束携带由该器官或空腔中的流体散射的发光体到所述的检测器以上。

2. 发明申请

WO2009094034A1 APPARATUS AND METHODS FOR EARLY STAGE PERITONITIS DETECTION INCLUDING SELF-CLEANING EFFLUENT CHAMBER 审中-公开
标题翻译：用于早期阶段周期检测的装置和方法，包括自清洁液体室
公开(公告)号：WO2009094034A1
公开(公告)日：2009-07-30
申请号：PCT/US2008/052056
申请日：2008-01-25
申请人： FRESENIUS MEDICAL CARE HOLDINGS, INC. , LANDHERR, Frank, Joseph , LAN, Jay, M.
发明人： LANDHERR, Frank, Joseph , LAN, Jay, M.
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61B5/0084 , A61B5/14546 , A61M1/285 , A61M2202/0439 , A61M2205/331 , A61M2205/3313 , A61M2206/14 , G01N21/05 , G01N21/15 , G01N21/53 , G01N2015/008 , G01N2021/058
摘要： The invention provides, inter alia, automated medical methods and apparatus that test PD effluent in a flow path (e g, with an APD system or CAPD setup) to detect, for example, the onset of peritonitis, based on optical characteristics of the effluent resolved at cellular scales of distance For example, according to one aspect of the invention, an APD machine includes, in an effluent flow path, apparatus for early stage peritonitis detection comprising an illumination source and a detector The source is arranged to illuminate peritoneal effluent in a chamber that forms part of the flow path, and the detector is arranged to detect illuminant scattered by the effluent.
摘要翻译：本发明尤其提供了一种自动化医疗方法和装置，其基于流出物的光学特性来测定PD流出物在流动路径（例如，使用APD系统或CAPD装置）中以检测例如腹膜炎的发作，在距离的细胞尺度例如，根据本发明的一个方面，APD机器在流出物流动路径中包括用于早期腹膜炎检测的装置，其包括照明源和检测器。源被设置为照射腹膜内流出物室，其形成流路的一部分，并且检测器被布置成检测由流出物散射的发光体。

3. 发明申请

WO2006083653A2 SYSTEMS AND METHODS FOR DELIVERY OF PERITONEAL DIALYSIS (PD) SOLUTIONS 审中-公开
标题翻译：用于输送透析（PD）解决方案的系统和方法
公开(公告)号：WO2006083653A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/002674
申请日：2006-01-26
申请人： FRESENIUS MEDICAL CARE NORTH AMERICA , JENSEN, Lynn, E. , TUOMINN, Olli , LAN, Jay, M.
发明人： JENSEN, Lynn, E. , TUOMINN, Olli , LAN, Jay, M.
IPC分类号： A61K31/70 , A61K31/19 , B01D11/02
CPC分类号： A61J1/10 , A61J1/201 , A61J1/2027 , A61J1/2089 , A61M1/1668 , A61M1/287 , A61M5/1409 , A61M39/221
摘要： The invention provides container systems, kits and methods for peritoneal dialysis (PD) solutions. Such a system, for example, includes a first compartment that contains a PD osmotic agent and a second compartment that contains a PD buffer agent. The compartments maintain their respective contents separately from one another for purposes of transport, storage and/or sterilization. However, the compartments are fluidly couplable, so that their respective contents can be combined with one another, e.g., following sterilization of the agents and prior to their introduction into the patient's abdomen. The invention provides, in other aspects, such systems, kits and methods that provide protective structure which inhibits breaking of a seal prior between the second compartment and an outlet of the system, prior to breaking of a seal between the first and second compartments.
摘要翻译：本发明提供了用于腹膜透析（PD）解决方案的容器系统，试剂盒和方法。这样的系统例如包括含有PD渗透剂的第一隔室和含有PD缓冲剂的第二隔室。为了运输，储存和/或灭菌的目的，隔间将它们各自的内容物彼此分开。然而，隔室是可流体耦合的，使得它们各自的内容物可以彼此组合，例如在药剂灭菌之后并且在引入患者腹部之前。在其他方面，本发明提供了在破坏第一和第二隔室之间的密封件之前提供防止在第二隔室与系统的出口之间破坏密封件的保护结构的这种系统，套件和方法。

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