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1. 发明申请

WO2022115503A1 TREATMENT AND PREVENTION OF CORONAVIRUS INFECTION 审中-公开
公开(公告)号：WO2022115503A1
公开(公告)日：2022-06-02
申请号：PCT/US2021/060679
申请日：2021-11-24
申请人： DUPONT NUTRITION BIOSCIENCES APS , DANISCO US INC.
发明人： ESTELL, David , POWER, Scott D. , ZHU, Quinn Q. , FAN, Xiaochun , HONG, Seung-Pyo , CAIMI, Perry , BENDEZU, Felipe O. , XUE, Zhixiong
IPC分类号： A61K39/215 , C07K14/165
摘要： Provided herein, inter alia, are recombinant Yarrowia cells comprising a nucleic acid encoding a viral protein or a fragment thereof for use in the treatment and prevention of viral disease as well as methods for making and using the same.

2. 发明申请

WO2021163439A1 IMPROVED YEASTS FOR BREWING 审中-公开
公开(公告)号：WO2021163439A1
公开(公告)日：2021-08-19
申请号：PCT/US2021/017800
申请日：2021-02-12
申请人： DUPONT NUTRITION BIOSCIENCES APS , DANISCO US INC
发明人： CRAMER, Jacob Flyvholm , ANTHONY, Larry Cameron , HONG, Seung-Pyo
IPC分类号： A23L27/00 , C12C11/00 , C12C12/00 , C12H1/00 , C12N9/06
摘要： The present invention relates to flavor stabilized beers and to methods of making flavor stabilized beers. More specifically, the instant disclosure provides methods and compositions for the production of flavor stabilized beer having low riboflavin using modified yeast to ferment a wort.

3. 发明申请

WO2017105991A1 METHODS AND COMPOSITIONS FOR T-RNA BASED GUIDE RNA EXPRESSION 审中-公开
标题翻译：基于T-RNA的指导RNA表达的方法和组合物
公开(公告)号：WO2017105991A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/065537
申请日：2016-12-08
申请人： DANISCO US INC.
发明人： BENDEZU, Felipe Oseas , FAN, Xiaochun , FRISCH, Ryan L. , HONG, Seung-Pyo
IPC分类号： C12N15/11 , C12N15/113 , C12N15/90 , C12N15/09 , C12N15/81
CPC分类号： C12N15/113 , C12N15/111 , C12N15/815 , C12N2310/20 , C12N2310/3519 , C12N2330/51
摘要： Compositions and methods are provided for editing nucleotides and/or altering target sites in the genome of a cell. The methods and compositions employ a recombinant DNA construct comprising a tRNA promoter operably linked to a polynucleotide encoding a single guide RNA, wherein said recombinant DNA construct does not comprise a nucleotide sequence encoding a ribozyme, wherein said guide RNA is capable of forming a guide RNA/Cas endonuclease complex, wherein said complex can bind to and cleave a target site sequence in the genome of a cell such as a microbial cell. The present disclosure further describes methods and compositions employing a recombinant DNA construct comprising a tRNA promoter operably linked to a spacer sequence and a polynucleotide encoding a single guide RNA, wherein said recombinant DNA construct does not comprise a nucleotide sequence encoding a ribozyme, wherein said guide RNA is capable of forming a guide RNA/Cas endonuclease complex, wherein said complex can bind to and cleave a target site sequence in the genome of a non-conventional yeast.
摘要翻译：提供用于编辑核苷酸和/或改变细胞基因组中的靶位点的组合物和方法。所述方法和组合物采用重组DNA构建体，所述重组DNA构建体包含可操作地连接至编码单个引导RNA的多核苷酸的tRNA启动子，其中所述重组DNA构建体不包含编码核酶的核苷酸序列，其中所述引导RNA能够形成指导RNA / Cas核酸内切酶复合物，其中所述复合物可以结合并切割细胞基因组中的靶位点序列，例如微生物细胞。本公开进一步描述了采用重组DNA构建体的方法和组合物，所述重组DNA构建体包含可操作地连接至间隔序列的tRNA启动子和编码单个引导RNA的多核苷酸，其中所述重组DNA构建体不包含编码核酶的核苷酸序列， RNA能够形成引导RNA / Cas核酸内切酶复合物，其中所述复合物可以结合并切割非常规酵母的基因组中的靶位点序列。

4. 发明申请

WO2017106414A1 METHODS AND COMPOSITIONS FOR POLYMERASE II (POL-II) BASED GUIDE RNA EXPRESSION 审中-公开
标题翻译：基于聚合酶II（POL-II）的指导RNA表达的方法和组合物
公开(公告)号：WO2017106414A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066772
申请日：2016-12-15
申请人： DANISCO US INC.
发明人： BENDEZU, Felipe Oseas , FAN, Xiaochun , FRISCH, Ryan L. , HONG, Seung-Pyo
IPC分类号： C12N15/11 , C12N15/113 , C12N15/09 , C12N15/81
CPC分类号： C12N15/113 , C12N15/102 , C12N15/111 , C12N15/815 , C12N2310/10 , C12N2310/20 , C12N2310/3519 , C12N2330/51
摘要： Compositions and methods are provided for editing nucleotides and/or altering target sites in the genome of a cell. The methods and compositions employ a recombinant DNA construct comprising a Pol-ll promoter operably linked to a polynucleotide encoding a single guide RNA, wherein said guide RNA is capable of forming a guide RNA/Cas endonuclease complex, wherein said complex can bind to and cleave a target site sequence in the genome of a cell such as a eukaryote cell. The present disclosure further describes methods and compositions employing said recombinant DNA construct to modify the genome of non-conventional yeast.
摘要翻译：提供用于编辑核苷酸和/或改变细胞基因组中的靶位点的组合物和方法。所述方法和组合物采用包含与编码单一引导RNA的多核苷酸可操作连接的Pol-II启动子的重组DNA构建体，其中所述引导RNA能够形成引导RNA / Cas核酸内切酶复合物，其中所述复合体可以结合并切割细胞基因组中的靶位点序列，例如真核细胞。本公开还描述了使用所述重组DNA构建体来修饰非常规酵母的基因组的方法和组合物。

5. 发明申请

WO2019032688A1 INCREASED ETHANOL PRODUCTION BY YEAST HARBORING CONSTITUTIVE TRANSCRIPTIONAL ACTIVATOR MAL ALLELES 审中-公开
公开(公告)号：WO2019032688A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045789
申请日：2018-08-08
申请人： DANISCO US INC
发明人： HONG, Seung-Pyo , TEUNISSEN, Paula, Johanna, Maria , ZHU, Quinn, Qun
IPC分类号： C12N1/16
摘要： Described are compositions and methods relating to modified yeast harboring constitutive transcriptional activator MAL alleles. The yeast produces an increased amount of ethanol, or have an increased rate of ethanol production, which does not appear to be the result of maltose metabolism. Such yeast is particularly useful for ethanol production utilizing starch substrates.

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