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1. 发明申请

WO2012078934A2 TRUNCATED HER2 SRM/MRM ASSAY 审中-公开
标题翻译：截断的HER2 SRM / MRM测定
公开(公告)号：WO2012078934A2
公开(公告)日：2012-06-14
申请号：PCT/US2011/064045
申请日：2011-12-08
申请人： EXPRESSION PATHOLOGY, INC. , KRIZMAN, David B.
发明人： KRIZMAN, David B.
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , C07K14/71 , G01N30/72 , G01N30/7233 , G01N33/6848 , G01N33/74 , G01N2333/71
摘要： This disclosure provides ten (10) specific peptides, and particular peptide characteristics, from the cell membrane-bound Her2 protein and a diagnostic assay useful for determining the presence and amount of full length and truncated versions of the full-length Her2 protein in cells derived from formalin fixed paraffin embedded tissue.
摘要翻译：本公开提供了来自细胞膜结合的Her2蛋白的十（10）种特异性肽和特定的肽特征以及用于确定全长和截短形式的全长Her2蛋白在来自福尔马林固定石蜡包埋组织的细胞中。

2. 发明申请

WO2016183590A1 SRM/MRM ASSAY FOR THE MESOTHELIN (MSLN) PROTEIN 审中-公开
标题翻译：梅毒素（MSLN）蛋白质的SRM / MRM测定
公开(公告)号：WO2016183590A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032775
申请日：2016-05-16
申请人： EXPRESSION PATHOLOGY, INC.
发明人： KRIZMAN, David B. , HEMBROUGH, Todd , BLACKLER, Adele , THYPARAMBIL, Sheeno , AN, Eunkyung
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： G01N33/6848 , G01N33/574 , G01N2333/47 , G01N2333/976 , G01N2800/56 , G01N2800/7028
摘要： The current disclosure provides methods for quantifying the MSLN protein directly in biological samples, including samples that have been fixed in formalin by Selected Reaction Monitoring/Multiple Reaction Monitoring (SRM/MRM) mass spectrometry. Samples that can be assayed include tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded. Methods to prepare a protein sample from such a biological sample are provided and MSLN protein is quantitated by SRM/MRM mass spectrometry by quantitating in the protein sample at least one or more of the peptides described.
摘要翻译：本公开提供了在生物样品中直接定量MSLN蛋白的方法，包括通过选择反应监测/多反应监测（SRM / MRM）质谱法在福尔马林中固定的样品。可以测定的样品包括用含甲醛的试剂/固定剂（包括福尔马林固定的组织/细胞，福尔马林固定/石蜡包埋（FFPE）组织/细胞，FFPE组织块和来自那些块的细胞）和组织培养细胞已被福尔马林固定和石蜡包埋。提供从这样的生物样品制备蛋白质样品的方法，并通过SRM / MRM质谱法定量蛋白质样品中至少一种或多种所述的肽定量MSLN蛋白质。

3. 发明申请

WO2013173627A1 SRM/MRM ASSAY FOR SUBTYPING LUNG HISTOLOGY 审中-公开
标题翻译：用于分组肺组织学的SRM / MRM测定
公开(公告)号：WO2013173627A1
公开(公告)日：2013-11-21
申请号：PCT/US2013/041424
申请日：2013-05-16
申请人： EXPRESSION PATHOLOGY, INC.
发明人： KRIZMAN, David B. , LIAO, Wei-Li , THYPARAMBIL, Sheeno , HEMBROUGH, Todd
IPC分类号： C40B30/10
CPC分类号： G01N33/57492 , G01N33/57423 , G01N33/57484 , G01N33/6848 , G01N2033/57453 , G01N2333/47 , G01N2333/4704 , G01N2333/4742 , G01N2333/70596 , G01N2333/96472 , G01N2458/15 , G01N2560/00
摘要： The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the KRTS, KRT7, NapsinA, TTFI, TP63, and/or MUCI proteins that are particularly advantageous for quantifying the KRTS, KRT7, NapsinA, TTFI, TP63, and/or MUCI proteins directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological' samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
摘要翻译：目前的公开内容提供来自KRTS，KRT7，NapsinA，TTFI，TP63和/或MUCI蛋白质的特定肽和衍生的电离特征，其特别有利于定量KRTS，KRT7，NapsinA，TTFI，TP63，和/或MUCI蛋白直接在已经通过选择反应监测（SRM）质谱法的方法固定在福尔马林中的生物样品中，或者也可以称为多反应监测（MRM）质谱法。这种生物样品是化学保存和固定的，其中所述生物样品选自用含甲醛的试剂/固定剂（包括福尔马林固定的组织/细胞，福尔马林固定/石蜡包埋的（FFPE）组织/细胞，FFPE组织块和来自这些区块的细胞，以及已被福尔马林固定和石蜡包埋的组织培养细胞。

4. 发明申请

WO2012092302A1 CMET PROTEIN SRM/MRM ASSAY 审中-公开
标题翻译： CMET蛋白SRM / MRM测定
公开(公告)号：WO2012092302A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/067439
申请日：2011-12-27
申请人： EXPRESSION PATHOLOGY, INC. , KRIZMAN, David B. , HEMBROUGH, Todd , THYPARAMBIL, Sheeno
发明人： KRIZMAN, David B. , HEMBROUGH, Todd , THYPARAMBIL, Sheeno
IPC分类号： G01N30/72 , G01N33/483 , A61K38/18
CPC分类号： G01N33/6872 , G01N33/4833 , G01N33/68 , G01N33/6848 , G01N33/74 , G01N2030/8831 , G01N2333/71 , G01N2333/82 , G01N2560/00 , G01N2800/52 , G01N2800/56
摘要： Specific peptides are provided, and derived ionization characteristics of those peptides, from the Hepatocyte Growth Factor Receptor (cMET) protein. The peptides are advantageous for quantifying, by the method of Selected Reaction Monitoring (SRM) mass spectrometry, the cMET protein directly in biological samples that have been fixed in formalin, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed where the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including: formalin-fixed tissue/cells; formalinfixed/ paraffin embedded (FFPE) tissue/cells; FFPE tissue blocks and cells from those blocks; and tissue culture cells that have been formalin fixed and or paraffin embedded.
摘要翻译：提供特异性肽，并从肝细胞生长因子受体（cMET）蛋白提供这些肽的衍生电离特征。这些肽通过选择反应监测（SRM）质谱法的方法定量，直接在已经在福尔马林中固定的生物样品中的cMET蛋白质，或者也称为多反应监测（MRM）质谱法是有利的。这种生物样品被化学保存和固定，其中生物样品选自用含甲醛的试剂/固定剂处理的组织和细胞，包括：福尔马林固定的组织/细胞; 福尔马林固定/石蜡包埋（FFPE）组织/细胞; FFPE组织块和来自这些区块的细胞; 和已被福尔马林固定和石蜡包埋的组织培养细胞。

5. 发明申请

WO2011087862A1 INSULIN RECEPTOR SUBSTRATE 1 (IRS1) PROTEIN SRM/MRM ASSAY 审中-公开
标题翻译：胰岛素受体底物1（IRS1）蛋白SRM / MRM测定
公开(公告)号：WO2011087862A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/061909
申请日：2010-12-22
申请人： EXPRESSION PATHOLOGY, INC. , KRIZMAN, David B. , HEMBROUGH, Todd , THYPARAMBIL, Sheeno
发明人： KRIZMAN, David B. , HEMBROUGH, Todd , THYPARAMBIL, Sheeno
IPC分类号： G01N31/00 , A61K38/00
CPC分类号： G01N33/57496 , G01N33/574 , G01N33/6848 , G01N2333/4703 , G01N2333/62 , G01N2333/72 , G01N2440/14 , G01N2440/38 , G01N2560/00 , G01N2800/52
摘要： The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the Insulin Receptor Substrate 1 (IRS 1 ) protein that are particularly advantageous for quantifying the IRS 1 protein directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed wherein said biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded. A protein sample is prepared from said biological sample using the Liquid Tissue™ reagents and protocol and the IRS 1 protein is quantitated in the Liquid Tissue™ sample by the method of SRM/MRM mass spectrometry by quantitating in the protein sample at least one or more of the peptides described. These peptides can be quantitated if they reside in a modified or an unmodified form. An example of a modified form of an IRS 1 peptide is phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence.
摘要翻译：目前的公开内容提供了来自胰岛素受体底物1（IRS 1）蛋白质的特异性肽和衍生的离子化特征，其特别有利于通过该方法在福尔马林中固定的生物样品中直接定量IRS 1蛋白的选择反应监测（SRM）质谱，或什么也可以称为多反应监测（MRM）质谱。这样的生物样品被化学保存和固定，其中所述生物样品选自用含甲醛的试剂/固定剂（包括福尔马林固定的组织/细胞，福尔马林固定/石蜡包埋的（FFPE）组织/细胞，FFPE组织块）和来自这些区块的细胞和已被福尔马林固定和石蜡包埋的组织培养细胞。使用Liquid TissueTM试剂和方案从所述生物样品制备蛋白质样品，并且通过SRM / MRM质谱法的方法在液体组织样品中定量IRS 1蛋白质，通过在蛋白质样品中定量至少一种或多种描述的肽。如果它们以修饰或未修饰的形式存在，则可以定量这些肽。 IRS 1肽的修饰形式的实例是肽序列内的酪氨酸，苏氨酸，丝氨酸和/或其它氨基酸残基的磷酸化。

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