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1. 发明申请

WO2008156691A1 ANITCOAGULANTS AS ANTIFOULING AGENTS 审中-公开
标题翻译： ANITCOAGULANTS作为防伪剂
公开(公告)号：WO2008156691A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/007433
申请日：2008-06-13
申请人： DUKE UNIVERSITY , RITTSCHOF, Daniel , DICKINSON, Gary, H. , ORIHUELA De Diaz, Beatriz , HOLM, Eric, R.
发明人： RITTSCHOF, Daniel , DICKINSON, Gary, H. , ORIHUELA De Diaz, Beatriz , HOLM, Eric, R.
IPC分类号： C09D5/16
CPC分类号： C09D5/1606
摘要： Methods and compositions are provided for the reduction of fouling of objects present in marine environments. The methods and compositions include anticoagulants, such as, for example, glycosaminoglycans, coumarin- type molecules, metal chelators, plasminogen activators and platelet inhibitors. The methods include reducing marine fouling, comprising incorporating an anticoagulant compound into a marine coating. In addition, the methods include identifying compounds useful for reducing marine fouling, comprising measuring either blood coagulation or barnacle cement polymerization in the presence and absence of the compound, wherein a reduction in the blood coagulation or the barnacle cement polymerization in the presence of the compound identifies the compound as useful for reducing marine fouling. The coagulation or the polymerization can be measured by a serine protease activity or a transglutaminase activity.
摘要翻译：提供的方法和组合物用于减少存在于海洋环境中的物体的结垢。所述方法和组合物包括抗凝血剂，例如糖胺聚糖，香豆素型分子，金属螯合剂，纤溶酶原激活剂和血小板抑制剂。所述方法包括减少海洋污染，包括将抗凝血剂化合物掺入海洋涂料中。此外，所述方法包括鉴定可用于减少海洋结垢的化合物，包括在化合物存在和不存在下测量血液凝固或藤壶水泥聚合，其中在化合物存在下凝血或藤壶水泥聚合的减少鉴定该化合物对减少海洋污染有用。凝血或聚合可以通过丝氨酸蛋白酶活性或转谷氨酰胺酶活性来测量。

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