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1. 发明申请

WO2014200211A1 LIQUID PHARMACEUTICAL COMPOSITION CONTAINING PIROXICAM AND HYALURONIC ACID FOR THE TREATMENT OF OSTEOARTHRITIS 审中-公开
标题翻译：含有PIROXICAM和HYALURONIC酸的液体药物组合物用于治疗OSTEOARTHRITIS
公开(公告)号：WO2014200211A1
公开(公告)日：2014-12-18
申请号：PCT/KR2014/004745
申请日：2014-05-27
申请人： DONG-A ST CO., LTD
发明人： KIM, Soon-Hoe , SON, Mi-Won , JANG, Sun-Woo , PARK, Chan-Woong , MA, Kyung-Wan , JUNG, Sang-Won
IPC分类号： A61K31/54 , A61K31/728 , A61P19/02 , A61P19/00
CPC分类号： A61K31/728 , A61K9/0019 , A61K31/5415 , A61K47/02 , A61K2300/00
摘要： The present invention relates to the pharmaceutical composition for the treatment of osteoarthritis comprising piroxicam or pharmaceutically acceptable salt thereof and hyaluronic acid or pharmaceutically acceptable salt thereof at a specific ratio that generates synergistic effect on both anti-inflammatory and analgesic effects simultaneously. The present invention provides a pharmaceutical composition for the treatment of osteoarthritis comprising 0.25-10.0 wt% of piroxicam or its pharmaceutically acceptable salt and 0.5-5.0 wt% of hyaluronic acid or its pharmaceutically acceptable salt, where the weight ratio between piroxicam or its pharmaceutically acceptable salt and hyaluronic acid or its pharmaceutically acceptable salt is between 1:1 and 1:3. The liquid pharmaceutical composition according to the present invention has an outstanding therapeutic effect simultaneously on both inflammation and pain, thus providing an injectable formulation for intra-articular injection with synergistic effect on the treatment of osteoarthritis.
摘要翻译：本发明涉及用于治疗骨关节炎的药物组合物，其包含吡罗昔康或其药学上可接受的盐和透明质酸或其药学上可接受的盐，其特定比例同时产生对抗炎和镇痛作用的协同作用。本发明提供了用于治疗骨关节炎的药物组合物，其包含0.25-10.0重量％的吡罗昔康或其药学上可接受的盐和0.5-5.0重量％的透明质酸或其药学上可接受的盐，其中，炎痛喜酸或其药学上可接受的盐的重量比盐和透明质酸或其药学上可接受的盐在1:1至1:3之间。根据本发明的液体药物组合物在炎症和疼痛方面同时具有突出的治疗效果，因此提供关节内注射的可注射制剂，对治疗骨关节炎具有协同作用。

2. 发明申请

WO2014084568A1 TOPICAL GEL COMPOSITION CONTAINING DEXIBUPROFEN EMULSION WITH ENHANCED PERMEABILITY 审中-公开
标题翻译：含有DEXIBUPROFEN乳液的局部凝胶组合物具有增强渗透性
公开(公告)号：WO2014084568A1
公开(公告)日：2014-06-05
申请号：PCT/KR2013/010786
申请日：2013-11-26
申请人： DONG-A ST CO.,LTD
发明人： KIM, Soon-Hoe , SON, Mi-Won , JANG, Sun-Woo , JIN, Sung-Giu , DO, Eui-Seon , HAN, Sang-Dug , PARK, Chan-Woong , KANG, Myung-Joo
IPC分类号： A61K31/192 , A61K9/06 , A61K47/30
CPC分类号： A61K47/10 , A61K9/0014 , A61K9/06 , A61K31/192 , A61K47/14 , A61K47/26 , A61K47/32
摘要： The present invention provides an emulsion gel composition of dexibuprofen, with clear pharmacological activity without needing to be metabolized or otherwise processed, wherein the dexibuprofen is finely dispersed in the gel carrier while dissolved in the emulsion and cosolvent. The present invention provides a fine gel formulation of dexibuprofen, a poorly water-soluble drug, enabling enhanced skin absorption of dexibuprofen and reduced content of alcoholic solvent and thus minimizing skin irritation. Moreover, the fine droplets allow for a pleasant feeling when applied to the skin.
摘要翻译：本发明提供了一种具有明显的药理活性而不需要代谢或以其它方式加工的右旋布洛芬的乳液凝胶组合物，其中，当溶解在乳液和助溶剂中时，将解联苯丙酮细分散在凝胶载体中。本发明提供了一种精细的凝胶配方，即一种难溶于水的药物dexibuprofen，能够增强皮肤吸收去甲苯磺酸和降低酒精溶剂含量，从而最大限度地减少皮肤刺激。此外，细小的液滴允许在施用于皮肤时具有愉快的感觉。

3. 发明申请

WO2013133647A1 STABLE LIQUID PHARMACEUTICAL COMPOSITION CONTAINING PIROXICAM OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND HYALURONIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND THE MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：含有吡罗昔康或其药学上可接受的盐和羟丙酸或其药学上可接受的盐的稳定的液体药物组合物及其制备方法
公开(公告)号：WO2013133647A1
公开(公告)日：2013-09-12
申请号：PCT/KR2013/001856
申请日：2013-03-07
申请人： DONG-A ST CO., LTD.
发明人： KIM, Soon-Hoe , SON, Mi-Won , JANG, Sun-Woo , KANG, Myung-Joo , MA, Kyung-Wan
IPC分类号： A61K31/54 , A61K31/728 , A61P29/00 , A61P25/00
CPC分类号： A61K47/40 , A61K9/0019 , A61K31/5415 , A61K31/728 , A61K47/10 , A61K2300/00
摘要： The present invention relates to a novel liquid composition comprised of piroxicam or its pharmaceutically acceptable salt (a non-steroid anti-inflammatory drug) and hyaluronic acid or its pharmaceutically acceptable salt (used for treatment of degenerative arthritis). Specifically, the invention provides a highly physicochemically stable liquid injection, comprising piroxicam and hyaluronic acid as active ingredients and β-cyclodextrin or its derivative and polyethylene glycol as additives to enhance its physicochemical stability, and the preparation method thereof. Therefore, the novel composition and the formulation method thereof provided by the present invention may be used to produce a liquid injection composition of piroxicam and hyaluronic acid.
摘要翻译：本发明涉及由吡罗昔康或其药学上可接受的盐（非类固醇抗炎药）和透明质酸或其药学上可接受的盐（用于治疗退行性关节炎）组成的新型液体组合物。具体地说，本发明提供高度物理化学稳定的液体注射剂，其包含作为活性成分的吡罗昔康和透明质酸，以及β-环糊精或其衍生物和聚乙二醇作为添加剂，以增强其物理化学稳定性及其制备方法。因此，本发明提供的新型组合物及其制备方法可用于制备吡罗昔康和透明质酸的液体注射组合物。

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