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1. 发明申请

WO2006062723A2 COMBINATION OF IMMUNO GENE THERAPY AND CHEMOTHERAPY FOR TREATMENT OF CANCER AND HYPERPROLIFERATIVE DISEASES 审中-公开
标题翻译：免疫基因治疗与化疗联合治疗肿瘤及高增殖性疾病
公开(公告)号：WO2006062723A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/041935
申请日：2005-11-17
申请人： EXPRESSION GENETICS, INCORPORATED , FEWELL, Jason, G. , MATAR, Majed , RICE, Jennifer , LEWIS, Danny, H. , ANWER, Khursheed
发明人： FEWELL, Jason, G. , MATAR, Majed , RICE, Jennifer , LEWIS, Danny, H. , ANWER, Khursheed
IPC分类号： A61K48/00 , A61K31/7076 , A61K31/7072 , A61K31/704 , A61K31/4745 , A61K31/337 , A61K9/14 , A61K31/28 , A61K33/24
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0085 , A61K31/17 , A61K31/28 , A61K31/337 , A61K31/4745 , A61K31/664 , A61K31/704 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K38/208 , A61K39/39558 , A61K47/10 , A61K47/6951 , A61K48/0041 , A61K48/005 , B82Y5/00 , C12N15/87 , A61K2300/00
摘要： Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
摘要翻译：包含用于治疗哺乳动物癌症或过度增殖性疾病的核酸，基因递送聚合物和至少一种辅助化学治疗药物的药物组合物及其用于治疗哺乳动物癌症或过度增殖性疾病的方法通过瘤内，腹膜内或全身注射。

2. 发明申请

WO2006052649A2 BIODEGRADABLE CROSS-LINKED CATIONIC MULTI-BLOCK COPOLYMERS FOR GENE DELIVERY AND METHODS OF MAKING THEREOF 审中-公开
标题翻译：用于基因输送的可生物降解的交联阳离子多嵌段共聚物及其制备方法
公开(公告)号：WO2006052649A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/039779
申请日：2005-11-03
申请人： EXPRESSION GENETICS, INCORPORATED , SLOBODKIN, Gregory , MATAR, Majed , FEWELL, Jason , ANWER, Khursheed
发明人： SLOBODKIN, Gregory , MATAR, Majed , FEWELL, Jason , ANWER, Khursheed
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： C08G73/0206 , A61K47/34 , A61K48/00
摘要： A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks is linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
摘要翻译：线性聚乙烯亚胺（LPEI）的可生物降解的交联阳离子多嵌段共聚物及其制备方法，其中所述LPEI嵌段通过亲水性接头与可生物降解的二硫键连接在一起。生物可降解的交联阳离子多嵌段共聚物还可以包含优选为受体配体，膜渗透剂，内体裂解剂，核定位序列，pH敏感性内体裂解肽，发色或荧光染料的侧挂官能部分。

3. 发明申请

WO2009021017A3 NUCLEIC ACID-LIPOPOLYMER COMPOSITIONS 审中-公开
公开(公告)号：WO2009021017A3
公开(公告)日：2009-02-12
申请号：PCT/US2008/072306
申请日：2008-08-06
申请人： EXPRESSION GENETICS, INC. , MATAR, Majed , FEWELL, Jason , LEWIS, Danny, H. , ANWER, Khursheed
发明人： MATAR, Majed , FEWELL, Jason , LEWIS, Danny, H. , ANWER, Khursheed
IPC分类号： A61K9/19 , A61K9/00 , A61K47/26 , A61K47/36 , A61K47/38
摘要： Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.

4. 发明申请

WO2010108108A2 POLYAMINE DERIVATIVES 审中-公开
标题翻译：聚氨酯衍生物
公开(公告)号：WO2010108108A2
公开(公告)日：2010-09-23
申请号：PCT/US2010/028000
申请日：2010-03-19
申请人： EGEN, INC. , SLOBODKIN, Gregory , CONGO, Richard , MATAR, Majed , FEWELL, Jason , ANWER, Khursheed , SPARKS, Brian, Jeffery
发明人： SLOBODKIN, Gregory , CONGO, Richard , MATAR, Majed , FEWELL, Jason , ANWER, Khursheed , SPARKS, Brian, Jeffery
IPC分类号： C07C233/38 , C12N15/88 , A61K9/127
CPC分类号： A61K47/48061 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/542 , A61K47/6911 , C07C233/38 , C07C235/10 , C07C235/60 , C07D475/04 , C07H15/10 , C07K7/23 , C07K7/64
摘要： Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
摘要翻译：公开了用于全身和局部递送生物活性分子的化合物，组合物和方法。

5. 发明申请

WO2009108891A2 MODIFIED POLOXAMERS FOR GENE EXPRESSION AND ASSOCIATED METHODS 审中-公开
标题翻译：修饰的用于基因表达的泊洛沙姆及相关方法
公开(公告)号：WO2009108891A2
公开(公告)日：2009-09-03
申请号：PCT/US2009/035543
申请日：2009-02-27
申请人： EGEN, INC. , SLOBODKIN, Gregory , MATAR, Majed , SPARKS, Brian, Jeffery , FEWELL, Jason , ANWER, Khursheed
发明人： SLOBODKIN, Gregory , MATAR, Majed , SPARKS, Brian, Jeffery , FEWELL, Jason , ANWER, Khursheed
IPC分类号： C08G65/329 , A61K47/34 , C12N15/87
CPC分类号： C08G65/329 , A61K9/0019 , A61K47/34
摘要： Nucleotide delivery polymers, compositions, and associated methods for the enhancement of gene delivery and expression in solid tissues are provided. In one aspect, for example, a nucleotide delivery polymer may include a poloxamer backbone having a metal chelator covalently coupled to at least one terminal end of the poloxamer backbone. In another aspect, the nucleotide expression polymer has a metal chelator coupled to at least two terminal ends of the poloxamer backbone.
摘要翻译：提供了用于增强基因递送和在固体组织中表达的核苷酸递送聚合物，组合物和相关方法。在一个方面，例如，核苷酸递送聚合物可以包括具有与泊洛沙姆骨架的至少一个末端共价偶联的金属螯合剂的泊洛沙姆骨架。另一方面，核苷酸表达聚合物具有与泊洛沙姆骨架的至少两个末端偶联的金属螯合剂。

6. 发明申请

WO2009114854A1 BIODEGRADABLE CROSS-LINKED BRANCHED POLY (ALKYLENE IMINES) 审中-公开
标题翻译：可生物降解的交联聚合物（亚苄基）
公开(公告)号：WO2009114854A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/037290
申请日：2009-03-16
申请人： EGEN, INC. , SLOBODKIN, Gregory , MATAR, Majed , SPARKS, Brian, Jeffrey , FEWELL, Jason , ANWER, Khursheed
发明人： SLOBODKIN, Gregory , MATAR, Majed , SPARKS, Brian, Jeffrey , FEWELL, Jason , ANWER, Khursheed
IPC分类号： C08G73/02 , A61K47/34
CPC分类号： A61K9/0019 , A61K9/0051 , A61K9/0085 , A61K47/34 , C08G73/0206 , C12N2770/24211
摘要： Disclosed is a cross-linked branched poly (alkylenimine) and compositions thereof and nucleotide molecules. Also disclosed are methods for preparing the cross-linked branched poly (alkylenimine).
摘要翻译：公开了交联支链聚（亚烷基亚胺）及其组合物和核苷酸分子。还公开了制备交联支链聚（亚烷基亚胺）的方法。

7. 发明申请

WO2005060934A1 A NOVEL CATIONIC LIPOPOLYMER AS A BIOCOMPATIBLE GENE DELIVERY AGENT 审中-公开
标题翻译：作为生物易感基因递送剂的新型阳离子脂质体
公开(公告)号：WO2005060934A1
公开(公告)日：2005-07-07
申请号：PCT/US2003/039317
申请日：2003-12-10
申请人： EXPRESSION GENETICS, INC. , MAHATO, Ram, I. , HAN, Sang-Oh , FURGESON, Darin, Y. , ANWER, Khursheed
发明人： MAHATO, Ram, I. , HAN, Sang-Oh , FURGESON, Darin, Y. , ANWER, Khursheed
IPC分类号： A61K9/127
CPC分类号： C08G73/0206 , A61K9/1272 , A61K47/645 , A61K48/0041
摘要： A biodegradable cationic lipopolymer comprising a polyethylenimine (PEI), a lipid, and a biocompatible hydrophilic polymer, wherein 1) the lipid and the biocompatible hydrophilic polymer are directly linked to the PEI backbone or 2) the lipid is linked to the PEI backbone through the biocompatible hydrophilic polymer. The cationic lipopolymers of the present invention can be used for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.
摘要翻译：包含聚乙烯亚胺（PEI），脂质和生物相容性亲水性聚合物的可生物降解的阳离子脂质聚合物，其中1）脂质和生物相容的亲水性聚合物直接连接到PEI主链或2）脂质通过生物相容性亲水性聚合物。本发明的阳离子脂质体聚合物可用于在局部或全身给药后将核酸或任何阴离子生物活性剂递送至各种器官和组织。

8. 发明申请

WO2010105277A1 COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE RNAS 审中-公开
标题翻译：用于递送生物活性RNAs的组合物和方法
公开(公告)号：WO2010105277A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027365
申请日：2010-03-15
申请人： EGEN, INC. , POLACH, Kevin , FEWELL, Jason , ANWER, Khursheed
发明人： POLACH, Kevin , FEWELL, Jason , ANWER, Khursheed
IPC分类号： C12N15/63 , A61K31/7052
CPC分类号： C12N15/113 , C12N15/63 , C12N15/85 , C12N15/87
摘要： The present invention provides novel compounds, compositions, and methods for the delivery of biologically active RNA molecules to cells. Specifically, the invention provides novel nucleic acid molecules, polypeptides, and RNA-protein complexes useful for the delivery of biologically active RNAs to cells and polynucleotides encoding the same. The invention also provides vectors for expressing said polynucleotides. In addition, the invention provides cells and compositions comprising the novel compounds and vectors, which can be used as transfection reagents. The invention further provides methods for producing said compounds, vectors, cells, and compositions. Additionally, vectors and methods for delivering biologically active RNA molecules to cells and/or tissues are provided. The novel compounds, vectors, cells, and compositions are useful, for example, in delivering biologically active RNA molecules to cells to modulate target gene expression in the diagnosis, prevention, amelioration, and/or treatment of diseases, discorders, or conditions in a subject or organism.
摘要翻译：本发明提供了用于将生物活性RNA分子递送至细胞的新型化合物，组合物和方法。具体地说，本发明提供了可用于将生物活性RNA递送到细胞的新型核酸分子，多肽和RNA-蛋白复合物，以及编码该核酸的多核苷酸。本发明还提供用于表达所述多核苷酸的载体。此外，本发明提供了可用作转染试剂的包含新化合物和载体的细胞和组合物。本发明还提供了生产所述化合物，载体，细胞和组合物的方法。另外，提供了将生物活性RNA分子递送到细胞和/或组织的载体和方法。新型化合物，载体，细胞和组合物可用于例如将生物活性RNA分子递送至细胞以调节靶基因表达在诊断，预防，改善和/或治疗疾病，不便者或疾病中的病症主体或生物体。

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