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1. 发明申请

WO2006031885A3 KDR AND VEGF/KDR BINDING PEPTIDES 审中-公开
标题翻译： KDR和VEGF / KDR结合肽
公开(公告)号：WO2006031885A3
公开(公告)日：2006-08-17
申请号：PCT/US2005032740
申请日：2005-09-13
申请人： DYAX CORP , BRACCO INT BV , SATO AARON K , SEXTON DANIEL J , DRANSFIELD DANIEL T , LADNER ROBERT C , ARBOGAST CHRISTOPHE , BUSSAT PHILLIPE , FAN HONG , KHURANA SUDHA , LINDER KAREN E , MARINELLI EDMUND R , NANJAPPAN PALANIAPPA , SONG BO , SWENSON ROLF E , VON WRONSKI MATHEW A , NUNN ADRIAN D , PILLAI RADHAKRISHNA , POCHON SIBYLLE , RAMALINGAM KONDAREDDIAR , SHRIVASTAVA AJAY
发明人： SATO AARON K , SEXTON DANIEL J , DRANSFIELD DANIEL T , LADNER ROBERT C , ARBOGAST CHRISTOPHE , BUSSAT PHILLIPE , FAN HONG , KHURANA SUDHA , LINDER KAREN E , MARINELLI EDMUND R , NANJAPPAN PALANIAPPA , SONG BO , SWENSON ROLF E , VON WRONSKI MATHEW A , NUNN ADRIAN D , PILLAI RADHAKRISHNA , POCHON SIBYLLE , RAMALINGAM KONDAREDDIAR , SHRIVASTAVA AJAY
IPC分类号： C07K7/06 , A61K38/00 , A61K38/10 , C07K7/08 , C07K14/00 , G01N33/574 , G01N33/58 , G01N33/60 , G01N33/68
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/001 , G01N33/574 , G01N33/6872 , G01N2333/515 , G01N2500/00
摘要： The present invention provides, inter alia, peptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K D
摘要翻译：本发明尤其提供了包含至少一个KDR或VEGF / KDR复合物结合部分的肽，肽二聚体和多聚体复合物，其在治疗，检测，分离或定位血管发生的任何地方都具有多种用途。特别公开的是能够以高亲和力结合KDR或VEGF / KDR复合物的合成，分离的多肽（例如，具有K 1μM），以及包含这些多肽的二聚体和多聚体构建体。

2. 发明申请

WO03074005A8 KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
公开(公告)号：WO03074005A8
公开(公告)日：2005-07-21
申请号：PCT/US0306731
申请日：2003-03-03
申请人： DYAX CORP , BRACCO INT BV , SATO AARON K , SEXTON DANIEL J , LADNER ROBERT C , DRANSFIELD DANIEL T , SWENSON ROLF E , MARINELLI EDMUND R , RAMALINGAM KONDAREDDIAR , NUNN ADRIAN D , VON WRONSKI MATHEW A , SHRIVASTAVA AJAY , POCHON SIBYLLE , BUSSAT PHILIPPE , ARBOGAST CHRISTOPHE , PILLAI RADHAKRISHNA , FAN HONG , LINDER KAREN E , SONG BO , NANJAPPAN PALANIAPPA
发明人： SATO AARON K , SEXTON DANIEL J , LADNER ROBERT C , DRANSFIELD DANIEL T , SWENSON ROLF E , MARINELLI EDMUND R , RAMALINGAM KONDAREDDIAR , NUNN ADRIAN D , VON WRONSKI MATHEW A , SHRIVASTAVA AJAY , POCHON SIBYLLE , BUSSAT PHILIPPE , ARBOGAST CHRISTOPHE , PILLAI RADHAKRISHNA , FAN HONG , LINDER KAREN E , SONG BO , NANJAPPAN PALANIAPPA
IPC分类号： A61K38/00 , A61K49/22 , A61K51/08 , C07K7/08 , C07K14/00 , C07K14/52 , C07K14/71 , C07K7/00
CPC分类号： C07K7/08 , A61K38/00 , A61K49/223 , A61K51/088 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00
摘要： The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e . g ., having a K D

3. 发明申请

WO2004064595A3 MULTIVALENT CONSTRUCTS FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS 审中-公开
标题翻译：用于治疗和诊断应用的多功能结构
公开(公告)号：WO2004064595A3
公开(公告)日：2005-03-31
申请号：PCT/US0328838
申请日：2003-09-11
申请人： BRACCO INT BV , DYAX CORP , ARBOGAST CHRISTOPHE , BUSSAT PHILIPPE , DRANSFIELD DANIEL T , FAN HONG , LINDER KAREN , MARINELLI EDMUND R , NANJAPPAN PALANIAPPA , NUNN ADRIAN , PILLAI RADHAKRISHNA , POCHON SYBILLE , RAMALINGAM KONDAREDDIAR , SATO AARON , SHRIVASTAVA AJAY , SONG BO , SWENSON ROLF E , VON WRONSKI MATHEW A , WALKER SHARON MICHELE
发明人： ARBOGAST CHRISTOPHE , BUSSAT PHILIPPE , DRANSFIELD DANIEL T , FAN HONG , LINDER KAREN , MARINELLI EDMUND R , NANJAPPAN PALANIAPPA , NUNN ADRIAN , PILLAI RADHAKRISHNA , POCHON SYBILLE , RAMALINGAM KONDAREDDIAR , SATO AARON , SHRIVASTAVA AJAY , SONG BO , SWENSON ROLF E , VON WRONSKI MATHEW A , WALKER SHARON MICHELE
IPC分类号： A61K47/48 , C07K7/08 , C07K7/64 , A61K38/00 , C07K19/00
CPC分类号： C07K7/08 , A61K47/60 , A61K47/64 , C07K7/64
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译：本发明提供用于治疗和诊断应用的组合物和方法。

4. 发明申请

WO2009076388A2 TARGETING VECTOR-PHOSPHOLIPID CONJUGATES 审中-公开
标题翻译：靶向载体 - 磷脂结合体
公开(公告)号：WO2009076388A2
公开(公告)日：2009-06-18
申请号：PCT/US2008086136
申请日：2008-12-10
申请人： BRACCO INT BV , BUSSAT PHILIPPE , CHERKAOUI SAMIR , FAN HONG HELEN , LAMY BERNARD , NANJAPPAN PALANIAPPA , PILLAI RADHAKRISHNA K , POCHON SIBYLLE , SONG BO , SWENSON ROLF E
发明人： BUSSAT PHILIPPE , CHERKAOUI SAMIR , FAN HONG HELEN , LAMY BERNARD , NANJAPPAN PALANIAPPA , PILLAI RADHAKRISHNA K , POCHON SIBYLLE , SONG BO , SWENSON ROLF E
IPC分类号： A61P35/00 , A61B8/00 , C07K14/00
CPC分类号： A61K49/227 , C07K14/00 , C07K14/52
摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
摘要翻译：提供具有高KDR结合亲和力的肽载体和用于制备此类载体的方法。肽载体可以与磷脂结合并包含在超声造影剂组合物中。这样的超声造影剂在治疗和诊断方法中是特别有用的，例如在成像含KDR组织和评估和治疗与肿瘤病症相关的血管生成过程中。本发明还提供大规模生产高纯度二聚体和单体肽磷脂共轭物以及用于形成缀合物的前体材料的方法。本发明还提供了大规模生产含有非常低水平的TFA的高纯度肽磷脂缀合物的方法。

5. 发明申请

WO2007067979A3 TARGETING VECTOR-PHOSPHOLIPID CONJUGATES 审中-公开
标题翻译：靶向载体 - 磷脂结合体
公开(公告)号：WO2007067979A3
公开(公告)日：2008-07-31
申请号：PCT/US2006061793
申请日：2006-12-08
申请人： BRACCO INT BV , BUSSAT PHILIPPE , CHERKAOUI SAMIR , FAN HONG HELEN , LAMY BERNARD , NANJAPPAN PALANIAPPA , PILLAI RADHAKRISHNA K , POCHON SIBYLLE , SONG BO , SWENSON ROLF E
发明人： BUSSAT PHILIPPE , CHERKAOUI SAMIR , FAN HONG HELEN , LAMY BERNARD , NANJAPPAN PALANIAPPA , PILLAI RADHAKRISHNA K , POCHON SIBYLLE , SONG BO , SWENSON ROLF E
IPC分类号： C12P21/04 , A61K38/16 , C07K1/00
CPC分类号： C07K14/00 , A61K47/544 , A61K49/223
摘要： Peptide vectors having high KLDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
摘要翻译：提供了具有高KLDR结合亲和力的肽载体和用于制备此类载体的方法。肽载体可以与磷脂结合并包含在超声造影剂组合物中。这样的超声造影剂在治疗和诊断方法中是特别有用的，例如在成像含KDR组织和评估和治疗与肿瘤病症相关的血管生成过程中。本发明还提供大规模生产高纯度二聚体和单体肽磷脂共轭物以及用于形成缀合物的前体材料的方法。本发明还提供了大规模生产含有非常低水平的TFA的高纯度肽磷脂缀合物的方法。

6. 发明申请

WO2008073458A3 FIBRIN-BINDING PEPTIDES AND CONJUGATES THEREOF 审中-公开
标题翻译：纤维蛋白结合蛋白及其结合
公开(公告)号：WO2008073458A3
公开(公告)日：2008-10-02
申请号：PCT/US2007025403
申请日：2007-12-11
申请人： BRACCO IMAGING SPA , BUSSAT PHILIPPE , LAMY BERNARD , MARINELLI EDMUND R , POCHON SIBYLLE , SONG BO , SWENSON ROLF E
发明人： BUSSAT PHILIPPE , LAMY BERNARD , MARINELLI EDMUND R , POCHON SIBYLLE , SONG BO , SWENSON ROLF E
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/14 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/124 , C07K7/06 , G01N33/532 , G01N33/574 , G01N33/86 , G01N2500/04
摘要： Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.
摘要翻译：提供了与先前已知的纤维蛋白结合肽相比具有高结合亲和力和优异物理特性的纤维蛋白结合肽。这些纤维蛋白结合肽可以缀合到可检测标记或治疗剂，并用于检测和促进治疗与血纤维蛋白如血栓形成和血管生成和肿瘤状况有关的病理状况。这些肽可用于诸如MRI，超声和核医学成像（例如PET，闪烁照相成像等）的成像过程中。肽也可以在治疗上使用。本发明还提供了制备和使用这些肽及其缀合物的方法和方法。

7. 发明申请

WO2008071679A1 FIBRIN BINDING PEPTIDE CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS. 审中-公开
标题翻译：纤维蛋白结合肽联合用于诊断和治疗应用。
公开(公告)号：WO2008071679A1
公开(公告)日：2008-06-19
申请号：PCT/EP2007063659
申请日：2007-12-11
申请人： BRACCO IMAGING SPA , MARINELLI EDMUND , RAMALINGAM KONDAREDDIAR , SWENSON ROLF , SONG BO , LATTUADA LUCIANO , UGGERI FULVIO , LORUSSO VITO , AIME SILVIO , MOROSINI PIERFRANCESCO , CHAABANE LINDA
发明人： MARINELLI EDMUND , RAMALINGAM KONDAREDDIAR , SWENSON ROLF , SONG BO , LATTUADA LUCIANO , UGGERI FULVIO , LORUSSO VITO , AIME SILVIO , MOROSINI PIERFRANCESCO , CHAABANE LINDA
IPC分类号： C07K7/06 , A61K49/00 , G01N33/86
CPC分类号： A61K49/14 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/124 , C07K7/06 , G01N33/532 , G01N33/574 , G01N33/86 , G01N2500/04
摘要： The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel peptides able to bind fibrin, to a process for their preparation and to compositions thereof for use in therapy and diagnostics. The compounds of the invention bind, in particular, to fibrin present in the extracellular matrix (EC) of tumor or connective tissue of stroma thus acting as targeting moieties able to bring and successfully bound an active moiety linked thereto to fibrin depositions inside solid tumors.
摘要翻译：本发明涉及一类新的诊断或治疗有效化合物，其包含能够结合纤维蛋白的新肽，其制备方法及其组合物用于治疗和诊断。本发明的化合物特别结合存在于基质的肿瘤或结缔组织的细胞外基质（EC）中的纤维蛋白，因此作为靶向部分，其能够使与其连接的活性部分成功结合固体肿瘤内的纤维蛋白沉积。

8. 发明申请

WO2009149318A3 MIRNAS AS THERAPEUTIC TARGETS IN CANCER 审中-公开
标题翻译： MIRNAS作为癌症中的治疗目标
公开(公告)号：WO2009149318A3
公开(公告)日：2010-06-17
申请号：PCT/US2009046353
申请日：2009-06-05
申请人： UNIV NEW YORK STATE RES FOUND , JU JINGFANG , SONG BO , WANG YUAN
发明人： JU JINGFANG , SONG BO , WANG YUAN
IPC分类号： A61K31/70
CPC分类号： C12N15/1137 , A61K31/7088 , A61K45/06 , C12N15/113 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2320/31 , C12Q1/6886 , C12Q2600/136 , C12Q2600/178
摘要： MicroRNAs (miRNAs) are a class of non-coding small RNA molecules that regulate gene expression at the post-transcriptional level by interacting with 3' untranslated regions (UTRs) of their target mRNAs. The invention relates to the application of miR-192 and miR-215. Both of these miRNAs impact cellular proliferation through the p53-miRNA circuit, and interact with dihydrofolate reductase (DHFR) and thymidylate synthase (TS). Particularly, upregulation of these miRNAs reduces cellular proliferation. The invention relates to this discovery. For example, inhibiting miR-192 and/or miR-215 sensitizes a neoplasm or a subject with a neoplasm to chemotherapeutic agents. Furthermore, measuring the levels of miR-192 and/or miR-215 provides one with information regarding whether the neoplasm or subject will respond to chemotherapeutic agents. Accordingly, the invention relates to composition and methods relating to the identification, characterization and modulation of the expression of miR-192 and miR-215.
摘要翻译：微RNA（miRNA）是一类非编码小RNA分子，通过与其靶mRNA的3'非翻译区（UTR）相互作用来调节转录后水平的基因表达。本发明涉及miR-192和miR-215的应用。这两种miRNA通过p53-miRNA电路影响细胞增殖，并与二氢叶酸还原酶（DHFR）和胸苷酸合酶（TS）相互作用。特别地，这些miRNA的上调减少细胞增殖。本发明涉及这一发现。例如，抑制miR-192和/或miR-215使肿瘤或具有肿瘤的受试者对化学治疗剂敏感。此外，测量miR-192和/或miR-215的水平提供了关于肿瘤或受试者是否将对化学治疗剂作出反应的信息。因此，本发明涉及与miR-192和miR-215的表达的鉴定，表征和调节相关的组合物和方法。

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