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1. 发明申请

WO2014168458A1 USE OF COMPOUNDS ISOLATED FROM MORUS BARK 审中-公开
标题翻译：使用从MORUS BARK分离的化合物
公开(公告)号：WO2014168458A1
公开(公告)日：2014-10-16
申请号：PCT/KR2014/003163
申请日：2014-04-11
申请人： DONG WHA PHARM. CO., LTD.
发明人： CHANG, Hwan Bong , YOON, Joobyoung , LEE, Hyunyong , RHO, Yang Kook
IPC分类号： A61K31/05 , A61K31/045 , A61K36/605 , A61P3/10
CPC分类号： A61K36/605 , A23L33/105 , A61K31/352
摘要： The present invention relates to pharmaceutical composition for the prevention and treatment of diabetic complications, or health food, comprising Cathayanin B or Kuwanol A isolated from Morus Bark. The compound Cathayanin B according to the present invention is isolated from Morus Bark and inhibits the formation of advanced glycation end-products (AGEs), which cause diabetic complications, and inhibits aldose reductase activity. Kuwanol A, another compound isolated from Morus Bark, inhibits TGF-β1 signaling. Therefore, the pharmaceutical composition or health food comprising Cathayanin B or Kuwanol A according to the present invention can be used to inhibit diabetic nephritis, diabetic retinopathy, and diabetic neuropathy, which are diabetic complications. In particular, Kuwanol A can also be used for pharmaceutical composition for the prevention and treatment of various fibrosis and metastasis conditions as well as health food to improve said conditions.
摘要翻译：本发明涉及用于预防和治疗糖尿病并发症的药物组合物或保健食品，其包含从桑树分离的Cathayanin B或Kuwanol A。根据本发明的化合物Cathayanin B从桑树皮分离并抑制引起糖尿病并发症并抑制醛糖还原酶活性的晚期糖基化终产物（AGEs）的形成。 Kuwanol A，从Morus Bark分离的另一种化合物抑制TGF-β1信号传导。因此，根据本发明的包含Cathayanin B或Kuwanol A的药物组合物或保健食品可用于抑制作为糖尿病并发症的糖尿病性肾炎，糖尿病性视网膜病变和糖尿病性神经病变。特别地，Kuwanol A也可用于预防和治疗各种纤维化和转移病症的药物组合物以及保健食品以改善所述条件。

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