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1. 发明申请

WO2008058121A2 SOL-GEL PRECURSORS AND METHODS FOR MAKING LEAD-BASED PEROVSKITE FILMS 审中-公开
标题翻译： SOL-凝胶前体和制备基于铅的钙钛矿薄膜的方法
公开(公告)号：WO2008058121A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/083767
申请日：2007-11-06
申请人： DREXEL UNIVERSITY , SHIH, Wei-heng , SHIH, Wan, Y. , SHEN, Zuyan , LI, Huidong , GAO, Xiaotong
发明人： SHIH, Wei-heng , SHIH, Wan, Y. , SHEN, Zuyan , LI, Huidong , GAO, Xiaotong
IPC分类号： C04B41/45 , C04B41/50
CPC分类号： H01L41/318 , H01L41/094 , H01L41/0973 , H01L41/1875
摘要： A simple, economical sol-gel method was invented to produce thick and dense lead zirconate titanate (PZT) thin films that exhibit the stoichiometric chemical composition and unprecedented electrical and dielectric properties. The PZT films are the foundation of many microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS) for micro/nano sensors and actuators applications.
摘要翻译：发明了一种简单经济的溶胶 - 凝胶方法来生产厚而致密的锆钛酸铅（PZT）薄膜，其具有化学计量的化学组成和前所未有的电和介电性能。 PZT薄膜是许多用于微/纳米传感器和执行器应用的微机电系统（MEMS）和纳机电系统（NEMS）的基础。

2. 发明申请

WO2008067386A2 PIEZOELECTRIC MICROCANTILEVER SENSORS FOR BIOSENSING 审中-公开
标题翻译：用于生物传感的压电微型传感器
公开(公告)号：WO2008067386A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/085771
申请日：2007-11-28
申请人： DREXEL UNIVERSITY , SHIH, Wan, Y. , SHIH, Wei-heng , SHEN, Zuyan , MCGOVERN, John-Paul , ZHU, Qing , CAPOBIANCO, Joseph
发明人： SHIH, Wan, Y. , SHIH, Wei-heng , SHEN, Zuyan , MCGOVERN, John-Paul , ZHU, Qing , CAPOBIANCO, Joseph
IPC分类号： G01N5/02 , B81B3/00
CPC分类号： G01N29/022 , B82Y5/00 , B82Y35/00 , G01N29/036 , G01N29/245 , G01N33/54306 , G01N33/57415 , G01N2291/0255 , G01N2291/0256 , G01N2291/0257 , G01N2291/0427
摘要： A piezoelectric microcantilever for sensing compounds or molecules. The piezoelectric microcantilever, may include at least one electrode, an insulation layer, a receptor, an immobilization layer, a non-piezoelectric layer and a piezoelectric layer The sensor is capable of self actuation and detection. The piezoelectric layer may be constructed from a highly piezoelectric thin lead magnesium niobate-lead titanate film, a highly piezoelectric thin zirconate titanate film, a highly piezoelectric lead-free film. Methods of using the sensors and flow cells and arrays including the sensors are also described.
摘要翻译：用于感测化合物或分子的压电微悬臂梁。压电微悬臂梁可以包括至少一个电极，绝缘层，接收器，固定层，非压电层和压电层。传感器能够自我启动和检测。压电层可以由高压电薄铌酸铅铅钛酸铅膜，高压电性薄锆钛酸盐膜，高压电无铅膜构成。还描述了使用传感器和流动池和包括传感器的阵列的方法。

3. 发明申请

WO2005043126A2 PIEZOELECTRIC CANTILEVER SENSORS 审中-公开
标题翻译：压电式CANTILEVER传感器
公开(公告)号：WO2005043126A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036705
申请日：2004-10-27
申请人： DREXEL UNIVERSITY , SHIH, Wan, Y. , SHIH, Wei-Heng , SHEN, Zuyan
发明人： SHIH, Wan, Y. , SHIH, Wei-Heng , SHEN, Zuyan
IPC分类号： G01N
CPC分类号： G01N29/022 , G01N5/02 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0422 , G01N2291/0426 , G01N2291/0427
摘要： A piezoelectric cantilever with a non-piezoelectric, or piezoelectric tip useful as mass and viscosity sensors. The change in the cantilever mass can be accurately quantified by monitoring a resonance frequency shift of the cantilever. For bio-detection, antibodies or other specific receptors of target antigens may be immobilized on the cantilever surface, preferably on the non-piezoelectric tip. For chemical detection, high surface-area selective absorbent materials are coated on the cantilever tip. Binding of the target antigens or analytes to the cantilever surface increases the cantilever mass. Detection of target antigens or analytes is achieved by monitoring the cantilever's resonance frequency and determining the resonance frequency shift that is due to the mass of the adsorbed target antigens on the cantilever surface. The use of a piezoelectric unimorph cantilever allows both electrical actuation and electrical sensing. Incorporating a non-piezoelectric tip enhances the sensitivity of the sensor. In addition, the piezoelectric cantilever can withstand damping in highly viscous liquids and can be used as a viscosity sensor in wide viscosity range.
摘要翻译：具有非压电或压电尖端的压电悬臂，可用作质量和粘度传感器。通过监测悬臂的共振频率偏移可以准确量化悬臂质量的变化。为了生物检测，靶抗原的抗体或其他特异性受体可以固定在悬臂表面上，优选地固定在非压电尖端上。对于化学检测，高表面积选择性吸收材料涂覆在悬臂尖端。目标抗原或分析物与悬臂表面的结合增加了悬臂质量。通过监测悬臂的共振频率并确定由于悬臂表面上吸附的靶抗原的质量而引起的共振频移，实现了靶抗原或分析物的检测。使用压电单块悬臂可以实现电致动和电感测。结合非压电尖端增强了传感器的灵敏度。此外，压电悬臂可以承受高粘度液体中的阻尼，可用作宽粘度范围内的粘度传感器。

4. 发明申请

WO2009079154A2 LEAD-FREE PIEZOELECTRIC CERAMIC FILMS AND A METHOD FOR MAKING THEREOF 审中-公开
标题翻译：无铅压电陶瓷薄膜及其制造方法
公开(公告)号：WO2009079154A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/084190
申请日：2008-11-20
申请人： DREXEL UNIVERSITY , SHIH, Wei-heng , SHIH, Wan, Y. , LI, Huidong
发明人： SHIH, Wei-heng , SHIH, Wan, Y. , LI, Huidong
IPC分类号： H01L41/187
CPC分类号： G01N27/12 , H01L41/1873 , H01L41/314 , H01L41/43
摘要： This invention relates to lead-free piezoelectric ceramic films and a method of making thereof. Specifically, the invention is directed to a method for fabricating lead-free piezoelectric free standing films having enhanced piezoelectric properties. The films may be used for a number of applications including incorporation in microelectronic devices such as energy harvesting devices and sesor technologies.
摘要翻译：本发明涉及无铅压电陶瓷膜及其制造方法。具体地，本发明涉及一种制造具有增强的压电性能的无铅压电自立式膜的方法。这些膜可以用于许多应用，包括并入微电子器件，例如能量收集装置和芝麻技术。

5. 发明申请

WO2009140660A2 SYSTEM AND METHOD FOR EVALUATING TISSUE 审中-公开
标题翻译：用于评估组织的系统和方法
公开(公告)号：WO2009140660A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/044250
申请日：2009-05-15
申请人： DREXEL UNIVERSITY , PHILADELPHIA HEALTH & EDUCATION CORPORATION d/b/a DREXEL UNIVERSITY COLLEGE OF MEDICINE , SHIH, Wan, Y. , SHIH, Wei-Heng , YEGINGIL, Hakki , BROOKS, Ari, D.
发明人： SHIH, Wan, Y. , SHIH, Wei-Heng , YEGINGIL, Hakki , BROOKS, Ari, D.
IPC分类号： G01N33/483 , C12Q1/02
CPC分类号： A61B5/0053 , A61B5/4244 , A61B5/4312 , A61B5/4381 , A61B5/441 , A61B5/442 , A61B8/085 , A61B8/403 , A61B8/485 , G01N29/0672 , G01N2291/02475 , G01N2291/02827
摘要： A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.
摘要翻译：用于测量弹性模量和剪切模量的传感器系统和用于评估组织的方法。本发明涉及使用压电手指传感器（PEFS）系统确定异常生长的存在和/或表征异常生长的方法。 PEFS系统可能特别适用于筛选肿瘤和各种形式的癌症。此外，PEFS系统可用于各种皮肤病学应用。

6. 发明申请

WO2009126378A2 ENHANCED DETECTION SENSITIVITY WITH PIEZOELECTRIC MICROCANTILEVER SENSORS 审中-公开
标题翻译：用压电微机械传感器提高检测灵敏度
公开(公告)号：WO2009126378A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/036048
申请日：2009-03-04
申请人： DREXEL UNIVERSITY , SHIH, Wan, Y. , SHIH, Wei-Heng , ZHU, Qing
发明人： SHIH, Wan, Y. , SHIH, Wei-Heng , ZHU, Qing
IPC分类号： B81B3/00
CPC分类号： G01N29/2437 , G01N29/036 , G01N33/54373 , G01N2291/0257
摘要： A method for enhancing the detection sensitivity of a piezoelectric microcantilever sensor. The method may involve providing a piezoelectric microcantilever and inducing a change in the Young's modulus during detection of a species of interest. The change in the Young's modulus may be induced or enhanced by the application of a DC bias electric field to the piezoelectric layer that enhances non-180° polarization domain switching of the piezoelectric layer. The change in the Young's modulus may also result from binding of the species of interest to the piezelectric microcantilever sensor or a combination of binding and application of a DC bias electric field. Significantly enhanced detection sensitity results from the changed Young's modulus of the piezoelectric layer.
摘要翻译：一种用于提高压电微悬臂梁传感器的检测灵敏度的方法。该方法可以包括提供压电微悬臂梁并且在检测感兴趣的物质期间引起杨氏模量的变化。杨氏模量的变化可以通过向压电层施加直流偏置电场来引起或增强，所述电场提高非180°，压电层的极化域切换。杨氏模量的变化也可能是由感兴趣的物质与分压电微悬臂梁传感器的结合或者直流偏置电场的结合和施加的组合引起的。压电层的杨氏模量发生变化，检测灵敏度显着提高。

7. 发明申请

WO2008006060A1 ELECTRICAL INSULATION OF DEVICES WITH THIN LAYERS 审中-公开
标题翻译：具有薄层的器件的电绝缘
公开(公告)号：WO2008006060A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/072940
申请日：2007-07-06
申请人： DREXEL UNIVERSITY , SHIH, Wan, Y. , SHIH, Wei-Heng , CAPOBIANCO, Joseph
发明人： SHIH, Wan, Y. , SHIH, Wei-Heng , CAPOBIANCO, Joseph
IPC分类号： C12Q1/68 , G01N33/543 , H01L21/31
CPC分类号： G01N33/553 , G01N33/54353 , Y10T428/26 , Y10T428/265 , Y10T428/31663 , Y10T428/31678
摘要： A novel, economical electrical insulation method for the production of ultra-thin insulation layers using a solution coating method. Thin hydrophobic self-assembled bi- functional layers of less than 10 nm thick were deposited by a simple solution method and demonstrated to electrically insulate micro-/nano-devices for in-water detection applications. The insulation layer includes a hydrophobic group which repels water and permits superb insulation properties of the ultra-thin layers. The insulation layer has the additional advantages that it binds to a metal or metal oxide surface and to sensing receptors by covalent bonding using standard silane chemistry.
摘要翻译：一种新颖，经济的电绝缘方法，用于使用溶液涂布法生产超薄绝缘层。通过简单的溶液方法沉积小于10nm厚的疏水性自组装双功能层，并证明将微/纳米器件电绝缘在水中检测应用。绝缘层包括排斥水的疏水基团，并且允许超薄层的绝佳绝缘性能。绝缘层具有附加的优点，即它与金属或金属氧化物表面结合，并通过使用标准硅烷化学的共价键来感测受体。

8. 发明申请

WO2015105827A1 DEPTH MEASUREMENT IN TISSUE USING PIEZOELECTRIC SENSORS HAVING DIFFERENT PROBE SIZES 审中-公开
标题翻译：使用具有不同探头尺寸的压电传感器进行组织深度测量
公开(公告)号：WO2015105827A1
公开(公告)日：2015-07-16
申请号：PCT/US2015/010412
申请日：2015-01-07
申请人： DREXEL UNIVERSITY , SHIH, Wan, Y. , SHIH, Wei-Heng , XU, Xin
发明人： SHIH, Wan, Y. , SHIH, Wei-Heng , XU, Xin
IPC分类号： A61B5/06 , A61B5/103 , A61B19/00
CPC分类号： A61B5/444 , A61B5/1075 , A61B2562/0247
摘要： An apparatus and method for determining the depth of an object below a surface or the thickness of the dermis. The apparatus and method use a plurality of piezoelectric fingers having probes with differently sized contact areas. A plurality of measurements is taken using each of the probes with differently sized contact areas in order to determine the depth of an object below a surface or the thickness of the dermis.
摘要翻译：用于确定物体在表面下方的深度或真皮厚度的装置和方法。该装置和方法使用具有不同尺寸的接触区域的探针的多个压电指状物。使用具有不同尺寸的接触区域的每个探针进行多个测量，以便确定物体在表面下方的深度或真皮的厚度。

9. 发明申请

WO2008121429A2 ENERGY HARVESTING DEVICE 审中-公开
标题翻译：能量采集设备
公开(公告)号：WO2008121429A2
公开(公告)日：2008-10-09
申请号：PCT/US2008/052292
申请日：2008-01-29
申请人： DREXEL UNIVERSITY , SHIH, Wei-heng , SHIH, Wan, Y. , YEGINGIL, Hakki
发明人： SHIH, Wei-heng , SHIH, Wan, Y. , YEGINGIL, Hakki
CPC分类号： H01L41/1136 , H01L41/1875 , H02N2/188
摘要： A piezoelectric energy harvesting device (PEHD) comprising a driving element, conducting element, piezoelectric layer and non-piezoelectric layer capable of converting ambient mechanical energy into electrical energy. The piezoelectric layer may be constructed from PMN-PT or PZT having a thickness of about 1-150 ?m. The PEHD may be used to generate about 1 W. The harvested energy may be stored and used to power microelectronic devices and rechargeable battery technologies.
摘要翻译：一种压电能量收集装置（PEHD），包括能够将环境机械能转换为电能的驱动元件，导电元件，压电层和非压电层。压电层可以由具有约1-150μm的厚度的PMN-PT或PZT构成。 PEHD可用于产生约1W。收获的能量可以被存储并用于为微电子器件和可充电电池技术供电。

10. 发明申请

WO2013066408A2 CLEAR MARGIN DETERMINATION DURING CANCER SURGERY 审中-公开
标题翻译：癌症手术过程中清除边缘的确定
公开(公告)号：WO2013066408A2
公开(公告)日：2013-05-10
申请号：PCT/US2012/039532
申请日：2012-05-25
申请人： DREXEL UNIVERSITY , PHILADELPHIA HEALTH & EDUCATION CORPORATION , SHIH, Wei-Heng , SHIH, Wan, Y. , AU, Giang , BROOKS, Ari, D. , SWAMI, Vanlila, K.
发明人： SHIH, Wei-Heng , SHIH, Wan, Y. , AU, Giang , BROOKS, Ari, D. , SWAMI, Vanlila, K.
CPC分类号： G01N33/57488 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C07K16/22 , C07K16/30 , G01N33/532 , G01N33/533 , G01N33/574 , G01N33/57484 , G01N33/57492 , G01N33/588 , G01N2333/475 , G01N2333/705 , G01N2400/00 , G01N2458/00 , Y10S977/774 , Y10S977/824 , Y10S977/892 , Y10S977/927
摘要： One or more aqueous, near infrared emitting, high yield, highly photoluminescent, stable quantum dots conjugated to one or more biomarkers specific moieties. The conjugated quantum dots have an enhanced detection sensitivity and selectivity and may be formed using a novel and efficient method for conjugating one or more biomarker specific moieties to the quantum dots. The invention is further directed to a method for using the conjugated quantum dots for cancer detection in the margin of excised tissue.
摘要翻译：一种或多种与一种或多种生物标志物特异性部分缀合的水性，近红外发射，高产量，高度光致发光的稳定量子点。共轭量子点具有增强的检测灵敏度和选择性，并且可以使用用于将一个或多个生物标志物特异性部分缀合到量子点的新颖且有效的方法形成。本发明还涉及一种使用共轭量子点在切除组织边缘进行癌症检测的方法。

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