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1. 发明申请

WO2006125496A3 PHARMACEUTICAL FORMULATIONS COMPRISING ACTIVE PHARMACEUTICAL PRINCIPLES ABSORBED ON TITANIUM DIOXIDE NANOPARTICLES 审中-公开
公开(公告)号：WO2006125496A3
公开(公告)日：2006-11-30
申请号：PCT/EP2006/003348
申请日：2006-04-12
申请人： FLAMMA S.P.A. , MARRA, Alberto , DONDONI, Alessandro , BIGNOZZI, Carlo, Alberto , CANEVOTTI, Renato , NEGRISOLI, Gian Paolo , DISSETTE, Valeria
发明人： MARRA, Alberto , DONDONI, Alessandro , BIGNOZZI, Carlo, Alberto , CANEVOTTI, Renato , NEGRISOLI, Gian Paolo , DISSETTE, Valeria
IPC分类号： A61K9/51
摘要： The invention provides methods for the adsorption of an active pharmaceutical ingredient on titianium dioxide nanoparticles which can be orally ingested allowing the drug release into the intestine without causing side effects to the upper gastrointestinal region.

2. 发明申请

WO2008020460A1 NANOMATERIAL COATINGS FOR OSTEOINTEGRATED BIOMEDICAL PROSTHESES 审中-公开
标题翻译：用于骨化生物医学前体的纳米涂层
公开(公告)号：WO2008020460A1
公开(公告)日：2008-02-21
申请号：PCT/IT2006/000450
申请日：2006-08-14
申请人： NM TECH LTD. , BIGNOZZI, Carlo, Alberto , CARINCI, Valeria , CARAMORI, Stefano , DISSETTE, Valeria
发明人： BIGNOZZI, Carlo, Alberto , CARINCI, Valeria , CARAMORI, Stefano , DISSETTE, Valeria
IPC分类号： A61L27/30 , A61L27/50
CPC分类号： A61L27/306 , A61L27/50 , A61L2430/02
摘要： The present invention proposes novel materials and methods, for preparation of coatings based on titanium dioxide for osteointegrated biomedical prostheses. The coatings are realized with nanomaterials having antibacterial properties, and have the purpose of : promoting osteointegration of the implants, and, at the same time, reducing rejection attributable to inflammatory processes which derive from infections which may develop in the neighborhood of the implants. In particular, the present invention relates to an endo-osseous implant comprised of biocompatible metallic materials; characterized in that said implant comprises a coating comprised of nanocrystalline material comprising nanoparticles of formula (I) AO x - (L- Me n+ ) i , (I) where AO x represents TiO 2 or ZrO 2 ; Me n+ is a metallic ion having antibacterial activity, with n = 1 or 2; L is a bi functional organic molecule which can simultaneously bind to the metal oxide and to the metallic ion Me n+ ; and i is the number of L-Me n+ groups bound to one nanoparticle of AO x .
摘要翻译：本发明提出了用于制备用于骨整合生物医学假体的基于二氧化钛的涂层的新型材料和方法。涂层由具有抗菌性能的纳米材料实现，并且其目的是：促进植入物的骨整合，并且同时减少归因于可能在植入物附近发展的感染的炎症过程。特别地，本发明涉及由生物相容性金属材料构成的骨内植入物; 其特征在于，所述植入物包括由纳米晶体材料构成的涂层，所述纳米晶体材料包含式（I）的纳米颗粒，其中AO < SUB> x表示TiO 2或ZrO 2; n + n +是具有抗菌活性的金属离子，n = 1或2; L是可以同时结合金属氧化物和金属离子的双功能有机分子。并且i是与一个纳米颗粒结合的L-Me N + 基团的数目。

3. 发明申请

WO2006136931A1 SUSPENSIONS OF TITANIUM DIOXIDE AND METHOD FOR OBTAINING THEM 审中-公开
标题翻译：二氧化钛的悬浮液及其获取方法
公开(公告)号：WO2006136931A1
公开(公告)日：2006-12-28
申请号：PCT/IB2006/001697
申请日：2006-06-22
申请人： NEW PHOTOCATALYST SOLUTION LIMITED , DELLA VALLE, Renato, Ambrogio , BIGNOZZI, Carlo, Alberto
发明人： DELLA VALLE, Renato, Ambrogio , BIGNOZZI, Carlo, Alberto
IPC分类号： C09D17/00
CPC分类号： C09D5/028 , C09D17/008
摘要： A colloidal suspension comprises titanium dioxide from approximately 0.5% w/v to approximately 5% w/v, a surface- active agent from approximately 0.1% w/v to approximately 5% w/v and water. A method for eliminating polluting substances and a method for eliminating microorganisms near a surface provides preparing a colloidal suspension of titanium dioxide and depositing said colloidal suspension on said surface.
摘要翻译：胶态悬浮液包含约0.5％w / v至约5％w / v的二氧化钛，约0.1％w / v至约5％w / v的表面活性剂和水。消除污染物质的方法和消除表面附近的微生物的方法提供制备二氧化钛的胶体悬浮液并将所述胶体悬浮液沉积在所述表面上。

4. 发明申请

WO2006043166A3 METHOD FOR PREPARING ENDOSSEOUS IMPLANTS WITH ANATASE TITANIUM DIOXIDE COATING 审中-公开
公开(公告)号：WO2006043166A3
公开(公告)日：2006-04-27
申请号：PCT/IB2005/003155
申请日：2005-10-13
申请人： GUYA BIOSCIENCE S.R.L. , CARINCI, Francesco , BIGNOZZI, Carlo, Alberto , MINERO, Claudio , MAURINO, Valter
发明人： CARINCI, Francesco , BIGNOZZI, Carlo, Alberto , MINERO, Claudio , MAURINO, Valter
IPC分类号： A61L27/30 , A61L27/54 , A61C8/00 , A61F2/30
摘要： The method includes the following steps: formulation of liquid, non-gelled and stable precursor by solvolysis of Ti(IV) compounds; precursor deposition on endosseous implant surface; thermal treatment to achieve film densification, in the presence of oxygen, of a complex formed by the above mentioned endosseous implant and precursor, to obtain on the implant surface a thin film of nanocrystalline titanium dioxide with good mechanical and chemical stability; The complex above, under a persistent UV irradiation modify its surface status conferring a sensible increasing of wettability chemical and biological decontamination.

5. 发明申请

WO2002010286A3 PROCESS FOR THE PREPARATION OF CARBOXYLATE AND PHOSPHONATE RUTHENIUM POLYPYRIDINE DYES AND A PROCESS FOR THE PREPARATION OF REACTION INTERMEDIATES USED IN SUCH PROCESS 审中-公开
公开(公告)号：WO2002010286A3
公开(公告)日：2002-02-07
申请号：PCT/EP2001/007972
申请日：2001-07-11
申请人： NEOMAT S.A. , ALEBBI, Monica , BIGNOZZI, Carlo, Alberto , COSTA, Emiliana
发明人： ALEBBI, Monica , BIGNOZZI, Carlo, Alberto , COSTA, Emiliana
IPC分类号： C07F15/00 , H01G9/20 , C09B57/10
摘要： The present invention relates to processes indicated by method A and B for the preparation of carboxylate and phosphonate Ruthenium Polypyridine Dyes and for the preparation of reaction intermediates used in such process.

6. 发明申请

WO2007122651A1 FUNCTIONAL NANOMATERIALS WITH ANTIBACTERIAL AND ANTIVIRAL ACTIVITY 审中-公开
标题翻译：具有抗菌活性的功能性纳米材料
公开(公告)号：WO2007122651A1
公开(公告)日：2007-11-01
申请号：PCT/IT2006/000280
申请日：2006-04-24
申请人： NM TECH NANOMATERIALS MICRODEVICE TECHNOLOGY LTD. ogy , BIGNOZZI, Carlo, Alberto , DISSETE, Valeria , CORALLINI, Alfredo , CARRA, Giacomo , DELLA VALLE, Renato
发明人： BIGNOZZI, Carlo, Alberto , DISSETE, Valeria , CORALLINI, Alfredo , CARRA, Giacomo , DELLA VALLE, Renato
IPC分类号： B22F1/02 , C07F5/02 , C07F15/00
CPC分类号： C07F1/005 , B22F2999/00 , C07B2200/11 , C07D213/79 , B22F1/0022 , B22F1/0062 , B22F1/025
摘要： The present invention relates to nanomaterials comprised of metal oxides associated with cationic metals having antibacterial activity. In particular, the present invention relates to nanocrystalline compounds of formula (I) : AOx- (L-Men+) i, (I) where AOx represents the metal oxide or metalloid oxide, with x = 1 or 2; Me11"1" is a metal ion having antibacterial activity, with n = 1 or 2; L is a bifunctional molecule, either organic or organometallic, capable of binding simultaneously with the metal oxide or metalloid oxide and the metal ion Men+; and i represents the number of L-Men+ groups bound to a AOx nanoparticle.
摘要翻译：本发明涉及由与具有抗菌活性的阳离子金属相关的金属氧化物组成的纳米材料。特别地，本发明涉及式（I）的纳米晶体化合物：AOx-（L-Men +）i，（I）其中AOx表示金属氧化物或类金属氧化物，x = 1或2; Me11“1”是具有抗菌活性的金属离子，n = 1或2; L是能够与金属氧化物或准金属氧化物和金属离子Men +同时结合的双官能分子，无论是有机的还是有机金属的，并且i表示与AOx纳米颗粒结合的L-Men +基团的数目。

7. 发明申请

WO2006043168A3 METHOD FOR PREPARING ENDOSSEOUS IMPLANTS WITH ZIRCON DIOXIDE COATING 审中-公开
公开(公告)号：WO2006043168A3
公开(公告)日：2006-04-27
申请号：PCT/IB2005/003162
申请日：2005-10-13
申请人： GUYA BIOSCIENCE S.R.L. , CARINCI, Francesco , BIGNOZZI, Carlo, Alberto , MINERO, Claudio , MAURINO, Valter , CARAMORI, Stefano
发明人： CARINCI, Francesco , BIGNOZZI, Carlo, Alberto , MINERO, Claudio , MAURINO, Valter , CARAMORI, Stefano
IPC分类号： A61L27/30 , A61L27/54 , A61C8/00 , A61F2/30
摘要： The method includes the following steps: formulation of liquid, non-gelled and stable precursors by solvolysis of ZV (IV) compounds; precursor deposition on endosseous implant surface; thermal treatment to achieve film densification, in the presence of oxygen, of a complex formed by the said endosseous implant and precursor, to obtain on the implant surface a thin nanocrystalline zirconium dioxide film.

8. 发明申请

WO2003038508A3 METAL COMPLEX-BASED ELECTRON-TRANSFER MEDIATORS IN DYE-SENSITIZED SOLAR CELLS 审中-公开
公开(公告)号：WO2003038508A3
公开(公告)日：2003-05-08
申请号：PCT/US2002/034883
申请日：2002-10-30
申请人： COLORADO STATE UNIVERSITY RESEARCH FOUNDATION , UNIVERSITY OF FERRARA , ELLIOTT, C., Michael , SAPP, Shawn, A. , BIGNOZZI, Carlo, Alberto , CONTADO, Cristiano , CARAMORI, Stefano
发明人： ELLIOTT, C., Michael , SAPP, Shawn, A. , BIGNOZZI, Carlo, Alberto , CONTADO, Cristiano , CARAMORI, Stefano
IPC分类号： C07F15/02
摘要： This present invention provides a metal-ligand complex and methods for using and preparing the same. In particular, the metal-ligand complex of the present invention is of the formula:L a -M-X b where L, M, X, a, and b are those define herein. The metal-ligand complexes of the present invention are useful in a variety of applications including as electron-transfer mediators in dye-sensitized solar cells and related photoelectrochromic devices.

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