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1. 发明申请

WO2012118958A2 HAND-HELD FIXED-FOCUS OPTICAL PROBE 审中-公开
标题翻译：手持固定焦点光学探头
公开(公告)号：WO2012118958A2
公开(公告)日：2012-09-07
申请号：PCT/US2012027261
申请日：2012-03-01
申请人： DIAGNOSTIC PHOTONICS INC , BOPPART STEPHEN A , CARNEY PAUL SCOTT , CITTADINE ANDREW
发明人： BOPPART STEPHEN A , CARNEY PAUL SCOTT , CITTADINE ANDREW
IPC分类号： A61B5/00 , A61B17/24 , G01B9/02
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/0084 , G01B9/0203 , G01B9/0205 , G01B9/02063 , G01B9/02083 , G01B9/02091 , G01B2290/65
摘要： An intraoperative probe and a system for optically imaging a surgically significant volume of tissue or other scattering medium. An illumination source generates an illuminating beam that is conveyed to the vicinity of the tissue and a beam splitter, that may be no more than an optical phase reference, splits the illuminating beam into a sample beam along a sample beam path and a reference beam along a reference beam path. A scanning mechanism scans a portion of the sample beam across a section of the scattering medium, while a detector detects return beams from both the reference beam path and the sample beam path and generates an interference signal. A processor computationally moves an effective focus of the sample beam without physical variation of focus of the sample beam. The probe may have a sterilizable fairing that may be detachable.
摘要翻译：术中探针和用于光学地成像外科手术显着体积的组织或其它散射介质的系统。照明源产生被传送到组织附近的照明光束，并且可以不超过光相位参考的分束器将照明光束沿着样本光束路径和参考光束沿着样本光束分裂参考光束路径。扫描机构扫描样品束的一部分横跨散射介质的一部分，而检测器检测来自参考光束路径和样本光束路径的返回光束，并产生干涉信号。处理器计算地移动样本波束的有效焦点，而样品波束的焦点没有物理变化。探头可以具有可拆卸的可消毒整流罩。

2. 发明申请

WO2012102887A3 COMPUTATIONAL ADAPTIVE OPTICS FOR INTERFEROMETRIC SYNTHETIC APERTURE MICROSCOPY AND OTHER INTERFEROMETRIC IMAGING 审中-公开
标题翻译：用于干涉合成孔径显微镜和其他干涉成像的计算自适应光学
公开(公告)号：WO2012102887A3
公开(公告)日：2012-10-04
申请号：PCT/US2012021426
申请日：2012-01-16
申请人： UNIV ILLINOIS , ADIE STEVEN G , CARNEY PAUL SCOTT , BOPPART STEPHEN A
发明人： ADIE STEVEN G , CARNEY PAUL SCOTT , BOPPART STEPHEN A
IPC分类号： G01B9/02 , G01B9/04
CPC分类号： G06T11/008 , G02B21/0056
摘要： Methods for correcting for aberrations in the image or three-dimensional reconstruction of a sampled region obtained by broadband interferometry. The sampled region is illuminated with a broadband beam of light, and light returned from the sample is detected, along with a reference beam, in order to derive an interference signal for pixels of a volume spanned by wavenumber and axes transverse to the beam propagation direction. An optimization procedure is performed with respect to a specified criterion so as to obtain an aberration-corrected image of at least one plane of the sampled region, either in a plane-specific manner or in a space-invariant manner throughout the sampled region. A filter function, which may be derived from the interference signal attendant to irradiating a sparsely distributed plurality of point scatterers, or otherwise, corrects for a detected aberrated point spread function. Methods of the present invention may be used for aberration correction in reading information from an optical data storage medium.
摘要翻译：用于校正通过宽带干涉测量获得的采样区域的图像中的像差或三维重建的方法。用宽带光束照射采样区域，并且与参考光束一起检测从样本返回的光，以便导出由波数和横向于光束传播方向的轴的像素的干涉信号。针对特定标准执行优化过程，以便在整个采样区域以平面特定的方式或以空间不变的方式获得采样区域的至少一个平面的像差校正图像。可以从伴随照射稀疏分布的多个点散射体的干扰信号导出的滤波器功能，或以其他方式校正检测到的像差点扩展函数。本发明的方法可以用于从光学数据存储介质读取信息中的像差校正。

3. 发明申请

WO2008008774B1 INTERFEROMETRIC SYNTHETIC APERTURE MICROSCOPY 审中-公开
标题翻译：干涉合成孔径显微镜
公开(公告)号：WO2008008774B1
公开(公告)日：2008-07-24
申请号：PCT/US2007073146
申请日：2007-07-10
申请人： UNIV ILLINOIS , RALSTON TYLER S , MARKS DANIEL L , CARNEY PAUL SCOTT , BOPPART STEPHEN A
发明人： RALSTON TYLER S , MARKS DANIEL L , CARNEY PAUL SCOTT , BOPPART STEPHEN A
IPC分类号： G02B21/36
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of substantially collimated light characterized by a temporally dependent spectrum. The beam is focused in a plane characterized by a fixed displacement along the propagation axis of the beam, and scattered light from the sample is superposed with a reference beam derived from the substantially collimated source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measured data to structure of an object to allow solution of an inverse scattering problem based upon the interference signal so that a three-dimensional structure of the sample may be inferred in near real time.
摘要翻译：用于样品的三维成像的方法和设备。提供由时间依赖性频谱表征的基本准直光束的源。光束聚焦在沿着光束的传播轴以固定位移表征的平面中，并且来自样品的散射光与从基本上准直的光源导出的参考光束叠加到焦平面检测器阵列上以提供干涉信号。推导出前向散射模型，其将测量数据与物体的结构相关联，以允许基于干涉信号解决逆散射问题，从而可近实时地推断出样品的三维结构。

4. 发明申请

WO2008008774A3 INTERFEROMETRIC SYNTHETIC APERTURE MICROSCOPY 审中-公开
公开(公告)号：WO2008008774A3
公开(公告)日：2008-05-15
申请号：PCT/US2007073146
申请日：2007-07-10
申请人： UNIV ILLINOIS , RALSTON TYLER S , MARKS DANIEL L , CARNEY PAUL SCOTT , BOPPART STEPHEN A
发明人： RALSTON TYLER S , MARKS DANIEL L , CARNEY PAUL SCOTT , BOPPART STEPHEN A
IPC分类号： G02B21/36
CPC分类号： G02B21/0056 , G01N21/4795 , G02B21/0064 , G02B27/58
摘要： Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of substantially collimated light characterized by a temporally dependent spectrum. The beam is focused in a plane characterized by a fixed displacement along the propagation axis of the beam, and scattered light from the sample is superposed with a reference beam derived from the substantially collimated source onto a focal plane detector array to provide an interference signal. A forward scattering model is derived relating measured data to structure of an object to allow solution of an inverse scattering problem based upon the interference signal so that a three-dimensional structure of the sample may be inferred in near real time.

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