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1. 发明申请

WO2005021142A3 PARTICLE PREPARATION USING SUPERCRITICAL FLUID AND MIXERS 审中-公开
标题翻译：使用超临界流体和混合器制备颗粒
公开(公告)号：WO2005021142A3
公开(公告)日：2005-05-26
申请号：PCT/US2004028584
申请日：2004-09-02
申请人： FERRO CORP , SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
发明人： SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
IPC分类号： B01D11/00 , B01D11/04 , B01F20060101 , B29B9/00 , B65D1/00 , B65D85/48 , H01L20060101 , H05B6/00
CPC分类号： B01J2/02 , A61K9/1647 , A61K9/1694 , B01D11/0411
摘要： The present invention provides method and an apparatus for forming particles using supercritical fluid. A load material is mixed with a first flow of supercritical fluid in first mixing chamber (110) having primary mixing device (180) to form a melt. The melt is transferred to second mixing chamber (120) having secondary mixing device (200) to form a lower viscosity melt and then expanded across a pressure drop into an expansion chamber (130) that is at a subcritical pressure of the supercritical fluid to thereby precipitate the load material in the form of particles.
摘要翻译：本发明提供了使用超临界流体形成颗粒的方法和装置。负载材料与具有主混合装置（180）的第一混合室（110）中的第一流动超临界流体混合以形成熔体。将熔体转移到具有二次混合装置（200）的第二混合室（120）中以形成较低粘度的熔体，然后在压降下膨胀到膨胀室（130）中，膨胀室（130）处于超临界流体的亚临界压力以颗粒的形式沉积负载材料。

2. 发明申请

WO2004071410A3 LYOPHILIZATION METHOD AND APPARATUS FOR PRODUCING PARTICLES 审中-公开
标题翻译：用于生产颗粒的沥青方法和装置
公开(公告)号：WO2004071410A3
公开(公告)日：2005-03-24
申请号：PCT/US2004000265
申请日：2004-01-07
申请人： FERRO CORP , SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
发明人： SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
IPC分类号： A61K9/16 , A61K9/19 , F25B9/02 , F25D3/10 , F26B5/06 , F25D17/02
CPC分类号： F25D3/102 , A61K9/1623 , A61K9/1694 , A61K9/19 , F25B9/02 , F26B5/065
摘要： A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and t he fluid together to form a mixture. T he mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.
摘要翻译：一种用于生产颗粒的方法和装置，该装置包括提供溶液的溶液源和供应流体的流体源。溶液包括溶剂和溶质。混合器接收来自源的溶液和流体，并将溶液和流体混合在一起形成混合物。混合物在第一压力下从混合器供应到膨胀组件。膨胀组件基本上同时喷雾和膨胀混合物以形成冷冻液滴，并且优选地形成冷冻液滴的低密度粉末。冷冻干燥装置使颗粒中的溶剂升华。粉末床的高质量转移率和均匀的开放结构提高了冷冻干燥过程。获得具有受控尺寸分布的固体颗粒。颗粒优选具有适于不同药物递送应用的中空或多孔形态以包括气溶胶制剂。

3. 发明申请

WO2004071645A3 METHOD AND APPARATUS FOR SUPERCRITICAL FLUID ASSISTED PARTICLE PRODUCTION 审中-公开
标题翻译：超临界流体辅助颗粒生产的方法和装置
公开(公告)号：WO2004071645A3
公开(公告)日：2004-12-02
申请号：PCT/US2004003575
申请日：2004-01-30
申请人： FERRO CORP , CHATTOPADHYAY PRATIBHASH , SHEKUNOV BORIS Y , SEITZINGER JEFFREY S
发明人： CHATTOPADHYAY PRATIBHASH , SHEKUNOV BORIS Y , SEITZINGER JEFFREY S
IPC分类号： A61K9/14 , A61K9/16 , A61L2/16 , A61L2/23 , B01J20060101 , B01J2/04 , B29B9/00 , B29B9/16 , C08J3/12 , C08J3/16
CPC分类号： C08J3/16 , A61K9/145 , A61K9/1617 , A61K9/1694 , B01F3/0807 , B01F7/22 , B01F2003/0064 , B01J2/04 , C08J3/02 , C08J2391/00 , Y02P20/544
摘要： The present invention provides an apparatus and methods of producing particles that include a polymer, a wax and/or lipid and, optionally, a biologically active substance. A load stock including a polymer, a wax, and/or a lipid that is a solid at standard temperature and pressure and, optionally, a biologically active substance is provided. The load stock is contacted with a supercritical fluid to form a melt. The melt is contacted with a polar solvent under suitable conditions to form an emulsion. The emulsion is expanded across a pressure drop to form solid particles that include the load stock. The methods and apparatus facilitate the production of very small particles that have a narrow particle size distribution. An apparatus is shown in Figure 1. The apparatus (100) includes an emulsion and mixing apparatus (102) and an expansion apparatus (104). The emulsification apparatus includes an emulsification vessel (110) and an emulsion assembly (116).
摘要翻译：本发明提供了一种生产包括聚合物，蜡和/或脂质以及任选的生物活性物质的颗粒的装置和方法。提供了包括聚合物，蜡和/或在标准温度和压力下为固体的脂质和任选的生物活性物质的负载储备。负载原料与超临界流体接触以形成熔体。在合适的条件下使熔体与极性溶剂接触以形成乳液。乳液在压降下膨胀以形成包括负载原料的固体颗粒。该方法和装置有助于生产具有窄粒度分布的非常小的颗粒。装置如图1所示。装置（100）包括乳液和混合装置（102）和膨胀装置（104）。乳化装置包括乳化容器（110）和乳液组件（116）。

4. 发明申请

WO2004110603A2 METHOD FOR PREPARATION OF PARTICLES FROM SOLUTION-IN-SUPERCRITICAL FLUID OR COMPRESSED GAS EMULSIONS 审中-公开
标题翻译：从溶液超临界流体或压缩气体乳液中制备颗粒的方法
公开(公告)号：WO2004110603A2
公开(公告)日：2004-12-23
申请号：PCT/US2004017451
申请日：2004-06-02
申请人： FERRO CORP , CHATTOPADHYAY PRATIBHASH , SHEKUNOV BORIS Y , SEITZINGER JEFFREY S
发明人： CHATTOPADHYAY PRATIBHASH , SHEKUNOV BORIS Y , SEITZINGER JEFFREY S
IPC分类号： A61K9/14 , A61K48/00 , B01F20060101 , B01J2/04 , B01F
CPC分类号： A61K48/00 , A61K9/1605 , A61K9/19 , B01J2/04
摘要： The present invention provides a method of producing particles from solution-in-supercritical fluid or compressed gas emulsions. In accordance with the method of the invention, a solution that includes a solute dissolved in a solvent is contacted with supercritical fluid or compressed gas to form a solution-in-supercritical fluid or compressed gas emulsion. The emulsion is sprayed through an orifice to create spray droplets. The supercritical fluid or compressed gas and the solvent are removed from the spray droplets resulting in the formation of particles that include the solute. In one embodiment of the invention, the solvent is removed from the spray droplets by lyophilization. In another embodiment of the invention, the solvent is removed from the spray droplets by evaporation.
摘要翻译：本发明提供了一种从超临界流体或压缩气体乳液中制备颗粒的方法。根据本发明的方法，将包含溶解在溶剂中的溶质的溶液与超临界流体或压缩气体接触以形成超临界流体或压缩气体乳液。通过孔喷雾乳液以产生喷雾液滴。从喷雾液滴中除去超临界流体或压缩气体和溶剂，导致形成包括溶质的颗粒。在本发明的一个实施方案中，通过冷冻干燥从喷雾液滴中除去溶剂。在本发明的另一个实施方案中，通过蒸发从喷雾液滴中除去溶剂。

5. 发明申请

WO2004108265A2 NANOPARTICLES FROM SUPERCRITICAL FLUID ANTISOLVENT PROCESS USING PARTICLE GROWTH AND AGGLOMERATION RETARDANTS 审中-公开
标题翻译：使用颗粒生长和凝聚阻滞剂的超临界流体抗菌工艺的纳米颗粒
公开(公告)号：WO2004108265A2
公开(公告)日：2004-12-16
申请号：PCT/US2004017211
申请日：2004-05-28
申请人： FERRO CORP , SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
发明人： SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
IPC分类号： A61K9/14 , A61K9/16 , B01J20060101 , B01J
CPC分类号： A61K9/1694 , A61K9/1635 , A61K9/1641 , A61K9/1647
摘要： The present invention provides a method of forming particles using supercritical fluid (SCF). In accordance with the method, one or more growth retardant compounds having both SCF-philic and SCF-phobic groups are present when one or more solute materials reach a supersaturation point and begin to form particle nuclei. The growth retardant compounds can reduce the particle growth rate, increase the nucleation rate and also prevent particle agglomeration. Preferred growth retardant compounds include sugar acetates and fluorocarbons.
摘要翻译：本发明提供使用超临界流体（SCF）形成颗粒的方法。根据该方法，当一种或多种溶质材料达到过饱和点并开始形成颗粒核时，存在一种或多种具有SCF亲和和SCF-恐怕基团的生长阻滞化合物。生长阻滞化合物可以降低颗粒生长速率，增加成核速率，并且还可防止颗粒聚集。优选的生长阻滞化合物包括糖醋酸盐和碳氟化合物。

6. 发明申请

WO2006016981A2 PRODUCTION OF POROUS MATERIALS BY SUPERCRITICAL FLUID PROCESSING 审中-公开
标题翻译：通过超临界流体处理生产多孔材料
公开(公告)号：WO2006016981A2
公开(公告)日：2006-02-16
申请号：PCT/US2005021970
申请日：2005-06-21
申请人： FERRO CORP , CHATTOPADHYAY PRATIBHASH , SHEKUNOV BORIS Y , SEITZINGER JEFFREY S
发明人： CHATTOPADHYAY PRATIBHASH , SHEKUNOV BORIS Y , SEITZINGER JEFFREY S
CPC分类号： A61K9/1688 , A61K9/0073 , A61K9/1647
摘要： The present invention provides a method of producing porous structures, particles or matrixes, which may be comprised of one or a plurality of components, an apparatus for carrying out the method and particles formed in accordance with the method. The method is particularly suitable for producing porous composite or pure particles for pharmaceutical applications. In accordance with the method, a composite comprising a material such as a pharmaceutical, a biodegradable polymers and/or a biological agent is formed. The composite must further comprise a material that is soluble in supercritical fluid. Extraction of the supercritical fluid soluble material produces porous structures, which may be in the form of particles or matrixes.
摘要翻译：本发明提供一种生产可由一种或多种组分组成的多孔结构，颗粒或基体的方法，用于实施根据该方法形成的方法和颗粒的装置。该方法特别适用于生产用于药物应用的多孔复合物或纯颗粒。根据该方法，形成包含诸如药物，可生物降解的聚合物和/或生物试剂的材料的复合材料。复合材料还必须包含可溶于超临界流体的材料。超临界流体可溶物质的提取产生多孔结构，其可以是颗粒或基体的形式。

7. 发明申请

WO2004071614A3 METHOD AND APPARATUS FOR PRODUCING PARTICLES VIA SUPERCRITICAL FLUID PROCESSING 审中-公开
标题翻译：通过超临界流体处理生产颗粒的方法和装置
公开(公告)号：WO2004071614A3
公开(公告)日：2005-04-14
申请号：PCT/US2004002915
申请日：2004-02-02
申请人： FERRO CORP
发明人： SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
IPC分类号： A61K9/16 , B01D11/04 , B01F7/00 , B01J2/04 , B01D11/00 , A61K9/14 , A62C5/02 , B01D12/00 , B01D17/00 , B01F13/00 , B01F15/00 , B29B9/00 , C02F1/26 , C02F1/44
CPC分类号： B01J2/04 , A61K9/1688 , B01D11/0411 , B01F7/008 , B01F7/00908 , B01F2003/0064
摘要： An apparatus and method for producing particles using supercritical fluid with enhanced mixing. The process includes a vessel having an inner surface defining a chamber. A high-speed shear or turbulent mixer is incorporated inside the vessel in order to create a region of enhanced mixing (mixing zone). A supercritical fluid pump communicates with the first inlet, and supplies supercritical fluid into the mixing zone through the first inlet. A solution pump communicates with the second inlet, and supplies solution into the mixing zone through the second inlet. A mixer assembly includes a motor drive and a rotor. The rotor is in the mixing zone and can mix the solution and the supercritical fluid. Particles are produced when the solution and the supercritical fluid are pumped into the mixing zone while the rotor is mixing. The design of the mixer and the direction of the flow of materials into the chamber creates a plug flow in the mixing zone. The plug flow allows the particles to be removed from the mixing zone as soon as they are precipitated. Because of the high intensity homogeneous mixing and plug flow configuration, the particle uniformity is enhanced and production of composite particles facilitated.
摘要翻译：一种使用超临界流体加强混合生产颗粒的装置和方法。该方法包括具有限定室的内表面的容器。将高速剪切或湍流混合器并入容器内，以产生增强混合区域（混合区）。超临界流体泵与第一入口连通，并通过第一入口将超临界流体供应到混合区。溶液泵与第二入口连通，并通过第二入口将溶液供入混合区。混合器组件包括马达驱动器和转子。转子处于混合区，可以混合溶液和超临界流体。当溶液和超临界流体在转子混合时泵送到混合区域时产生颗粒。混合器的设计和材料流入腔室的方向在混合区域中产生塞子流。插塞流允许颗粒在沉淀时立即从混合区域中移除。由于高强度均匀混合和活塞流动配置，颗粒均匀性得到提高，并且复合颗粒的生产有助于。

8. 发明申请

WO2004071634A3 METHOD FOR PARTICLE PRODUCTION USING SUPERCRITICAL FLUID 审中-公开
标题翻译：使用超临界流体生产颗粒的方法
公开(公告)号：WO2004071634A3
公开(公告)日：2008-08-07
申请号：PCT/US2004001625
申请日：2004-01-21
申请人： FERRO CORP
发明人： SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
IPC分类号： A61K9/14 , B01D11/04 , B01J13/02
CPC分类号： B01J13/02 , B01D11/0403 , B01D11/0407 , B01D11/0411 , B01D11/0484
摘要： A method and an apparatus for continuously producing particles from an emulsion by supercritical fluid extraction. The emulsion includes a solute suspended or dissolved in the supercritical fluid soluble first phase. The supercritical fluid and the emulsion contact each other such that the first phase dissolves from the emulsion into the supercritical fluid and the solute precipitates to form a suspension in a non supercritical fluid soluble second phase of the emulsion. The supercritical fluid carries away the dissolved first phase. The solvent bearing supercritical fluid, together with the solute suspended in the second phase, is removed from an extraction chamber at a rate that is about the same as the rate that the emulsion and the supercritical fluid flow into the extraction chamber. Thus, a constant mass and pressure is maintained in the extraction chamber and the particles are produced continuously.
摘要翻译：一种通过超临界流体萃取从乳液中连续生产颗粒的方法和装置。乳液包括悬浮或溶解在超临界流体可溶的第一相中的溶质。超临界流体和乳液彼此接触，使得第一相从乳液溶解到超临界流体中，并且溶质沉淀以在乳液的非超临界流体溶解的第二相中形成悬浮液。超临界流体带走溶解的第一相。溶剂轴承超临界流体与悬浮在第二相中的溶质一起以与乳液和超临界流体流入萃取室的速率大致相同的速率从萃取室中除去。因此，在提取室中保持恒定的质量和压力，并且连续地产生颗粒。

9. 发明申请

WO2005005010A3 METHODS AND APPARATUS FOR PRODUCING COMPOSITE PARTICLES USING SUPERCRITICAL FLUID AS PLASTICIZING AND EXTRACTING AGENT 审中-公开
标题翻译：使用超临界流体作为增塑剂和提取剂生产复合颗粒的方法和装置
公开(公告)号：WO2005005010A3
公开(公告)日：2005-04-07
申请号：PCT/US2004004756
申请日：2004-02-18
申请人： FERRO CORP
发明人： SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S
IPC分类号： B01D20060101 , B01D11/00 , B01D11/04
CPC分类号： B01D11/0411 , B01D11/0203 , B01D11/0403
摘要： The present invention provides methods and apparatus for producing composite particles using supercritical fluid as a plasticizing and extracting agent. The methods employ providing a polymer, wax and/or a lipid substance that is solid at standard temperature and pressure to be contacted with a supercritical fluid in vessel (10) to form a melt, either before or after the substance is contacted with a solution made up of solute dissolved in a solvent. The supercritical fluid plasticizes the substance and extracts the solvent from the solution, resulting in the formation of a two-fraction system including a first melt-rich fraction that includes the plasticized melt and dispersed fine particles of precipitated solute, and a second fraction that includes the supercritical fluid and the solvent. The first fraction is expanded in expansion chamber (160) across a pressure drop resulting in formation of composite particles that include the polymer, wax and/or lipid and the solute.
摘要翻译：本发明提供使用超临界流体作为增塑剂和提取剂制备复合颗粒的方法和装置。该方法采用提供在标准温度和压力下为固体的聚合物，蜡和/或脂质物质，以在物质与溶液接触之前或之后与容器（10）中的超临界流体接触以形成熔体由溶解在溶剂中的溶质组成。超临界流体使物质增塑并从溶液中提取溶剂，从而形成包括第一富熔体馏分的二馏分体系，所述第一富熔体馏分包括增塑的熔体和分散的沉淀的溶质的细颗粒，以及包括超临界流体和溶剂。第一部分在膨胀室（160）中通过压降膨胀，导致形成包括聚合物，蜡和/或脂质和溶质的复合颗粒。

10. 发明申请

WO2005025728A2 METHOD AND APPARATUS FOR ENHANCED SIZE REDUCTION OF PARTICLES 审中-公开
标题翻译：用于增强粒度减少颗粒的方法和装置
公开(公告)号：WO2005025728A2
公开(公告)日：2005-03-24
申请号：PCT/US2004005412
申请日：2004-02-24
申请人： FERRO CORP
发明人： SHEKUNOV BORIS Y , CHATTOPADHYAY PRATIBHASH , SEITZINGER JEFFREY S , HUFF ROBERT W
IPC分类号： B01F20060101 , B01F1/00 , B01F3/08 , B01J2/04 , B29B9/00 , B01F
CPC分类号： B01F3/0853 , A61K9/146 , A61K9/1652 , A61K9/1694 , B01D3/06 , B01D11/0411 , B01F2003/0064 , B01J2/02 , C08J3/12 , C08J2305/00 , C08J2333/00 , C08J2367/00 , C08J2371/00 , C08J2389/00
摘要： The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composte particles.
摘要翻译：本发明提供了通过超临界流体处理生产颗粒的方法和装置。在一个实施方案中，该方法包括在压降下扩张超临界流体增塑的熔体，以形成同时分散，发泡和冷却的固体复合颗粒，并研磨生产的固体颗粒以达到所需的尺寸分布。在另一个实施方案中，将包含超临界流体增塑的熔体的压力容器减压以形成冷却的固体多孔质量块，然后将其研磨以获得固体堆肥颗粒。

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