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    • 1. 发明申请
    • STEROID KIT AND FOAMABLE COMPOSITION AND USES THEREOF
    • STEROID包装和可泡沫组合物及其用途
    • WO2007012977A2
    • 2007-02-01
    • PCT/IB2006002832
    • 2006-04-18
    • FOAMIX LTDFREIDMAN DORONBESONOV ALEXTAMAKRIN DOVEINI MEIR
    • FREIDMAN DORONBESONOV ALEXTAMAKRIN DOVEINI MEIR
    • A61K8/04A61K8/67A61K31/07A61K31/203A61L9/04A61M11/00A61Q19/00
    • A61K9/122A61K8/046A61K8/671A61K9/0014A61K31/07A61K31/203A61K31/56A61K31/568A61K31/573A61Q19/00
    • A composition and therapeutic kit including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a steroid; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01 % to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof.
    • 一种组合物和治疗试剂盒,其包括气溶胶包装组件,包括:容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口; 其中所述加压产品包括可发泡组合物,其包含:i。 类固醇 II。 选自浓度为约2%至约50%重​​量的至少一种选自疏水性有机载体,极性溶剂,润肤剂及其混合物的有机载体; III。 表面活性剂; IV。 约0.01重量%至约5重量%的至少一种选自生物粘附剂,胶凝剂,成膜剂和相变剂的聚合物添加剂; v。水 和vi。 液化或压缩气体推进剂的浓度为总组合物重量的约3%至约25%。 组合物还可以包括治疗活性的泡沫佐剂,其选自脂肪醇,脂肪酸,羟基脂肪酸; 及其混合物。