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    • 8. 发明申请
    • LYOPHILIZATION METHOD AND APPARATUS FOR PRODUCING PARTICLES
    • 用于生产颗粒的沥青方法和装置
    • WO2004071410A2
    • 2004-08-26
    • PCT/US2004/000265
    • 2004-01-07
    • FERRO CORPORATIONSHEKUNOV, Boris, Y.CHATTOPADHYAY, PratibhashSEITZINGER, Jeffrey, S.
    • SHEKUNOV, Boris, Y.CHATTOPADHYAY, PratibhashSEITZINGER, Jeffrey, S.
    • A61K
    • F25D3/102A61K9/1623A61K9/1694A61K9/19F25B9/02F26B5/065
    • A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and t he fluid together to form a mixture. T he mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.
    • 一种用于生产颗粒的方法和装置,该装置包括提供溶液的溶液源和供应流体的流体源。 溶液包括溶剂和溶质。 混合器接收来自源的溶液和流体,并将溶液和流体混合在一起形成混合物。 混合物在第一压力下从混合器供应到膨胀组件。 膨胀组件基本上同时喷雾和膨胀混合物以形成冷冻液滴,并且优选地形成冷冻液滴的低密度粉末。 冷冻干燥装置使颗粒中的溶剂升华。 粉末床的高质量转移率和均匀的开放结构提高了冷冻干燥过程。 获得具有受控尺寸分布的固体颗粒。 颗粒优选具有适于不同药物递送应用的中空或多孔形态以包括气溶胶制剂。
    • 9. 发明申请
    • COMPOSITE PARTICLES AND METHOD FOR PREPARING
    • 复合颗粒和制备方法
    • WO2005016485A1
    • 2005-02-24
    • PCT/US2003/031472
    • 2003-10-06
    • FERRO CORPORATION
    • CHATTOPADHYAY, PratibhashSHEKUNOV, Boris, Y.SEITZINGER, Jeffrey, S.HUFF, Robert, W.
    • B01D11/02
    • B01D11/0411B01J13/02
    • A method and apparatus for producing composite particles using a supercritical fluid extraction technique on an emulsion. First and second materials for example, a polymer and a biologically active material are dissolved or suspended in a non-polar solvent to form solution or dispersion. The solution or dispersion is emulsified in a polar solvent to form an oil-in-water or water-in-oil-emulsion that is held in an extraction chamber (104). The emulsion is contacted with a supercritical fluid from fluid source (150) to extract the solvent. Removal of the solvent by the supercritical fluid from the emulsion supersaturates at least the materials in the solution causing it to precipitate out of the solution as composite materials that include both the first and second materials.
    • 一种使用超临界流体萃取技术在乳液上制备复合颗粒的方法和装置。 将第一和第二材料例如聚合物和生物活性材料溶解或悬浮在非极性溶剂中以形成溶液或分散体。 将溶液或分散体在极性溶剂中乳化以形成保持在萃取室(104)中的油包水或油包水乳液。 将乳液与来自流体源(150)的超临界流体接触以萃取溶剂。 由超临界流体从乳液中除去溶剂至少使溶液中的材料过饱和,导致溶液沉淀出溶液,作为包括第一和第二材料的复合材料。
    • 10. 发明申请
    • METHOD AND APPARATUS FOR CONTINUOUS PARTICLE PRODUCTION USING SUPERCRITICAL FLUID
    • 使用超临界流体连续生产颗粒的方法和装置
    • WO2004071634A2
    • 2004-08-26
    • PCT/US2004/001625
    • 2004-01-21
    • FERRO CORPORATION
    • SHEKUNOV, Boris, Y.CHATTOPADHYAY, PratibhashSEITZINGER, Jeffrey, S.
    • B01F
    • B01J13/02B01D11/0403B01D11/0407B01D11/0411B01D11/0484
    • A method and an apparatus for continuously producing particles from an emulsion by supercritical fluid extraction. The emulsion includes a solute suspended or dissolved in the supercritical fluid soluble first phase. The supercritical fluid and the emulsion contact each other such that the first phase dissolves from the emulsion into the supercritical fluid and the solute precipitates to form a suspension in a non supercritical fluid soluble second phase of the emulsion. The supercritical fluid carries away the dissolved first phase. The solvent bearing supercritical fluid, together with the solute suspended in the second phase, is removed from an extraction chamber at a rate that is about the same as the rate that the emulsion and the supercritical fluid flow into the extraction chamber. Thus, a constant mass and pressure is maintained in the extraction chamber and the particles are produced continuously.
    • 一种通过超临界流体萃取从乳液中连续生产颗粒的方法和装置。 乳液包括悬浮或溶解在超临界流体可溶的第一相中的溶质。 超临界流体和乳液彼此接触,使得第一相从乳液溶解到超临界流体中,并且溶质沉淀以在乳液的非超临界流体溶解的第二相中形成悬浮液。 超临界流体带走溶解的第一相。 溶剂轴承超临界流体与悬浮在第二相中的溶质一起以与乳液和超临界流体流入萃取室的速率大致相同的速率从萃取室中除去。 因此,在提取室中保持恒定的质量和压力,并且连续地产生颗粒。