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1. 发明申请

WO1996014399A1 PORCINE STRIATAL CELLS AND THEIR USE IN TREATMENT OF NEUROLOGICAL DEFICITS DUE TO NEURODEGENERATIVE DISEASE 审中-公开
标题翻译： PORCINE STRIATAL细胞及其用于治疗神经病变疾病的神经缺陷的用途
公开(公告)号：WO1996014399A1
公开(公告)日：1996-05-17
申请号：PCT/US1995014453
申请日：1995-11-07
申请人： DIACRIN, INC. , THE MCLEAN HOSPITAL CORPORATION
发明人： DIACRIN, INC. , THE MCLEAN HOSPITAL CORPORATION , ISACSON, Ole , DINSMORE, Jonathan
IPC分类号： C12N05/06
CPC分类号： C12N5/0618 , A61K35/30 , A61K38/13 , A61K39/001 , A61K2035/122 , C07K16/2833 , C07K2317/54 , Y10S424/809 , A61K2300/00
摘要： Porcine striatal cells and methods for using the cells to treat neurological deficits due to neurodegeneration are described. The porcine striatal cells can be modified to be suitable for transplantation into a xenogeneic subject, such as a human. For example, the porcine striatal cells can be modified such that an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in a xenogeneic subject is altered (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof) to inhibit rejection of the cell when introduced into the subject. In one embodiment, the porcine striatal cells are obtained from a pig which is essentially free from organisms or substances which are capable of transmitting infection or disease to the recipient subject. The porcine striatal cells of the present invention can be used to treat neurological deficits due to neurodegeneration in the brain of a xenogeneic subject (e.g., a human with epilepsy, head trauma, stroke, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, or Huntington's disease) by introducing the cells into the brain of the subject.
摘要翻译：描述了猪纹状体细胞和使用细胞治疗由于神经变性引起的神经缺陷的方法。猪纹状体细胞可以被修饰为适合于移植到异种受试者（例如人）中。例如，可以修饰猪纹状体细胞，使得在异种受试者中能够刺激针对细胞的免疫应答的细胞表面上的抗原（例如MHC I类抗原）被改变（例如，通过与抗MHC I类抗体或其片段或衍生物），以抑制当引入受试者时细胞的排斥反应。在一个实施方案中，猪纹状体细胞从基本上不含能够将感染或疾病传播给接受者的生物或物质的猪获得。本发明的猪纹状体细胞可用于治疗异种受试者的脑部神经变性（例如，患有癫痫，头部创伤，中风，肌萎缩性侧索硬化，帕金森病，阿尔茨海默病或亨廷顿病疾病）通过将细胞引入受试者的脑中。

2. 发明申请

WO2003080798A3 MUSCLE CELLS AND THEIR USE IN CARDIAC REPAIR 审中-公开
公开(公告)号：WO2003080798A3
公开(公告)日：2003-10-02
申请号：PCT/US2003/008518
申请日：2003-03-20
申请人： DIACRIN, INC. , EDGE, Albert , DINSMORE, Jonathan
发明人： EDGE, Albert , DINSMORE, Jonathan
IPC分类号： C12N5/00
摘要： Muscle cells and methods for using the muscle cells are provided. In one embodiment, the invention provides transplantable skeletal muscle cell compositions and their methods of use. In one embodiment, the muscle cells can be transplanted into patients having disorders characterized by insufficient cardiac function, e.g. , congestive heart failure, in a subject by administering the skeletal myoblasts to the subject. The muscle cells can be autologous, allogeneic, or xenogeneic to the recipient.

3. 发明申请

WO1996014397A1 PORCINE CORTICAL CELLS AND THEIR USE IN TREATMENT OF NEUROLOGICAL DEFICITS DUE TO NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：磷酸钙细胞及其用于治疗神经病变疾病的神经缺陷
公开(公告)号：WO1996014397A1
公开(公告)日：1996-05-17
申请号：PCT/US1995014451
申请日：1995-11-07
申请人： DIACRIN, INC.
发明人： DIACRIN, INC. , DINSMORE, Jonathan
IPC分类号： C12N05/06
CPC分类号： C12N5/0618 , A61K35/30 , A61K38/13 , A61K39/001 , A61K2035/122 , C07K16/2833 , C07K2317/54 , A61K2300/00
摘要： Porcine cortical cells and methods for using the cells to treat neurological deficits due to neurodegeneration are described. The porcine cortical cells can be modified to be suitable for transplantation into a xenogeneic subject, such as a human. For example, the porcine cortical cells can be modified such that an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in a xenogeneic subject is altered (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof) to inhibit rejection of the cell when introduced into the subject. In one embodiment, the porcine cortical cells are obtained from a pig which is essentially free from organisms or substances which are capable of transmitting infection or disease to the recipient subject. The porcine cortical cells of the present invention can be used to treat neurological deficits due to neurodegeneration in the brain of a xenogeneic subject (e.g., a human with epilepsy, head trauma, stroke, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, or Huntington's disease) by introducing the cells into the brain of the subject.
摘要翻译：描述了猪皮质细胞和使用细胞治疗由于神经变性引起的神经功能缺损的方法。猪皮质细胞可以被修饰为适合于移植到异种受试者（例如人）中。例如，可以修饰猪皮层细胞，使得在异种受试者中能够刺激针对细胞的免疫应答的细胞表面上的抗原（例如，MHC I类抗原）被改变（例如，通过与抗MHC I类抗体或其片段或衍生物），以抑制当引入受试者时细胞的排斥反应。在一个实施方案中，猪皮质细胞从基本上不含能够将感染或疾病传播给受试者的生物或物质的猪获得。本发明的猪皮质细胞可用于治疗异种受试者（例如，癫痫患者，头部外伤，中风，肌萎缩性侧索硬化，帕金森病，阿尔茨海默病或亨廷顿舞蹈症）的神经变性引起的神经缺陷疾病）通过将细胞引入受试者的脑中。

4. 发明申请

WO2003080798A2 MUSCLE CELLS AND THEIR USE IN CARDIAC REPAIR 审中-公开
标题翻译：肌肉细胞及其在心脏修复中的应用
公开(公告)号：WO2003080798A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/008518
申请日：2003-03-20
申请人： DIACRIN, INC. , EDGE, Albert , DINSMORE, Jonathan
发明人： EDGE, Albert , DINSMORE, Jonathan
IPC分类号： C12N
CPC分类号： C12N5/0658 , A61K35/12 , C12N5/0656 , C12N5/0657 , C12N2501/11 , C12N2501/60 , C12N2510/00
摘要： Muscle cells and methods for using the muscle cells are provided. In one embodiment, the invention provides transplantable skeletal muscle cell compositions and their methods of use. In one embodiment, the muscle cells can be transplanted into patients having disorders characterized by insufficient cardiac function, e.g. , congestive heart failure, in a subject by administering the skeletal myoblasts to the subject. The muscle cells can be autologous, allogeneic, or xenogeneic to the recipient.
摘要翻译：提供肌肉细胞和使用肌肉细胞的方法。在一个实施方案中，本发明提供可移植的骨骼肌细胞组合物及其使用方法。在一个实施方案中，通过向受试者施用骨骼成肌细胞，肌肉细胞可以移植到患有特征在于心脏功能不足（例如充血性心力衰竭）的病症的患者中。肌肉细胞可以是自体的，同种异体的或异种的接受者。

5. 发明申请

WO1996012794A2 ISOLATED PORCINE PANCREATIC CELLS FOR USE IN TREATMENT OF DISEASES CHARACTERIZED BY INSUFFICIENT INSULIN ACTIVITY 审中-公开
标题翻译：用于治疗由绝经胰岛素活性表征的疾病的分离的PORCINE胰腺细胞
公开(公告)号：WO1996012794A2
公开(公告)日：1996-05-02
申请号：PCT/US1995012877
申请日：1995-10-18
申请人： DIACRIN, INC.
发明人： DIACRIN, INC. , DINSMORE, Jonathan
IPC分类号： C12N05/06
CPC分类号： C12N5/0678 , A61K35/12 , A61K35/39 , A61K39/35 , Y10S514/866
摘要： Isolated porcine pancreatic cells, isolated populations of such cells and methods for isolating and using the cells to treat subjects with diseases characterized by insufficient insulin activity are described. The porcine pancreatic cells are preferably non-insulin-secreting porcine pancreatic cell having the ability to differentiate into aninsulin-secreting cell upon introduction into a xenogeneic subject, such as a human subject. Such cells include embryonic porcine pancreatic cells obtained from embryonic pigs between about day 31 and day 35 of gestation. The porcine pancreatic cells can be modified to be suitable for transplantation into a xenogeneic subject, for example, by altering an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in the subject (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof). The isolated porcine pancreatic cells of the invention can be used to treat diseases characterized by insufficient insulin activity, e.g., Type I and Type II diabetes, by administering the cells to a subject having such a disease.
摘要翻译：描述了分离的猪胰腺细胞，分离的这种细胞群体以及用于分离和使用细胞治疗以胰岛素活性不足为特征的疾病的受试者的方法。猪胰腺细胞优选是非胰岛素分泌型猪胰腺细胞，其在引入异种受试者如人受试者时具有分化成胰岛素分泌细胞的能力。这样的细胞包括在妊娠约31天和第35天之间从胚胎猪获得的胚胎猪胰腺细胞。猪胰腺细胞可以被修饰为适合于移植到异种受试者中，例如通过改变细胞表面上的能够刺激细胞免疫应答的抗原（例如MHC I类抗原）受试者（例如，通过与抗MHC I类抗体或其片段或衍生物接触）。本发明的分离的猪胰腺细胞可以通过向具有这种疾病的受试者施用细胞来治疗以胰岛素活性不足为特征的疾病，例如I型和II型糖尿病。

6. 发明申请

WO1996038544A1 PORCINE CARDIOMYOCYTES AND THEIR USE IN TREATMENT OF INSUFFICIENT CARDIAC FUNCTION 审中-公开
标题翻译： PORCINE CARDIOMYOCYTES及其在治疗不良心脏功能中的应用
公开(公告)号：WO1996038544A1
公开(公告)日：1996-12-05
申请号：PCT/US1996007894
申请日：1996-05-29
申请人： DIACRIN, INC.
发明人： DIACRIN, INC. , DINSMORE, Jonathan
IPC分类号： C12N05/06
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0657
摘要： Porcine cardiomyocytes and methods for using the cardiomyocytes to treat disorders characterized by insufficient cardiac function are described. The porcine cardiomyocytes are preferably embryonic porcine cardiomyocytes. The porcine cardiomyocytes can be modified to be suitable for transplantation into a xenogeneic subject, such as a human. For example, the porcine cardiomyocytes can be modified such that an antigen (e.g., an MHC class I antigen) on the cardiomyocyte surface which is capable of stimulating an immune response against the cardiomyocytes in a xenogeneic subject is altered (e.g., by contact with an anti-MHC class I antibody, or a fragment or derivative thereof) to inhibit rejection of the cardiomyocyte when introduced into the subject. In one embodiment, the porcine cardiomyocytes are obtained from a pig which is essentially free from organisms or substances which are capable of transmitting infection or disease to the recipient subject. The porcine cardiomyocytes of the present invention can be used to treat disorders characterized by insufficient cardiac function, e.g., congestive heart failure, in a xenogeneic subject by administering the cardiomyocytes to the subject.
摘要翻译：描述了猪心肌细胞和使用心肌细胞治疗以心脏功能不足为特征的疾病的方法。猪心肌细胞优选是胚胎猪心肌细胞。猪心肌细胞可以被修饰为适合于移植到异种受试者（例如人）中。例如，可以修饰猪心肌细胞，使得能够刺激对异种受试者中的心肌细胞的免疫应答的心肌细胞表面上的抗原（例如，MHC I类抗原）被改变（例如，通过与抗MHC I类抗体或其片段或衍生物），以在被引入受试者时抑制心肌细胞的排斥。在一个实施方案中，猪心肌细胞从基本上不含能够将感染或疾病传播给受试者的生物或物质的猪获得。本发明的猪心肌细胞可用于通过向受试者施用心肌细胞来治疗异种受试者的特征在于心脏功能不足（例如充血性心力衰竭）的病症。

7. 发明申请

WO1996014398A1 PORCINE MESENCEPHALIC CELLS AND THEIR USE IN TREATMENT OF NEUROLOGICAL DEFICITS DUE TO NEURODEGENERATIVE DISEASES 审中-公开
标题翻译： PORCINE MESENCEPHALIC细胞及其用于治疗神经病变性疾病的神经缺陷
公开(公告)号：WO1996014398A1
公开(公告)日：1996-05-17
申请号：PCT/US1995014452
申请日：1995-11-07
申请人： DIACRIN, INC.
发明人： DIACRIN, INC. , FRASER, Thomas , DINSMORE, Jonathan
IPC分类号： C12N05/06
CPC分类号： C12N5/0618 , A61K35/30 , A61K38/13 , A61K39/001 , A61K2035/122 , C07K16/2833 , C07K2317/54 , A61K2300/00
摘要： Porcine mesencephalic cells and methods for using the cells to treat neurological deficits due to neurodegeneration are described. The porcine mesencephalic cells can be modified to be suitable for transplantation into a xenogeneic subject, such as a human. For example, the porcine mesencephalic cells can be modified such that an antigen (e.g., an MHC class I antigen) on the cell surface which is capable of stimulating an immune response against the cell in a xenogeneic subject is altered (e.g., by contact with an anti-MHC class I antibody, or a fragment of derivative thereof) to inhibit rejection of the cell when introduced into the subject. In one embodiment, the porcine mesencephalic cells are obtained from a pig which is essentially free from organisms or substances which are capable of transmitting infection or disease to the recipient subject. The porcine mesencephalic cells of the present invention can be used to treat neurological deficits due to neurodegeneration in the brain of a xenogeneic subject (e.g., a human with epilepsy, head trauma, stroke, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, or Huntington's disease) by introducing the cells into the brain of the subject.
摘要翻译：描述了猪中脑细胞和使用细胞治疗神经变性引起的神经功能缺损的方法。猪中脑细胞可以被修饰为适合于移植到异种受试者（例如人）中。例如，可以对猪中脑细胞进行修饰，使得在异种受试者中能够刺激对细胞的免疫应答的细胞表面上的抗原（例如，MHC I类抗原）被改变（例如，通过与抗MHC I类抗体或其衍生物的片段），以抑制当引入受试者时细胞的排斥反应。在一个实施方案中，猪中脑细胞从基本上没有能够将感染或疾病传播给受试者的生物或物质的猪获得。本发明的猪中脑细胞可用于治疗异种受试者（例如，患有癫痫，头部创伤，中风，肌萎缩性侧索硬化，帕金森氏病，阿尔茨海默氏病或亨廷顿舞蹈病的脑中的神经变性的神经缺陷）疾病）通过将细胞引入受试者的脑中。

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