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1. 发明申请

WO2006086727A2 TREATING DIABETES WITH GLUCAGON-LIKE PEPTIDE-1 SECRETAGOGUES 审中-公开
标题翻译：用胰高血糖素肽-1糖蛋白治疗糖尿病
公开(公告)号：WO2006086727A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004922
申请日：2006-02-09
申请人： ENTELOS, INC. , POLIDORI, David , SILER, Scott
发明人： POLIDORI, David , SILER, Scott
IPC分类号： A61K31/155 , A61K31/444 , A61P3/10
CPC分类号： A61K31/155 , A61K31/201 , A61K31/444 , A61K38/04 , A61K38/30 , A61K45/06 , A61K2300/00
摘要： In general this invention can be viewed as encompassing novel methods of treating diabetes and insulin resistance. The inventors have made the discovery that increasing secretion of endogenous glucagon-like peptide-1 (GLP-1) in combination with inhibiting the activity of dipeptidyl peptidase I (DPP-IV) can have a significant impact on hyperglycemia and insulin secretion in subjects suffering from diabetes and/or insulin resistance. Further the invention encompasses methods of identifying subjects having elevated secretion of GLP-1, methods of assessing sensitivity to a GLP-1 secretagogue, and methods of treating diabetes in these subjects by administering a GLP-1 secretagogue to alleviate at least one symptom of diabetes.
摘要翻译：一般而言，本发明可被视为包括治疗糖尿病和胰岛素抵抗的新方法。本发明人已经发现增加内源性胰高血糖素样肽-1（GLP-1）的分泌与抑制二肽基肽酶I（DPP-IV）活性的组合可对受试者中的高血糖症和胰岛素分泌具有显着影响来自糖尿病和/或胰岛素抵抗。此外，本发明包括鉴定具有升高的GLP-1分泌的受试者的方法，评估对GLP-1促分泌素的敏感性的方法，以及通过施用GLP-1促分泌素以缓解糖尿病的至少一种症状来治疗这些受试者中的糖尿病的方法

2. 发明申请

WO2007076538A2 HORMONE AND DRUG CONCENTRATIONS IN THE PORTAL VEIN AND HEPATIC SINUSOIDS 审中-公开
标题翻译：门静脉和静脉麻醉药物中的HORMONE和DRUG浓度
公开(公告)号：WO2007076538A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/062724
申请日：2006-12-29
申请人： ENTELOS, INC. , HALL, Kevin , POLIDORI, David , SILER, Scott
发明人： HALL, Kevin , POLIDORI, David , SILER, Scott
IPC分类号： G06F19/00
CPC分类号： G01N33/74 , G06F19/3468 , G16H50/50
摘要： The invention relates to novel methods of informing a medical decision by determining a hormone or drug concentration in a portal vein or hepatic sinusoid of a mammal. The invention also relates to methods of determining hormone or drug concentration in the portal vein or hepatic sinusoids. Further the invention relates to methods of utilizing these concentrations to calculate infusion rates for hormone or drugs in order to achieve a desired portal vein or hepatic sinusoid concentration of such a hormone or drug.
摘要翻译：本发明涉及通过确定哺乳动物的门静脉或肝窦状体中的激素或药物浓度来通知医学决定的新方法。本发明还涉及确定门静脉或肝窦腔内激素或药物浓度的方法。此外，本发明涉及利用这些浓度来计算激素或药物的输注速率以达到期望的门静脉或这种激素或药物的肝窦状液浓度的方法。

3. 发明申请

WO2006099544A2 APPARATUS AND METHOD FOR COMPUTER MODELING TYPE 1 DIABETES 审中-公开
标题翻译：计算机建模1型糖尿病的装置和方法
公开(公告)号：WO2006099544A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009546
申请日：2006-03-15
申请人： ENTELOS, INC. , GADKAR, Kapil , KREUWEL, Huub , PATERSON, Thomas , POLIDORI, David , RAMANUJAN, Saroja , SHODA, Lisl, K. , WHITING, Chan, D. , YOUNG, Daniel, L. , ZHANG, Yanan
发明人： GADKAR, Kapil , KREUWEL, Huub , PATERSON, Thomas , POLIDORI, David , RAMANUJAN, Saroja , SHODA, Lisl, K. , WHITING, Chan, D. , YOUNG, Daniel, L. , ZHANG, Yanan
IPC分类号： G01N33/53
CPC分类号： G06F19/12 , G01N2800/042 , G06F19/00 , G06F19/18 , G06Q50/24 , G16H50/50
摘要： The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.
摘要翻译：本发明包括用于开发哺乳动物中1型糖尿病计算机模型的新方法。特别地，模型可以包括与胰腺淋巴结和一个或多个胰岛相关联的生物过程的表示。或者，模型可以包括与选自自身反应性T细胞产生，自身反应性T细胞引发，胰岛炎和高血糖的至少两种病症相关的生物学过程的表示。本发明还提供了开发1型糖尿病非胰岛素替代治疗计算机模型的方法。本发明还包括1型糖尿病的计算机模型，模拟1型糖尿病的方法和用于模拟1型糖尿病的计算机系统及其用途。

4. 发明申请

WO2008051660A2 APPARATUS AND METHOD FOR COMPUTER MODELING CHEMICAL SENSITIVITY OF SKIN 审中-公开
标题翻译：用于计算机模拟皮肤化学敏感性的装置和方法
公开(公告)号：WO2008051660A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/078325
申请日：2007-09-12
申请人： ENTELOS, INC. , BAJARIA, Seema , FRIEDRICH, Christina, M. , KUDRYCKI, Katherine , MACKAY, Cameron , PATERSON, Thomas S. , POLIDORI, David , RAMANUJAN, Saroja , SHAVER, Gregory M.
发明人： BAJARIA, Seema , FRIEDRICH, Christina, M. , KUDRYCKI, Katherine , MACKAY, Cameron , PATERSON, Thomas S. , POLIDORI, David , RAMANUJAN, Saroja , SHAVER, Gregory M.
IPC分类号： G06F19/00
CPC分类号： G01N33/5082 , G06F19/12 , G16H50/50
摘要： The invention encompasses novel computer models of chemical sensitivity of skin and systems for predicting chemical sensitivity of skin. In particular, the computer model of chemical sensitivity of skin comprises a) an epidermal compartment comprising a mathematical representation of exposure of an epidermal tissue to a chemical and a mathematical representation of a first population of antigen presenting cells interacting with the chemical; and b) a lymph node compartment comprising a mathematical representation of a second population of antigen presenting cells, and a mathematical representation of a population of T cells, wherein at least a subpopulation of the population of T cells interacts with the second population of antigen presenting cells.
摘要翻译：本发明包括用于预测皮肤化学敏感性的皮肤化学敏感性和系统的新型计算机模型。具体而言，皮肤的化学敏感性的计算机模型包括a）表皮区室，其包含表皮组织与化学物质接触的数学表示以及与该化学物质相互作用的第一群抗原呈递细胞的数学表示; 和b）包含抗原呈递细胞的第二群体的数学表示的T淋巴结区间和T细胞群体的数学表示，其中T细胞群体的至少一个亚群与第二抗原呈递群体相互作用细胞

5. 发明申请

WO2005052120A2 APPARATUS AND METHODS FOR ASSESSING METABOLIC SUBSTRATE UTILIZATION 审中-公开
标题翻译：用于评估代用基板利用的装置和方法
公开(公告)号：WO2005052120A2
公开(公告)日：2005-06-09
申请号：PCT/US2004/038882
申请日：2004-11-19
申请人： ENTELOS, INC. , POLIDORI, David
发明人： POLIDORI, David
IPC分类号： C12N
CPC分类号： G16H10/20 , G06F19/00
摘要： Apparatus and methods for assessing metabolic substrate utilization are described. In one embodiment, a processor-readable medium includes code to receive data indicative of a plasma glucose concentration, a plasma free fatty acid concentration, and a respiratory quotient of a subject. The processor-readable medium also includes code to calculate, based on the data, respective values of a set of metabolic parameters. The set of metabolic parameters includes a first metabolic parameter and a second metabolic parameter. The value of the first metabolic parameter is indicative of whether the subject has a predisposition towards oxidation of a first type of metabolic substrate or a second type of metabolic substrate, and the value of the second metabolic parameter is indicative of the subject’s responsiveness to a change in availability of the first typo of metabolic substrate or the second type of metabolic substrate.
摘要翻译：描述了用于评估代谢底物利用的装置和方法。在一个实施例中，处理器可读介质包括用于接收指示受试者的血浆葡萄糖浓度，血浆游离脂肪酸浓度和呼吸商的数据的代码。处理器可读介质还包括用于基于数据计算一组代谢参数的相应值的代码。该组代谢参数包括第一代谢参数和第二代谢参数。第一代谢参数的值表示受试者是否具有倾向于第一类型代谢底物或第二类型代谢底物的氧化，并且第二代谢参数的值表示受试者对变化的反应性在第一种类型的代谢底物或第二种代谢底物的可用性。

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