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1. 发明申请

WO2005030804A3 A METHOD OF MODULATING CELL SURVIVAL, DIFFERENTIATION AND/OR SYNAPTIC PLASTICITY 审中-公开
标题翻译：调节细胞存活率，差异和/或症状塑性的方法
公开(公告)号：WO2005030804A3
公开(公告)日：2005-08-11
申请号：PCT/DK2004000659
申请日：2004-09-29
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR , SOROKA VLADYSLAV
发明人： BOCK ELISABETH , BEREZIN VLADIMIR , SOROKA VLADYSLAV
IPC分类号： A61K38/00 , C07K5/093 , C07K14/705 , C07K5/00 , A61K38/04 , A61K38/17 , C07K7/00 , C07K14/00 , G01N33/68
CPC分类号： A61K38/00 , C07K5/0819 , C07K14/70503 , C07K2299/00
摘要： The present invention relates to a method of modulating differentiation, adhesion and/or survival of the neural cell adhesion molecule (NCAM) presenting cells by providing compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM. The invention provides candidate compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM by using methods for screening and testing described in the application. The invention further relates to pharmaceutical compositions comprising compounds capable of modulating the interaction between the Ig1, Ig2 and/or Ig3 modules of NCAM and to use of the pharmaceutical compositions and compounds for the modulation of differentiation, adhesion and/or survival of NCAM presenting cells.
摘要翻译：本发明涉及通过提供能够调节NCAM的Ig1，Ig2和/或Ig3模块之间的相互作用的化合物来调节呈递细胞的神经细胞粘附分子（NCAM）的分化，粘附和/或存活的方法。本发明提供能够通过应用中描述的筛选和测试方法调节NCAM的Ig1，Ig2和/或Ig3模块之间相互作用的候选化合物。本发明还涉及包含能够调节NCAM的Ig1，Ig2和/或Ig3模块之间的相互作用的化合物的药物组合物，以及用于调节NCAM呈递细胞的分化，粘附和/或存活的药物组合物和化合物。

2. 发明申请

WO2007110079A3 TARGETED DELIVERY OF FGFR LIGANDS INTO THE BRAIN 审中-公开
标题翻译：将FGFR配体定向送入脑
公开(公告)号：WO2007110079A3
公开(公告)日：2008-03-20
申请号：PCT/DK2007000152
申请日：2007-03-28
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR , KISELYOV VLADISLAV V
发明人： BOCK ELISABETH , BEREZIN VLADIMIR , KISELYOV VLADISLAV V
IPC分类号： C07K14/825
CPC分类号： C07K14/825
摘要： The present invention relates to a compound consisting of metallothionein (MT) and a peptide sequence, wherein said peptide sequence and metallotionein are bound to each other via a non-covalent bond. A peptide sequence comprised by the compound is a biologically active short peptide sequence which comprises at most 25 amino acid residues. The peptide sequence is capable of binding to and modulating activity of a functional cell receptor, in particular fibroblast growth factor receptor (FGFR). The invention relates to pharmaceutical compositions comprising such compound or such peptide sequence and use of the compound, peptide sequence and pharmaceutical composition for treatment of conditions and diseases where modulating activity of FGFR is beneficial for treatment. In preferred embodiments the use is for treatment of conditions and diseases of the brain including conditions requiring stimulating brain cell proliferation, differentiation and/or survival, stimulating neural plasticity associated with learning and memory, modulating adhesion and motility of cells, in particular cancer cells. The compound of the invention is capable of penetrating the blood brain barrier (BBB).
摘要翻译：本发明涉及由金属硫蛋白（MT）和肽序列组成的化合物，其中所述肽序列和金属蛋白酶通过非共价键彼此结合。由化合物组成的肽序列是包含至多25个氨基酸残基的生物活性短肽序列。肽序列能够结合并调节功能性细胞受体，特别是成纤维细胞生长因子受体（FGFR）的活性。本发明涉及包含这种化合物或这种肽序列的药物组合物，以及该化合物，肽序列和药物组合物用于治疗调节FGFR活性对治疗有利的病症和疾病的用途。在优选的实施方案中，用于治疗脑的病症和疾病包括需要刺激脑细胞增殖，分化和/或存活的条件，刺激与学习和记忆相关的神经可塑性，调节细胞特别是癌细胞的粘附和运动性。本发明的化合物能够穿透血脑屏障（BBB）。

3. 发明申请

WO2005014623A2 COMPOUNDS COMPRISING LPA 审中-公开
标题翻译：包含LPA的化合物
公开(公告)号：WO2005014623A2
公开(公告)日：2005-02-17
申请号：PCT/DK2004000527
申请日：2004-08-06
申请人： ENKAM PHARMACEUTICALS AS , ALBRECHTSEN MORTEN , BOCK ELISABETH , BEREZIN VLADIMIR , HOLM ARNE
发明人： ALBRECHTSEN MORTEN , BOCK ELISABETH , BEREZIN VLADIMIR , HOLM ARNE
IPC分类号： C07K14/705 , C07K14/71 , C07K14/78 , C07K19/00 , C07K7/00
CPC分类号： C07K14/71 , C07K14/70503 , C07K14/78 , C07K19/00
摘要： The present invention relates to new peptide compounds capable of binding to fibroblast growth factor receptor (FGFR), said compounds comprising two individual amino acid sequences, wherein at least one of the two amino acid sequences is capable of binding to FGFR. The invention discloses the amino acid sequences of the compounds and features pharmaceutical compositions comprising thereof. Invention also relates to uses of the compounds and pharmaceutical compositions comprising thereof for the treatment or prevention of different pathological conditions, wherein FGFR plays a role in pathology and/or recovery from the disease. New peptide compounds of the invention are obtainable by the ligand presenting assembly (LPA) method.
摘要翻译：本发明涉及能够结合成纤维细胞生长因子受体（FGFR）的新肽化合物，所述化合物包含两个单独的氨基酸序列，其中两个氨基酸序列中的至少一个能够结合FGFR。本发明公开了所述化合物的氨基酸序列并且特征在于包含其的药物组合物。本发明还涉及所述化合物和包含其的药物组合物用于治疗或预防不同病理学病症的用途，其中FGFR在疾病的病理学和/或恢复中起作用。本发明的新肽化合物可通过配体呈递组装（LPA）方法获得。

4. 发明申请

WO03020749A2 NCAM BINDING COMPOUNDS 审中-公开
标题翻译： NCAM结合化合物
公开(公告)号：WO03020749A2
公开(公告)日：2003-03-13
申请号：PCT/DK0200574
申请日：2002-09-04
申请人： ENKAM PHARMACEUTICALS AS , ROENN LARS CHRISTIAN BIILMANN , OLSEN MARIANNE , BEREZIN VLADIMIR , BOCK ELISABETH , POULSEN FLEMMING MARTIN , HOLM ARNE VALDEMAR , SOROKA VLADISLAV , OESTERGAARD SOEREN
发明人： ROENN LARS CHRISTIAN BIILMANN , OLSEN MARIANNE , BEREZIN VLADIMIR , BOCK ELISABETH , POULSEN FLEMMING MARTIN , HOLM ARNE VALDEMAR , SOROKA VLADISLAV , OESTERGAARD SOEREN
IPC分类号： C12N5/02 , A61K38/00 , A61L27/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P13/12 , A61P15/00 , A61P17/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07K4/00 , C07K7/00 , C07K7/06 , C07K14/00
CPC分类号： C07K7/06
摘要： The present invention concerns an NCAM (neural cell adhesion molecule) binding compound capable of stimulating NCAM signalling and/or interfering with cell adhesion. The compound is a peptide having a sequence of the formula L1-A-L2-B-L3-C-L4, wherein A,B or Cis any amino acid residue, with the proviso that at least B or C is an acidic amino acid residue, and at least A, B, or C is a hydrophobic amino acid residue or Y, or A, B or C is any amino acid residue, with the proviso that at least B or C is an basic amino acid residue, and at least A, B, or C is a hydrophobic amino acid residue or Y, and L1, L2, L3 and L4 is individually selected from a chemical bond or an amino acid sequence having n amino acid residues, wherein n is an integer of from 0 to 5. According to the invention the compound may be used for the manufacture of a medicament for the treatment of normal, degenerated or damaged NCAM presenting cells, such as in various diseases or conditions of the central and peripheral nervous system.
摘要翻译：本发明涉及能够刺激NCAM信号传导和/或干扰细胞粘附的NCAM（神经细胞粘附分子）结合化合物。该化合物是具有式L1-A-L2-B-L3-C-L4的序列的肽，其中A，B或任何氨基酸残基，条件是至少B或C是酸性氨基酸并且至少A，B或C是疏水性氨基酸残基或Y或A，B或C是任何氨基酸残基，条件是至少B或C是碱性氨基酸残基，并且在至少A，B或C是疏水性氨基酸残基或Y，L1，L2，L3和L4分别选自具有n个氨基酸残基的化学键或氨基酸序列，其中n为0的整数根据本发明，该化合物可用于制备用于治疗正常，退化或损伤的NCAM呈递细胞的药物，例如在中枢和外周神经系统的各种疾病或病症中。

5. 发明申请

WO2009068042A3 NOVEL PEPTIDES DERIVED FROM NCAM (FGLS) 审中-公开
标题翻译： NCAM衍生的新肽（FGLS）
公开(公告)号：WO2009068042A3
公开(公告)日：2009-07-30
申请号：PCT/DK2008050282
申请日：2008-11-28
申请人： ENKAM PHARMACEUTICALS AS , COPENHAGEN UNIVERSITY , BEREZIN VLADIMIR , BOCK ELISABETH , EBDRUP SOEREN , KLEMENTIEV BORIS
发明人： BEREZIN VLADIMIR , BOCK ELISABETH , EBDRUP SOEREN , KLEMENTIEV BORIS
IPC分类号： C07K14/705 , A61P25/00 , C07K19/00
CPC分类号： C07K14/70503 , A61K38/00
摘要： The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,Il module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to the use of said compounds for production of a medicament for treatment of conditions and diseases, wherein NCAM and/or FGFR play a prominent role.
摘要翻译：本发明涉及新型化合物，其包含至少13个来源于3型纤连蛋白的连续氨基酸残基，神经细胞粘附分子（NCAM）的II模块或其变体或片段，其能够与FGFR相互作用，从而化合物能够诱导分化，调节增殖，刺激再生，细胞的神经元可塑性和/或存活。此外，本发明涉及所述化合物在制备用于治疗病症和疾病的药物中的用途，其中NCAM和/或FGFR发挥显着作用。

6. 发明申请

WO2007045247A3 FIBROBLAST GROWTH FACTOR RECEPTOR-DERIVED PEPTIDES 审中-公开
标题翻译：成纤维细胞生长因子受体衍生肽
公开(公告)号：WO2007045247A3
公开(公告)日：2007-06-14
申请号：PCT/DK2006000585
申请日：2006-10-17
申请人： ENKAM PHARMACEUTICALS AS , BEREZIN VLADIMIR , KISELYOV VLADISLAV V , BOCK ELISABETH
发明人： BEREZIN VLADIMIR , KISELYOV VLADISLAV V , BOCK ELISABETH
IPC分类号： C07K14/71 , C07K14/47
CPC分类号： C07K14/71 , A61K38/00
摘要： The present invention relates to novel peptides capable of binding to a receptor of the fibroblast growth factor receptor family (FGFRs) and modulating activity of said receptor. The peptides of the invention are fragments of FGFRs, wherein said fragments comprise amino acid residues involved in the reciprocal interaction of the Immunoglobulin-like modules 2 (Ig2) and Immunoglobulin-like module 1 (Ig1) of FGFR. The invention discloses amino acid sequences derived from the reciprocal Ig 1 -to-lg2 binding site of FGFR and relates to use of the peptides comprising said amino acid sequences for the treatment of different pathological conditions, wherein FGFRs play a prominent role. Accordingly, pharmaceutical compositions comprising the compounds of the invention are also concerned.
摘要翻译：本发明涉及能够结合成纤维细胞生长因子受体家族（FGFR）受体并调节所述受体活性的新型肽。本发明的肽是FGFR的片段，其中所述片段包含涉及FGFR的免疫球蛋白样组件2（Ig2）和免疫球蛋白样组件1（Ig1）的相互作用的氨基酸残基。本发明公开了衍生自FGFR的互补Ig 1至Ig 1结合位点的氨基酸序列，并且涉及包含所述氨基酸序列的肽用于治疗不同病理学病症的用途，其中FGFR发挥显着作用。因此，包含本发明化合物的药物组合物也受到关注。

7. 发明申请

WO0247719A2 SURVICAL PROMOTING NCAM BINDING AND NCAM LIGAND BIDING COMPOUNDS 审中-公开
标题翻译：支持NCAM绑定和NCAM配对绑定化合物
公开(公告)号：WO0247719A2
公开(公告)日：2002-06-20
申请号：PCT/DK0100822
申请日：2001-12-12
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR , KOEHLER LENE BORDING
发明人： BOCK ELISABETH , BEREZIN VLADIMIR , KOEHLER LENE BORDING
IPC分类号： A61K38/00 , A61K39/395 , A61P3/10 , A61P9/10 , A61P13/12 , A61P15/00 , A61P21/02 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/28 , C07K14/47 , C07K14/705
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/505
摘要： The present invention relates to compounds capable of stimulating survival of cells presenting the neural cell adhesion molecule (NCAM) or an NCAM-ligand (counter-receptor), such as neurons. Further, the present invention relates to the use of pharmaceutical compositions and medicaments in the treatment or protection of cells presenting NCAM or NCAM ligands. More particularly the invention describes the use of a compound comprising a peptide comprising at least 5 contiguous amino acid residues from an amino acid sequence of NCAM, a fragment thereof, or a variant thereof or a mimic thereof, for the preparation of a medicament for preventing cell death of cells presenting said NCAM or an NCAM ligand.
摘要翻译：本发明涉及能够刺激呈现神经细胞粘附分子（NCAM）的细胞或NCAM-配体（反受体）如神经元的存活的化合物。此外，本发明涉及药物组合物和药物在治疗或保护呈现NCAM或NCAM配体的细胞中的用途。更具体地，本发明描述了包含由NCAM的氨基酸序列至少5个连续氨基酸残基的肽的化合物，其片段或其变体或其模拟物在制备用于预防呈现所述NCAM或NCAM配体的细胞的细胞死亡。

8. 发明申请

WO2005123759A3 FGFR binding peptides 审中-公开
标题翻译： FGFR结合肽
公开(公告)号：WO2005123759A3
公开(公告)日：2006-05-04
申请号：PCT/DK2005000400
申请日：2005-06-17
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCH ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K7/00 , C07K14/705 , A61K38/17 , A61P25/28 , C07K16/28
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译：本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。

9. 发明申请

WO2005121168A3 HEPARIN BINDING PEPTIDE 审中-公开
公开(公告)号：WO2005121168A3
公开(公告)日：2006-03-16
申请号：PCT/DK2005000382
申请日：2005-06-10
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395 , A61P25/28 , C07K7/00 , C07K16/28
CPC分类号： C07K14/70503
摘要： The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.
摘要翻译：本发明涉及能够刺激神经突生长，刺激细胞存活，刺激与记忆和学习相关的神经可塑性以及调节细胞运动性的新肽片段。肽片段的生物活性与其结合并激活Trk家族的神经营养因子受体的能力相关。本发明的肽片段包含对于结合并激活Trk家族的神经营养因子受体必需的氨基酸基序。本发明还涉及包含该化合物的药物组合物及其用于预防和/或治疗病症和/或疾病的用途，其中神经刺激素，Tkr受体和/或NCAM起重要作用，并且其中刺激神经突生长，细胞存活，神经元与记忆和学习相关的可塑性和/或调节细胞运动性对治疗是有益的。

10. 发明申请

WO2005123759A8 FGFR BINDING PEPTIDES 审中-公开
标题翻译： FGFR结合肽
公开(公告)号：WO2005123759A8
公开(公告)日：2006-03-09
申请号：PCT/DK2005000400
申请日：2005-06-17
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K7/00 , C07K14/705 , A61K38/17 , A61P25/28 , C07K16/28
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译：本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。

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