专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023021529A1 IMPROVED ENZYMATIC SYNTHESIS OF SITAGLIPTIN OR ITS SALTS THEREOF 审中-公开
公开(公告)号：WO2023021529A1
公开(公告)日：2023-02-23
申请号：PCT/IN2022/050743
申请日：2022-08-17
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , WADHAVANE, Sachin , MURALIDHARAN, Krishna , TRIVIKRAM, Sreenath
IPC分类号： C07C27/20 , C12N9/10
摘要： The present invention discloses an improved enzymatic synthesis of Sitalgiptin or its pharmaceutically acceptable salts in good yield and purity. The present invention provides novel intermediate (R)- 3-Acetamido-4-(2,4,5-Trifluorophenyl) butanoic acid (5).

2. 发明申请

WO2020245845A1 AN IMPROVED PROCESS TO SYNTHESIZE 5-(3-PYRIDYL)-2,2'-BITHIOPHENE(SENSITIZER) 审中-公开
公开(公告)号：WO2020245845A1
公开(公告)日：2020-12-10
申请号：PCT/IN2020/050506
申请日：2020-06-08
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , TRIVIKRAM, Sreenath , DEGAONKAR, Gajanan
IPC分类号： C07D413/14 , C07D409/14
摘要： The present invention discloses an improved catalytic process for the synthesis of 5-(3-pyridyl)-2, 2'-bithiophene in high yield and purity.

3. 发明申请

WO2019053742A1 SOLVENT FREE PROCESS FOR EXTRACTION OF CHOLESTEROL FROM MILK FAT 审中-公开
公开(公告)号：WO2019053742A1
公开(公告)日：2019-03-21
申请号：PCT/IN2018/050590
申请日：2018-09-12
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , TRIVIKRAM, Sreenath , SHIRSATH, Amol
IPC分类号： C07J9/00 , A61K31/56
摘要： The present invention discloses solvent free process for extracting cholesterol free of impurities from milk fat. The so isolated cholesterol is useful for the further preparation of vitamin D3. The present invention further provides pharmaceutical grade cholesterol from milk fat of high purity.

4. 发明申请

WO2015170341A1 PROCESS FOR PREPARATION OF 7-DEHYDROCHOLESTEROL 审中-公开
标题翻译：制备7-脱氢胆甾醇的方法
公开(公告)号：WO2015170341A1
公开(公告)日：2015-11-12
申请号：PCT/IN2015/000198
申请日：2015-05-06
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , TAMORE, Jagdish , TRIVIKRAM, Sreenath
IPC分类号： C07J9/00 , C07J31/00
CPC分类号： C07J9/00 , C07J31/003
摘要： The invention discloses an improved cost-effective process for preparation of 7-Dehydrocholesterol of formula I with good yield and purity, comprising:a) epimerizing 7(alpha+beta) bromo protected cholesterol in presence of tetrabutyl ammonium bromide in toluene or a ketonic solvent or combinations thereof to obtain predominantly 7.alpha-bromo 3-protected cholesterol; b) Reacting 7.apha-bromo 3- protected cholesterol with substituted or unsubstituted thiophenol or its salts in presence of a liquor ammonia to obtain predominantly 7.beta.-thiophenyl)-3-protected cholesterol; c) Oxidizing 7. beta. - thiophenyl 3-protected cholesterol in presence of Cumene hydrogen peroxide and Titanium tetraisopropoxide to obtain 7. beta. -phenyl sulfoxide 3-protected cholesterol; d) Converting 7. beta. -phenyl sulfoxide 3-protected cholesterol into 7-Dehydro 3-protected cholesterol in presence of base; e) purifying 7-Dehydro 3-protected cholesterol by suspending in a suitable organic solvent; and f) Deprotecting the 7-Dehydro 3-protected cholesterol by treating with alkali in presence of methanol to obtain 7-Dehydrocholesterol followed by purification of 7-Dehydrocholesterol from an organic solvent.
摘要翻译：本发明公开了一种用于制备具有良好产率和纯度的式I的7-脱氢胆固醇的改进的成本有效的方法，其包括：a）在甲苯或酮溶剂中存在四丁基溴化铵的7（α+β）溴保护的胆固醇差向异构化或其组合以主要获得7.α-溴3-保护的胆固醇; b）在液氨的存在下，将7-溴-3-保护的胆固醇与取代或未取代的苯硫酚或其盐反应，主要得到7.β-噻吩基）-3-保护的胆固醇; c）氧化7.β。在苯甲酸过氧化氢和四异丙氧基钛的存在下，将噻吩-3-保护的胆固醇得到7.β。苯基亚砜3-保护胆固醇; d）转换7. beta。苯基亚砜将3-保护的胆固醇转化为7-脱氢3-保护的胆固醇，在碱的存在下; e）通过悬浮在合适的有机溶剂中纯化7-脱氢3-保护的胆固醇; 和f）通过在甲醇存在下用碱处理来脱保护7-脱氢3-保护的胆固醇，得到7-脱氢胆固醇，然后从有机溶剂中纯化7-脱氢胆固醇。

5. 发明申请

WO2022195603A1 A ONE STEP PROCESS FOR THE ENZYMATIC SYNTHESIS OF SEMISYNTHETIC β-LACTAM ANTIBIOTICS 审中-公开
公开(公告)号：WO2022195603A1
公开(公告)日：2022-09-22
申请号：PCT/IN2021/050537
申请日：2021-06-03
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , ASHAR, Trupti Krishnakant , MURALIDHARAN, Krishna , JAIN, Rina Sumit , KADAM, Sachin Vasant , JOHN, Joseph Mandanath
IPC分类号： C12N9/84
摘要： A one step process for the enzymatic synthesis of semisynthetic β-lactam antibiotics The present invention relates to a blended purified enzyme having origin of a mNPGA (mutant penicillin G acylase) from Achromobacter and Penicillin G acylase expressed in Escherichia coli. The present invention further relates to an immobilized blended purified enzyme and an enzymatic process for synthesis of semisynthetic β-lactam antibiotic in a single step reaction starting with beta lactam core nucleus and activated phenylglycine derivative as acyl donor in presence phenylacetic byproduct formed which is competitive inhibitor of Penicillin acylase enzyme. The present process for synthesis of semisynthetic β- lactam antibiotic using blended purified Penicillin G acylase enzyme derived from Escherichia coli and Achromobacter spp. CCM4824 requires no isolation of antibiotic intermediate which reduces the time of downstream purification.

6. 发明申请

WO2021019558A1 AN EFFICIENT METHOD FOR SYNTHESIS OF 5-(3-PYRIDYL)-2,2'-BITHIOPHENE(SENSITIZER) 审中-公开
公开(公告)号：WO2021019558A1
公开(公告)日：2021-02-04
申请号：PCT/IN2020/050646
申请日：2020-07-27
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , PRABHU, Manojkumar Sadanand , KADAM, Sachin Vasant
IPC分类号： C07D409/04 , C07D409/14 , C07D333/02 , C07D333/04
摘要： The present invention discloses an efficient process for synthesis of photosensitizer, 5-(3-pyridyl)-2,2'-bithiophene in high yield and purity.

7. 发明申请

WO2023021530A1 IMPROVED SHORT PROCESS FOR SYNTHESIS OF MOLNUPIRAVIR 审中-公开
公开(公告)号：WO2023021530A1
公开(公告)日：2023-02-23
申请号：PCT/IN2022/050744
申请日：2022-08-17
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , PRABHU, Manojkumar Sadanand , TRIVIKRAM, Sreenath , DEGAONKAR, Gajanan Subhash , WADHAVANE, Sachin Govind , SHIRSATH, Amol , PAWAR, Prasad
IPC分类号： C07D207/416 , C07C227/02
摘要： The present invention discloses an economical and improved, short process for synthesis of Molnupiravir from cytidine. The process of the present invention provides a novel intermediate N-Hydroxy Cytidine isobutyryl ester (13) which can be enzymatically converted to Molnupiravir in good yield and purity.

8. 发明申请

WO2021140526A1 MUTANT PENICILLIN G ACYLASES OF ACHROMOBACTER CCM4824 审中-公开
公开(公告)号：WO2021140526A1
公开(公告)日：2021-07-15
申请号：PCT/IN2021/050022
申请日：2021-01-08
申请人： FERMENTA BIOTECH LIMITED
发明人： DESAI, Anupama Datla , NAGRE, Prashant , TAMORE, Jagdish , KRISHNA, Muralidharan , ASHAR, Trupti
IPC分类号： C12N9/84 , C12R1/025
摘要： The present invention discloses mutant semi-synthetic β-lactam antibiotics synthesizing enzymes of penicillin G acylase from Achromobacter sp. CCM4824 generated by site directed mutations with substitution of one or more amino acid positions. The gene sequence encoding mutant penicillin acylase borne on plasmid pKARA9 is expressed in E.coli BL21. The enzymes so obtained from recombinant E.coli BL21 showed improved penicillin acylase activity, S/H ratio, lower input ratio of acyl donor and improved yields compared to parent penicillin acylase enzyme from Achromobacter sp CCM 4824.

9. 发明申请

WO2021019559A1 SYNTHESIS OF 5-(3-PYRIDYL)-2,2'-BITHIOPHENE(SENSITIZER) 审中-公开
公开(公告)号：WO2021019559A1
公开(公告)日：2021-02-04
申请号：PCT/IN2020/050647
申请日：2020-07-27
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , PRABHU, Manojkumar Sadanand , KADAM, Sachin Vasant
IPC分类号： C07D409/04 , C07D409/14 , C07D333/02 , C07D333/04
摘要： Disclosed herein is a novel simple, short process for synthesis of the photosensitizer, 5-(3-pyridyl)-2,2'-bithiophene.

10. 发明申请

WO2021005619A1 IMPROVED, COST EFFECTIVE PROCESS FOR SYNTHESIS OF VITAMIN D3 AND ITS ANALOGUE CALCIFEDIOL FROM ERGOSTEROL 审中-公开
公开(公告)号：WO2021005619A1
公开(公告)日：2021-01-14
申请号：PCT/IN2020/050577
申请日：2020-07-02
申请人： FERMENTA BIOTECH LIMITED
发明人： DATLA, Anupama , NAGRE, Prashant , TAMORE, Jagdish , PRABHU, Manojkumar Sadanand , KADAM, Sachin Vasant
IPC分类号： C07C401/00
摘要： Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式