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1. 发明申请

WO2018044885A1 DEVELOPMENT OF SPINAL CORD ON A MICROFLUIDIC CHIP 审中-公开
标题翻译：微流控芯片脊髓的研制
公开(公告)号：WO2018044885A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049115
申请日：2017-08-29
申请人： EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
发明人： KERNS, Jordan , WEN, Norman , LUCCHESI, Carol , HINOJOSA, Christopher , FRASER, Jacob , HAMILTON, Geraldine , VATINE, Gad , SANCES, Sam , SVENDSEN, Clive , LEVNER, Daniel , SAREEN, Dhruv
IPC分类号： C12N5/071 , C12N5/079 , C12N5/0793 , C12N5/0797 , C12N15/85
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
摘要翻译：本发明涉及在细胞模拟血脑屏障的结构和功能的条件下，在流体装置中培养脑内皮细胞以及任选的星形胶质细胞和神经元。在微流体装置中培养这种细胞，不管是单独还是与其他细胞组合，都比现有系统更成熟和/或分化。

2. 发明申请

WO2017070224A1 MICROFLUIDIC MODEL OF THE BLOOD BRAIN BARRIER 审中-公开
标题翻译：血脑屏障的微流体模型
公开(公告)号：WO2017070224A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/057724
申请日：2016-10-19
申请人： EMULATE, INC. , CEDARS-SINAI MEDICAL CENTER
发明人： KERNS, Jordan , WEN, Norman , LUCCHESI, Carol , HINOJOSA, Chris , FRASER, Jacob , HAMILTON, Geraldine , VATINE, Gad , SANCES, Sam , SVENDSEN, Clive , LEVNER, Daniel , SAREEN, Dhruv
IPC分类号： C12M1/34 , C12M3/00 , C12N5/0793 , C12N5/0797
CPC分类号： C12M23/16 , C12M25/02 , C12M35/08 , C12N5/0618 , C12N5/069 , C12N2506/45 , C12N2531/00 , C12N2535/10
摘要： The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
摘要翻译：本发明涉及在细胞模拟血脑屏障的结构和功能的条件下，在流体装置中培养脑内皮细胞以及任选的星形胶质细胞和神经元。在微流体装置中培养这种细胞，不管是单独还是与其他细胞组合，都比现有系统更成熟和/或分化。

3. 发明申请

WO2018044934A1 METHODS AND COMPOSITIONS FOR SPINAL CORD CELLS 审中-公开
标题翻译：脊髓细胞的方法和组合物
公开(公告)号：WO2018044934A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/049193
申请日：2017-08-29
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： VATINE, Gad , SANCES, Sam , SVENDSEN, Clive , SAREEN, Dhruv , KERL, Alexis J.
IPC分类号： A61K35/24 , A61K35/30 , C12M3/00 , C12N5/0797
摘要： Described here are systems and methods for deriving both spinal motor neurons and brain microvascular endothelial cells from induced pluripotent stem cells using distinct methods and combining them in a chip format. Neurons cultured alone in chip microvolume displayed increased calcium transient function and chip-specific gene expression. When seeded with endothelial cells, interaction further enhanced neural function, elicited vascular-neural interaction, niche gene expression with enhanced in vivo-like signatures arising from the chip co-cultures. Development of novel media formulations further allow for improved readout of differentiation process, by eliminating additives that otherwise confound differentiation processes and resulting phenotypes.
摘要翻译：这里描述了用于使用不同的方法从诱导的多能干细胞衍生脊髓运动神经元和脑微血管内皮细胞并将它们以芯片形式组合的系统和方法。以微芯片单独培养的神经元显示增加的钙瞬变功能和芯片特异性基因表达。当用内皮细胞接种时，相互作用进一步增强了神经功能，引发了血管 - 神经相互作用，小生境基因表达以及来自芯片共培养的增强的体内样特征。新型培养基制剂的开发进一步改善了分化过程的读出，消除了添加剂，否则会影响分化过程和产生的表型。

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