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1. 发明申请

WO2012028526A3 TETRANECTIN-APOLIPOPROTEIN A-I, LIPID PARTICLES CONTAINING IT AND ITS USE 审中-公开
公开(公告)号：WO2012028526A3
公开(公告)日：2012-03-08
申请号：PCT/EP2011/064602
申请日：2011-08-25
申请人： F. HOFFMANN-LA ROCHE AG , BADER, Martin , BAEHNER, Monika , FINGERLE, Juergen , KOHNERT, Ulrich , MARY, Jean-Luc , MOHL, Silke
发明人： BADER, Martin , BAEHNER, Monika , FINGERLE, Juergen , KOHNERT, Ulrich , MARY, Jean-Luc , MOHL, Silke
IPC分类号： A61K9/127 , A61K38/47 , C07K14/775 , C12N15/62 , A61K9/00
摘要： Herein is reported a lipid particle comprising an apolipoprotein, a phosphatidylcholine and a lipid, such as a phospholipid, fatty acid or steroid lipid. In one embodiment the lipid particle comprises only one apolipoprotein. In one embodiment the lipid particle is consisting of one apolipoprotein, a phospholipid, a lipid, and a detergent. In one embodiment the lipid is a second phosphatidylcholine, wherein the first phosphatidylcholine and the second phosphatidylcholine differ in one or two fatty acid residues or fatty acid residue derivatives which are esterified to the glycerol backbone of the phosphatidylcholine. In one embodiment the apolipoprotein is selected from an apolipoprotein that has the amino acid sequence selected from SEQ ID NO: 01, 02, 06, 66, and 67, or is a variant thereof that has at least 70 % sequence identity with the selected sequence.

2. 发明申请

WO2011076684A1 SEQUENCE DEPENDENT AGGREGATION 审中-公开
标题翻译：序列依赖性聚集
公开(公告)号：WO2011076684A1
公开(公告)日：2011-06-30
申请号：PCT/EP2010/070063
申请日：2010-12-17
申请人： F. Hoffmann-La Roche AG , KETTENBERGER, Hubert , KLOSTERMANN, Stefan , KOHNERT, Ulrich , NEUMANN, Sebastian
发明人： KETTENBERGER, Hubert , KLOSTERMANN, Stefan , KOHNERT, Ulrich , NEUMANN, Sebastian
IPC分类号： C07K16/00 , C07K16/28
CPC分类号： C07K16/2866 , C07K16/00 , C07K16/2875 , C07K16/461 , C07K2317/24 , C07K2317/567
摘要： Herein is reported a method for reducing the aggregation of an immunoglobulin in solution comprising the steps of i) comparing the amino acid sequence of the fourth framework region of the heavy chain of an antibody with a reference or germline sequence and determining whether one or more threonine residues and/or serine residues have been replaced by a different amino acid residue, and ii) modifying the amino acid sequence of the immunoglobulin by reverting the exchanged threonine residues and/or serine residues back to threonine or serine of the reference or germline sequence and thereby reducing the aggregation of an immunoglobulin in solution.
摘要翻译：本文报道了用于减少溶液中免疫球蛋白聚集的方法，包括以下步骤：i）比较抗体重链的第四框架区的氨基酸序列与参照或种系序列，并确定一个或多个苏氨酸残基和/或丝氨酸残基已经被不同的氨基酸残基替代，和ii）通过将交换的苏氨酸残基和/或丝氨酸残基还原回参考或种系序列的苏氨酸或丝氨酸来修饰免疫球蛋白的氨基酸序列，以及从而减少溶液中免疫球蛋白的聚集。

3. 发明申请

WO2004024199A1 METAL IMPLANT COATED UNDER REDUCED OXYGEN CONCENTRATION WITH OSTEOINDUCTIVE PROTEIN 审中-公开
标题翻译：金属植入物与氧化蛋白质的还原氧化浓度
公开(公告)号：WO2004024199A1
公开(公告)日：2004-03-25
申请号：PCT/EP2003/007439
申请日：2003-07-09
申请人： SCIL TECHNOLOGY GMBH , HELLERBRAND, Klaus , BEAUCAMP, Nicola , KOHNERT, Ulrich
发明人： HELLERBRAND, Klaus , BEAUCAMP, Nicola , KOHNERT, Ulrich
IPC分类号： A61L27/04
CPC分类号： A61L27/04 , A61C8/0012 , A61C8/0013 , A61F2/30767 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61F2/4241 , A61F2/44 , A61F2310/00023 , A61F2310/00976 , A61L27/227 , Y10T428/31678
摘要： The present invention relates to a method for producing a device comprising the steps of (a) providing a solution comprising dissolved osteoinductive protein, (b) contacting the solution of the preceding step with a carrier containing a surface of metal or metal alloy, (c) allowing coating of the surface of said carrier with said dissolved protein and (d) drying of the coated carrier obtained in step (c) wherein steps (b) to (d) are carried out under a reduced concentration of oxygen. The invention also encompasses a device obtainable by the method of the present invention. Moreover, the present invention relates to a pharmaceutical composition comprising the said device and to the use of the device for the preparation of a pharmaceutical composition to be used for an accelerated osseointegration and new bone formation. Finally, the present invention relates to a kit comprising the device of the present invention.
摘要翻译：本发明涉及一种用于制备器件的方法，包括以下步骤：（a）提供包含溶解的骨诱导蛋白的溶液，（b）使前述步骤的溶液与含有金属或金属合金表面的载体接触，（c ）允许用所述溶解的蛋白质涂覆所述载体的表面，和（d）干燥步骤（c）中获得的涂覆载体，其中步骤（b）至（d）在减少的氧浓度下进行。本发明还包括可通过本发明的方法获得的装置。此外，本发明涉及包含所述装置的药物组合物和用于制备用于加速骨整合和新骨形成的药物组合物的该装置的用途。最后，本发明涉及包含本发明装置的试剂盒。

4. 发明申请

WO2003043673A1 DEVICE HAVING OSTEOINDUCTIVE AND OSTEOCONDUCTIVE PROPERTIES 审中-公开
标题翻译：具有磁化和磁性特性的器件
公开(公告)号：WO2003043673A1
公开(公告)日：2003-05-30
申请号：PCT/EP2002/003463
申请日：2002-03-27
申请人： SCIL BIOMEDICALS GMBH , KOHNERT, Ulrich , PÖHLING, Sylke , HELLERBRAND, Klaus , HAPPERSBERGER, Peter
发明人： KOHNERT, Ulrich , PÖHLING, Sylke , HELLERBRAND, Klaus , HAPPERSBERGER, Peter
IPC分类号： A61L27/34
CPC分类号： A61L27/227 , A61L24/02 , A61L24/108 , A61L27/12 , A61L27/34
摘要： The present invention relates to a device having osteoinductive and osteoconductive properties in vivo comprising a carrier containing calcium phosphate and an osteoinductive protein, wherein said carrier is homogenously coated with said protein. Moreover, the present invention relates to a method for the production of a device having osteoinductive and osteoconductive properties in vivo. The invention encompasses a pharmaceutical composition comprising the device of the invention or a device which is obtainable by the method of the invention and relates to the use of said device for the preparation of a pharmaceutical composition to be used for bone augmentation, for treating bone defects, for treating degenerative and traumatic disc disease, for treating bone dehiscence or to be used for sinus floor elevation. Finally, the invention relates to a kit comprising the device of the invention or a device which is obtainable by the method of the invention.
摘要翻译：本发明涉及一种在体内具有骨诱导和骨传导性质的装置，其包含含有磷酸钙和骨诱导蛋白的载体，其中所述载体均匀地涂覆有所述蛋白质。此外，本发明涉及在体内制造具有骨诱导性和骨传导性的装置的方法。本发明包括药物组合物，其包含本发明的装置或可通过本发明的方法获得的装置，并且涉及所述装置用于制备用于骨增大的药物组合物用于治疗骨缺损的用途用于治疗退行性和创伤性椎间盘疾病，用于治疗骨开裂或用于窦底抬高。最后，本发明涉及包含本发明的装置或可通过本发明的方法获得的装置的试剂盒。

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