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    • 1. 发明申请
    • MEANS AND METHODS FOR TREATING BACTERIAL INFECTIONS
    • 手段和方法治疗细菌感染
    • WO2017140770A1
    • 2017-08-24
    • PCT/EP2017/053487
    • 2017-02-16
    • FORSCHUNGSZENTRUM BORSTEL LEIBNIZ-ZENTRUM FÜR MEDIZIN UND BIOWISSENSCHAFTENFREIE UNIVERSITÄT BERLINUNIVERSITÄT ZU LÜBECKRHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    • BRANDENBURG, KlausHEINBOCKEL, LenaREILING, NorbertMARTINEZ DE TEJADA, GuillermoSCHÜRHOLZ, TobiasMAUSS, KarlWEINDL, Günther
    • A61K38/10C07K7/08C07K14/47
    • C07K14/4723A61K38/00C07K7/08Y02A50/473
    • The present invention relates to a pharmaceutical composition comprising or consisting of a combination of (a) two or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking; or (b) one or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11 ) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking, and one or more antibiotics selected from small organic molecule antibiotics such as ceftriaxone, oxacillin, amoxicillin, amikacin, ciprofloxacin, erythromycin, imipenem and tetracycline, and peptidic antibiotics such as daptomycin and vancomycin.
    • 本发明涉及一种药物组合物,其包含(a)两种或更多种肽的组合或由其组成,所述组合由(a)两种或更多种肽组成,每种肽由17至23个氨基酸组成或其组成,其中位置1 从N端计数到23,如下(1)G,S或缺乏; (2)C或缺乏; (3)K或R; (4)K或R; (5)Y,W或F; (6)K或R; (7)K或R; (8)F,W或L; (9)K或R; (10)K或L或缺乏; (11)W,L或F; (12)K或R; (13)F,Y或C; (14)K或R; (15)G或Q; (16)K或R; (17)F,L或W; (18)F或W; (19)F,L或W; (20)W或F; (21)C或缺乏; (22)F或G或缺乏; (23)G或缺乏; 或(b)一种或多种肽,每种肽由17至23个氨基酸组成或包含17至23个氨基酸,其中从N端计数的1至23位的氨基酸如下(1)G,S或缺失; (2)C或缺乏; (3)K或R; (4)K或R; (5)Y,W或F; (6)K或R; (7)K或R; (8)F,W或L; (9)K或R; (10)K或L或缺乏; (11)W,L或F; (12)K或R; (13)F,Y或C; (14)K或R; (15)G或Q; (16)K或R; (17)F,L或W; (18)F或W; (19)F,L或W; (20)W或F; (21)C或缺乏; (22)F或G或缺乏; (23)G或缺乏,以及一种或多种选自小有机分子抗生素如头孢曲松,苯唑西林,阿莫西林,阿米卡星,环丙沙星,红霉素,亚胺培南和四环素以及肽类抗生素如达托霉素和万古霉素的抗生素。