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1. 发明申请

WO2017165245A2 METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATED EXPANSION THEREOF 审中-公开
公开(公告)号：WO2017165245A2
公开(公告)日：2017-09-28
申请号：PCT/US2017/023112
申请日：2017-03-19
申请人： F1 ONCOLOGY, INC. , F1 ONCOLOGY, SEZC
发明人： FROST, Gregory Ian , ONUFFER, James Joseph , GUIBINGA, Ghiabe H. , KUNDU, Anirban
IPC分类号： C12N15/10 , C12N15/867 , C12N5/0783 , C12N5/10 , C07K14/725 , C07K14/705 , C07K14/715 , A61K48/00
摘要： The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells without prior ex vivo stimulation. The methods typically include engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted CAR. Additional elements of such engineered signaling polypeptides are provided herein, as well as vectors, such as retroviral vectors, packaging cell lines and methods of making the same. Furthermore, recombinant retroviruses and methods of making the same are provided. Numerous controls are provided, including ribos witches that are controlled, for example in vivo, by nucleoside analogues.

2. 发明申请

WO2017165245A3 METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATED EXPANSION THEREOF 审中-公开
标题翻译：用于转染淋巴细胞的方法和组合物及其调节的扩增
公开(公告)号：WO2017165245A3
公开(公告)日：2017-09-28
申请号：PCT/US2017/023112
申请日：2017-03-19
申请人： F1 ONCOLOGY, INC. , F1 ONCOLOGY, SEZC
发明人： FROST, Gregory Ian , ONUFFER, James Joseph , GUIBINGA, Ghiabe H. , KUNDU, Anirban
IPC分类号： C12N15/10 , C12N15/867 , C12N5/0783 , C12N5/10 , C07K14/725 , C07K14/705 , C07K14/715 , A61K48/00
摘要： The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells without prior ex vivo stimulation. The methods typically include engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted CAR. Additional elements of such engineered signaling polypeptides are provided herein, as well as vectors, such as retroviral vectors, packaging cell lines and methods of making the same. Furthermore, recombinant retroviruses and methods of making the same are provided. Numerous controls are provided, including ribos witches that are controlled, for example in vivo, by nucleoside analogues.
摘要翻译：本公开提供了用于遗传修饰淋巴细胞的方法和用于进行过继性细胞治疗的方法，其包括在没有事先离体刺激的情况下转导T细胞和/或NK细胞。所述方法通常包括可包含淋巴组织增生元件和/或嵌合抗原受体（CAR）的工程信号转导多肽，例如限制微环境的CAR。本文提供了此类工程化信号转导多肽的其他元件以及载体，如逆转录病毒载体，包装细胞系及其制备方法。此外，提供了重组逆转录病毒及其制备方法。提供了许多控制，包括例如在体内由核苷类似物控制的核糖女巫。

3. 发明申请

WO2018161064A1 METHODS AND COMPOSITIONS FOR TRANSDUCING AND EXPANDING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF 审中-公开
公开(公告)号：WO2018161064A1
公开(公告)日：2018-09-07
申请号：PCT/US2018/020818
申请日：2018-03-03
申请人： F1 ONCOLOGY, INC.
发明人： FROST, Gregory Ian , ONUFFER, James Joseph , GUIBINGA, Ghiabe H. , HAERIZADEH, Farzad
IPC分类号： C12N15/10 , C12N15/867 , C12N5/0783 , C12N5/10 , C07K14/725 , C07K14/705 , C07K14/715 , A61K48/00 , C12N15/86
摘要： The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted biologic CAR (MRB-CAR). Additional elements of such engineered signaling polypeptides are provided herein, such as those that drive proliferation and regulatory elements therefor, as well as replication incompetent recombinant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically modified T cells and/or NK cells are provided, such as, for example, those including riboswitches, MRB-CARs, recognition domains, and/or pH-modulating agents.

4. 发明申请

WO2018161064A9 METHODS AND COMPOSITIONS FOR TRANSDUCING AND EXPANDING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF 审中-公开
公开(公告)号：WO2018161064A9
公开(公告)日：2018-09-07
申请号：PCT/US2018/020818
申请日：2018-03-03
申请人： F1 ONCOLOGY, INC.
发明人： FROST, Gregory Ian , ONUFFER, James Joseph , GUIBINGA, Ghiabe H. , HAERIZADEH, Farzad
IPC分类号： C12N15/10 , C12N15/867 , C12N5/0783 , C12N5/10 , C07K14/725 , C07K14/705 , C07K14/715 , A61K48/00 , C12N15/86
摘要： The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted biologic CAR (MRB-CAR). Additional elements of such engineered signaling polypeptides are provided herein, such as those that drive proliferation and regulatory elements therefor, as well as replication incompetent recombinant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically modified T cells and/or NK cells are provided, such as, for example, those including riboswitches, MRB-CARs, recognition domains, and/or pH-modulating agents.

5. 发明申请

WO2018009923A9 METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF 审中-公开
公开(公告)号：WO2018009923A9
公开(公告)日：2018-01-11
申请号：PCT/US2017/041277
申请日：2017-07-08
申请人： F1 ONCOLOGY, INC.
发明人： FROST, Gregory Ian , GUIBINGA, Ghiabe H. , ONUFFER, James Joseph , HAERIZADEH, Farzad
IPC分类号： C12N15/10 , C12N15/867 , C12N5/0783 , C12N5/10 , C07K14/725 , C07K14/705 , C07K14/715 , A61K48/00
摘要： The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted biologic CAR (MRB-CAR). Additional elements of such engineered signaling polypeptides are provided herein, such as those that drive proliferation and regulatory elements therefor, as well as replication incompetent recombinant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically modified T cells and/or NK cells are provided, such as, for example, those including ribos witches, MRB-CARs, recognition domains, and/or pH-modulating agents.

6. 发明申请

WO2018009923A1 METHODS AND COMPOSITIONS FOR TRANSDUCING LYMPHOCYTES AND REGULATING THE ACTIVITY THEREOF 审中-公开
标题翻译：转染淋巴细胞并调节其活性的方法和组合物
公开(公告)号：WO2018009923A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/041277
申请日：2017-07-08
申请人： F1 ONCOLOGY, INC.
发明人： FROST, Gregory Ian , GUIBINGA, Ghiabe H. , ONUFFER, James Joseph , HAERIZADEH, Farzad
IPC分类号： C12N15/10 , C12N15/867 , C12N5/0783 , C12N5/10 , C07K14/725 , C07K14/705 , C07K14/715 , A61K48/00
摘要： The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted biologic CAR (MRB-CAR). Additional elements of such engineered signaling polypeptides are provided herein, such as those that drive proliferation and regulatory elements therefor, as well as replication incompetent recombinant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically modified T cells and/or NK cells are provided, such as, for example, those including ribos witches, MRB-CARs, recognition domains, and/or pH-modulating agents.
摘要翻译：本公开提供了用于遗传修饰淋巴细胞的方法和用于进行过继性细胞疗法的方法，其包括转导T细胞和/或NK细胞。所述方法可以包括抑制性RNA分子和/或可包含淋巴组织增生元件和/或嵌合抗原受体（CAR）的工程信号传导多肽，例如微环境限制性生物CAR（MRB-CAR）。本文提供了此类工程改造的信号传导多肽的其它元件，诸如驱动其增殖和调控元件的那些元件，以及复制不良重组逆转录病毒颗粒和包装细胞系及其制备方法。提供了用于调节转导的和/或遗传修饰的T细胞和/或NK细胞的许多元件和方法，例如包括核糖魔鬼，MRB-CAR，识别结构域和/或pH调节剂的那些元件和方法。 p>

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