专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009132980A1 PYRIMIDINYL PYRIDONE INHIBITORS OF JNK. 审中-公开
标题翻译：吡咯烷酮吡咯烷酮抑制剂。
公开(公告)号：WO2009132980A1
公开(公告)日：2009-11-05
申请号：PCT/EP2009/054638
申请日：2009-04-20
申请人： F. HOFFMANN-LA ROCHE AG , BROOKFIELD, Frederick , DILLON, Michael, Patrick , EUSTACHE, Florence , GOLDSTEIN, David, Michael , GONG, Leyi , HAN, Xiaochun , HOGG, Joan, Heather , PARK, Jaehyeon , REUTER, Deborah, Carol , SJOGREN, Eric, Brian
发明人： BROOKFIELD, Frederick , DILLON, Michael, Patrick , EUSTACHE, Florence , GOLDSTEIN, David, Michael , GONG, Leyi , HAN, Xiaochun , HOGG, Joan, Heather , PARK, Jaehyeon , REUTER, Deborah, Carol , SJOGREN, Eric, Brian
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： This application discloses novel pyrimidinyl pyridone derivatives according to formula (I), wherein A, R 1 , R 2 , R 3 , and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula (I) and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
摘要翻译：本申请公开了根据式（I）的新型嘧啶基吡啶酮衍生物，其中A，R1，R2，R3和m如本文所述限定，其抑制JNK。本文公开的化合物可用于调节JNK的活性并治疗与过量JNK活性相关的疾病。这些化合物可用于治疗自身免疫性，炎性，代谢和神经疾病以及癌症。还公开了包含式（I）化合物和治疗方法的组合物，其包括向有需要的受试者施用治疗有效量的式I化合物。

2. 发明申请

WO2006032518A1 NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS 审中-公开
标题翻译：新型苯乙烯酮衍生物，作为AURORA-KINASE抑制剂
公开(公告)号：WO2006032518A1
公开(公告)日：2006-03-30
申请号：PCT/EP2005/010311
申请日：2005-09-23
申请人： F. HOFFMANN-LA ROCHE AG , BOYD, Edward , BROOKFIELD, Frederick , GEORGES, Guy , GOLLER, Bernhard , HUENSCH, Sabine , RUEGER, Petra , RUETH, Matthias , SCHEIBLICH, Stefan , SCHUELL, Christine , VON DER SAAL, Wolfgang , WARNE, Justin , WEIGAND, Stefan
发明人： BOYD, Edward , BROOKFIELD, Frederick , GEORGES, Guy , GOLLER, Bernhard , HUENSCH, Sabine , RUEGER, Petra , RUETH, Matthias , SCHEIBLICH, Stefan , SCHUELL, Christine , VON DER SAAL, Wolfgang , WARNE, Justin , WEIGAND, Stefan
IPC分类号： C07D403/12
CPC分类号： C07D403/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备方法，以及上述用途，提及的化合物在控制或预防诸如癌症的疾病中。

3. 发明申请

WO2007054139A2 STYRYLSULFONAMIDES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：酪氨酸聚糖，其制造和用作药物代理
公开(公告)号：WO2007054139A2
公开(公告)日：2007-05-18
申请号：PCT/EP2006/004756
申请日：2006-05-19
申请人： F. HOFFMANN-LA ROCHE AG , BOYD, Edward , BROOKFIELD, Frederick , GRIDLEY, Jonathan , KOERNER, Matthias , KUBBIES, Manfred , LAU, Raymond , REIFF, Ulrike , TIEFENTHALER, Georg , VON DER SAAL, Wolfgang , WOODCOCK, Timothy
发明人： BOYD, Edward , BROOKFIELD, Frederick , GRIDLEY, Jonathan , KOERNER, Matthias , KUBBIES, Manfred , LAU, Raymond , REIFF, Ulrike , TIEFENTHALER, Georg , VON DER SAAL, Wolfgang , WOODCOCK, Timothy
IPC分类号： C07C311/51 , C07C303/40 , A61K31/18
CPC分类号： C07C311/51
摘要： Objects of the present invention are the compounds of formula (I) Their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）的化合物：其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在控制或预防癌症等疾病。

4. 发明申请

WO2007014707A1 HETEROCYCLIC BENZYLAMINO DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：杂环烷基苯胺衍生物及其制备和用作药物代理
公开(公告)号：WO2007014707A1
公开(公告)日：2007-02-08
申请号：PCT/EP2006/007479
申请日：2006-07-28
申请人： F. HOFFMANN-LA ROCHE AG , BOYD, Edward , BROOKFIELD, Frederick , GRIDLEY, Jonathan , HONOLD, Konrad , LAU, Raymond , SCHEIBLICH, Stefan
发明人： BOYD, Edward , BROOKFIELD, Frederick , GRIDLEY, Jonathan , HONOLD, Konrad , LAU, Raymond , SCHEIBLICH, Stefan
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法以及上述用途所述化合物可用于控制或预防诸如癌症等疾病。

5. 发明申请

WO2008138594A1 ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译： ARYL PYRIDYL磺胺衍生物，其制造和用作药物代理
公开(公告)号：WO2008138594A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/003852
申请日：2008-05-14
申请人： F. HOFFMANN-LA ROCHE AG , BROOKFIELD, Frederick , KLING, Lothar , REIFF, Ulrike , VON DER SAAL, Wolfgang , VON HIRSCHHEYDT, Thomas
发明人： BROOKFIELD, Frederick , KLING, Lothar , REIFF, Ulrike , VON DER SAAL, Wolfgang , VON HIRSCHHEYDT, Thomas
IPC分类号： C07D213/71 , A61K31/435 , A61P35/00
CPC分类号： C07D213/71
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在控制或预防癌症等疾病。

6. 发明申请

WO2008049605A1 HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：间苯二酚吡啶酰胺衍生物及其制备和用作药物代理
公开(公告)号：WO2008049605A1
公开(公告)日：2008-05-02
申请号：PCT/EP2007/009238
申请日：2007-10-24
申请人： F. HOFFMANN-LA ROCHE AG , BROOKFIELD, Frederick , GRIDLEY, Jonathan , KLING, Lothar , PRIME, Michael , REIFF, Ulrike , VON DER SAAL, Wolfgang , VON HIRSCHHEYDT, Thomas
发明人： BROOKFIELD, Frederick , GRIDLEY, Jonathan , KLING, Lothar , PRIME, Michael , REIFF, Ulrike , VON DER SAAL, Wolfgang , VON HIRSCHHEYDT, Thomas
IPC分类号： C07D295/04 , A61K31/496 , A61P35/00
CPC分类号： C07D295/04
摘要： Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在对照中的用途或预防癌症等疾病。

7. 发明申请

WO2007107298A1 PHTHALAZINONE PYRAZOLE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：苯并噻唑酮衍生物及其制备方法及用作药物代理
公开(公告)号：WO2007107298A1
公开(公告)日：2007-09-27
申请号：PCT/EP2007/002332
申请日：2007-03-16
申请人： F. HOFFMANN-LA ROCHE AG , BOYD, Edward , BROOKFIELD, Frederick , COURTNEY, Steve , GEORGES, Guy , GOLLER, Bernhard , LIMBERG, Anja , PRIME, Michael , RUEGER, Petra , RUETH, Matthias
发明人： BOYD, Edward , BROOKFIELD, Frederick , COURTNEY, Steve , GEORGES, Guy , GOLLER, Bernhard , LIMBERG, Anja , PRIME, Michael , RUEGER, Petra , RUETH, Matthias
IPC分类号： C07D403/12 , C07D401/14 , A61K31/495 , A61P35/00
CPC分类号： C07D403/12 , C07D401/14
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备方法，以及上述用途，提及的化合物在控制或预防诸如癌症的疾病中。

8. 发明申请

WO2004073709A1 ANTIMICROBIAL AGENTS 审中-公开
标题翻译：抗菌药物
公开(公告)号：WO2004073709A1
公开(公告)日：2004-09-02
申请号：PCT/GB2004/000621
申请日：2004-02-17
申请人： PROLYSIS LIMITED , CZAPLEWSKI, Lloyd , ERRINGTON, Jeffrey , BAYSTON, Dan , BOYD, Andrew , BROOKFIELD, Frederick , HATCHER, Stuart
发明人： CZAPLEWSKI, Lloyd , ERRINGTON, Jeffrey , BAYSTON, Dan , BOYD, Andrew , BROOKFIELD, Frederick , HATCHER, Stuart
IPC分类号： A61K31/415
CPC分类号： C07D213/61 , A61K31/13 , A61K31/135 , A61K31/415 , A61K31/4164 , A61K31/425 , C07C211/29 , C07C217/58 , C07C257/16 , C07C257/18 , C07C275/70 , C07C279/12 , C07C279/18 , C07C279/28 , C07C2601/14 , C07D209/08 , C07D209/14 , C07D209/86 , C07D213/38 , C07D215/12 , C07D231/06 , C07D231/12 , C07D231/16 , C07D233/48 , C07D233/64 , C07D239/26 , C07D249/08 , C07D277/10 , C07D277/28 , C07D277/64 , C07D307/52 , C07D307/81 , C07D311/14 , C07D317/58 , C07D333/20 , C07D333/58 , C07D409/12
摘要： Compounds of formula (I) are antibacterial agents: wherein B represents R 2 R 3 N-, R 2 NH-C(=NR 3 )-, or R 2 NH-C(=NR 3 )-NR 4 - wherein each of R 2 , R 3 and R 4 represents hydrogen or a C 1 -C 6 alkyl, phenyl, phenyl(C 1 -C 6 alkyl)-, monocyclic heteroaryl, monocyclic heteroaryl (C 1 -C 6 alkyl)-, or cyano group, or R 2 and R 3 form a ring together with the nitrogen atoms to which they are attached; L represents a divalent radical of formula (II): -(Alk 1 ) m -(CYC 1 )p (Alk 2 ) n -[(Alk 3 ) r (CyC 2 ) s -(Alk 4 ) t ] w -, wherein Alk 1 , Alk 2 , Alk 3 and Alk 4 each independently represent (i) an optionally substituted divalent C 1 -C 3 alkylene radical which may optionally contain an ether (-0-), thioether (-S-) or amino (-NR A- ) link wherein R A is hydrogen or C 1 -C 3 alkyl, (ii) an optionally substituted -CH=CH- radical, or (iii) a -C=C- radical; Cyc 1 and Cyc 2 each independently represent an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having from 5 to 8 ring atoms; m, n, p, r, s, t and w each independently represent 0 or 1, provided that at least one of m, n and p is 1; R represents an optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, or Cyc-, (Cyc)-(C 1 -C 6 alkyl)-, (Cyc)-(C 2 -C 6 alkenyl)-, or (Cyc)-(C 2 -C 6 alkynyl)- radical wherein Cyc represents a monocyclic carbocyclic or heterocyclic radical having from 5 to 8 ring atoms; and R 1 represents an optionally substituted (aryl)-(C 1 -C 6 alkyl)-, (aryl)-(C 2 -C 6 alkenyl)-(aryl)-(C 2 -C 6 alkynyl)-, (heteroaryl)-(C 1 -C 6 alkyl)-, (heteroaryl)-(C 2 -C 6 alkenyl)- or (heteroaryl)-(C 2 -C 6 alkynyl)- radical.
摘要翻译：式（I）化合物是抗菌剂：其中B表示R2R3N-，R2NH-C（= NR3） - 或R2NH-C（= NR3）-NR4-，其中R2，R3和R4各自表示氢或C1- C6烷基，苯基，苯基（C1-C6烷基） - ，单环杂芳基，单环杂芳基（C1-C6烷基） - 或氰基，或R2和R3与它们所连接的氮原子一起形成环; L表示式（II）的二价基团： - （Alk 1）m-（CYC 1）p（Alk 2）n - [（Alk 3）r（CyC 2）] - （Alk 4）t] w-，其中Alk 1，Alk 2，Alk 3和Alk 4各自独立地表示（i）任选取代的二价C 1 -C 3亚烷基，其可任选地含有醚（-O-），硫醚（-S-）或氨基（-NR A - ）连接，其中R aA是氢或C 1 -C 3烷基，（ii）任选取代的-CH = CH- 或（iii）-C = C-基团; Cyc 1和Cyc 2各自独立地表示具有5至8个环原子的任选取代的二价单环碳环或杂环基; m，n，p，r，s，t和w各自独立地表示0或1，条件是m，n和p中的至少一个为1; R代表任选取代的C 1 -C 6烷基，C 2 -C 6烯基，C 2 -C 6炔基或环 - ，（环） - （C 1 -C 6烷基） - ，（Cyc） - （C 2 -C 6烯基） Cyc） - （C 2 -C 6炔基） - 基，其中Cyc表示具有5至8个环原子的单环碳环或杂环基; 并且R 1表示任选取代的（芳基） - （C 1 -C 6烷基） - ，（芳基） - （C 2 -C 6烯基） - （芳基） - （C 2 -C 6炔基） - ，（杂芳基）） - ，（杂芳基） - （C 2 -C 6烯基） - 或（杂芳基） - （C 2 -C 6炔基） - 基。

9. 发明申请

WO2014023258A1 PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：吡唑羧酰胺化合物，组合物和使用方法
公开(公告)号：WO2014023258A1
公开(公告)日：2014-02-13
申请号：PCT/CN2013/081136
申请日：2013-08-09
申请人： F.HOFFMANN-LA ROCHE AG , GENENTECH, INC. , BROOKFIELD, Frederick , BURCH, Jason , GOLDSMITH, Richard A. , HU, Baihua , LAU, Kevin Hon Luen , MACKINNON, Colin H. , ORTWINE, Daniel Fred , PEI, Zhonghua , WU, Guosheng , YUEN, Po-wai , ZHANG, Yamin
发明人： BROOKFIELD, Frederick , BURCH, Jason , GOLDSMITH, Richard A. , HU, Baihua , LAU, Kevin Hon Luen , MACKINNON, Colin H. , ORTWINE, Daniel Fred , PEI, Zhonghua , WU, Guosheng , YUEN, Po-wai , ZHANG, Yamin
IPC分类号： C07D231/56 , A61K31/416 , A61P37/00
CPC分类号： C07D403/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/10 , C07D491/044 , C07D491/10 , C07D491/107 , C07D495/10 , Y02P20/582
摘要： Provided herein are compounds of formula (AA): N N H HN O N N R R 6 A (R a ) p, (AA) stereoisomers or a pharmaceutically acceptable salt thereof, wherein A, R a, p, R and R 6 are defined herein, compositions including the compounds and methods of manufacturing and using the compounds for the treatment of diseases.
摘要翻译：本文提供了式（AA）的化合物：其中A，R a，p，R和R 6如本文所定义，其组合物包括：制备和使用化合物治疗疾病的化合物和方法。

10. 发明申请

WO2011091153A1 CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：某些京那奈因-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：WO2011091153A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/021890
申请日：2011-01-20
申请人： CHDI, INC. , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , WINKLER, Dirk , BROOKFIELD, Frederick , DE AGUIAR PENA, Paula, C.
发明人： DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia, M. , WINKLER, Dirk , BROOKFIELD, Frederick , DE AGUIAR PENA, Paula, C.
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D403/04 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4245 , C07D401/04 , C07D413/04 , C07D417/04
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式