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    • 5. 发明申请
    • METHOD AND DEVICE FOR SELECTIVELY DETECTING FERROMAGNETIC OR SUPERPARAMAGNETIC PARTICLES
    • 方法和装置选择性检测FERRO磁性或超顺磁性粒子
    • WO2004077044A8
    • 2005-09-01
    • PCT/DE2004000149
    • 2004-01-30
    • FORSCHUNGSZENTRUM JUELICH GMBHMIETHE PETERKRAUSE HANS-JOACHIMZHANG YIWOLTERS NORBERTPLAKSIN DMITRY
    • MIETHE PETERKRAUSE HANS-JOACHIMZHANG YIWOLTERS NORBERTPLAKSIN DMITRY
    • G01N27/74G01N33/543
    • G01N27/745
    • The invention relates to a method for selectively detecting and/or quantifying superparamagnetic and/or ferromagnetic particles on analytes. The method is characterized in that a frequency component of magnetic fields (15, 18), which is generated due to the non-linearity of the magnetization characteristic curve of the particles, is measured at a mixing frequency. A device for selectively detecting and/or quantifying superparamagnetic and/or ferromagnetic particles on analytes comprises: a container (12) that contains particles, which are to be detected and/or quantified, on analytes; at least one oscillator (13, 16; 25) for generating frequencies of alternating magnetic fields (15, 18); at least one field generator (14, 17) for subjecting the analytes to alternating magnetic fields (15, 18); a magnetic field sensor (20) for measuring a response magnetic field (19) of the particles, and; at least one phase-sensitive detector (21, 23). These elements are configured in such a manner as to enable a frequency component of the magnetic fields (15, 18), which is generated due to the non-linearity of the magnetization characteristic curve of the particles, to be measured at a mixing frequency.
    • 一种用于超顺磁性和/或铁磁性颗粒的分析物的选择性地检测和/或定量方法。 该方法的特征在于,所产生的由于(15,18)在混合频率被测量磁场的粒子频率分量的磁化特性的非线性。 一种用于超顺磁性和/或铁磁颗粒的选择性地检测和/或定量装置包括分析物:一个容器(12),其具有nachzuweisendem和/或进行定量颗粒与分析物,至少一个振荡器(13,16; 25),用于产生 用于作用在分析物与交变磁场(15,18),一个磁场传感器(20),用于测量所述颗粒的响应磁场(19)的交变磁场(15,18),至少一个场发生器(14,17)的频率 至少一个相敏检测器(21,23),其特征在于,所述组分由于磁场(15,18)的粒子的频率分量的磁化特性的非线性构造成使得产生的在混合频率被测量。