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1. 发明申请

WO2005092850A1 AMINO ACID AND PEPTIDE CONJUGATES OF ARYLALKYLIC ACIDS FOR COSMETIC USE 审中-公开
标题翻译：用于化妆品使用的亚油酸的氨基酸和肽结合
公开(公告)号：WO2005092850A1
公开(公告)日：2005-10-06
申请号：PCT/EP2005/003116
申请日：2005-03-23
申请人： DSM IP ASSETS B.V. , KLOCK, Jochen , MAILLAN, Philippe Emmanuel , VOLLHARDT, Juergen H. , BEUMER, Raphael
发明人： KLOCK, Jochen , MAILLAN, Philippe Emmanuel , VOLLHARDT, Juergen H. , BEUMER, Raphael
IPC分类号： C07D207/16
CPC分类号： C07D207/16
摘要： The invention provides novel compounds of general formula (I), wherein R 1 , R 2 and R 3 are independently hydrogen, OR 4 , C 1 -C 6 alkyl or C 2 -C 6 alkenyl, R 4 is hydrogen, C 1 -C 6 alkyl or C 2 -C 6 alkenyl, -N-(AA) represents the residue of an amino acid or of a peptide which is bonded over the N-terminus of the amino acid or the peptide and the peptide is composed of 2 to 6, that means 2, 3, 4, 5 or 6, amino acids, wherein the C-terminus of the amino acid or the peptide is optionally esterified with a C 1 -C 16 hydrocarbon moiety and n is an integer of 1 to 5. The compounds are in particular useful for cosmetic applications.
摘要翻译：本发明提供了通式（I）的新化合物，其中R 1，R 2和R 3独立地是氢，OR 4，C 1 -C 6烷基或C 2 -C 6烯基，R 4，是氢，C 1 -C 6烷基或C 2 -C 6烯基，-N-（AA）表示氨基酸的残基或与氨基酸或肽的N末端键合的肽的残基，为2至6个，意味着2,3,4,5或6个氨基酸，其中氨基酸或肽的C末端任选被C 1 -C 16烃部分酯化，n为1至该化合物特别适用于化妆品应用。

2. 发明申请

WO2005092283A1 COMPOSITION COMPRISING AN HDAC INHIBITOR IN COMBINATION WITH A RETINOID 审中-公开
标题翻译：包含HDAC抑制剂与组合物的组合物
公开(公告)号：WO2005092283A1
公开(公告)日：2005-10-06
申请号：PCT/EP2005/003115
申请日：2005-03-23
申请人： DSM IP ASSETS B.V. , SCHEHLMANN, Volker , KLOCK, Jochen , MAILLAN, Philippe, Emmanuel , VOLLHARDT, Juergen, H. , RAWLINGS, Anthony , BEUMER, Raphael
发明人： SCHEHLMANN, Volker , KLOCK, Jochen , MAILLAN, Philippe, Emmanuel , VOLLHARDT, Juergen, H. , RAWLINGS, Anthony , BEUMER, Raphael
IPC分类号： A61K7/48
CPC分类号： A61K8/671 , A61K8/36 , A61K8/361 , A61K8/37 , A61K2800/782 , A61Q7/00 , A61Q19/02 , A61Q19/08
摘要： The present invention is directed to compositions which contain a combination of at least one histone deacetylase inhibitor (HDAC inhibitor) and a retinoid. The composition is in particular a cosmetic preparation. It was found that the combination of an HDAC inhibitor and retinol or a derivative thereof is in particular useful for treating wrinkles but also for thickening the epidermis and for improving hair growth.
摘要翻译：本发明涉及含有至少一种组蛋白脱乙酰酶抑制剂（HDAC抑制剂）和类维生素A的组合的组合物。该组合物特别是化妆品制剂。发现HDAC抑制剂和视黄醇或其衍生物的组合特别可用于治疗皱纹，但也用于增厚表皮和改善毛发生长。

3. 发明申请

WO2006005455A3 AMINO, AMINO ACID OR PEPTIDE CONJUGATES OF RETINOIC ACID 审中-公开
公开(公告)号：WO2006005455A3
公开(公告)日：2006-01-19
申请号：PCT/EP2005/007134
申请日：2005-07-01
申请人： DSM IP ASSETS B.V. , BEUMER, Raphael , KLOCK, Jochen , VOLLHARDT, Juergen, H. , MAILLAN, Philippe, Emmanuel , STÖCKLI, Stefan
发明人： BEUMER, Raphael , KLOCK, Jochen , VOLLHARDT, Juergen, H. , MAILLAN, Philippe, Emmanuel , STÖCKLI, Stefan
IPC分类号： C07C403/20 , A61K7/48 , C07D211/60 , C07D233/54 , C07D213/65
摘要： The invention provides the use of retinoyl derivatives for the cosmetic treatment or prophylaxis of wrinkles, skin aging and/or for thickening the epidermis.

4. 发明申请

WO2004062635A1 COMPOSITIONS FOR SKIN LIGHTENING COMPRISING BIS-PANTOYL-CYSTAMINE 审中-公开
标题翻译：用于皮肤护理的组合物，包含双 - 苯并咪唑
公开(公告)号：WO2004062635A1
公开(公告)日：2004-07-29
申请号：PCT/EP2003/010702
申请日：2003-09-25
申请人： DSM IP ASSETS B.V. , BURDICK, David, Carl , MAILLAN, Philippe, Emmanuel , KLOCK, Jochen , WESTENFELDER, Horst , SCHEHLMANN, Volker , SAECKER, Christine
发明人： BURDICK, David, Carl , MAILLAN, Philippe, Emmanuel , KLOCK, Jochen , WESTENFELDER, Horst , SCHEHLMANN, Volker , SAECKER, Christine
IPC分类号： A61K7/48
CPC分类号： A61Q19/02 , A61K8/46
摘要： The invention relates to topical compositions which comprise bis-pantoyl cystamine or a derivative thereof, and a vehicle conventionally used in topical compositions.
摘要翻译：本发明涉及包含双 - 泛酰基胱胺或其衍生物和常规用于局部组合物的载体的局部组合物。

5. 发明申请

WO2007051596A1 NOVEL RETINYL BIOTINATES AND USE THEREOF 审中-公开
标题翻译：新生儿生物利用及其使用
公开(公告)号：WO2007051596A1
公开(公告)日：2007-05-10
申请号：PCT/EP2006/010478
申请日：2006-10-31
申请人： DSM IP ASSETS B.V. , BEUMER, Raphael , KLOCK, Jochen , MAI, Brigitte , STOECKLI, Stefan, Martin
发明人： BEUMER, Raphael , KLOCK, Jochen , MAI, Brigitte , STOECKLI, Stefan, Martin
IPC分类号： C07D495/04 , A61K31/4188 , A61P17/00
CPC分类号： C07D495/04
摘要： The present invention relates to novel retinyl esters of biotin i.e. retinyl biotinates, particularly all- trans retinyl D-biotinate. In a further aspect, the invention relates to compositions, in particular to topical compositions for cosmetic or pharmaceutical use, containing the novel retinyl biotinates. Furthermore, the invention relates to the use of the retinyl biotinates for lightening human skin.
摘要翻译：本发明涉及生物素，即视黄基生物素，特别是全反式视黄酰基D-生物素的新型视黄酯。在另一方面，本发明涉及组合物，特别是涉及用于化妆品或药物用途的含有新型视黄基生物素的局部组合物。此外，本发明涉及视黄酯生物素用于减轻人体皮肤的用途。

6. 发明申请

WO2007039059A1 NOVEL CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：新型羧酸衍生物
公开(公告)号：WO2007039059A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/008965
申请日：2006-09-14
申请人： DSM IP ASSETS B.V. , BEUMER, Raphael , KLOCK, Jochen , STÖCKLI, Stefan, Martin
发明人： BEUMER, Raphael , KLOCK, Jochen , STÖCKLI, Stefan, Martin
IPC分类号： C07C235/08 , C07C69/612 , C07D213/82 , C07D473/34 , A61K8/37 , A61K8/42 , A61K8/49 , A61Q19/08
CPC分类号： C07D213/82 , A61K8/37 , A61K8/44 , A61K8/4926 , A61K8/4953 , A61Q19/08 , C07C69/612 , C07C235/08 , C07C2601/16 , C07D473/34
摘要： The present invention is concerned with novel arylalkyl carboxylic acid derivatives, more specifically, with acylates of arylalkyl carboxylic acids with naturally occurring, non-toxic hydroxy, sulfhydryl, amino or imino compounds, and to compositions containing them. The compositions are preferably cosmetic preparations.
摘要翻译：本发明涉及新型芳基烷基羧酸衍生物，更具体地涉及芳基烷基羧酸与天然存在的，无毒的羟基，巯基，氨基或亚氨基化合物的酰化物，以及含有它们的组合物。组合物优选为化妆品制剂。

7. 发明申请

WO2006029818A2 NOVEL COSMETIC COMPOSITIONS 审中-公开
标题翻译：新型化妆品组合物
公开(公告)号：WO2006029818A2
公开(公告)日：2006-03-23
申请号：PCT/EP2005/009832
申请日：2005-09-13
申请人： DSM IP ASSETS B.V. , BEUMER, Raphael , KLOCK, Jochen
发明人： BEUMER, Raphael , KLOCK, Jochen
IPC分类号： A61K8/67 , A61K8/42 , A61Q19/00
CPC分类号： A61K8/40 , A61K8/671 , A61Q7/00 , A61Q19/00 , A61Q19/004 , A61Q19/005 , A61Q19/007 , A61Q19/08
摘要： The present invention is directed to cosmetic compositions comprising a compound of the general formula (I) wherein L is hydrogen, branched alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, hydroxyl, OR, HO-(CH 2 -CH 2 -O) n, HO-(CH 2 -O) n , HO-(CH 2 -CH 2 -CH 2 -O) n , HO(CH 2 -CH(CH 3 )-O) n , HO-(CH(CH 3 )-CH 2 -O) n , NR 4 R 5 , C(O)NR 6 R 7 , with R being C 1-4 -alkyl or C 2-18 -alkanoyl; n being an integer from 1 to 8; R 4 , R 5 , R 6 and R 7 being independently from each other hydrogen or C 1-18 -alkyl; R 1 is alkylene, alkenylene or alkinylene, optionally substituted with one or more methyl or ethyl groups; R 2 is hydrogen or alkyl; and R 3 is hydrogen, alkyl, or a cosmetically acceptable cation; and a carrier conventionally used in cosmetic compositions. The compositions preferably comprise additionally a retinoid. The present invention concerns further inter alia the use of such compositions for the treatment or prevention of wrinkles or dry skin or sensitive skin or any symptoms caused by negative developments of the physiological homeostasis of healthy skin, promotion of hair growth, protection from hair loss, a thickening of the epidermis, anti-acne, the inhibition of senescence of skin cells, prevention or treatment of photodamage, prevention or treatment of oxidative stress phenomena, prevention or treatment of cellulite, prevention and treatment of disturbances in ceramide and lipid synthesis, prevention of excess sebum production, reduction of activities of matrix metallo proteases or other proteases in the skin, treatment and prevention of inflammatory skin conditions including atopic eczema, polymorphic light eruption, psoriasis, vertiligo, prevention and treatment of itchy or irritated skin, as well as such treatment and prevention methods themselves.
摘要翻译：本发明涉及包含通式（I）的化合物的化妆品组合物，其中L是氢，支链烷基，芳基，杂芳基，环烷基，杂环烷基，羟基，OR，HO-（CH 2） -CH 2 - （O）n，HO - （CH 2 -O）n，HO-（CH H（CH 2）2 CH 2 CH 2 CH 2 CH 2 CH 3（CH 3 CH 3）-O（CH 2 CH 2 CH 3）-O） > - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - 其中R为C 1-4 - 烷基或C 2-18烷基; n为1至8的整数; R 4，R 5，R 6和R 7彼此独立地为氢或C 1 -C 6烷基， 1-18 - 烷基; R 1是亚烷基，亚烯基或亚炔基，任选被一个或多个甲基或乙基取代; R 2是氢或烷基; R 3是氢，烷基或化妆品可接受的阳离子; 和通常用于化妆品组合物中的载体。组合物优选另外含有类视色素。本发明尤其涉及使用这种组合物来治疗或预防皱纹或干性皮肤或敏感皮肤或由健康皮肤的生理平衡的负面发展引起的任何症状，促进毛发生长，防止脱发，表皮增厚，抗痤疮，皮肤细胞衰老的抑制，预防或治疗光损伤，预防或治疗氧化应激现象，预防或治疗脂肪团，预防和治疗神经酰胺和脂质合成紊乱，预防过量皮脂产生，皮肤中基质金属蛋白酶或其他蛋白酶的活性降低，治疗和预防炎性皮肤病，包括特应性湿疹，多形性光疹，牛皮癣，眩晕，预防和治疗瘙痒或刺激性皮肤，以及这样的治疗和预防方法本身。

8. 发明申请

WO2007121916A2 USE OF OPIOID RECEPTOR ANTAGONISTS 审中-公开
标题翻译：阿片受体拮抗剂的用途
公开(公告)号：WO2007121916A2
公开(公告)日：2007-11-01
申请号：PCT/EP2007/003431
申请日：2007-04-19
申请人： DSM IP ASSETS B.V. , BEUMER, Raphael , KLOCK, Jochen , MASSA, Daniela , MENDROK-EDINGER, Christine , TREMBLEY, Marcella
发明人： BEUMER, Raphael , KLOCK, Jochen , MASSA, Daniela , MENDROK-EDINGER, Christine , TREMBLEY, Marcella
IPC分类号： A61K31/00 , A61K31/485 , A61Q5/00 , A61Q5/10
CPC分类号： A61K8/49 , A61K8/64 , A61K31/00 , A61K31/485 , A61Q5/00 , A61Q5/006 , A61Q5/02 , A61Q5/065 , A61Q5/10 , A61Q5/12 , A61Q7/00
摘要： The present invention relates to a new use of opioid receptor antagonists. More particularly, the present invention relates to the use of opioid receptor antagonists in hair care, particularly for the prevention of the graying of hair and/ or for restoration and/ or maintenance of the natural hair color.
摘要翻译：本发明涉及阿片受体拮抗剂的新用途。更具体地说，本发明涉及阿片受体拮抗剂在头发护理中的用途，特别是用于防止头发变灰和/或恢复和/或维持天然头发颜色。

9. 发明申请

WO2007039058A3 USE OF OPIOID RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007039058A3
公开(公告)日：2007-04-12
申请号：PCT/EP2006/008962
申请日：2006-09-14
申请人： DSM IP ASSETS B.V. , BEUMER, Raphael , KLOCK, Jochen
发明人： BEUMER, Raphael , KLOCK, Jochen
IPC分类号： A61K31/485 , A61K31/045 , A61K31/12 , A61K31/343 , A61K31/05 , A61K45/06 , A61P17/00 , A61K8/49 , A61K8/34 , A61K8/35 , A61Q19/02
摘要： The present invention relates to a new use of opioid receptor antagonists. More particularly, the present invention relates to the use of opioid receptor antagonists for the manufacture of topical compositions for suppression of melanin formation in the human skin; to topical, particularly cosmetic, compositions for suppression of melanin formation in the human skin comprising an opioid receptor antagonist; and to a method of lightening human skin and/or treatment of pigmentation disorders which comprises topically administering an effective amount of an opioid receptor antagonist to the appropriate skin area of a person in need of such treatment.

10. 发明申请

WO2008028636A1 SKIN CARE COMPOSITION 审中-公开
标题翻译：皮肤护理组合物
公开(公告)号：WO2008028636A1
公开(公告)日：2008-03-13
申请号：PCT/EP2007/007724
申请日：2007-09-05
申请人： DSM IP ASSETS B.V. , GORALCZYK, Regina , KLOCK, Jochen , SCHWEIKERT, Loni
发明人： GORALCZYK, Regina , KLOCK, Jochen , SCHWEIKERT, Loni
IPC分类号： A61K8/34 , A61K8/36 , A61K8/37 , A61Q19/08
CPC分类号： A61K8/361 , A61K8/31 , A61K8/347 , A61K8/37 , A61K8/498 , A61K8/67 , A61K8/673 , A61K31/01 , A61K31/05 , A61K31/202 , A61K2800/92 , A61Q19/08
摘要： The present invention relates to an oral composition containing an optimal combination of polyunsaturated fatty acids and polyphenols at high concentrations and at optimal ratios in order to maintain and/or achieve health and/or beautiful look of the skin.
摘要翻译：本发明涉及一种口服组合物，其含有高浓度和最佳比例的多不饱和脂肪酸和多酚的最佳组合，以维持和/或达到皮肤的健康和/或美丽外观。

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