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1. 发明申请

WO2008150741A1 CONTROLLED RELEASE DOPAMINE AGONIST COMPOSITIONS 审中-公开
标题翻译：受控释放多巴胺激动剂组合物
公开(公告)号：WO2008150741A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/064772
申请日：2008-05-23
申请人： DRUGTECH CORPORATION , BORTZ, Jonathan David , GRIMSHAW, Michael , ERKOBONI, David F.
发明人： BORTZ, Jonathan David , GRIMSHAW, Michael , ERKOBONI, David F.
IPC分类号： A61K9/52 , A61K9/22
CPC分类号： A61K31/428 , A61K9/2077 , A61K9/209 , A61K9/5084
摘要： The present invention relates to a multiphase release oral pharmaceutical formulation having a dopamine agonist as an active ingredient. The multiphase composition comprises at least two different release components. The invention relates to controlled release pharmaceutical compositions of pramipexole or a pharmaceutically acceptable salt thereof for once-daily administration.
摘要翻译：本发明涉及具有多巴胺激动剂作为活性成分的多相释放口服药物制剂。多相组合物包含至少两种不同的释放组分。本发明涉及普拉克索的控释药物组合物或其药学上可接受的盐，用于每日一次给药。

2. 发明申请

WO2009032699A1 ANTI-PROLIFERATIVE COMBINATIONS 审中-公开
标题翻译：抗增生组合
公开(公告)号：WO2009032699A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/074479
申请日：2008-08-27
申请人： DRUGTECH CORPORATION , BORTZ, Jonathan David
发明人： BORTZ, Jonathan David
IPC分类号： A01N41/10 , A61K31/10
CPC分类号： A61K45/06 , A61K31/10 , A61K31/20 , A61K31/202 , A61K2300/00
摘要： Combinations of a polyunsaturated fatty acid and diindolylmethane and pharmaceutical composition containing such combinations. Further provided are combinations including a polyunsaturated fatty acid, diindolylmethane, and folic acid. Also provided are combinations including diindolylmethane and folic acid. Also provided is a method for increasing the number of normal cells and decreasing the number of aberrant cells in a subject having the steps of administering to the subject a combination comprising a polyunsaturated fatty acid and diindolylmethane.
摘要翻译：多不饱和脂肪酸和二吲哚基甲烷的组合以及含有这些组合的药物组合物。还提供了包括多不饱和脂肪酸，二吲哚基甲烷和叶酸的组合。还提供了包括二吲哚基甲烷和叶酸的组合。还提供了一种增加正常细胞数量并减少受试者中异常细胞数量的方法，其具有向受试者施用包含多不饱和脂肪酸和二吲哚基甲烷的组合的步骤。

3. 发明申请

WO2008144143A1 ENDOMETRIOSIS TREATMENT 审中-公开
标题翻译：内分泌治疗
公开(公告)号：WO2008144143A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/060869
申请日：2008-04-18
申请人： DRUGTECH CORPORATION , THOMPSON, Daniel J. , CUCA, Robert C. , RILEY, Thomas C., Jr. , BORTZ, Jonathan David
发明人： THOMPSON, Daniel J. , CUCA, Robert C. , RILEY, Thomas C., Jr. , BORTZ, Jonathan David
IPC分类号： A61K31/58 , A61F6/06
CPC分类号： A61K9/0034 , A61K9/06 , A61K31/58
摘要： A pharmaceutical composition comprises at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to a vaginal mocosal surface, and comprises danazol in an amount of about 3% to about 30% by weight of the composition, wherein upon application of the composition to the vaginal mucosal surface the danazol is released over a period of about 1 to about 10 days. The composition is useful for intravaginal administration to treat a condition such as endometriosis for which danazol is indicated.
摘要翻译：药物组合物包含至少一个非脂质内相和至少一种与阴道乳糖表面生物粘附的脂质外部相，并且包含按组合物重量计约3％至约30％的量的达那唑，其中应用组合物对阴道粘膜表面达那唑在约1至约10天的时间内释放。组合物可用于阴道内给药以治疗诸如表达达那唑的子宫内膜异位症的病症。

4. 发明申请

WO2008112388A1 SPATIAL ARRANGEMENT OF PARTICLES IN A DRINKING DEVICE FOR ORAL DELIVERY OF PHARMACEUTICALS 审中-公开
标题翻译：用于口服药物输送的饮料装置中的颗粒的空间布置
公开(公告)号：WO2008112388A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/054218
申请日：2008-02-18
申请人： DRUGTECH CORPORATION , LAGOVIYER, Yury , BRADY, Paul Timothy , BORTZ, Jonathan David
发明人： LAGOVIYER, Yury , BRADY, Paul Timothy , BORTZ, Jonathan David
IPC分类号： A61K9/24
CPC分类号： A61K9/50 , A61K9/0095
摘要： The present invention relates to spatially arranging a plurality of particles in a device for the oral delivery of a pharmaceutical. In particular, the plurality of particles is utilized for the oral delivery of a pharmaceutical to a subject via the drinking device.
摘要翻译：本发明涉及在用于口服给药的装置中空间布置多个颗粒。特别地，多个颗粒用于通过饮用装置将药物口服递送给受试者。

5. 发明申请

WO2008100767A1 COMPOSITIONS FOR IMPROVING GASTROINTESTINAL NUTRIENT AND DRUG ABSORPTION 审中-公开
标题翻译：改善胃肠营养和药物吸收的组合物
公开(公告)号：WO2008100767A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/053274
申请日：2008-02-07
申请人： DRUGTECH CORPORATION , HERMELIN, Marc S. , BORTZ, Jonathan David , LEVINSON, R. Saul
发明人： HERMELIN, Marc S. , BORTZ, Jonathan David , LEVINSON, R. Saul
IPC分类号： A61K9/22
CPC分类号： A61K45/06 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/56 , A61K33/06 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61K33/42 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions and methods for improving the absorption of nutrients and/or drugs in the gastrointestinal tract of a subject. Typically, the pharmaceutical compositions comprise a first agent that increases the pH of the stomach, and one or more agents selected from a pH lowering agent, a vitamin, a mineral, and a drug.
摘要翻译：本发明提供用于改善受试者胃肠道中营养物质和/或药物吸收的药物组合物和方法。通常，药物组合物包含增加胃的pH的第一药剂和选自pH降低剂，维生素，矿物质和药物的一种或多种药物。

6. 发明申请

WO2008079868A1 CLONIDINE COMPOSITION AND METHOD OF USE 审中-公开
标题翻译：螯合物组合物及其使用方法
公开(公告)号：WO2008079868A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/088113
申请日：2007-12-19
申请人： DRUGTECH CORPORATION , BORTZ, Jonathan David
发明人： BORTZ, Jonathan David
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K31/415 , A61K9/209 , A61K9/5084
摘要： A pharmaceutical composition comprises clonidine or a pharmaceutically acceptable salt or prodrug thereof. The composition, when administered to a patient in an amount delivering a clonidine dose of about 0.1 to about 2 mg/day, exhibits clonidine release properties providing a 24-hour profile of plasma clonidine concentration that (a) does not substantially or protractedly fall below about 0.2 ng/ml and exhibits a peak concentration that is therapeutically effective and does not cause unacceptable side effects in the patient; and/or (b) exhibits a peak that substantially coincides with or closely anticipates a time of maximum plasma concentration of a catecholamine occurring in a diurnal cycle of a patient having a catecholamine-mediated disease or disorder. A method for treating a disease or disorder for which clonidine is indicated in a patient comprises administering such a composition one to three times daily in a dose of about 0.1 to about 2 mg/day to patient.
摘要翻译：药物组合物包含可乐定或其药学上可接受的盐或前药。该组合物以递送约0.1至约2mg /天的可乐定剂量的量施用于患者时，显示可乐定释放性质，其提供等离子可乐定浓度的24小时曲线，（a）基本上或长期地不低于约0.2ng / ml，并且表现出治疗有效的峰值浓度，并且不会在患者中引起不可接受的副作用; 和/或（b）表现出与儿茶酚胺介导的疾病或病症的患者的昼夜循环中发生的儿茶酚胺的最大血浆浓度基本一致或严密地预期的峰值。用于治疗可乐定在患者中指示的疾病或病症的方法包括以约0.1至约2mg /天的剂量每天向患者施用该组合物一至三次。

7. 发明申请

WO2008073779A2 COMPOSITIONS AND METHODS FOR TREATING SEIZURES 审中-公开
标题翻译：组合物和治疗方法
公开(公告)号：WO2008073779A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/086502
申请日：2007-12-05
申请人： DRUGTECH CORPORATION , BORTZ, Jonathan David , LEVINSON, R. Saul , WANG, Jeremy Donald , GE, Jisheng
发明人： BORTZ, Jonathan David , LEVINSON, R. Saul , WANG, Jeremy Donald , GE, Jisheng
IPC分类号： A61K31/4164 , A61K31/505 , A61K31/5513 , A61K9/00 , A61P25/08
CPC分类号： A61K31/4164 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K31/505 , A61K31/5513 , A61K47/10 , A61K47/36 , A61K47/38
摘要： This invention relates generally to pharmaceutical compositions for treating seizures, and, more particularly, to pharmaceutical compositions that are bioadherent to oral and/or nasal mucosa, comprise one or more anti-acute seizure agents, and can be used to treat one or more conditions selected from the group consisting of acute seizure, repetitive seizures, and status epilepticus. This invention also relates generally to methods for preparing such compositions, methods of treatment using such compositions, uses of such compositions to prepare medicaments, and kits comprising such compositions.
摘要翻译：本发明一般涉及用于治疗癫痫发作的药物组合物，更具体地说，涉及对口腔和/或鼻粘膜生物粘附的药物组合物，包含一种或多种抗急性发作剂，并且可用于治疗一种或多种病症选自急性发作，重复性癫痫发作和癫痫持续状态组。本发明一般还涉及制备这种组合物的方法，使用这种组合物的治疗方法，这种组合物的用途来制备药物，以及包含这些组合物的试剂盒。

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