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1. 发明申请

WO2003097374A2 ERGONOMIC MULTIMEDIA FLIPBOOK 审中-公开
标题翻译：有机多媒体卷轴
公开(公告)号：WO2003097374A2
公开(公告)日：2003-11-27
申请号：PCT/US2003/015270
申请日：2003-05-16
申请人： FLIPP SPORTS , ROBERTS, Richard, J. , MULLEN, Andrew
发明人： ROBERTS, Richard, J. , MULLEN, Andrew
IPC分类号： B42D
CPC分类号： B42D1/00 , B42D1/003 , B42D1/009
摘要： A multimedia ergonomic flipbook for displaying sports images and optionally playing sounds corresponding to those images. The flipbook includes a plurality of pages with sequential images printed on both the obverse and reverse sides of the pages. For example, if the flipbook contains 32 pages, the pages can be flipped from page 1 to 32 to display one or more sets of animations, and the flipbook can be turned over and the pages can be flipped from pages 32 to 1 to display one or more sets of animations. The flipping ends of the pages can be cut stylistically so that the ends of the pages are straight or curved or any combination thereof so that the end of the flipbook is symmetrically beveled, which makes the pages of the flipbook easier to flip forwards or backwards. An example application of the inventions is a flipbook showing a particular player that could be shown making a great offensive play on one set of images and making a great defensive play on another set of images and with sound to accompany the animations.
摘要翻译：多媒体人体工程学翻转手册，用于显示运动图像和可选地播放与这些图像相对应的声音。该手册包括在页面的正面和反面都印有顺序图像的多页。例如，如果手写本包含32页，则页面可以从第1页翻转到32，以显示一组或多组动画，并且翻页可以翻转，并且页面可以从第32页翻转到1以显示一个或多组动画。页面的翻转端可以被风格剪裁，使得页面的端部是直的或弯曲的或其任何组合，使得翻盖的端部对称地倾斜，这使得翻盖的页面更容易向前或向后翻转。本发明的一个示例性应用是显示可以显示在一组图像上做出巨大进攻性游戏的特定玩家的幻灯片，并且在另一组图像上并伴随动画的声音进行极好的防御性玩法。

2. 发明申请

WO2003097374A3 ERGONOMIC MULTIMEDIA FLIPBOOK 审中-公开
公开(公告)号：WO2003097374A3
公开(公告)日：2003-11-27
申请号：PCT/US2003/015270
申请日：2003-05-16
申请人： FLIPP SPORTS , ROBERTS, Richard, J. , MULLEN, Andrew
发明人： ROBERTS, Richard, J. , MULLEN, Andrew
IPC分类号： B42D1/00
摘要： A multimedia ergonomic flipbook for displaying sports images and optionally playing sounds corresponding to those images. The flipbook includes a plurality of pages with sequential images printed on both the obverse and reverse sides of the pages. For example, if the flipbook contains 32 pages, the pages can be flipped from page 1 to 32 to display one or more sets of animations, and the flipbook can be turned over and the pages can be flipped from pages 32 to 1 to display one or more sets of animations. The flipping ends of the pages can be cut stylistically so that the ends of the pages are straight or curved or any combination thereof so that the end of the flipbook is symmetrically beveled, which makes the pages of the flipbook easier to flip forwards or backwards. An example application of the inventions is a flipbook showing a particular player that could be shown making a great offensive play on one set of images and making a great defensive play on another set of images and with sound to accompany the animations.

3. 发明申请

WO2010075375A1 COMPOSITIONS, METHODS AND RELATED USES FOR CLEAVING MODIFIED DNA 审中-公开
标题翻译：用于清除修饰的DNA的组合物，方法和相关用途
公开(公告)号：WO2010075375A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069175
申请日：2009-12-22
申请人： NEW ENGLAND BIOLABS, INC. , ZHENG, Yu , ROBERTS, Richard, J.
发明人： ZHENG, Yu , ROBERTS, Richard, J.
IPC分类号： C12N15/10 , C12Q1/68 , C07K16/00 , C07K14/00
CPC分类号： C12Q1/6809 , C12N9/22 , C12Q1/6827 , C12Q1/6869 , C12Q2521/331
摘要： Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at least 50% are similarly sized and have a centrally positioned modified nucleotide. In addition, an enzyme preparation is provided that includes one or more enzymes that recognize a modified nucleotide in a DNA and cleave the DNA at a site that is at a non-random distance from the modified nucleotide. The one or more enzymes are further characterized by an N- terminal conserved domain with greater than 90% amino acid sequence homology to WXD(X) 10 YXGD. The related uses include creating a methylome, methods of purifying DNA fragments containing a modified nucleotide and diagnostic applications.
摘要翻译：提供了与切割修饰的DNA有关的组合物，方法和相关用途。例如，描述了通过大量DNA的酶裂解可获得的一组DNA片段，其中至少50％的大小相似，并且具有中心定位的修饰的核苷酸。此外，提供了酶制剂，其包括识别DNA中的修饰的核苷酸的一种或多种酶，并且在与修饰的核苷酸处于非随机距离的位点处切割DNA。一种或多种酶的进一步特征在于具有与WXD（X）10YXGD具有大于90％氨基酸序列同源性的N-末端保守结构域。相关用途包括制备甲基黄嘌呤，纯化含有修饰核苷酸的DNA片段和诊断应用的方法。

4. 发明申请

WO2011025819A1 DETECTION AND QUANTIFICATION OF HYDROXYMETHYLATED NUCLEOTIDES IN A POLYNUCLEOTIDE PREPARATION 审中-公开
标题翻译：羟基甲基纤维素在多核苷酸制备中的检测和定量
公开(公告)号：WO2011025819A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046632
申请日：2010-08-25
申请人： NEW ENGLAND BIOLABS, INC. , BITINAITE, Jurate , VAISVILA, Romaldas , PRADHAN, Sriharsa , ZHENG, Yu , ROBERTS, Richard, J. , CHIN, Hang-gyeong , COHEN-KARNI, Devora , NOREN, Christopher , RALEIGH, Elisabeth, A.
发明人： BITINAITE, Jurate , VAISVILA, Romaldas , PRADHAN, Sriharsa , ZHENG, Yu , ROBERTS, Richard, J. , CHIN, Hang-gyeong , COHEN-KARNI, Devora , NOREN, Christopher , RALEIGH, Elisabeth, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2521/331 , C12Q2525/191 , C12Q2531/113
摘要： Methods and compositions are described for detecting hydroxymethylated nucleotides (hmNs) in a polynucleotide preparation with a view to mapping the location of hmNs in a genome, quantifying the occurrence of hmNs at selected loci and correlating the occurrence of hmNs with gene expression and phenotypic traits. Embodiments describe the use of modifying enzymes together with site-specific endonucleases to detect the hmNs.
摘要翻译：描述了用于检测多核苷酸制备物中的羟甲基化核苷酸（hmN）的方法和组合物，以便映射基因组中hmN的位置，定量选择的位点的hmN的发生，并将hmNs的发生与基因表达和表型性状相关联。实施方案描述了使用将酶修饰酶与位点特异性内切核酸酶一起检测hmN。

5. 发明申请

WO2008103900A2 SELECTION AND ENRICHMENT OF PROTEINS USING IN VITRO COMPARTMENTALIZATION 审中-公开
标题翻译：蛋白质选择和增殖使用体细胞化学
公开(公告)号：WO2008103900A2
公开(公告)日：2008-08-28
申请号：PCT/US2008/054709
申请日：2008-02-22
申请人： NEW ENGLAND BIOLABS, INC. , ZHENG, Yu , ROBERTS, Richard, J.
发明人： ZHENG, Yu , ROBERTS, Richard, J.
IPC分类号： C12N15/10 , C12N15/55 , C12N9/22 , C12Q1/68
CPC分类号： C12N15/1058 , C12N9/22 , C12N15/1075
摘要： Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a genetic sequence. The selection and enrichment occurs in aqueous droplets formed in an emulsion that compartmentalize individual polynucleotides from the library or a plurality of polynucleotides that may include polynucleotides not derived from the library, transcription and translation reagents and optionally additional chemical and enzyme reagents. The selection and enrichment method utilizes a polynucleotide adaptor which when ligated to the polynucleotide fragment enables amplification to occur in the presence of an adaptor specific primer.
摘要翻译：提供了组合物和方法用于从多基因序列文库中选择和富集靶基因，所述多核苷酸序列可能由基因组形成，或通过遗传序列的随机诱变。选择和富集发生在形成于乳剂中的水性液滴中，其从文库分离单个多核苷酸或多个多核苷酸，其可以包括不衍生自文库，转录和翻译试剂以及任选的其它化学和酶试剂的多核苷酸。选择和富集方法利用多核苷酸衔接子，当连接到多核苷酸片段时，可以在衔接子特异性引物的存在下进行扩增。

6. 发明申请

WO2014074453A1 COMPOSITIONS AND METHODS FOR OXYGENATION OF NUCLEIC ACIDS CONTAINING 5-METHYLPYRIMIDINE 审中-公开
标题翻译：含有5-甲基嘧啶的核酸的组合物和方法
公开(公告)号：WO2014074453A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068298
申请日：2013-11-04
申请人： NEW ENGLAND BIOLABS, INC. , ZHENG, Yu , SALEH, Lana , PAIS, June , DAI, Nan , ROBERTS, Richard, J. , CORREA, Ivan, R. , MABUCHI, Megumu
发明人： ZHENG, Yu , SALEH, Lana , PAIS, June , DAI, Nan , ROBERTS, Richard, J. , CORREA, Ivan, R. , MABUCHI, Megumu
IPC分类号： C12Q1/68 , C12N9/00
CPC分类号： C12N9/0069 , C07H19/06 , C07H21/00 , C07K14/47 , C07K2319/80 , C07K2319/81 , C12N9/1051 , C12N9/22 , C12P19/18 , C12P19/30 , C12P19/34 , C12Q1/68 , C12Q1/6806 , C12Q1/6809 , C12Q1/6827 , C12Q1/683 , Y02P20/52 , C12Q2521/301 , C12Q2523/115 , C12Q2525/101 , C12Q2527/125 , C12Q2537/164
摘要： 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described.
摘要翻译：描述了5-甲基嘧啶加氧酶及其在核酸修饰中的用途。

7. 发明申请

WO2007097778A2 NOVEL RESTRICTION ENDONUCLEASES, DNA ENCODING THESE ENDONUCLEASES AND METHODS FOR IDENTIFYING NEW ENDONUCLEASES WITH THE SAME OR VARIED SPECIFICITY 审中-公开
标题翻译：新的限制性内切核酸酶，编码这些内切核酸酶的DNA和鉴定具有相同或不同的特异性的新内切核酸酶的方法
公开(公告)号：WO2007097778A2
公开(公告)日：2007-08-30
申请号：PCT/US2006/030419
申请日：2006-08-03
申请人： NEW ENGLAND BIOLABS, INC. , MORGAN, Richard, D. , ROBERTS, Richard, J.
发明人： MORGAN, Richard, D. , ROBERTS, Richard, J.
IPC分类号： C07K14/43
CPC分类号： C12N9/22 , C12Q1/44 , G06F17/30386 , G06F19/22
摘要： Specified restriction endonucleases have been characterized for the first time by their amino acid and DNA sequences. These sequences and those with at least 90% identity thereto have been used as probes in sequence similarity analyses to identify sequence matches in a sequence database that corresponds to novel restriction endonucleases or isoschizomers. The sequence similarity analyses includes selecting a positive sequence match from any sequence producing an expectation value of less than or equal to e-02.
摘要翻译：特定的限制性内切核酸酶首次被它们的氨基酸和DNA序列表征。这些序列和与其具有至少90％同一性的那些序列已被用作序列相似性分析中的探针以鉴定对应于新的限制性内切核酸酶或同源异构体的序列数据库中的序列匹配。序列相似性分析包括从产生期望值小于或等于e-02的任何序列中选择正序列匹配。

8. 发明申请

WO2005121946A2 INFERRING FUNCTION FROM SHOTGUN SEQUENCING DATA 审中-公开
标题翻译：来自SHOTGUN序列数据的感染函数
公开(公告)号：WO2005121946A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019241
申请日：2005-06-01
申请人： NEW ENGLAND BIOLABS, INC. , ROBERTS, Richard, J.
发明人： ROBERTS, Richard, J.
IPC分类号： G06F9/00
CPC分类号： C12N15/1034 , C12N15/1089
摘要： Methods are described for detecting genes that encode toxic proteins using maps derived from shotgun libraries by determining the presence of gaps in clone start sites on either side of open reading frames. The method is exemplified by identifying a previously unknown restriction endonuclease gene.
摘要翻译：描述了用于通过确定在开放阅读框的任一侧上的克隆起始位点中存在间隙来检测编码毒性蛋白的基因的方法，所述基因来自霰弹枪库。该方法通过鉴定先前未知的限制性内切核酸酶基因来举例说明。

9. 发明申请

WO2005040342A3 CLEAVAGE OF RNA BY RESTRICTION ENDONUCLEASES 审中-公开
公开(公告)号：WO2005040342A3
公开(公告)日：2005-05-06
申请号：PCT/US2004/028307
申请日：2004-08-31
申请人： NEW ENGLAND BIOLABS, INC. , ROBERTS, Richard, J. , STICKEL, Shawn
发明人： ROBERTS, Richard, J. , STICKEL, Shawn
IPC分类号： C12N9/00
摘要： Methods of and uses for cleaving RNA/DNA duplexes with restriction endonucleases are provided as well as methods for determining whether a restriction endonuclease is capable of such cleavage.

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