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1. 发明申请

WO2004091480A2 TIE-2 MODULATORS AND METHODS OF USE 审中-公开
公开(公告)号：WO2004091480A2
公开(公告)日：2004-10-28
申请号：PCT/US2004010626
申请日：2004-04-08
申请人： EXELIXIS INC , CHEN JEFF , DALRYMPLE LISA , EPSHTEYN SERGERY , FORSYTH TIMOTHY , HUYNH TAI , LEAHY JAMES , MANN GRACE , MANN LARRY W , RIDGWAY BRIAN , SANGALANG JOAN C , TAKEUCHI CRAIG
发明人： CHEN JEFF , DALRYMPLE LISA , EPSHTEYN SERGERY , FORSYTH TIMOTHY , HUYNH TAI , LEAHY JAMES , MANN GRACE , MANN LARRY W , RIDGWAY BRIAN , SANGALANG JOAN C , TAKEUCHI CRAIG
IPC分类号： A61K20060101 , C07D401/04 , A61K
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/506
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.

2. 发明申请

WO2004092196A3 TIE-2 MODULATORS AND METHODS OF USE 审中-公开
标题翻译： TIE-2调节器和使用方法
公开(公告)号：WO2004092196A3
公开(公告)日：2005-03-17
申请号：PCT/US2004010858
申请日：2004-04-08
申请人： EXELIXIS INC , IBRAHIM MOHAMED , LEAHY JAMES , SANGALANG JOAN C , SCHNEPP KEVIN , SHI XIAN , NUSS JOHN
发明人： IBRAHIM MOHAMED , LEAHY JAMES , SANGALANG JOAN C , SCHNEPP KEVIN , SHI XIAN , NUSS JOHN
IPC分类号： A61K31/395 , A61K31/505 , C07D215/16 , C07D239/95 , C07D401/04 , C07D401/06 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/14 , C07K20060101
CPC分类号： C07D239/94 , C07D401/04 , C07D405/04
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译：本发明提供了调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵袭的化合物。本发明化合物抑制，调节和/或调节激酶，特别是Tie-2。使用该化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。

3. 发明申请

WO2006023903A3 AUTOMATED PILL CRUSHER 审中-公开
标题翻译：自动药丸破碎机
公开(公告)号：WO2006023903A3
公开(公告)日：2006-12-07
申请号：PCT/US2005029924
申请日：2005-08-19
申请人： UNIV NEW YORK STATE RES FOUND , PERON JAMES , LEAHY JAMES , LEAHY JONATHAN , WASHOUSKY ROBYN
发明人： PERON JAMES , LEAHY JAMES , LEAHY JONATHAN , WASHOUSKY ROBYN
IPC分类号： A47J42/00
CPC分类号： A61J7/0007 , Y10S241/27
摘要： The present invention broadly comprises an automated pill crusher (10) comprising a container (23) operatively arranged to hold at least one pill, means (13) for producing a linear force in a first direction upon at least one pill in the container, and, means (41) for producing a spring force in a second direction upon at ltast one pill in the container. The pill crusher further comprises means (37) for pulverizing at least one pill in the container.
摘要翻译：本发明广泛地包括一个自动化药丸破碎机（10），包括一个可操作地设置成容纳至少一个药丸的容器（23），用于在容器中的至少一个药丸上沿第一方向产生线性力的装置（13），用于在容器中的一个药丸上产生沿第二方向的弹簧力的装置（41）。药丸破碎机还包括用于粉碎容器中的至少一个药丸的装置（37）。

4. 发明申请

WO2013055388A3 LED ILLUMINATION SOURCE WITH IMPROVED VISUAL CHARACTERISTICS 审中-公开
标题翻译：具有改进的视觉特性的LED照明源
公开(公告)号：WO2013055388A3
公开(公告)日：2013-08-22
申请号：PCT/US2012000467
申请日：2012-10-03
申请人： SOLAIS LIGHTING INC , LEAHY JAMES , HARTSWICK CHRIS , JOHNSON STEVEN
发明人： LEAHY JAMES , HARTSWICK CHRIS , JOHNSON STEVEN
IPC分类号： F21S13/00 , H01L33/60
CPC分类号： F21K9/233 , F21V7/04 , F21V11/06 , F21Y2115/10
摘要： An illumination source is disclosed that features, in one embodiment, an at least generally conical body extending outward along an axis of illumination, a socket supported with respect to the body having a pair of connector surfaces for receiving power and having an axis of insertion at least generally parallel to the axis of illumination, and one or more LED illumination elements supported with respect to the body such that at least a portion of their illumination axes are at least generally parallel to. the axis of illumination of the source. A power supply has electrical inputs operatively connected to the socket and electrical outputs operatively connected to 'the LED illumination elements, and a front face is positioned opposite the socket along the illumination axis. An optical light-directing element is provided separate from any optical process or packaging surfaces built onto the LEDs, is disposed between the LED illumination elements and the front face, and has medial and distal ends, with the distal end being spaced away from the front face.
摘要翻译：公开了一种照明源，其特征在于，在一个实施例中，沿着照明轴线向外延伸的至少大致锥形的主体，相对于主体支撑的插座具有用于接收功率并具有插入轴线的一对连接器表面至少大致平行于照明轴线的一个或多个LED照明元件，以及相对于主体支撑的一个或多个LED照明元件，使得它们的照明轴线的至少一部分至少大致平行于该主体。源的照明轴。电源具有可操作地连接到插座的电输入和可操作地连接到“LED照明元件”的电输出，并且前面沿着照明轴线与插座相对定位。光引导元件与内置于LED上的任何光学工艺或封装表面分开设置，设置在LED照明元件与前表面之间，并具有内侧和远端，远端与前端间隔开面对。

5. 发明申请

WO2011130648A3 MINIATURE CELLULAR STRUCTURE FOR RETROFIT LED LAMP SECONDARY OPTICS 审中-公开
标题翻译：用于改造LED灯二次光学的微型细胞结构
公开(公告)号：WO2011130648A3
公开(公告)日：2012-02-02
申请号：PCT/US2011032711
申请日：2011-04-15
申请人： SOLAIS LIGHTING INC , LEAHY JAMES , RODRIGUEZ EDWARD T
发明人： LEAHY JAMES , RODRIGUEZ EDWARD T
IPC分类号： F21V5/00 , F21V3/04 , F21V17/12 , F21Y101/02
CPC分类号： F21V5/04 , F21K9/233 , F21V5/007 , F21Y2115/10
摘要： In one general aspect, an LED-based illumination source is disclosed that includes a screw-in household base with an outer thread centered about an insertion axis. A directional-type illumination housing is mechanically connected to the base and has a round light delivery end centered around the insertion axis and has a diameter that is larger than the base. One or more LED illumination elements occupy a portion of the round light delivery end of the directional-type illumination housing and each has an optical axis at least generally parallel with the insertion axis and face away from the base. One or more at least generally coplanar lenses have at least generally parallel optical axes each being aligned with one of the elements and being positioned opposite from the base with respect to the elements. A planar light-spreading element is positioned at least generally perpendicular to the optical axes and spans a portion of the round light delivery end of the directional-type illumination housing different from the portion of the round light delivery end of the directional-type illumination housing occupied by the illumination elements. The planar light-spreading element is optically coupled to the illumination elements, with the planar light-spreading element including an at least generally planar light-transmitting surface facing toward the base and with the planar light-transmitting surface defining lens elements each having an optical axis that is generally perpendicular to the light- transmitting surface.
摘要翻译：在一个一般方面，公开了一种基于LED的照明源，其包括具有以插入轴线为中心的外螺纹的旋入式家用基座。定向型照明壳体机械地连接到基座并且具有以插入轴线为中心的圆形光输送端，并且具有大于基座的直径。一个或多个LED照明元件占据定向型照明外壳的圆光输送端的一部分，并且每个具有至少大致平行于插入轴线并且远离基座的光轴。一个或多个至少大致共面的透镜具有至少大致平行的光轴，每个光轴与元件中的一个对准，并且相对于元件与基座相对定位。平面光扩散元件至少大致垂直于光轴定位并且跨越定向型照明外壳的圆光输送端的一部分，其不同于定向型照明外壳的圆光输送端部分被照明元件所占据。平面光扩散元件光学耦合到照明元件，平面光扩散元件包括面向基底的至少大致平面的透光表面，并且平面光透射表面限定每个具有光学元件的透镜元件大致垂直于透光面。

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