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1. 发明申请

WO2007004952A1 ANTIMICROBIAL AND ANTIINFLAMMATORY COMPOSITION 审中-公开
标题翻译：抗微生物和抗炎组合物
公开(公告)号：WO2007004952A1
公开(公告)日：2007-01-11
申请号：PCT/SE2006/000802
申请日：2006-06-30
申请人： DENOVASTELLA AB , FAERGEMANN, Jan , HEDNER, Thomas , STERNER, Olov , BJÖRK, Lars
发明人： FAERGEMANN, Jan , HEDNER, Thomas , STERNER, Olov , BJÖRK, Lars
IPC分类号： A61K31/352 , A61K36/28 , A61K36/282 , A61K36/85 , A61P31/00 , A01N43/16 , A01N65/00 , A01P1/00 , A61K8/97
CPC分类号： A61K31/352 , A61K8/0208 , A61K8/11 , A61K8/4973 , A61K8/498 , A61K8/97 , A61K31/047 , A61K31/341 , A61K31/343 , A61K36/28 , A61K36/282 , A61Q5/006 , A61Q5/02 , A61Q17/005 , A61Q19/00 , A61Q19/10 , A61K2300/00
摘要： The invention relates to the use of at least davanone and 1,8-cineol for the manufacture of an antimicrobial and/or antiinflammatory composition as well as a method of producing said composition.
摘要翻译：本发明涉及至少使用大分子酮和1,8-桉树脑来制造抗微生物剂和/或抗炎组合物以及生产所述组合物的方法。

2. 发明申请

WO2007063065A1 USE OF A COMPOSITION COMPRISING PENTANE-1, 5-DIOL AS DEODORANT 审中-公开
标题翻译：使用包含PENTANE-1，5-DIOL作为除臭剂的组合物
公开(公告)号：WO2007063065A1
公开(公告)日：2007-06-07
申请号：PCT/EP2006/069007
申请日：2006-11-28
申请人： AMBRIA DERMATOLOGY AB , FAERGEMANN, Jan , STERNER, Olov , HEDNER, Thomas
发明人： FAERGEMANN, Jan , STERNER, Olov , HEDNER, Thomas
IPC分类号： A01N31/02 , A61K8/02 , A61K8/34 , A61L9/01 , A61L9/14 , A61L15/20 , A61L15/46 , A61Q15/00
CPC分类号： A61L9/01 , A61K8/0208 , A61K8/345 , A61K2800/52 , A61K2800/70 , A61L9/145 , A61L15/20 , A61L15/46 , A61L2209/22 , A61L2300/404 , A61L2300/406 , A61L2300/408 , A61Q15/00
摘要： The present invention relates to the use of a composition comprising pentane-1, 5-diol to reduce and/or eliminate odour from a mammal, such as odour from such as urine, faeces, liquids from leg ulcers, decubital ulcers, blood and perspiration. The invention also relates to absorbent and/or sanitary products comprising pentane-1, 5- diol.
摘要翻译：本发明涉及包含戊烷-1,5-二醇的组合物用于减少和/或消除哺乳动物气味的用途，例如尿液，粪便，来自腿部溃疡的液体，褥疮溃疡，血液和排汗。本发明还涉及包含戊烷-1,5-二醇的吸收剂和/或卫生产品。

3. 发明申请

WO2006057616A1 A COMPOSITION COMPRISING AT LEAST 3 DIFFERENT DIOLS 审中-公开
标题翻译：一种包含至少3种不同成分的组合物
公开(公告)号：WO2006057616A1
公开(公告)日：2006-06-01
申请号：PCT/SE2005/001787
申请日：2005-11-29
申请人： AMBRIA DERMATOLOGY AB , FAERGEMANN, Jan , HEDNER, Thomas
发明人： FAERGEMANN, Jan , HEDNER, Thomas
IPC分类号： A61K31/047 , A01P3/00 , A61K8/34 , A61P31/04 , A61P31/12 , A01N31/02
CPC分类号： A61Q17/005 , A01N31/02 , A61K8/345 , A61K31/047 , A61K2800/524 , A61K2800/59 , A61Q19/00 , A01N2300/00
摘要： The present invention relates to a composition comprising at least 3 different diols, wherein said diols have the general structure (CH2)nH2O2, wherein n is the number of CH2 and being between 3 to 10, in a total amount of from about 0.1 to about 50 % (v/v), a method for producing the composition and its use, such as in therapy. The composition may be a pharmaceutical, cosmetic, antimicrobial or preservative composition. The composition is useful in inactivating microorganisms or preventing their growth.
摘要翻译：本发明涉及包含至少3种不同二醇的组合物，其中所述二醇具有通式结构（CH 2）n H 2 O 2，其中n是CH 2的数目，在3至10之间，总量为约0.1至约 50％（v / v），一种生产该组合物的方法及其用途，如治疗。组合物可以是药物，化妆品，抗微生物剂或防腐剂组合物。该组合物可用于灭活微生物或防止其生长。

4. 发明申请

WO2008119518A1 USE OF OLIGOMERS OF LACTIC ACID IN THE TREATMENT OF GYNAECOLOGICAL DISORDERS 审中-公开
标题翻译：使用乳酸低聚物治疗妇科疾病
公开(公告)号：WO2008119518A1
公开(公告)日：2008-10-09
申请号：PCT/EP2008/002505
申请日：2008-03-28
申请人： LACCURE AB , BATCHELLER, Greg , HEDNER, Thomas , JOHNSSON, Jörgen , SCHUBERT, Werner , SJÖGREN, Christer , STERNER, Olov , SZNITOWSKA, Malgorzat
发明人： BATCHELLER, Greg , HEDNER, Thomas , JOHNSSON, Jörgen , SCHUBERT, Werner , SJÖGREN, Christer , STERNER, Olov , SZNITOWSKA, Malgorzat
IPC分类号： A61K31/19 , A61K31/74 , A61K31/765 , A61P15/02
CPC分类号： C07C69/34 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/06 , A61K9/19 , A61K31/19 , A61K31/74 , A61K31/765 , A61K45/06 , A61K47/10 , A61K47/38 , A61K2300/00
摘要： Use of the one or more oligomers of lactic acid with the following formula (I) wherein n is an integer from 2 to 25 such as, e.g., from 2 to 20, from 3 to 25, from 3 to 20, from 2 to 15, from 3 to 15, from 2 to 10, from 3 to 10, from 4 to 10, or from 4 to 9 or a lactic acid oligomeric product for the prophylaxis and/or treatment of a disease or condition that benefit of an acidic environment especially a gynaecological infection such as a bacterial infection, such as bacterial vaginosis, unspecific colpitis, senile colpitis, cervicitis, and urethritis, a fungal infection, such as candidosis (Candida albicans), cryptococcosis, actinomycosis, or a viral infection, such as Human lmmunodefiency Virus (HIV), Herpes Simplex Virus (HSV), Human Papilloma Virus (HPV).
摘要翻译：使用一种或多种具有下式（I）的乳酸低聚物，其中n为2至25的整数，例如2至20,3至25，3至20，2至15 ，3至15，2至10，3至10，4至10，或4至9或用于预防和/或治疗有利于酸性环境的疾病或病症的乳酸低聚产物特别是诸如细菌性阴道炎，非特异性阴道炎，老年性阴道炎，子宫颈炎和尿道炎等细菌感染的妇科感染，真菌感染如念珠菌（白念珠菌），隐球菌病，放线菌病或病毒感染，如人免疫缺陷病毒（HIV），单纯疱疹病毒（HSV），人乳头状瘤病毒（HPV）。

5. 发明申请

WO2003035021A1 POTENTIATED TOPICAL COMPOSITION 审中-公开
标题翻译：潜在的局部组成
公开(公告)号：WO2003035021A1
公开(公告)日：2003-05-01
申请号：PCT/SE2002/001908
申请日：2002-10-18
申请人： FAERGEMANN, Jan , HEDNER, Thomas
发明人： FAERGEMANN, Jan , HEDNER, Thomas
IPC分类号： A61K7/40
CPC分类号： A61K8/345 , A61K8/0208 , A61K9/0014 , A61K47/10 , A61Q1/06 , A61Q19/00 , A61Q19/007
摘要： A topical composition for skin care or administration of a pharmacologically active agent in form of a lotion, cream or similar comprises from 5 % to 70 % by weight of pentane-1,5-diol and a cosmetically or pharmaceutically acceptable carrier, with the proviso that the composition does not comprise polysiloxane, volatile siloxane, phosphatidylcholine, creatine, carnitine, panthenol, pyruvic acid, monoglyceride of lauric acid, monoglyceride of myristic acid. Also disclosed are corresponding methods of administration, a patch for holding said composition against the skin, and methods for preventing or treating a dry skin condition and of keeping skin in a humid state.
摘要翻译：用于皮肤护理或施用洗剂，乳膏或类似物形式的药理活性剂的局部组合物包含5重量％至70重量％的戊烷-1,5-二醇和化妆品或药学上可接受的载体，其条件是组合物不包含聚硅氧烷，挥发性硅氧烷，磷脂酰胆碱，肌酸，肉毒碱，泛醇，丙酮酸，月桂酸单甘油酯，肉豆蔻酸单甘油酯。还公开了相应的施用方法，用于将所述组合物保持在皮肤上的贴剂，以及用于预防或治疗干性皮肤病症并保持皮肤处于潮湿状态的方法。

6. 发明申请

WO2004112765A1 METHOD FOR INHIBITING THE GROWTH OF ANTIBIOTIC-RESISTANT OF BACTERIA BY USING PENTANE-1,5-DIOL 审中-公开
标题翻译：通过使用PENTANE-1,5-DIOL抑制细菌抗菌生长的方法
公开(公告)号：WO2004112765A1
公开(公告)日：2004-12-29
申请号：PCT/SE2004/001001
申请日：2004-06-23
申请人： FAERGEMANN, Jan , HEDNER, Thomas
发明人： FAERGEMANN, Jan , HEDNER, Thomas
IPC分类号： A61K31/045
CPC分类号： A01N31/02 , A61K9/7007 , A61K31/045 , A61L2/0088 , Y02A50/473 , Y10T442/2525
摘要： A method for inhibiting the growth of multiple-resistant bacteria comprises the topical administration of a pharmaceutical composition comprising 15% by weight or more of pentane-1,5-diol and a pharmaceutical acceptable carrier. Also disclosed is a method of preparing a corresponding medicament. A method of disinfecting a surface contaminated with multiple-resistant bacteria comprises providing a disinfecting composition comprising 15% or more by weight of pentane-1,5-diol and an aqueous carrier, applying the composition to the surface; optionally, keeping it in contact with the surface for a period of time from 5 min to 24 hrs at ambient temperature, and rinsing the surface with water or an aqueous detergent composition. Also disclosed is the use of a corresponding bacteriostatic composition.
摘要翻译：抑制多重耐药细菌生长的方法包括局部施用包含15重量％或更多戊烷-1,5-二醇和药学上可接受的载体的药物组合物。还公开了制备相应药物的方法。消毒被多重耐药细菌污染的表面的方法包括提供包含15重量％或更多的戊烷-1,5-二醇和水性载体的消毒组合物，将组合物施用于表面; 任选地，在环境温度下保持其与表面接触5分钟至24小时的时间段，并用水或含水洗涤剂组合物冲洗该表面。还公开了使用相应的抑菌组合物。

7. 发明申请

WO2010115615A1 IMPROVED GLUCOCORTICOID THERAPY 审中-公开
标题翻译：改善GLUCOCORTICOID治疗
公开(公告)号：WO2010115615A1
公开(公告)日：2010-10-14
申请号：PCT/EP2010/002178
申请日：2010-04-07
申请人： DUOCORT PHARMA AB , LENNERNÄS, Hans , JOHNSSON, Jörgen , HEDNER, Thomas , JOHANNSSON, Gudmundur , SKRTIC, Stanko
发明人： LENNERNÄS, Hans , JOHNSSON, Jörgen , HEDNER, Thomas , JOHANNSSON, Gudmundur , SKRTIC, Stanko
IPC分类号： A61K31/573 , A61P5/44
CPC分类号： A61K31/573 , A61K9/28 , A61K47/38
摘要： The present invention relates to improved glucocorticoid therapy and to treatment or prevention of a number of disorders that are due to a diminished or disrupted endogenous glucocorticoid secretory pattern. The invention is based on the findings that producing a specific serum Cortisol time profile that mimics the circadian rhythm of Cortisol of a healthy subject in a subject suffering from a diminished or disrupted glucocorticoid secretory pattern gives benefits with respect to reduction of side-effects.
摘要翻译：本发明涉及改善的糖皮质激素治疗以及治疗或预防由于内源性糖皮质激素分泌模式减少或破坏引起的许多病症。本发明基于以下发现：产生特异性血清皮质醇时间曲线，其模拟在患有糖皮质激素分泌模式减少或破坏的受试者中健康受试者的皮质醇的昼夜节律，从而有助于减少副作用。

8. 发明申请

WO2005102287A2 Pharmaceutical compositions for acute glucocorticoid therapy 审中-公开
标题翻译：急性糖皮质激素治疗药物组合物
公开(公告)号：WO2005102287A2
公开(公告)日：2005-11-03
申请号：PCT/EP2005/004399
申请日：2005-04-21
申请人： DUOCORT AB , SKRTIC, Stanko , JOHNSSON, Jörgen , LENNERNÄS, Hans , HEDNER, Thomas , JOHANNSSON, Gudmundur
发明人： SKRTIC, Stanko , JOHNSSON, Jörgen , LENNERNÄS, Hans , HEDNER, Thomas , JOHANNSSON, Gudmundur
IPC分类号： A61K9/20
CPC分类号： A61K9/0095 , A61K9/006 , A61K9/2018 , A61K9/5078 , A61K9/7007 , A61K31/00 , A61K31/573
摘要： The present invention relates to glucocorticoid-containing pharmaceutical compositions or kits for use in acute emergency situations where acute glucocorticoid therapy is required. Notably, the invention relates to pharmaceutical compositions and kits that are designed to be administered by non-medically trained persons outside a hospital or another medical or clinical setting. The invention also relates to a method for treating a disorder requiring acute glucocorticoid therapy by providing a fast onset of action of a glucocorticoid
摘要翻译：本发明涉及用于需要急性糖皮质激素治疗的急性紧急情况下的含糖皮质激素的药物组合物或试剂盒。值得注意的是，本发明涉及被设计为由医院外的非医学训练者或其他医学或临床环境施用的药物组合物和试剂盒。本发明还涉及通过提供糖皮质激素的快速起效来治疗需要急性糖皮质激素治疗的疾病的方法

9. 发明申请

WO2005102271A2 PHARMACEUTICAL COMPOSITIONS FOR GLUCOCORTICOID REPLACEMENT THERAPY 审中-公开
标题翻译：用于葡萄糖替代治疗的药物组合物
公开(公告)号：WO2005102271A2
公开(公告)日：2005-11-03
申请号：PCT/EP2005/004400
申请日：2005-04-21
申请人： DUOCORT AB , SKRTIC, Stanko , JOHNSSON, Jörgen , LENNERNÄS, Hans , HEDNER, Thomas , JOHANNSSON, Gudmundur
发明人： SKRTIC, Stanko , JOHNSSON, Jörgen , LENNERNÄS, Hans , HEDNER, Thomas , JOHANNSSON, Gudmundur
IPC分类号： A61K9/00
CPC分类号： A61K31/573 , A61K9/2031 , A61K9/209 , A61K9/28
摘要： The invention relates to glucocorticoid replacement therapy and provides pharmaceutical compositions and kits designed to deliver one or more glucocorticoids to a subject in need thereof in a manner that results in serum levels of the glucocorticoid that essentially mimic that of a healthy subject for a clinically relevant period of time. The pharmaceutical composition comprises one or more glucocorticoids, wherein a first part of one or more glucocorticoids is substantially immediately released and a second part of one or more glucocorticoids is released over an extended period of time of at least about 8 hours, and the amount of the one or more glucocorticoids of the first part, expressed as hydrocortisone equivalents, is in a range of from about 15 to about 50% of the total hydrocortisone equivalents. The invention also relates to a kit comprising a first and a second component, the first component designed to release one or more glucocorticoids substantially immediately and the second component is designed to release one or more glucocorticoids over an extended period of time of at least 8 hours. The invention also relates to a method for treating diseases requiring glucocorticoid treatment such as in subjects having a glucocorticoid deficiency disorder. In another aspect the invention relates to the use of a first and a second amount of one or more glucocorticoids for the preparation of a pharmaceutical composition or kit for the treatment of a glucocorticoid deficiency disorder.
摘要翻译：本发明涉及糖皮质激素替代疗法，并且提供药物组合物和试剂盒，其设计用于将一种或多种糖皮质激素递送至有需要的受试者，其方式使得糖皮质激素的血清水平基本上模拟健康受试者在临床相关期间的时间。药物组合物包含一种或多种糖皮质激素，其中一种或多种糖皮质激素的第一部分基本上立即释放，并且一种或多种糖皮质激素的第二部分在至少约8小时的延长时间内释放，表示为氢化可的松当量的第一部分的一种或多种糖皮质激素在总氢化可的松当量的约15至约50％的范围内。本发明还涉及包含第一和第二组分的试剂盒，第一组分被设计成基本上立即释放一种或多种糖皮质激素，并且第二组分被设计成在至少8小时的延长的时间段内释放一种或多种糖皮质激素。本发明还涉及治疗需要糖皮质激素治疗的疾病的方法，例如具有糖皮质激素缺乏症的受试者。在另一方面，本发明涉及第一和第二量的一种或多种糖皮质激素在制备用于治疗糖皮质激素缺乏症的药物组合物或试剂盒中的用途。

10. 发明申请

WO2011144327A1 POSOLOGY AND ADMINISTRATION OF GLUCOCORTICOID BASED COMPOSITIONS 审中-公开
标题翻译：基于GLUCOCORTICOID的组合物的生物学和药理学
公开(公告)号：WO2011144327A1
公开(公告)日：2011-11-24
申请号：PCT/EP2011/002466
申请日：2011-05-18
申请人： DUOCORT PHARMA AB , HEDNER, Thomas , SIMONSSON, Ulrika, Sigrida, Helena , JOHANNSSON, Gudmundur , LENNERNÄS, Hans , SKRTIC, Stanko
发明人： HEDNER, Thomas , SIMONSSON, Ulrika, Sigrida, Helena , JOHANNSSON, Gudmundur , LENNERNÄS, Hans , SKRTIC, Stanko
IPC分类号： A61K31/573 , A61P5/44 , A61K9/00
CPC分类号： A61K31/573 , A61K9/2009 , A61K9/2013 , A61K9/2054 , A61K9/2059 , A61K9/209 , A61K9/28 , G01N33/743
摘要： The present invention relates to an improved method of administration of glucocorticoid based compositions in glucocorticoid replacement therapies enabling an objectively based regimen for administration enabling correct individual dosing of glucocorticoids resulting in an optimised individual replacement therapy and thus an improved long-term outcome for patients with temporary or chronic adrenal insufficiency.
摘要翻译：本发明涉及一种在糖皮质激素替代疗法中施用基于糖皮质激素的组合物的改进方法，其使得能够基于客观的方案进行给药，从而能够对糖皮质激素进行正确的个体给药，从而导致优化的个体替代疗法，从而改善临时患者的长期结果或慢性肾上腺功能不全。

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