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1. 发明申请

WO2007118854A1 BENZENESULFONAMIDE COMPOUNDS AND THE USE THEREOF 审中-公开
标题翻译：苯并咪唑化合物及其用途
公开(公告)号：WO2007118854A1
公开(公告)日：2007-10-25
申请号：PCT/EP2007/053622
申请日：2007-04-13
申请人： EURO-CELTIQUE S.A. , SHIONOGI & CO., LTD. , MATSUMURA, Akira , MIKAMIYAMA, Hidenori , TSUNO, Naoki , YAO, Jiangchao , SHAO, Bin
发明人： MATSUMURA, Akira , MIKAMIYAMA, Hidenori , TSUNO, Naoki , YAO, Jiangchao , SHAO, Bin
IPC分类号： C07D211/58 , A61K31/4468 , A61P29/02
CPC分类号： C07D211/58 , A61K31/4468 , A61K31/4545
摘要： The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 , Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前体药物或溶剂合物，其中R 1至R 3，，Z，p和q定义如说明书中所述。本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。本发明的化合物特别适用于治疗疼痛。

2. 发明申请

WO2008008398A3 OXIME COMPOUNDS AND THE USE THEREOF 审中-公开
公开(公告)号：WO2008008398A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/015827
申请日：2007-07-12
申请人： SHIONOGI & CO., LTD. , EURO-CELTIQUE S.A , MATSUMURA, Akira , MIKAMIYAMA, Hidenori , TSUNO, Naoki , KYLE, Donald, J. , SHAO, Bin , YAO, Jiangchao
发明人： MATSUMURA, Akira , MIKAMIYAMA, Hidenori , TSUNO, Naoki , KYLE, Donald, J. , SHAO, Bin , YAO, Jiangchao
IPC分类号： A61K31/40 , C07D207/14
摘要： The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO 2 , CR 3 R 4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R 3 and R 4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is O, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

3. 发明申请

WO2009027820A2 SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF 审中-公开
标题翻译：替代 - 喹喔啉型哌啶化合物及其用途
公开(公告)号：WO2009027820A2
公开(公告)日：2009-03-05
申请号：PCT/IB2008/002291
申请日：2008-08-29
申请人： PURDUE PHARMA L.P. , SHIONOGI & CO., LTD. , GOEHRING, Richard, R. , MATSUMURA, Akira , SHAO, Bin , TAODA, Yoshiyuki , TSUNO, Naoki , WHITEHEAD, John, William, Frank , YAO, Jiangchao
发明人： GOEHRING, Richard, R. , MATSUMURA, Akira , SHAO, Bin , TAODA, Yoshiyuki , TSUNO, Naoki , WHITEHEAD, John, William, Frank , YAO, Jiangchao
IPC分类号： C07D401/04 , C07D401/14 , C07D451/04 , C07D451/14 , C07D471/14 , A61K31/498 , A61K31/4985 , A61P25/04
CPC分类号： C07D451/14 , A61K31/498 , C07D401/04 , C07D401/14 , C07D451/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D498/08 , C07D519/00
摘要： The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.
摘要翻译：本发明涉及取代的喹喔啉型哌啶化合物，包含有效量的取代的喹喔啉型哌啶化合物的组合物和治疗或预防诸如疼痛的病症的方法，包括向有需要的动物施用有效量的取代的喹喔啉型哌啶化合物。

4. 发明申请

WO2007118853A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS 审中-公开
标题翻译：苯并咪唑化合物及其作为钙通道阻断剂的使用
公开(公告)号：WO2007118853A1
公开(公告)日：2007-10-25
申请号：PCT/EP2007/053620
申请日：2007-04-13
申请人： EURO-CELTIQUE S.A. , YAO, Jiangchao , SHAO, Bin , KYLE, Donald, J. , SHA, Deyou , CHEN, Zhengming , ISLAM, Khondaker , ZHOU, Xiaoming
发明人： YAO, Jiangchao , SHAO, Bin , KYLE, Donald, J. , SHA, Deyou , CHEN, Zhengming , ISLAM, Khondaker , ZHOU, Xiaoming
IPC分类号： C07D211/58 , A61K31/445 , A61P25/00
CPC分类号： C07D211/58
摘要： The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 , Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式（I）的哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R 1，R 3，Z和q是如本说明书中所述。本发明还涉及使用式（I）化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道的病症。本发明的化合物特别适用于治疗疼痛。

5. 发明申请

WO2007110449A1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE 审中-公开
标题翻译：苯并呋喃类化合物及其用途
公开(公告)号：WO2007110449A1
公开(公告)日：2007-10-04
申请号：PCT/EP2007/053053
申请日：2007-03-29
申请人： EURO-CELTIQUE S.A. , CHEN, Zhengming , ISLAM, Khondaker , SHAO, Bin , YAO, Jiangchao , ZHOU, Xiaoming , KYLE, Donald J.
发明人： CHEN, Zhengming , ISLAM, Khondaker , SHAO, Bin , YAO, Jiangchao , ZHOU, Xiaoming , KYLE, Donald J.
IPC分类号： C07D207/14 , C07D211/42 , C07D401/12 , A61K31/445 , A61P25/00
CPC分类号： C07D211/42 , C07D207/14 , C07D401/12
摘要： The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 and Z are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式I的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂合物，其中R 1〜Z 3和Z为如本说明书中所述。本发明还涉及使用式I的化合物来治疗，预防或改善对阻断钙通道，特别是N型钙通道有响应的病症。本发明的化合物特别适用于治疗疼痛。

6. 发明申请

WO2010014257A2 TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF 审中-公开
标题翻译：四氢吡啶并二氢吡喃化合物及其用途
公开(公告)号：WO2010014257A2
公开(公告)日：2010-02-04
申请号：PCT/US2009/004437
申请日：2009-08-03
申请人： PURDUE PHARMA L.P. , SHIONOGI & CO., LTD. , MIKAMIYAMA, Hidenori , NI, Chiyou , SHAO, Bin , TAFESSE, Laykea
发明人： MIKAMIYAMA, Hidenori , NI, Chiyou , SHAO, Bin , TAFESSE, Laykea
CPC分类号： C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D451/02
摘要： The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R 1 , R 2 , m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译：本发明涉及式（I）的四氢吡啶基和二氢吡咯基化合物及其药学上可接受的盐，前药或溶剂合物，其中X，Y，Z，R 1，R 2，m和n如说明书所述定义。本发明还涉及式（I）化合物用于治疗对阻断钙通道，特别是N型钙通道有响应的病症。本发明的化合物特别适用于治疗疼痛。

7. 发明申请

WO2005075459A1 SYNTHESIS OF CYANOIMINO-BENZOIMIDAZOLES 审中-公开
标题翻译： CYANOIMINO-BENZOIMIDAZOLES的合成
公开(公告)号：WO2005075459A1
公开(公告)日：2005-08-18
申请号：PCT/US2005/002824
申请日：2005-02-02
申请人： EURO-CELTIQUE S.A. , GOEHRING, R., Richard , WHITEHEAD, John , SHAO, Bin
发明人： GOEHRING, R., Richard , WHITEHEAD, John , SHAO, Bin
IPC分类号： C07D401/04
CPC分类号： C07D471/10 , C07D401/04
摘要： Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
摘要翻译：在某些实施方案中公开了合成式（V）化合物及其盐的方法。

8. 发明申请

WO2005056524A2 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 审中-公开
标题翻译：治疗药物有用的治疗药物
公开(公告)号：WO2005056524A2
公开(公告)日：2005-06-23
申请号：PCT/US2004/041378
申请日：2004-12-09
申请人： EURO-CELTIQUE S.A. , SHAO, Bin
发明人： SHAO, Bin
IPC分类号： C07D
CPC分类号： C07D471/04 , C07D491/04
摘要： The Invention provides a compound of formula (I), (where A, X, Y, Z, R 3 , R 4 , R 5 , R 6 , m and n are disclosed herein) or a pharmaceutically acceptable salt thereof (the compound or pharmaceutically acceptable salt thereof being a "Piperazine Compound"); pharmaceutical compositions comprising an effective amount of a Piperazine Compound; and methods for treating pain, as well as other conditions, comprising administering to an animal in need thereof an effective amount of a Piperazine Compound.
摘要翻译：本发明提供式（I）化合物（其中A，X，Y，Z，R 3，R 4，R 5，R 6，m和n在本文中公开）或其药学上可接受的盐（该化合物或其药学上可接受的盐作为“哌嗪化合物”）; 包含有效量的哌嗪化合物的药物组合物; 以及用于治疗疼痛以及其它病症的方法，包括向有需要的动物施用有效量的哌嗪化合物。

9. 发明申请

WO2003022276A1 ARYL SUBSTITUTED PYRIDINECARBOXAMIDES AND THEIR USE AS SODIUM CHANNEL BLOCKERS 审中-公开
标题翻译： ARYL取代的吡啶甲酰胺和它们作为钠通道阻断剂使用
公开(公告)号：WO2003022276A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/028298
申请日：2002-09-06
申请人： EURO-CELTIQUE S.A. , SHAO, Bin , GOEHRING, R., Richard , VICTORY, Samuel, F. , SUN, Qun
发明人： SHAO, Bin , GOEHRING, R., Richard , VICTORY, Samuel, F. , SUN, Qun
IPC分类号： A61K31/4418
CPC分类号： C07D213/81 , C07D213/82 , Y10T436/145555
摘要： This invention relates aryl substituted pyridines of Formula (I),or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 -R 4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译：本发明涉及式（I）的芳基取代的吡啶，或其药学上可接受的盐，前药或溶剂合物，其中Ar和R 1 -R 4置于说明书中。本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途作为抗惊厥剂，作为抗惊厥剂，作为抗躁狂抑制剂，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

10. 发明申请

WO2003022285A1 HETEROCYCLIC SUBSTITUTED 2- (4-PHENOXY) PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEURONAL DAMAGE AND NEURODEGENERATIVE CONDITIONS 审中-公开
标题翻译：杂环取代的2-（4-苯氧基）吡啶衍生物及相关化合物作为治疗神经损伤和神经营养因子的钠通道阻断剂
公开(公告)号：WO2003022285A1
公开(公告)日：2003-03-20
申请号：PCT/US2002/028299
申请日：2002-09-06
申请人： EURO-CELTIQUE S.A. , SHAO, Bin , GOEHRING, R., Richard
发明人： SHAO, Bin , GOEHRING, R., Richard
IPC分类号： A61K31/5377
CPC分类号： C07D213/64 , C07D213/81
摘要： This invention relates to aryl substituted pyridines of Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: Ar is selected from the group consisting of Ar 1 , Ar 2 , Ar 3 and Ar 4 , wherein Ar 1 is R 1 is selected from the group consisting of an optionally substituted alkyl, amino, alkylthiol, C(O)R 10 , SO 2 R 10 , and OC(O)NH 2 ; R 2 is Y m -(CH 2 ) n -Z, wherein Y is O, S or NR 11 , wherein R 11 is hydrogen or alkyl, Z is a saturated heterocyclic ring optionally substituted at one or more carbon atoms, m is 0 or 1, and n is 0-6; or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R 1 -R 4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyothrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, including diabetic neuropathy, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, and as antiarrhythmics.
摘要翻译：本发明涉及式（I）的芳基取代的吡啶或其药学上可接受的盐，前药或溶剂合物，其中：Ar选自Ar1，Ar2，Ar3和Ar4，其中Ar1是R1选自由任选取代的烷基，氨基，烷基硫醇，C（O）R 10，SO 2 R 10和OC（O）NH 2组成; R2是Ym-（CH2）nZ，其中Y是O，S或NR11，其中R11是氢或烷基，Z是在一个或多个碳原子上任意取代的饱和杂环，m是0或1，n是0 -6; 或其药学上可接受的盐，前药或溶剂合物，其中Ar和R 1 -R 4置于说明书中。本发明还涉及式I化合物用于治疗全身和局部缺血后的神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善急性或慢性疼痛，包括糖尿病性神经病，作为抗惊厥药，抗惊厥药，抗抑郁药，作为局部麻醉剂，以及作为抗心律失常药。

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