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1. 发明申请

WO2009084827A2 SYNTHETIC INTERMEDIATES, PROCESS FOR PREPARING PYRROLYLHEPTANOIC ACID DERIVATIVES THEREFROM 审中-公开
标题翻译：合成中间体，由此制备吡咯烷基庚酸衍生物的方法
公开(公告)号：WO2009084827A2
公开(公告)日：2009-07-09
申请号：PCT/KR2008/007350
申请日：2008-12-12
申请人： DONG-A PHARM.CO., LTD. , KIM, Moon-Sung , YOO, Moo-Hi , RHEE, Jae-Keol , KIM, Yong-Jik , PARK, Seong-Jin , CHOI, Jun-Ho , SUNG, Si-Young , LIM, Hong-Gyu , CHA, Dae-Won
发明人： KIM, Moon-Sung , YOO, Moo-Hi , RHEE, Jae-Keol , KIM, Yong-Jik , PARK, Seong-Jin , CHOI, Jun-Ho , SUNG, Si-Young , LIM, Hong-Gyu , CHA, Dae-Won
IPC分类号： C07D207/34
CPC分类号： C07D207/416
摘要： There are provided intermediates used to prepare a derivative, (3R,5R)-7-[2-(4-fluorphenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-lH-pyrrol-l-yl]-3,5-di hydroxyheptanoic acid, which has an effect to suppress cholesterol in blood, and a process for preparing pyrrolylheptanoic acid derivatives therefrom. In accordance with the present invention, the 5-(4-fluorphenyl)-2-isopropyl-4-phenyl-lH-pyrrole-3-carbonyl derivative is provided as one of the novel synthetic intermediates that are used to prepare pyrrolylheptanoic acid derivatives including a derivative, (3R,5R)-7-[2-(4-fluorphenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-lH-pyrrol-l-yl]-3,5-di hydroxyheptanoic acid. Therefore, the (3R,5R)-7-[2-(4-fluorphenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-lH-pyrrol-l-yl]-3,5-di hydroxyheptanoic acid derivative may be prepared from the carbonyl derivative in a high yield for a short time period under a moderate condition.
摘要翻译：提供用于制备衍生物的中间体，（3R，5R）-7- [2-（4-氟苯基）-5-异丙基-3-苯基-4-（苯基氨基甲酰基）-1H - 吡咯-1-基] -3,5-二羟基庚酸，其具有抑制血液中胆固醇的作用，以及由其制备吡咯基庚酸衍生物的方法。根据本发明，提供5-（4-氟苯基）-2-异丙基-4-苯基-1H-吡咯-3-羰基衍生物作为用于制备吡咯基庚酸衍生物的新型合成中间体之一，包括（3R，5R）-7- [2-（4-氟苯基）-5-异丙基-3-苯基-4-（苯基氨基甲酰基）-1H-吡咯-1-基] -3,5-二羟基庚酸的衍生物。因此，（3R，5R）-7- [2-（4-氟苯基）-5-异丙基-3-苯基-4-（苯基氨基甲酰基）-1H-吡咯-1-基] -3,5-二羟基庚酸衍生物可以在中等条件下由羰基衍生物以高产率短时间制备。

2. 发明申请

WO2007069838A1 A MANUFACTURING PROCESS OF 2',2'-DIFLUORONUCLEOSIDE AND INTERMEDIATE 审中-公开
标题翻译： 2'，2'-二氟硼烷和中间体的制造方法
公开(公告)号：WO2007069838A1
公开(公告)日：2007-06-21
申请号：PCT/KR2006/005372
申请日：2006-12-11
申请人： DONG-A PHARM.CO., LTD. , KIM, Moon-Sung , KIM, Yong-Jik , CHOI, Jun-Ho , LIM, Hong-Gyu , CHA, Dae-Won
发明人： KIM, Moon-Sung , KIM, Yong-Jik , CHOI, Jun-Ho , LIM, Hong-Gyu , CHA, Dae-Won
IPC分类号： C07D307/32
CPC分类号： C07D307/33 , C07D307/20 , C07D405/04 , C07H19/06 , Y02P20/55
摘要： The present invention relates to more improved process for preparing 2'-deoxy-2',2'-difluoronucleoside and its intermediate. The present invention provide a process for preparing an erythro enantiomer in greater than 98% purity, comprising forming a lactone ring by hydrolyzing ethyl (3RS )-2,2-difluoro-3-hydroxy-3-(2,2-dimethyloxolan-4-yl)propionate is hydrolyzed in the presence of hydrolysis reagents selected from acetic acid or chloroacetic acid, water and a mixture of organic solvents selected from the group comprising acetonitrile, dioxane, tetrahydrofuran or toluene, in¬ troducing a substituted benzoyl protecting group at the 3-position and 5-position, and recrys- tallizing said erythro enantiomer. Further, the present invention provides a process for selectively preparing, in greater than 99% purity, a beta-anomer 2'-deoxy-2',2'-difluoronucleoside at the 3'-position and 5'-position that are protected by a substituted benzoyl in a 2:3 alpha/beta anomeric ratio.
摘要翻译：本发明涉及制备2'-脱氧-2'，2'-二氟核苷及其中间体的更加改进的方法。本发明提供制备纯度高于98％的赤式对映异构体的方法，包括通过水解（3RS）-2,2-二氟-3-羟基-3-（2,2-二甲基氧基-4- - 基）丙酸酯在选自乙酸或氯乙酸的水解试剂，水和选自乙腈，二恶烷，四氢呋喃或甲苯的有机溶剂的混合物存在下水解，在该溶剂中引入取代的苯甲酰基保护基 3位和5位，并重新显示所述红色对映异构体。此外，本发明提供了在大于99％的纯度中选择性地制备在3'-位和5'-位上的β-端基异构体2'-脱氧-2'，2'-二氟核苷的方法，其被 2：3α/β端基异构体取代的苯甲酰基。

3. 发明申请

WO2011118929A2 NOVEL CRYSTAL FORMS OF EPIRUBICIN HYDROCHLORIDE 审中-公开
标题翻译： EPIRUBICIN HYDROCHLORIDE的新型晶体形式
公开(公告)号：WO2011118929A2
公开(公告)日：2011-09-29
申请号：PCT/KR2011/001706
申请日：2011-03-11
申请人： DONG-A PHARM.CO.,LTD. , KIM, Moon-Sung , KIM, Soon-Hoe , CHOI, Jun-Ho , SUNG, Si-Young , LIM, Hong-Gyu , CHA, Dae-Won , SON, Byoung-Hwa , RYU, Ki-Moon
发明人： KIM, Moon-Sung , KIM, Soon-Hoe , CHOI, Jun-Ho , SUNG, Si-Young , LIM, Hong-Gyu , CHA, Dae-Won , SON, Byoung-Hwa , RYU, Ki-Moon
IPC分类号： C07H15/252 , A61P35/00
CPC分类号： C07H15/252
摘要： The present invention relates to the crystal form of Epirubicin hydrochloride stable against heat and water and the preparation method thereof. The novel crystal form has the physiochemical property stable against heat and water according to the present invention and it improves the excellent stability of the agents by preventing the relative substances from the one containing it. Furthermore, the crystal form of Epirubicin hydrochloride is suitable for mass production since it is easily prepared.
摘要翻译：本发明涉及耐热和水稳定的盐酸表柔比星的晶型及其制备方法。该新型结晶形式具有本发明的热和水稳定的物理化学性质，通过防止含有相对物质的相对物质，提高了其优异的稳定性。此外，盐酸表柔比星的结晶形式容易制备，因此适合批量生产。

4. 发明申请

WO2012115402A2 CRYSTALLINE FORM OF DOCETAXEL AND PROCESS FOR PREPARATION THEREOF 审中-公开
标题翻译： DOCETAXEL的结晶形式及其制备方法
公开(公告)号：WO2012115402A2
公开(公告)日：2012-08-30
申请号：PCT/KR2012/001238
申请日：2012-02-20
申请人： DONG-A PHARM.CO.,LTD. , SUNG, Si-Young , SON, Byoung-Hwa , RYU, Ki-Moon , KIM, Moon-Sung , KIM, Dong-Sung , KIM, Soon-Hoe
发明人： SUNG, Si-Young , SON, Byoung-Hwa , RYU, Ki-Moon , KIM, Moon-Sung , KIM, Dong-Sung , KIM, Soon-Hoe
IPC分类号： C07D305/14 , A61K31/337 , A61P35/00
CPC分类号： C07D305/14
摘要： The present invention relates to a novel anhydrous crystalline form of docetaxel. The novel anhydrous crystalline form of docetaxel according to the present invention is significant since it solves drawbacks the prior art such as stability and accompanying its relative substances increase. Moreover, the present invention provides a process for preparing the anhydrous crystalline form of docetaxel, which can solve the problems such as low yield, long processing time and low purity of the prior art. Also, the present invention provides a process for preparing the crystalline form of docetaxel trihydrates, which can solve the problems such as low yield, difficult reaction condition, long reaction time and time of drying. Therefore the crystalline form of docetaxel trihydrates is produced with the high yield in the mild condition by the process for preparing it.
摘要翻译：本发明涉及多西紫杉醇的新型无水结晶形式。根据本发明的多西紫杉醇的新型无水结晶形式是显着的，因为它解决了现有技术的缺点，例如稳定性和伴随其相对物质增加。此外，本发明提供了制备多西紫杉醇的无水结晶形式的方法，其可以解决现有技术的低产率，长处理时间和低纯度等问题。此外，本发明提供了制备多西他赛三水合物的结晶形式的方法，其可以解决低产率，难以反应条件，长反应时间和干燥时间等问题。因此，多烯紫杉醇三水合物的结晶形式通过其制备方法在温和条件下以高产率生产。

5. 发明申请

WO2007066963A1 METHOD FOR TRANSFERRING DATA FRAME END-TO-END USING VIRTUAL SYNCHRONIZATION ON LOCAL AREA NETWORK AND NETWORK DEVICES APPLYING THE SAME 审中-公开
标题翻译：使用本地区域网络虚拟同步端到端传输数据帧的方法及其应用的网络设备
公开(公告)号：WO2007066963A1
公开(公告)日：2007-06-14
申请号：PCT/KR2006/005216
申请日：2006-12-06
申请人： ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE , JOO, Seong-Soon , CHUNG, Young-Sik , PARK, Tae-Joon , LEE, Jin-Young , LEE, Yoo-Kyoung , JUNG, Hae-Won , BANG, Young-Cheol , KIM, Moon-Sung , LEE, Kang-Yong , LIM, Kyung-Mook
发明人： JOO, Seong-Soon , CHUNG, Young-Sik , PARK, Tae-Joon , LEE, Jin-Young , LEE, Yoo-Kyoung , JUNG, Hae-Won , BANG, Young-Cheol , KIM, Moon-Sung , LEE, Kang-Yong , LIM, Kyung-Mook
IPC分类号： H04L29/02
CPC分类号： H04L69/32 , H04L29/12047 , H04L61/15
摘要： A method for transferring data frame end-to-end in a local area network is provided. In the method, a virtual synch frame shaper is loaded on a frame transmission layer structure provided in end stations in transmitting and receiving sides, which transmits data frame passing through a plurality of Ethernet switches in the LAN. Then, slot counters, which are counted through the virtual synch frame shaper, are exchanged between the end stations, and the slot counters are synchronized. Afterward, the transmit time slot is allocated based on the synchronized slot counters for transmitting data frames between the end stations. Finally, data frames are transmitted based on the synchronized slot counters and the allocated transmit time slot.
摘要翻译：提供了一种在局域网中端到端传送数据帧的方法。在该方法中，将虚拟同步帧整形器加载到发送和接收侧的终端站中提供的帧传输层结构上，发送和接收侧发送通过LAN中的多个以太网交换机的数据帧。然后，通过虚拟同步帧整形器计数的时隙计数器在终端站之间交换，并且时隙计数器被同步。之后，基于用于在终端站之间发送数据帧的同步时隙计数器来分配发送时隙。最后，基于同步的时隙计数器和分配的发送时隙来发送数据帧。

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