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1. 发明申请

WO2004008120A1 MOLECULAR DETECTOR ARRANGEMENT 审中-公开
标题翻译：分子检测器安排
公开(公告)号：WO2004008120A1
公开(公告)日：2004-01-22
申请号：PCT/GB2003/002962
申请日：2003-07-09
申请人： E2V TECHNOLOGIES LIMITED , GILBERT, Richard , XHOU, Xiao-Feng , ALLEN, Brian, Philip
发明人： GILBERT, Richard , XHOU, Xiao-Feng , ALLEN, Brian, Philip
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , G01N21/554 , G01N2021/651
摘要： A detector assembly for detecting the presence of analyte molecules, in particular, proteins, uses both Surface Enhanced Raman Scattering (SERS) and Surface Plasmon Resonance (SPR) in synergy. The excitation laser used for SERS provides scattering from a reporter dye to which an analyte molecule is attached in the vicinity of a conducting surface. Simultaneously, a second laser is provided at the critical angle to the conducting surface. The second laser causes a field to be created in the region of the analyte which enhances the Raman scattering effect.
摘要翻译：用于检测分析物分子，特别是蛋白质的存在的检测器组件使用表面增强拉曼散射（SERS）和表面等离子体共振（SPR）的协同作用。用于SERS的激发激光提供来自分析物分子附着在导电表面附近的报道染料的散射。同时，以与导电表面成临界角的方式设置第二激光器。第二激光导致在分析物的区域中产生增强拉曼散射效应的场。

2. 发明申请

WO2004097384A1 MOLECULAR DETECTOR ARRANGEMENT 审中-公开
标题翻译：分子检测器安排
公开(公告)号：WO2004097384A1
公开(公告)日：2004-11-11
申请号：PCT/GB2004/001788
申请日：2004-04-23
申请人： E2V TECHNOLOGIES LIMITED , ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
发明人： ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , G01J3/44 , G01N21/03 , G01N2021/0346
摘要： An analyte carrier, such as a microtiter plate, microfluidic chip or other suitable arrangements for supporting an analyte has a conducting layer for receipt of an analyte having a non-random surface structure pattern designed to enhance the Raman scattering from molecules in an analysis region. The designed surface structure pattern has regions of high curvature, which increase the electromagnetic field provided from the surface, thereby enhancing the energy transfer from electrons in the metal surface to molecules in a region above the surface. This provides energy to electron bandgap levels in the molecules, thereby enhancing Raman scattering which can be detected by a separate detector.
摘要翻译：分析物载体，例如微量滴定板，微流体芯片或用于支持分析物的其它合适布置具有用于接收具有设计用于增强分析区域中的分子的拉曼散射的非随机表面结构图案的分析物的导电层。设计的表面结构图形具有高曲率的区域，这增加了从表面提供的电磁场，从而增强了从金属表面的电子到表面上方的分子的能量传递。这为分子中的电子带隙水平提供了能量，从而增强了可以通过单独的检测器检测的拉曼散射。

3. 发明申请

WO2004003224A1 ELECTROCHEMICAL SENSING USING AN ENZYME ELECTRODE 审中-公开
标题翻译：电化学感应使用酶电极
公开(公告)号：WO2004003224A1
公开(公告)日：2004-01-08
申请号：PCT/GB2003/002756
申请日：2003-06-27
申请人： E2V TECHNOLOGIES LIMITED , ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
发明人： ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
IPC分类号： C12Q1/00
CPC分类号： C12Q1/005 , C12Q1/004
摘要： Electrodes for use in electrochemical assays to determine whether a candidate drug is metabolised by an oxidative drug-metabolising enzyme (DME) are described. In a first type of electrode the DME is immobilised at the surface of the electrode. In a second type of electrode, a surface of the electrode is modified by the covalent or non covalent addition of chemical groups to allow efficient transfer of electrons from the electrode to the DME in solution. Use of the electrodes in electrochemical assays are described, as well as electrochemical reaction chambers comprising the electrodes.
摘要翻译：描述了用于电化学测定以确定候选药物是否被氧化药物代谢酶（DME）代谢的电极。在第一类电极中，DME被固定在电极的表面。在第二种类型的电极中，通过共价或非共价添加化学基团来修饰电极的表面，以允许电子从电极到溶液中的DME的有效转移。在电化学测定中使用电极，以及包括电极的电化学反应室。

4. 发明申请

WO2003060513A3 METHOD AND APPARATUS FOR CANCER DETECTION 审中-公开
公开(公告)号：WO2003060513A3
公开(公告)日：2003-07-24
申请号：PCT/GB2002/005850
申请日：2002-12-20
申请人： E2V TECHNOLOGIES LIMITED , ALLEN, Brian, Philip , SPELLER, Robert , HORROCKS, Jane
发明人： ALLEN, Brian, Philip , SPELLER, Robert , HORROCKS, Jane
IPC分类号： G01N33/483
摘要： A method of detecting cancer in a patient includes the step of exposing a sample 4 of hair, removed from the patient, to an incident beam of X-rays from an X-ray source 1. The X-rays are scattered by the hair, which rays are then detected by a detector 11. Predetermined characteristics of the scattered X-rays are monitored; it has been found that these characteristics are different in patients who do not have cancer from those who do have cancer, or who are at greater risk of developing it. The X-ray source may be a standard, incoherent X-ray source, such as is found in clinics and laboratories.

5. 发明申请

WO2003060513A2 CANCER DETECTION 审中-公开
标题翻译：癌症检测
公开(公告)号：WO2003060513A2
公开(公告)日：2003-07-24
申请号：PCT/GB2002/005850
申请日：2002-12-20
申请人： E2V TECHNOLOGIES LIMITED , ALLEN, Brian, Philip , SPELLER, Robert , HORROCKS, Jane
发明人： ALLEN, Brian, Philip , SPELLER, Robert , HORROCKS, Jane
IPC分类号： G01N33/483
CPC分类号： G01N23/20 , G01N33/4833
摘要： A method of detecting cancer in a patient includes the step of exposing a sample 4 of hair, removed from the patient, to an incident beam of X-rays from an X-ray source 1. The X-rays are scattered by the hair, which rays are then detected by a detector 11. Predetermined characteristics of the scattered X-rays are monitored; it has been found that these characteristics are different in patients who do not have cancer from those who do have cancer, or who are at greater risk of developing it. The X-ray source may be a standard, incoherent X-ray source, such as is found in clinics and laboratories.
摘要翻译：一种检测患者癌症的方法包括：将从患者移除的毛发样品4暴露于来自X射线源1的X射线的入射光束的步骤。所述X射线被毛发散射，然后由检测器11检测射线。监测散射X射线的预定特征; 已经发现，那些患有癌症的患者或没有发生癌症的患者中，没有癌症的患者的这些特征是不同的。 X射线源可能是标准的，不相干的X射线源，例如在诊所和实验室中发现的。

6. 发明申请

WO2005017524A1 REACTION CONDITIONS SENSOR 审中-公开
标题翻译：反应条件传感器
公开(公告)号：WO2005017524A1
公开(公告)日：2005-02-24
申请号：PCT/GB2004/003143
申请日：2004-07-19
申请人： E2V TECHNOLOGIES (UK) LIMITED , ALLEN, Brian, Philip , GILBERT, Richard , ZHOU, Xiao, Feng
发明人： ALLEN, Brian, Philip , GILBERT, Richard , ZHOU, Xiao, Feng
IPC分类号： G01N33/487
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01J2219/00889 , B01J2219/00957 , B01L3/5027 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , C12Q1/001
摘要： A method and apparatus (1) for detecting adverse conditions during the analysis of chemical and biological processes are disclosed. In one embodiment, the reaction conditions in a microelectrochemical reaction chamber (7) are monitored. The reaction chamber (7) comprises electrodes (17a, 17b) arranged to pass an electric current through reaction mixture located within the reaction chamber, thereby inducing an electrochemical reaction. A detection circuit (19) is provided to detect and measure the electric current flowing between the electrodes (17a, 17b). The detection circuit (19) generates a signal indicating whether the measured current lies inside or outside a predetermined range of values. If the measured current lies outside the expected range of values, then the reaction conditions are adverse. A single pair of electrodes may perform a dual function of both inducing the electrochemical reaction detection. In another embodiment, electrodes are for detecting the presence of analytes Using the combined techniques of surface enhanced Raman scattering and surface plasmon resonance.
摘要翻译：公开了一种在化学和生物过程分析过程中检测不利条件的方法和装置（1）。在一个实施方案中，监测微电化学反应室（7）中的反应条件。反应室（7）包括布置成使电流通过位于反应室内的反应混合物从而引起电化学反应的电极（17a，17b）。提供检测电路（19）以检测和测量在电极（17a，17b）之间流动的电流。检测电路（19）产生指示测量电流是否在预定值范围内或之外的信号。如果测量的电流超出预期值的范围，则反应条件是不利的。一对电极可以执行诱导电化学反应检测的双重功能。在另一个实施方案中，电极用于检测分析物的存在使用表面增强拉曼散射和表面等离子体共振的组合技术。

7. 发明申请

WO2005014172A1 MICROFLUIDIC VALVE 审中-公开
标题翻译：微流控阀
公开(公告)号：WO2005014172A1
公开(公告)日：2005-02-17
申请号：PCT/GB2004/003389
申请日：2004-08-04
申请人： E2V TECHNOLOGIES (UK) LIMITED , ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
发明人： ALLEN, Brian, Philip , ZHOU, Xiao-Feng , GILBERT, Richard
IPC分类号： B01L3/00
CPC分类号： F16K99/0019 , B01L3/502738 , B01L2400/0633 , F16K15/183 , F16K25/005 , F16K31/02 , F16K99/0001 , F16K99/0023 , F16K99/0051
摘要： The invention provides a microfluidic valve comprising a first body for containing fluid having a fluid inlet and a fluid outlet and a plurality of electrodes, and arranged to contain, in use, a second body held within fluid contained in the first body, the second body being moveable toward or away from one of the fluid inlet or fluid outlet, the movement of the second body caused by a phase difference in the electric field generated by the electrodes, such that fluid flow into or out of the first body is controlled. The fluid flow is controlled using one of the dielectrophoretic, electrophoretic or electroosmotic effects. The invention also provides a method of controlling fluid flow, and a microfluidic switch, and microfluidic chip and a diagnostic device, wherein fluid flow is controlled in each.
摘要翻译：本发明提供了一种微流体阀，包括用于容纳具有流体入口和流体出口和多个电极的流体的第一体，并且被布置成在使用中包含保持在包含在第一体内的流体内的第二体，第二体可以朝向或远离流体入口或流体出口之一移动，由电极产生的电场的相位差引起的第二体的运动，使得流体流入或流出第一体的流体被控制。使用介电电泳，电泳或电渗效应之一来控制流体流动。本发明还提供了一种控制流体流动的方法，以及微流体开关，以及微流体芯片和诊断装置，其中流体流在每个中被控制。

8. 发明申请

WO2003008946A1 DETECTING ANALYTES 审中-公开
标题翻译：检测分析
公开(公告)号：WO2003008946A1
公开(公告)日：2003-01-30
申请号：PCT/GB2002/003220
申请日：2002-07-15
申请人： MARCONI APPLIED TECHNOLOGIES LIMITED , ALLEN, Brian, Philip
发明人： ALLEN, Brian, Philip
IPC分类号： G01N21/55
CPC分类号： G01N21/7703 , G01N21/552
摘要： A sensor arranged to detect an analyte comprises an optical waveguide (5), which includes a number of branches (6-10). A region (11-15) of each waveguide is associated with a material arranged to react selectively with an analyte. When a material interacts with an analyte, which may be introduced via the channel (2), a change in the refractive index occurs in the region of waveguide. This change may be detected by guiding a light beam into the waveguides and detecting a change in a characteristic of the emerging light, e.g. light intensity.
摘要翻译：布置成检测分析物的传感器包括光波导（5），其包括多个分支（6-10）。每个波导的区域（11-15）与布置为与分析物选择性反应的材料相关联。当材料与可通过通道（2）引入的分析物相互作用时，折射率的变化发生在波导区域中。可以通过将光束引入波导并检测出现的光的特性的变化来检测该变化，例如，光强度。

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