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1. 发明申请

WO2010043218A3 TETRATHIOL LIGANDS, METAL COMPLEXES, CONJUGATES, AND KITS, THE USE THEREOF IN NUCLEAR MEDICINE DIAGNOSTICS AND ENDORADIONUCLIDE THERAPY, AND METHOD FOR PRODUCING THE TETRATHIOL LIGANDS AND METAL COMPLEXES 审中-公开
标题翻译： Tetrathiol配体，金属配合物，结合物和试剂盒，它们在核医学诊断和ENDORADIONUKLIDTHERAPIE及其制造方法Tetrathiol配体和金属络合物
公开(公告)号：WO2010043218A3
公开(公告)日：2011-01-27
申请号：PCT/DE2009050056
申请日：2009-10-16
申请人： FORSCHUNGSZENTR DD ROSSENDORF , FOERSTER CHRISTIAN , PIETZSCH HANS-JUERGEN , SUHR MATTHIAS
发明人： FOERSTER CHRISTIAN , PIETZSCH HANS-JUERGEN , SUHR MATTHIAS
IPC分类号： C07D295/185 , A61K51/04 , A61K51/08 , C07D273/01 , C07F1/08 , C07F5/00 , C07F7/22 , C07F13/00
CPC分类号： C07D295/185 , C07D273/01 , C07F13/005
摘要： The invention relates to a ligand of formula (I), where (CH-R1) and (CH-R1') are substituted or non-substituted methylene bridges; the individual R1 and R1', and R3 and R3', are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups; and m and n are positive whole numbers, where m represents the number of (CH-R1') groups and n represents the number of (CH-R1) groups; wherein the sum of m and n is in the range from 4 to 10; R2 and R2' are selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted carboxyl groups, substituted or non-substituted aryl groups, or Z; X is a substituted or non-substituted methylene bridge having the formula CHR4 or a non-substituted amino group (N-H) or substituted amino group (N-Z); wherein Z stands for -(CH-R5)p-A, where (CH-R5) represents a substituted or non-substituted methylene bridge, and p is a whole number standing for the number of the (CH-R5) groups, wherein p is in the range from 2 through 8; A represents a linkable unit, wherein R4 and the individual R5 are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups.
摘要翻译：式（I），其中（CH-R 1）和（CH-R1“）代表取代或未取代的亚甲基桥，每个R 1和R 1”是，以及R 3和R 3“的配位体各自独立地选自氢，取代的或未取代的烷基，取代或未取代的芳基，m和n是正整数，其中m表示基团（CH-R1“）的数目，n是基团（CH-R 1）的数量，m，其中与n之和为4的范围内是如图10所示，具有式CHR 4基团或一个取代的氨基取代或未取代的亚甲基桥是R2和R2“独立地选自氢，取代的或未取代的烷基，取代或未取代的羧基，取代或未取代的芳基，或Z，X（NH）或取代的氨基（NZ），其中Z是 - （CH-R5）p，其中（CH-R 5）取代的或未取代的亚甲基表示桥且p为基团（CH-R 5），其中p为2至8的数量的整数，A是一个能够耦合单元，其中，R 4和每个R 5各自独立地选自氢，取代或未取代的烷基，取代或未取代的芳基。

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