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1. 发明申请

WO2013096958A8 COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE RNAS 审中-公开
标题翻译：用于递送生物活性RNAs的组合物和方法
公开(公告)号：WO2013096958A8
公开(公告)日：2014-07-24
申请号：PCT/US2012071576
申请日：2012-12-24
申请人： EGEN INC
发明人： POLACH KEVIN , FEWELL JASON , ANWER KHURSHEED , WILKINSON LESLIE S
IPC分类号： C12N15/11 , C12N15/115
CPC分类号： C12N15/111 , C07K2319/02 , C07K2319/10 , C07K2319/85 , C12N15/85 , C12N2320/32 , C12N2330/51 , C12N2830/48
摘要： Novel compounds, compositions, and methods for the delivery of biologically active RNA molecules to cells. Specifically, the invention provides novel nucleic acid molecules, polypeptides, and RNA-protein complexes useful for the delivery of biologically active RNAs to cells and polynucleotides encoding the same. The invention also provides vectors for expressing said polynucleotides. In addition, the invention provides cells and compositions comprising the novel compounds and vectors, which can be used as transfection reagents. The invention further provides methods for producing said compounds, vectors, cells, and compositions. Additionally, vectors and methods for delivering biologically active RNA molecules to cells and/or tissues are provided. The novel compounds, vectors, cells, and compositions are useful, for example, in delivering biologically active RNA molecules to cells to modulate target gene expression in the diagnosis, prevention, amelioration, and/or treatment of diseases, discorders, or conditions in a subject or organism.
摘要翻译：用于将生物活性RNA分子递送至细胞的新型化合物，组合物和方法。具体地说，本发明提供了可用于将生物活性RNA递送到细胞的新型核酸分子，多肽和RNA-蛋白复合物，以及编码该核酸的多核苷酸。本发明还提供用于表达所述多核苷酸的载体。此外，本发明提供了可用作转染试剂的包含新化合物和载体的细胞和组合物。本发明还提供了生产所述化合物，载体，细胞和组合物的方法。另外，提供了将生物活性RNA分子递送到细胞和/或组织的载体和方法。新型化合物，载体，细胞和组合物可用于例如将生物活性RNA分子递送至细胞以调节靶基因表达在诊断，预防，改善和/或治疗疾病，不便者或疾病中的病症主体或生物体。

2. 发明申请

WO2010108108A3 POLYAMINE DERIVATIVES 审中-公开
标题翻译：聚氨酯衍生物
公开(公告)号：WO2010108108A3
公开(公告)日：2011-04-07
申请号：PCT/US2010028000
申请日：2010-03-19
申请人： EGEN INC , SLOBODKIN GREGORY , CONGO RICHARD , MATAR MAJED , FEWELL JASON , ANWER KHURSHEED , SPARKS BRIAN JEFFERY
发明人： SLOBODKIN GREGORY , CONGO RICHARD , MATAR MAJED , FEWELL JASON , ANWER KHURSHEED , SPARKS BRIAN JEFFERY
IPC分类号： C07C233/38 , A61K9/127 , C12N15/88
CPC分类号： A61K47/48061 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/542 , A61K47/6911 , C07C233/38 , C07C235/10 , C07C235/60 , C07D475/04 , C07H15/10 , C07K7/23 , C07K7/64
摘要： Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
摘要翻译：公开了用于全身和局部递送生物活性分子的化合物，组合物和方法。

3. 发明申请

WO2009108891A3 MODIFIED POLOXAMERS FOR GENE EXPRESSION AND ASSOCIATED METHODS 审中-公开
标题翻译：用于基因表达和相关方法的改性POLOXAMERS
公开(公告)号：WO2009108891A3
公开(公告)日：2009-10-22
申请号：PCT/US2009035543
申请日：2009-02-27
申请人： EGEN INC , SLOBODKIN GREGORY , MATAR MAJED , SPARKS BRIAN JEFFERY , FEWELL JASON , ANWER KHURSHEED
发明人： SLOBODKIN GREGORY , MATAR MAJED , SPARKS BRIAN JEFFERY , FEWELL JASON , ANWER KHURSHEED
IPC分类号： C08G65/329 , A61K47/34 , C12N15/87
CPC分类号： C08G65/329 , A61K9/0019 , A61K47/34
摘要： Nucleotide delivery polymers, compositions, and associated methods for the enhancement of gene delivery and expression in solid tissues are provided. In one aspect, for example, a nucleotide delivery polymer may include a poloxamer backbone having a metal chelator covalently coupled to at least one terminal end of the poloxamer backbone. In another aspect, the nucleotide expression polymer has a metal chelator coupled to at least two terminal ends of the poloxamer backbone.
摘要翻译：提供了用于增强固体组织中基因递送和表达的核苷酸递送聚合物，组合物和相关方法。在一个方面，例如，核苷酸递送聚合物可以包括具有与泊洛沙姆主链的至少一个末端共价连接的金属螯合剂的泊洛沙姆骨架。另一方面，核苷酸表达聚合物具有与泊洛沙姆主链的至少两个末端连接的金属螯合剂。

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