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1. 发明申请

WO2011101862A1 STABILIZED FLUCONAZOLE POLYMORPH III FORMULATION 审中-公开
标题翻译：稳定的氟康唑III配方
公开(公告)号：WO2011101862A1
公开(公告)日：2011-08-25
申请号：PCT/IN2011/000084
申请日：2011-02-04
申请人： FDC LIMITED , CHANDAVARKAR, Nandan, Mohan , JINDAL, Kour, Chand , KULKARNI, Shailesh, Sharad
发明人： CHANDAVARKAR, Nandan, Mohan , JINDAL, Kour, Chand , KULKARNI, Shailesh, Sharad
IPC分类号： A61K9/20 , A61K31/4196
CPC分类号： A61K9/2009 , A61K9/2095 , A61K31/4196
摘要： Disclosed herein is a stabilized formulation of Fluconazole polymorph III and a method of stabilizing the formulation containing Fluconazole polymorph III.
摘要翻译：本文公开了氟康唑多晶型III的稳定化制剂和稳定含有氟康唑多晶型III的制剂的方法。

2. 发明申请

WO2011018800A2 A NOVEL IN-SITU GEL FORMING SOLUTION FOR OCULAR DRUG DELIVERY 审中-公开
标题翻译：一种新型口服凝胶形成溶液用于药物输送
公开(公告)号：WO2011018800A2
公开(公告)日：2011-02-17
申请号：PCT/IN2010/000536
申请日：2010-08-13
申请人： FDC LIMITED , CHANDAVARKAR, Nandan, Mohan , JINDAL, Kour, Chand , MALAYANDI, Rajkumar
发明人： CHANDAVARKAR, Nandan, Mohan , JINDAL, Kour, Chand , MALAYANDI, Rajkumar
IPC分类号： A61K9/00
CPC分类号： A61K9/0048 , A61K9/0024 , A61K9/0051 , A61K47/10 , A61K47/36 , A61K47/38
摘要： Disclosed herein is a novel in-situ gel forming system for ocular drug delivery comprises a combination of natural polysaccharide having thixotropic behavior, thermoreversible polymer and a vehicle alongwith one or more optional components selected from active pharmaceutical ingredient(s), buffer, preservative with or without stabilizer, pH modifier(s) and tonicity modifiers.
摘要翻译：本文公开了一种用于眼药物递送的新颖的原位凝胶形成系统，其包含具有触变行为的天然多糖，热可逆性聚合物和载体以及选自活性药物成分，缓冲剂，防腐剂或其中的一种或多种任选组分的组合，没有稳定剂，pH调节剂和张力调节剂。

3. 发明申请

WO2011125075A2 A NOVEL GASTRORETENTIVE DELIVERY OF MACROLIDE 审中-公开
标题翻译：一个新的GARTRTENTENTIVE交付的MACROLIDE
公开(公告)号：WO2011125075A2
公开(公告)日：2011-10-13
申请号：PCT/IN2011/000241
申请日：2011-04-07
申请人： FDC LIMITED , CHANDAVARKAR, Nandan, Mohan , JINDAL, Kour, Chand , MALAYANDI, Rajkumar
发明人： CHANDAVARKAR, Nandan, Mohan , JINDAL, Kour, Chand , MALAYANDI, Rajkumar
IPC分类号： A61K31/7048
CPC分类号： A61K9/0065 , A61K9/205 , A61K9/2054
摘要： Disclosed herein is a novel gastroretentive delivery system of macrolide consisting of a hydrophilic swellable floating matrix system either alone or in combination with a bioadhesive system, which comprises super-disintegrants together with hydrophilic polymers and in-situ gelling agents to improve the gastroretention of dosage forms.
摘要翻译：本文公开了一种新型的大环内酯类的胃滞留递送系统，其由单独或与生物粘附系统组合的亲水性可膨胀浮动基质体系组成，其包含超级崩解剂以及亲水性聚合物和原位胶凝剂，以改善剂型的胃滞。

4. 发明申请

WO2010100657A3 ORAL CONTROLLED RELEASE DOSAGE FORMS FOR WATER SOLUBLE DRUGS 审中-公开
公开(公告)号：WO2010100657A3
公开(公告)日：2010-09-10
申请号：PCT/IN2010/000121
申请日：2010-03-02
申请人： FDC LIMITED , CHANDAVARKAR, Mohan, Anand , JINDAL, Kour, Chand , MALAYANDI, Rajkumar
发明人： CHANDAVARKAR, Mohan, Anand , JINDAL, Kour, Chand , MALAYANDI, Rajkumar
IPC分类号： A61K9/20
摘要： Disclosed herein is an oral controlled release pharmaceutical formulation comprising water-soluble drug or pharmaceutically acceptable salts thereof, in a hydrophilic matrix system, further comprising pH independent polymers present in an amount of 5% to 90 % w/w in combination with acid insoluble polymer present in an amount of 1% to 70% w/w and/or a diluent, a lubricant and/or a glidant.

5. 发明申请

WO2007132479A1 COMPOSITION COMPRISING AT LEAST ONE HIGHER ALIPHATIC ALCOHOL AND AN EXTRACT OF GRIFFONIA SIMPLICIFOLIA 审中-公开
标题翻译：至少包含一种较高的脂肪醇和甘草的提取物的组合物
公开(公告)号：WO2007132479A1
公开(公告)日：2007-11-22
申请号：PCT/IN2007/000188
申请日：2007-05-09
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand
发明人： JAIN, Rajesh , JINDAL, Kour, Chand
IPC分类号： A61K36/48 , A61K31/045
CPC分类号： A61K36/48 , A61K31/045 , A61K36/82 , A61K2300/00
摘要： Novel compositions comprising a combination of at least one higher primary aliphatic alcohol preferably selected from those having 18 to 40 carbon atoms or mixtures thereof, at least one source of 5-hydroxytryptophan (5-HTP) optionally additionally comprising a source of caffeine and/or catechin-polyphenol and/or epigallocatechin gallate as active agents, either alone or in combination with other active agent(s), optionally with one or more excipient(s) are provided. Particularly, the invention relates to compositions and process for preparation of such compositions and method of use thereof for the management of obesity and associated disorders.
摘要翻译：包含至少一种优选选自具有18-40个碳原子的高级伯脂肪醇或其混合物的至少一种5-羟基色氨酸（5-HTP）的组合的新型组合物任选地另外包含咖啡因和/或儿茶素多酚和/或表没食子儿茶素没食子酸酯作为活性剂，单独或与其它活性剂，任选地与一种或多种赋形剂组合使用。特别地，本发明涉及用于制备这种组合物的组合物和方法及其用于治疗肥胖症和相关疾病的方法。

6. 发明申请

WO2007122636A1 PHARMACEUTICAL COMPOSITIONS CONTAINING LONG CHAIN FATTY ACIDS AS EXCIPIENTS AS WELL AS A PROCESS FOR MANUFACTURING THE SAME 审中-公开
标题翻译：含有长链脂肪酸的药物组合物作为制造方法的程序
公开(公告)号：WO2007122636A1
公开(公告)日：2007-11-01
申请号：PCT/IN2007/000161
申请日：2007-04-23
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , JINDAL, Kour, Chand , PATIL, Chandrashekhar, Shankar
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , PATIL, Chandrashekhar, Shankar
IPC分类号： A61K47/10 , A61P7/02
CPC分类号： A61K9/4866 , A61K9/2018 , A61K9/2054 , A61K9/2866 , A61K9/4858
摘要： Pharmaceutical compositions comprising at least one higher primary aliphatic alcohol selected from a group of alcohols having 20 to 39 carbon atoms or mixtures thereof and at least one platelet aggregation inhibitor, or its pharmaceutically acceptable salts, esters, solvates or hydrates thereof, preferably clopidogrel as active agent; optionally with one or more pharmaceutically acceptable excipient(s); and process of preparation of such compositions are provided. Also described are method of treatment and use of such compositions particularly for providing antiplatelet activity optionally with lipid lowering effect and usefulness for the management of cardiovascular disease associated with hyperlipidemia. The compositions of the present invention optionally comprises at least one another organic component selected from a group comprising resins and pigments, hydrocarbons, sterols, esters, ketones, aldehydes, phenolic compounds, and mixtures thereof.
摘要翻译：药物组合物，其包含至少一种选自具有20至39个碳原子的醇的醇或其混合物和至少一种血小板聚集抑制剂的高级伯脂肪醇，或其药学上可接受的盐，酯，溶剂合物或水合物，优选氯吡格雷为活性物质剂; 任选地与一种或多种药学上可接受的赋形剂; 并提供这些组合物的制备方法。还描述了这样的组合物的治疗和使用方法，特别是提供抗血小板活性，任选地具有降血脂作用和用于治疗与高脂血症相关的心血管疾病的有用性。本发明的组合物任选地包含至少一种选自树脂和颜料，烃，甾醇，酯，酮，醛，酚类化合物及其混合物的有机组分。

7. 发明申请

WO2007102171A2 NOVEL SALTS OF 1H-1-BENZAZEPINE-1-ACETIC ACID, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译： 1H-1-BENZAZEPINE-1-ACE酸的新型盐，其制备和药物组合物
公开(公告)号：WO2007102171A2
公开(公告)日：2007-09-13
申请号：PCT/IN2007/000084
申请日：2007-03-05
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Jaspal
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Jaspal
IPC分类号： C07D223/16
CPC分类号： C07D223/16
摘要： Novel water soluble amino acid salts of 1 H- 1-benzazepine- 1 -acetic acid, process of preparation of such novel salts and methods of using them are provided. Also provided are pharmaceutical compositions comprising such novel salts and method of using such compositions for the prophylaxis, amelioration and/or treatment of cardiovascular and other associated disorders which comprises the administration of an effective amount of such composition to a subject in need thereof. The novel salts of the present invention are obtained in highly pure solid form, possess appreciable aqueous solubility and good bioavailability, and can be easily formulated into any pharmaceutically acceptable dosage form such as solid oral, drinkable or injectable compositions.
摘要翻译：提供1 H- 1-苯并氮杂-1-乙酸的新型水溶性氨基酸盐，这种新型盐的制备方法和使用它们的方法。还提供了包含这种新型盐的药物组合物和使用这些组合物用于预防，改善和/或治疗心血管和其它相关疾病的方法，其包括向有需要的受试者施用有效量的此类组合物。本发明的新型盐以高纯度固体形式获得，具有明显的水溶性和良好的生物利用度，并且可以容易地配制成任何药学上可接受的剂型，例如固体口服，饮用或可注射组合物。

8. 发明申请

WO2005067943A1 COMPOSTIONS COMPRISING GLYCOSAMINOGLYCAN AND NONSTEROIDAL ANTI-INFLAMMATORY DRUG 审中-公开
标题翻译：包含谷氨酰胺糖和非甾体抗炎药的组合物
公开(公告)号：WO2005067943A1
公开(公告)日：2005-07-28
申请号：PCT/IN2005/000026
申请日：2005-01-19
申请人： PANACEA BIOTEC LTD., , JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet
IPC分类号： A61K31/726
CPC分类号： A61K31/726 , A61K9/205 , A61K9/2054 , A61K9/2866 , A61K9/4866 , A61K31/18 , A61K31/196 , A61K31/405 , A61K31/727 , A61K31/728 , A61K2300/00
摘要： Pharmaceutical compositions comprising of glycosaminoglycan or salts thereof, preferably chondroitin or salts thereof, more preferably chondroitin sulphate, and nonsteroidal anti-inflammatory drug(s) or salts thereof, optionally with pharmaceutically acceptable excipient(s) are described. The compositions of the present invention provide gastrosparing effect in conditions where nonsteroidal anti-inflammatory drug(s) or their salts are used, particularly in mammals. Also provided are process for the manufacture of such novel compositions and method to minimize the nonsteroidal anti-inflammatory drug(s) induced gastric toxicity.
摘要翻译：描述了包含糖胺聚糖或其盐的药物组合物，优选软骨素或其盐，更优选硫酸软骨素，以及任选与药学上可接受的赋形剂的非甾体抗炎药或其盐。本发明的组合物在使用非甾族抗炎药或其盐的情况下特别是在哺乳动物中提供胃镜效应。还提供了制备这种新型组合物和方法以使非甾体抗炎药物诱导的胃毒性最小化的方法。

9. 发明申请

WO2005065664A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A PROTON PUMP INHIBITOR AND A PROKINETIC AGENT 审中-公开
标题翻译：包含原料泵抑制剂和助剂的药物组合物
公开(公告)号：WO2005065664A1
公开(公告)日：2005-07-21
申请号：PCT/IN2005/000002
申请日：2005-01-05
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand , SING, Sukhjeet
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , SING, Sukhjeet
IPC分类号： A61K9/48
CPC分类号： A61K31/4439 , A61K9/2081 , A61K9/209 , A61K9/4808 , A61K9/5078 , A61K31/136 , A61K31/138
摘要： Oral pharmaceutical compositions and process for preparation thereof are provided comprising at least one gastric acid suppressing agent, preferably a proton pump inhibitor or its pharmaceutically acceptable salts, ester, hydrates, derivatives or prodrugs, and one or more prokinetic agent or its pharmaceutically acceptable salts, esters, hydrates, derivatives or prodrugs, optionally with other pharmaceutically acceptable excipients, characterized in that the gastric acid suppressing agent is present in a delayed release from and prokinetic agent is present in a bimodal release from such as an immediate release form to provide an initial loading dose, and a delayed release form to provide a dose with a lag time; with the provisio that the prokinetic agent is not formulated using a hydrophilic rate controlling polymer and is not present in a sustained release form. Method of treatment of gastro esophageal reflux disease, reflux esophagitis, peptic ulcer, gastric ulcer, and other gastric acid related disorders by administering to a patient such a pharmaceutical composition in need thereof is also provided.
摘要翻译：提供了口服药物组合物及其制备方法，其包含至少一种胃酸抑制剂，优选质子泵抑制剂或其药学上可接受的盐，酯，水合物，衍生物或前药，以及一种或多种促动力剂或其药学上可接受的盐，酯，水合物，衍生物或前药，任选地与其它药学上可接受的赋形剂，其特征在于胃酸抑制剂以延迟释放存在，促动力剂存在于双峰释放物中，例如立即释放形式，以提供初始加载剂量和延迟释放形式以提供具有滞后时间的剂量; 条件是促动剂不使用亲水性速率控制聚合物配制，并且不以缓释形式存在。还提供了通过向患者施用这种有此需要的药物组合物来治疗胃食管反流病，反流性食管炎，消化性溃疡，胃溃疡和其它胃酸相关疾病的方法。

10. 发明申请

WO2004016250A1 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION OF A CEPHALOSPORIN ANTIBIOTIC 审中-公开
标题翻译： CEPHALOSPORIN抗生素的持续释放药物组合物
公开(公告)号：WO2004016250A1
公开(公告)日：2004-02-26
申请号：PCT/IB2002/003320
申请日：2002-08-19
申请人： ORCHID HEALTH CARE , KSHIRSAGAR, Rajesh, Suresh , BOLDHANE, Sanjay, Parbhatrao , JINDAL, Kour, Chand
发明人： KSHIRSAGAR, Rajesh, Suresh , BOLDHANE, Sanjay, Parbhatrao , JINDAL, Kour, Chand
IPC分类号： A61K9/22
CPC分类号： A61K9/205 , A61K9/2027 , A61K9/204 , A61K9/2054 , A61K31/545 , A61K31/546
摘要： This invention relates to a sustained release pharmaceutical composition comprising at least a cephalosporin antibiotic, a mixture of polymers and other pharmaceutically acceptable excipients; in the composition, polymers are selected from mixture of galactomannans and neutral swellable polymers, which releases the active ingredient in a predetermined manner.
摘要翻译：本发明涉及包含至少头孢菌素抗生素，聚合物和其它药学上可接受的赋形剂混合物的缓释药物组合物; 在组合物中，聚合物选自半乳甘露聚糖和中性可溶胀聚合物的混合物，其以预定方式释放活性成分。

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